메뉴 건너뛰기




Volumn 13, Issue 3, 2011, Pages

Notch signaling as a therapeutic target for breast cancer treatment?

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; NOTCH4 RECEPTOR; PROTEIN JAGGED 1; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; RBPJ PROTEIN, MOUSE;

EID: 80054742750     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2875     Document Type: Review
Times cited : (52)

References (52)
  • 1
    • 64249172203 scopus 로고    scopus 로고
    • The canonical Notch signaling pathway: unfolding the activation mechanism
    • Kopan R, Ilagan MX: The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009, 137: 216-233. 10.1016/j.cell.2009.03.045.
    • (2009) Cell , vol.137 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.2
  • 2
    • 0030920376 scopus 로고    scopus 로고
    • The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)
    • Gallahan D, Callahan R: The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene. 1997, 14: 1883-1890. 10.1038/sj.onc.1201035.
    • (1997) Oncogene , vol.14 , pp. 1883-1890
    • Gallahan, D.1    Callahan, R.2
  • 3
    • 0029871104 scopus 로고    scopus 로고
    • Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis
    • Gallahan D, Jhappan C, Robinson G, Hennighausen L, Sharp R, Kordon E, Callahan R, Merlino G, Smith GH: Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis. Cancer Res. 1996, 56: 1775-1785.
    • (1996) Cancer Res , vol.56 , pp. 1775-1785
    • Gallahan, D.1    Jhappan, C.2    Robinson, G.3    Hennighausen, L.4    Sharp, R.5    Kordon, E.6    Callahan, R.7    Merlino, G.8    Smith, G.H.9
  • 4
    • 33644660241 scopus 로고    scopus 로고
    • Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors
    • Hu C, Dievart A, Lupien M, Calvo E, Tremblay G, Jolicoeur P: Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors. Am J Pathol. 2006, 168: 973-990. 10.2353/ajpath.2006.050416.
    • (2006) Am J Pathol , vol.168 , pp. 973-990
    • Hu, C.1    Dievart, A.2    Lupien, M.3    Calvo, E.4    Tremblay, G.5    Jolicoeur, P.6
  • 5
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    • Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR, Lockwood G, Egan SE: High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res. 2005, 65: 8530-8537. 10.1158/0008-5472.CAN-05-1069.
    • (2005) Cancer Res , vol.65 , pp. 8530-8537
    • Reedijk, M.1    Odorcic, S.2    Chang, L.3    Zhang, H.4    Miller, N.5    McCready, D.R.6    Lockwood, G.7    Egan, S.E.8
  • 7
    • 33748155240 scopus 로고    scopus 로고
    • Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials
    • Shi W, Harris AL: Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials. J Mammary Gland Biol Neoplasia. 2006, 11: 41-52. 10.1007/s10911-006-9011-7.
    • (2006) J Mammary Gland Biol Neoplasia , vol.11 , pp. 41-52
    • Shi, W.1    Harris, A.L.2
  • 9
    • 37549059579 scopus 로고    scopus 로고
    • Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias
    • Lee SH, Jeong EG, Yoo NJ, Lee SH: Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias. Apmis. 2007, 115: 1357-1363. 10.1111/j.1600-0463.2007.00751.x.
    • (2007) Apmis , vol.115 , pp. 1357-1363
    • Lee, S.H.1    Jeong, E.G.2    Yoo, N.J.3    Lee, S.H.4
  • 10
    • 14244269366 scopus 로고    scopus 로고
    • The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer
    • Parr C, Watkins G, Jiang WG: The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. Int J Mol Med. 2004, 14: 779-786.
    • (2004) Int J Mol Med , vol.14 , pp. 779-786
    • Parr, C.1    Watkins, G.2    Jiang, W.G.3
  • 13
    • 74549133972 scopus 로고    scopus 로고
    • Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis
    • Mittal S, Subramanyam D, Dey D, Kumar RV, Rangarajan A: Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis. Mol Cancer. 2009, 8: 128. 10.1186/1476-4598-8-128.
