CDKN1C/P57 is regulated by the Notch target gene Hes1 and induces senescence in human hepatocellular carcinoma

American Journal of Pathology

Volumn 181, Issue 2, 2012, Pages 413-422

  Giovannini, Catia ^a,b   Gramantieri, Laura ^a   Minguzzi, Manuela ^a,b   Fornari, Francesca ^a,b   Chieco, Pasquale ^a   Grazi, Gian Luca ^b   Bolondi, Luigi ^a,b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; BIOLOGICAL MARKER; CASPASE 3; COMPLEMENTARY DNA; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; MESSENGER RNA; NOTCH1 RECEPTOR; NOTCH3 RECEPTOR; PROTEIN BAX; PROTEIN NOXA; TRANSCRIPTION FACTOR HES 1;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER RECURRENCE; CANCER SURGERY; CELL GROWTH; CELL SHAPE; CELL STRUCTURE; CLINICAL ARTICLE; DNA TRANSFECTION; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER CELL CARCINOMA; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SENESCENCE; TUMOR GROWTH; UPREGULATION;

AGED; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOMA, HEPATOCELLULAR; CELL AGING; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CYCLIN-DEPENDENT KINASE INHIBITOR P57; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HOMEODOMAIN PROTEINS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; RECEPTOR, NOTCH1; RECEPTORS, NOTCH; RECURRENCE; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84864150714     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.04.019     Document Type: Article

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