Down-regulation of Notch1 signaling inhibits tumor growth in human hepatocellular carcinoma

American Journal of Translational Research

Volumn 1, Issue 4, 2009, Pages 358-366

  Ning, Li ^a   Wentworth, Lucy ^a   Chen, Herbert ^a   Weber, Sharon M ^a,b,c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^c University of Wisconsin Health   (United States)

Author keywords

Apoptosis; Curcumin; Hepatocellular carcinoma; Notch 1

Indexed keywords

CURCUMIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NOTCH1 RECEPTOR; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; WESTERN BLOTTING;

MUS MUSCULUS;

EID: 77953457718     PISSN: None     EISSN: 19438141     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Hann HW, Lee J, Bussard A, Liu C, Jin YR, Guha K, Clayton MM, Ardlie K, Pellini MJ and Feitelson MA. Preneoplastic markers of hepatitis B virus-associated hepatocellular carcinoma. Cancer Res. 2004; 64: 7329-7335.
2. Treiber G. Systemic treatment of hepatocellular carcinoma. Dig.Dis. 2001; 19: 311-323.
3. Roy M, Pear WS and Aster JC. The multifaceted role of Notch in cancer. Curr.Opin.Genet.Dev. 2007; 17: 52-59.
4. Wang Z, Zhang Y, Li Y, Banerjee S, Liao J and Sarkar FH. Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol.Cancer Ther. 2006; 5: 483-493.
5. Collins BJ, Kleeberger W and Ball DW. Notch in lung development and lung cancer. Semin.Cancer Biol. 2004; 14: 357-364.
6. Dang TP, Eichenberger S, Gonzalez A, Olson S and Carbone DP. Constitutive activation of Notch3 inhibits terminal epithelial differentiation in lungs of transgenic mice. Oncogene 2003; 22: 1988-1997.
7. Haruki N, Kawaguchi KS, Eichenberger S, Massion PP, Olson S, Gonzalez A, Carbone DP and Dang TP. Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers. Cancer Res. 2005; 65: 3555-3561.
8. Kuttan G, Kumar KB, Guruvayoorappan C and Kuttan R. Antitumor, anti-invasion, and antimetastatic effects of curcumin. Adv.Exp.Med.Biol. 2007; 595: 173-184.
9. Pari L, Tewas D and Eckel J. Role of curcumin in health and disease. Arch.Physiol Biochem. 2008; 114: 127-149.
10. Shishodia S, Chaturvedi MM and Aggarwal BB. Role of curcumin in cancer therapy. Curr.Probl.Cancer 2007; 31: 243-305.
11. Ning L, Greenblatt DY, Kunnimalaiyaan M and Chen H. Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells. Oncologist. 2008; 13: 98-104.
12. Ning L, Jaskula-Sztul R, Kunnimalaiyaan M and Chen H. Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma. Ann.Surg.Oncol. 2008; 15: 2600-2605.
13. Gramantieri L, Giovannini C, Lanzi A, Chieco P, Ravaioli M, Venturi A, Grazi GL and Bolondi L. Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma. Liver Int 2007; 27: 997-1007.
14. Maillard I and Pear WS. Notch and cancer: best to avoid the ups and downs. Cancer Cell 2003; 3: 203-205.
15. Allenspach EJ, Maillard I, Aster JC and Pear WS. Notch signaling in cancer. Cancer Biol.Ther. 2002; 1: 466-476.
16. Artavanis-Tsakonas S, Rand MD and Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999; 284: 770-776.
17. Bray SJ. Notch signalling: a simple pathway becomes complex. Nat.Rev.Mol.Cell Biol. 2006; 7: 678-689.
18. Chen H, Thiagalingam A, Chopra H, Borges MW, Feder JN, Nelkin BD, Baylin SB and Ball DW. Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc.Natl.Acad.Sci.U.S.A 1997; 94: 5355-5360.
19. Sa G and Das T. Anti cancer effects of curcumin: cycle of life and death. Cell Div. 2008; 3: 14.
20. Aggarwal BB, Kumar A and Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res. 2003; 23: 363-398.
21. Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S and Aggarwal BB. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol.Pharmacol. 2006; 69: 195-206.
22. Chen A and Xu J. Activation of PPAR{gamma} by curcumin inhibits Moser cell growth and mediates suppression of gene expression of cyclin D1 and EGFR. Am.J.Physiol Gastrointest.Liver Physiol 2005; 288: G447-G456.
23. Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y and Mori N. Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines. Leuk.Res. 2006; 30: 313-321.
24. Qi R, An H, Yu Y, Zhang M, Liu S, Xu H, Guo Z, Cheng T and Cao X. Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res 2003; 63: 8323-8329.
25. Cantarini MC, de la Monte SM, Pang M, Tong M, D'Errico A, Trevisani F and Wands JR. Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms. Hepatology 2006; 44: 446-457.
26. Gao J, Song Z, Chen Y, Xia L, Wang J, Fan R, Du R, Zhang F, Hong L, Song J, Zou X, Xu H, Zheng G, Liu J and Fan D. Deregulated expression of Notch receptors in human hepatocellular carcinoma. Dig.Liver Dis. 2008; 40: 114-121.