    • (2009) Mol Cancer , vol.8 , pp. 128
    • Mittal, S.1    Subramanyam, D.2    Dey, D.3    Kumar, R.V.4    Rangarajan, A.5
  • 14
    • 84877897704 scopus 로고    scopus 로고
    • Distinct expression profiles of Notch-1 protein in human solid tumors: Implications for development of targeted therapeutic monoclonal antibodies
    • Li Y, Burns JA, Cheney CA, Zhang N, Vitelli S, Wang F, Bett A, Chastain M, Audoly LP, Zhang ZQ: Distinct expression profiles of Notch-1 protein in human solid tumors: Implications for development of targeted therapeutic monoclonal antibodies. Biologics. 2010, 4: 163-171.
    • (2010) Biologics , vol.4 , pp. 163-171
    • Li, Y.1    Burns, J.A.2    Cheney, C.A.3    Zhang, N.4    Vitelli, S.5    Wang, F.6    Bett, A.7    Chastain, M.8    Audoly, L.P.9    Zhang, Z.Q.10
  • 15
    • 70350374350 scopus 로고    scopus 로고
    • Numb regulates postendocytic trafficking and degradation of Notch1
    • McGill MA, Dho SE, Weinmaster G, McGlade CJ: Numb regulates postendocytic trafficking and degradation of Notch1. J Biol Chem. 2009, 284: 26427-26438. 10.1074/jbc.M109.014845.
    • (2009) J Biol Chem , vol.284 , pp. 26427-26438
    • McGill, M.A.1    Dho, S.E.2    Weinmaster, G.3    McGlade, C.J.4
  • 17
    • 32944470488 scopus 로고    scopus 로고
    • Aberrant activation of notch signaling in human breast cancer
    • Stylianou S, Clarke RB, Brennan K: Aberrant activation of notch signaling in human breast cancer. Cancer Res. 2006, 66: 1517-1525. 10.1158/0008-5472.CAN-05-3054.
    • (2006) Cancer Res , vol.66 , pp. 1517-1525
    • Stylianou, S.1    Clarke, R.B.2    Brennan, K.3
  • 18
    • 77954610471 scopus 로고    scopus 로고
    • Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation
    • Hartman J, Lam EW, Gustafsson JA, Strom A: Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation. Breast Cancer Res. 2009, 11: R79. 10.1186/bcr2446.
    • (2009) Breast Cancer Res , vol.11 , pp. R79
    • Hartman, J.1    Lam, E.W.2    Gustafsson, J.A.3    Strom, A.4
  • 21
    • 79751472667 scopus 로고    scopus 로고
    • Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells
    • Sethi N, Dai X, Winter CG, Kang Y: Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell. 2011, 19: 192-205. 10.1016/j.ccr.2010.12.022.
    • (2011) Cancer Cell , vol.19 , pp. 192-205
    • Sethi, N.1    Dai, X.2    Winter, C.G.3    Kang, Y.4
  • 24
    • 50649125794 scopus 로고    scopus 로고
    • ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor
    • Osipo C, Patel P, Rizzo P, Clementz AG, Hao L, Golde TE, Miele L: ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. Oncogene. 2008, 27: 5019-5032. 10.1038/onc.2008.149.
    • (2008) Oncogene , vol.27 , pp. 5019-5032
    • Osipo, C.1    Patel, P.2    Rizzo, P.3    Clementz, A.G.4    Hao, L.5    Golde, T.E.6    Miele, L.7
  • 27
    • 72449211223 scopus 로고    scopus 로고
    • The cytotoxicity of gammasecretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition
    • Han J, Ma I, Hendzel MJ, Allalunis-Turner J: The cytotoxicity of gammasecretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Breast Cancer Res. 2009, 11: R57. 10.1186/bcr2347.
    • (2009) Breast Cancer Res , vol.11 , pp. R57
    • Han, J.1    Ma, I.2    Hendzel, M.J.3    Allalunis-Turner, J.4
  • 28
    • 77954351997 scopus 로고    scopus 로고
    • Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer
    • Dong Y, Li A, Wang J, Weber JD, Michel LS: Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer. Cancer Res. 2010, 70: 5465-5474. 10.1158/0008-5472.CAN-10-0173.
