-
1
-
-
64249172203
-
The canonical Notch signaling pathway: unfolding the activation mechanism
-
Kopan R, Ilagan MX: The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009, 137: 216-233. 10.1016/j.cell.2009.03.045.
-
(2009)
Cell
, vol.137
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.X.2
-
2
-
-
0030920376
-
The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)
-
Gallahan D, Callahan R: The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene. 1997, 14: 1883-1890. 10.1038/sj.onc.1201035.
-
(1997)
Oncogene
, vol.14
, pp. 1883-1890
-
-
Gallahan, D.1
Callahan, R.2
-
3
-
-
0029871104
-
Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis
-
Gallahan D, Jhappan C, Robinson G, Hennighausen L, Sharp R, Kordon E, Callahan R, Merlino G, Smith GH: Expression of a truncated Int3 gene in developing secretory mammary epithelium specifically retards lobular differentiation resulting in tumorigenesis. Cancer Res. 1996, 56: 1775-1785.
-
(1996)
Cancer Res
, vol.56
, pp. 1775-1785
-
-
Gallahan, D.1
Jhappan, C.2
Robinson, G.3
Hennighausen, L.4
Sharp, R.5
Kordon, E.6
Callahan, R.7
Merlino, G.8
Smith, G.H.9
-
4
-
-
33644660241
-
Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors
-
Hu C, Dievart A, Lupien M, Calvo E, Tremblay G, Jolicoeur P: Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors. Am J Pathol. 2006, 168: 973-990. 10.2353/ajpath.2006.050416.
-
(2006)
Am J Pathol
, vol.168
, pp. 973-990
-
-
Hu, C.1
Dievart, A.2
Lupien, M.3
Calvo, E.4
Tremblay, G.5
Jolicoeur, P.6
-
5
-
-
24944506696
-
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
-
Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR, Lockwood G, Egan SE: High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res. 2005, 65: 8530-8537. 10.1158/0008-5472.CAN-05-1069.
-
(2005)
Cancer Res
, vol.65
, pp. 8530-8537
-
-
Reedijk, M.1
Odorcic, S.2
Chang, L.3
Zhang, H.4
Miller, N.5
McCready, D.R.6
Lockwood, G.7
Egan, S.E.8
-
6
-
-
50849111710
-
Rational targeting of Notch signaling in cancer
-
Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L: Rational targeting of Notch signaling in cancer. Oncogene. 2008, 27: 5124-5131. 10.1038/onc.2008.226.
-
(2008)
Oncogene
, vol.27
, pp. 5124-5131
-
-
Rizzo, P.1
Osipo, C.2
Foreman, K.3
Golde, T.4
Osborne, B.5
Miele, L.6
-
7
-
-
33748155240
-
Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials
-
Shi W, Harris AL: Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials. J Mammary Gland Biol Neoplasia. 2006, 11: 41-52. 10.1007/s10911-006-9011-7.
-
(2006)
J Mammary Gland Biol Neoplasia
, vol.11
, pp. 41-52
-
-
Shi, W.1
Harris, A.L.2
-
8
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W, Morris JPt, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC: Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004, 306: 269-271. 10.1126/science.1102160.
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
Morris, J.P.4
Silverman, L.B.5
Sanchez-Irizarry, C.6
Blacklow, S.C.7
Look, A.T.8
Aster, J.C.9
-
9
-
-
37549059579
-
Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias
-
Lee SH, Jeong EG, Yoo NJ, Lee SH: Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias. Apmis. 2007, 115: 1357-1363. 10.1111/j.1600-0463.2007.00751.x.
-
(2007)
Apmis
, vol.115
, pp. 1357-1363
-
-
Lee, S.H.1
Jeong, E.G.2
Yoo, N.J.3
Lee, S.H.4
-
10
-
-
14244269366
-
The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer
-
Parr C, Watkins G, Jiang WG: The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer. Int J Mol Med. 2004, 14: 779-786.