    • (2010) Cancer Res , vol.70 , pp. 5465-5474
    • Dong, Y.1    Li, A.2    Wang, J.3    Weber, J.D.4    Michel, L.S.5
  • 30
    • 37249013019 scopus 로고    scopus 로고
    • Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients
    • Florena AM, Tripodo C, Guarnotta C, Ingrao S, Porcasi R, Martorana A, Lo Bosco G, Cabibi D, Franco V: Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients. Pathobiology. 2007, 74: 317-322. 10.1159/000110024.
    • (2007) Pathobiology , vol.74 , pp. 317-322
    • Florena, A.M.1    Tripodo, C.2    Guarnotta, C.3    Ingrao, S.4    Porcasi, R.5    Martorana, A.6    Lo Bosco, G.7    Cabibi, D.8    Franco, V.9
  • 31
    • 33644826798 scopus 로고    scopus 로고
    • The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila
    • Fuwa TJ, Hori K, Sasamura T, Higgs J, Baron M, Matsuno K: The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila. Mol Genet Genomics. 2006, 275: 251-263. 10.1007/s00438-005-0087-3.
    • (2006) Mol Genet Genomics , vol.275 , pp. 251-263
    • Fuwa, T.J.1    Hori, K.2    Sasamura, T.3    Higgs, J.4    Baron, M.5    Matsuno, K.6
  • 32
    • 48549085976 scopus 로고    scopus 로고
    • Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis
    • Lee CW, Raskett CM, Prudovsky I, Altieri DC: Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis. Cancer Res. 2008, 68: 5273-5281. 10.1158/0008-5472.CAN-07-6673.
    • (2008) Cancer Res , vol.68 , pp. 5273-5281
    • Lee, C.W.1    Raskett, C.M.2    Prudovsky, I.3    Altieri, D.C.4
  • 33
    • 67149138004 scopus 로고    scopus 로고
    • Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells
    • Rasul S, Balasubramanian R, Filipovic A, Slade MJ, Yague E, Coombes RC: Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009, 100: 1879-1888. 10.1038/sj.bjc.6605034.
    • (2009) Br J Cancer , vol.100 , pp. 1879-1888
    • Rasul, S.1    Balasubramanian, R.2    Filipovic, A.3    Slade, M.J.4    Yague, E.5    Coombes, R.C.6
  • 34
    • 40349100486 scopus 로고    scopus 로고
    • Activity of gamma-secretase on substrates other than APP
    • Lleo A: Activity of gamma-secretase on substrates other than APP. Curr Top Med Chem. 2008, 8: 9-16. 10.2174/156802608783334060.
    • (2008) Curr Top Med Chem , vol.8 , pp. 9-16
    • Lleo, A.1
  • 35
    • 67449116604 scopus 로고    scopus 로고
    • Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells
    • Meurette O, Stylianou S, Rock R, Collu GM, Gilmore AP, Brennan K: Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer Res. 2009, 69: 5015-5022.
    • (2009) Cancer Res , vol.69 , pp. 5015-5022
    • Meurette, O.1    Stylianou, S.2    Rock, R.3    Collu, G.M.4    Gilmore, A.P.5    Brennan, K.6
  • 36
    • 77949457142 scopus 로고    scopus 로고
    • RNAi-mediated knockdown of Notch-1 leads to cell growth inhibition and enhanced chemosensitivity in human breast cancer
    • Zang S, Chen F, Dai J, Guo D, Tse W, Qu X, Ma D, Ji C: RNAi-mediated knockdown of Notch-1 leads to cell growth inhibition and enhanced chemosensitivity in human breast cancer. Oncol Rep. 2010, 23: 893-899.
    • (2010) Oncol Rep , vol.23 , pp. 893-899
    • Zang, S.1    Chen, F.2    Dai, J.3    Guo, D.4    Tse, W.5    Qu, X.6    Ma, D.7    Ji, C.8
  • 38
    • 33646415906 scopus 로고    scopus 로고
    • Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53
    • Mungamuri SK, Yang X, Thor AD, Somasundaram K: Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53. Cancer Res. 2006, 66: 4715-4724. 10.1158/0008-5472.CAN-05-3830.