-
(2004)
Int J Mol Med
, vol.14
, pp. 779-786
-
-
Parr, C.1
Watkins, G.2
Jiang, W.G.3
-
11
-
-
77449089220
-
High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype
-
Zardawi SJ, Zardawi I, McNeil CM, Millar EK, McLeod D, Morey AL, Crea P, Murphy NC, Pinese M, Lopez-Knowles E, Oakes SR, Ormandy CJ, Qiu MR, Hamilton A, Spillane A, Soon Lee C, Sutherland RL, Musgrove EA, O'Toole SA: High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype. Histopathology. 2010, 56: 286-296. 10.1111/j.1365-2559.2009.03475.x.
-
(2010)
Histopathology
, vol.56
, pp. 286-296
-
-
Zardawi, S.J.1
Zardawi, I.2
McNeil, C.M.3
Millar, E.K.4
McLeod, D.5
Morey, A.L.6
Crea, P.7
Murphy, N.C.8
Pinese, M.9
Lopez-Knowles, E.10
Oakes, S.R.11
Ormandy, C.J.12
Qiu, M.R.13
Hamilton, A.14
Spillane, A.15
Soon Lee, C.16
Sutherland, R.L.17
Musgrove, E.A.18
O'Toole, S.A.19
-
12
-
-
48549103124
-
Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
-
Rizzo P, Miao H, D'Souza G, Osipo C, Song LL, Yun J, Zhao H, Mascarenhas J, Wyatt D, Antico G, Hao L, Yao K, Rajan P, Hicks C, Siziopikou K, Selvaggi S, Bashir A, Bhandari D, Marchese A, Lendahl U, Qin JZ, Tonetti DA, Albain K, Nickoloff BJ, Miele L: Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res. 2008, 68: 5226-5235. 10.1158/0008-5472.CAN-07-5744.
-
(2008)
Cancer Res
, vol.68
, pp. 5226-5235
-
-
Rizzo, P.1
Miao, H.2
D'Souza, G.3
Osipo, C.4
Song, L.L.5
Yun, J.6
Zhao, H.7
Mascarenhas, J.8
Wyatt, D.9
Antico, G.10
Hao, L.11
Yao, K.12
Rajan, P.13
Hicks, C.14
Siziopikou, K.15
Selvaggi, S.16
Bashir, A.17
Bhandari, D.18
Marchese, A.19
Lendahl, U.20
Qin, J.Z.21
Tonetti, D.A.22
Albain, K.23
Nickoloff, B.J.24
Miele, L.25
more..
-
13
-
-
74549133972
-
Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis
-
Mittal S, Subramanyam D, Dey D, Kumar RV, Rangarajan A: Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis. Mol Cancer. 2009, 8: 128. 10.1186/1476-4598-8-128.
-
(2009)
Mol Cancer
, vol.8
, pp. 128
-
-
Mittal, S.1
Subramanyam, D.2
Dey, D.3
Kumar, R.V.4
Rangarajan, A.5
-
14
-
-
84877897704
-
Distinct expression profiles of Notch-1 protein in human solid tumors: Implications for development of targeted therapeutic monoclonal antibodies
-
Li Y, Burns JA, Cheney CA, Zhang N, Vitelli S, Wang F, Bett A, Chastain M, Audoly LP, Zhang ZQ: Distinct expression profiles of Notch-1 protein in human solid tumors: Implications for development of targeted therapeutic monoclonal antibodies. Biologics. 2010, 4: 163-171.
-
(2010)
Biologics
, vol.4
, pp. 163-171
-
-
Li, Y.1
Burns, J.A.2
Cheney, C.A.3
Zhang, N.4
Vitelli, S.5
Wang, F.6
Bett, A.7
Chastain, M.8
Audoly, L.P.9
Zhang, Z.Q.10
-
15
-
-
70350374350
-
Numb regulates postendocytic trafficking and degradation of Notch1
-
McGill MA, Dho SE, Weinmaster G, McGlade CJ: Numb regulates postendocytic trafficking and degradation of Notch1. J Biol Chem. 2009, 284: 26427-26438. 10.1074/jbc.M109.014845.