    • (2006) Cancer Res , vol.66 , pp. 4715-4724
    • Mungamuri, S.K.1    Yang, X.2    Thor, A.D.3    Somasundaram, K.4
  • 41
    • 34247581697 scopus 로고    scopus 로고
    • Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways
    • Farnie G, Clarke RB, Spence K, Pinnock N, Brennan K, Anderson NG, Bundred NJ: Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. J Natl Cancer Inst. 2007, 99: 616-627. 10.1093/jnci/djk133.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 616-627
    • Farnie, G.1    Clarke, R.B.2    Spence, K.3    Pinnock, N.4    Brennan, K.5    Anderson, N.G.6    Bundred, N.J.7
  • 44
    • 0035955604 scopus 로고    scopus 로고
    • Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis
    • Saxena MT, Schroeter EH, Mumm JS, Kopan R: Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. J Biol Chem. 2001, 276: 40268-40273.
    • (2001) J Biol Chem , vol.276 , pp. 40268-40273
    • Saxena, M.T.1    Schroeter, E.H.2    Mumm, J.S.3    Kopan, R.4
  • 45
    • 77956328365 scopus 로고    scopus 로고
    • Biodiversity and noncanonical Notch signaling
    • Heitzler P: Biodiversity and noncanonical Notch signaling. Curr Top Dev Biol. 2010, 92: 457-481.
    • (2010) Curr Top Dev Biol , vol.92 , pp. 457-481
    • Heitzler, P.1
  • 46
    • 33644992638 scopus 로고    scopus 로고
    • The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C mediated transcription and is required for normal myogenesis
    • Shen H, McElhinny AS, Cao Y, Gao P, Liu J, Bronson R, Griffin JD, Wu L: The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C mediated transcription and is required for normal myogenesis. Genes Dev. 2006, 20: 675-688. 10.1101/gad.1383706.
    • (2006) Genes Dev , vol.20 , pp. 675-688
    • Shen, H.1    McElhinny, A.S.2    Cao, Y.3    Gao, P.4    Liu, J.5    Bronson, R.6    Griffin, J.D.7    Wu, L.8
  • 47
    • 34547603970 scopus 로고    scopus 로고
    • The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1
    • Liao WR, Hsieh RH, Hsu KW, Wu MZ, Tseng MJ, Mai RT, Wu Lee YH, Yeh TS: The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1. Carcinogenesis. 2007, 28: 1867-1876. 10.1093/carcin/bgm092.
    • (2007) Carcinogenesis , vol.28 , pp. 1867-1876
    • Liao, W.R.1    Hsieh, R.H.2    Hsu, K.W.3    Wu, M.Z.4    Tseng, M.J.5    Mai, R.T.6    Wu Lee, Y.H.7    Yeh, T.S.8
  • 49
    • 0034719383 scopus 로고    scopus 로고
    • Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signalling
    • Dumont E, Fuchs KP, Bommer G, Christoph B, Kremmer E, Kempkes B: Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signalling. Oncogene. 2000, 19: 556-561. 10.1038/sj.onc.1203352.
    • (2000) Oncogene , vol.19 , pp. 556-561
    • Dumont, E.1    Fuchs, K.P.2    Bommer, G.3    Christoph, B.4    Kremmer, E.5    Kempkes, B.6
  • 51
    • 79954623907 scopus 로고    scopus 로고
    • Characterization and comparison of protein complexes initiated by the intracellular domain of individual Notch paralogs
    • Han J, Allalunis-Turner J, Hendzel MJ: Characterization and comparison of protein complexes initiated by the intracellular domain of individual Notch paralogs. Biochem Biophys Res Commun. 2011, 407: 479-485. 10.1016/j.bbrc.2011.03.042.
    • (2011) Biochem Biophys Res Commun , vol.407 , pp. 479-485
    • Han, J.1    Allalunis-Turner, J.2    Hendzel, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.