-
(2009)
J Biol Chem
, vol.284
, pp. 26427-26438
-
-
McGill, M.A.1
Dho, S.E.2
Weinmaster, G.3
McGlade, C.J.4
-
16
-
-
7244250027
-
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
-
Pece S, Serresi M, Santolini E, Capra M, Hulleman E, Galimberti V, Zurrida S, Maisonneuve P, Viale G, Di Fiore PP: Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol. 2004, 167: 215-221. 10.1083/jcb.200406140.
-
(2004)
J Cell Biol
, vol.167
, pp. 215-221
-
-
Pece, S.1
Serresi, M.2
Santolini, E.3
Capra, M.4
Hulleman, E.5
Galimberti, V.6
Zurrida, S.7
Maisonneuve, P.8
Viale, G.9
Di Fiore, P.P.10
-
17
-
-
32944470488
-
Aberrant activation of notch signaling in human breast cancer
-
Stylianou S, Clarke RB, Brennan K: Aberrant activation of notch signaling in human breast cancer. Cancer Res. 2006, 66: 1517-1525. 10.1158/0008-5472.CAN-05-3054.
-
(2006)
Cancer Res
, vol.66
, pp. 1517-1525
-
-
Stylianou, S.1
Clarke, R.B.2
Brennan, K.3
-
18
-
-
77954610471
-
Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation
-
Hartman J, Lam EW, Gustafsson JA, Strom A: Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation. Breast Cancer Res. 2009, 11: R79. 10.1186/bcr2446.
-
(2009)
Breast Cancer Res
, vol.11
, pp. R79
-
-
Hartman, J.1
Lam, E.W.2
Gustafsson, J.A.3
Strom, A.4
-
19
-
-
51349169034
-
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
-
Chiang MY, Xu L, Shestova O, Histen G, L'Heureux S, Romany C, Childs ME, Gimotty PA, Aster JC, Pear WS: Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. J Clin Invest. 2008, 118: 3181-3194. 10.1172/JCI35090.
-
(2008)
J Clin Invest
, vol.118
, pp. 3181-3194
-
-
Chiang, M.Y.1
Xu, L.2
Shestova, O.3
Histen, G.4
L'Heureux, S.5
Romany, C.6
Childs, M.E.7
Gimotty, P.A.8
Aster, J.C.9
Pear, W.S.10
-
20
-
-
51649090695
-
JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer
-
Reedijk M, Pinnaduwage D, Dickson BC, Mulligan AM, Zhang H, Bull SB, O'Malley FP, Egan SE, Andrulis IL: JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer. Breast Cancer Res Treat. 2008, 111: 439-448. 10.1007/s10549-007-9805-3.
-
(2008)
Breast Cancer Res Treat
, vol.111
, pp. 439-448
-
-
Reedijk, M.1
Pinnaduwage, D.2
Dickson, B.C.3
Mulligan, A.M.4
Zhang, H.5
Bull, S.B.6
O'Malley, F.P.7
Egan, S.E.8
Andrulis, I.L.9
-
21
-
-
79751472667
-
Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells
-
Sethi N, Dai X, Winter CG, Kang Y: Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell. 2011, 19: 192-205. 10.1016/j.ccr.2010.12.022.
-
(2011)
Cancer Cell
, vol.19
, pp. 192-205
-
-
Sethi, N.1
Dai, X.2
Winter, C.G.3
Kang, Y.4
-
22
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
-
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Eystein Lønning P, Børresen-Dale AL: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 2001, 98: 10869-10874. 10.1073/pnas.191367098.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10869-10874
-
-
Sørlie, T.1
Perou, C.M.2
Tibshirani, R.3
Aas, T.4
Geisler, S.5
Johnsen, H.6
Hastie, T.7
Eisen, M.B.8
van de Rijn, M.9
Jeffrey, S.S.10
Thorsen, T.11
Quist, H.12
Matese, J.C.13
Brown, P.O.14
Botstein, D.15
Eystein Lønning, P.16
Børresen-Dale, A.L.17
-
23
-
-
34249098132
-
High-level JAG1 mRNA and protein predict poor outcome in breast cancer
-
Dickson BC, Mulligan AM, Zhang H, Lockwood G, O'Malley FP, Egan SE, Reedijk M: High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod Pathol. 2007, 20: 685-693. 10.1038/modpathol.3800785.
-
(2007)
Mod Pathol
, vol.20
, pp. 685-693
-
-
Dickson, B.C.1
Mulligan, A.M.2
Zhang, H.3
Lockwood, G.4
O'Malley, F.P.5
Egan, S.E.6
Reedijk, M.7
-
24
-
-
50649125794
-
ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor
-
Osipo C, Patel P, Rizzo P, Clementz AG, Hao L, Golde TE, Miele L: ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. Oncogene. 2008, 27: 5019-5032. 10.1038/onc.2008.149.
-
(2008)
Oncogene
, vol.27
, pp. 5019-5032
-
-
Osipo, C.1
Patel, P.2
Rizzo, P.3
Clementz, A.G.4
Hao, L.5
Golde, T.E.6
Miele, L.7
-
25
-
-
77955768470
-
Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer
-
Cohen B, Shimizu M, Izrailit J, Ng NF, Buchman Y, Pan JG, Dering J, Reedijk M: Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer. Breast Cancer Res Treat. 2010, 123: 113-124. 10.1007/s10549-009-0621-9.
-
(2010)
Breast Cancer Res Treat
, vol.123
, pp. 113-124
-
-
Cohen, B.1
Shimizu, M.2
Izrailit, J.3
Ng, N.F.4
Buchman, Y.5
Pan, J.G.6
Dering, J.7
Reedijk, M.8
-
26
-
-
40949092796
-
NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells
-
Yamaguchi N, Oyama T, Ito E, Satoh H, Azuma S, Hayashi M, Shimizu K, Honma R, Yanagisawa Y, Nishikawa A, Kawamura M, Imai J, Ohwada S, Tatsuta K, Inoue J, Semba K, Watanabe S: NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells. Cancer Res. 2008, 68: 1881-1888. 10.1158/0008-5472.CAN-07-1597.
-
(2008)
Cancer Res
, vol.68
, pp. 1881-1888
-
-
Yamaguchi, N.1
Oyama, T.2
Ito, E.3
Satoh, H.4
Azuma, S.5
Hayashi, M.6
Shimizu, K.7
Honma, R.8
Yanagisawa, Y.9
Nishikawa, A.10
Kawamura, M.11
Imai, J.12
Ohwada, S.13
Tatsuta, K.14
Inoue, J.15
Semba, K.16
Watanabe, S.17
-
27
-
-
72449211223
-
The cytotoxicity of gammasecretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition
-
Han J, Ma I, Hendzel MJ, Allalunis-Turner J: The cytotoxicity of gammasecretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Breast Cancer Res. 2009, 11: R57. 10.1186/bcr2347.
-
(2009)
Breast Cancer Res
, vol.11
, pp. R57
-
-
Han, J.1
Ma, I.2
Hendzel, M.J.3
Allalunis-Turner, J.4
-
28
-
-
77954351997
-
Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer
-
Dong Y, Li A, Wang J, Weber JD, Michel LS: Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer. Cancer Res. 2010, 70: 5465-5474. 10.1158/0008-5472.CAN-10-0173.
-
(2010)
Cancer Res
, vol.70
, pp. 5465-5474
-
-
Dong, Y.1
Li, A.2
Wang, J.3
Weber, J.D.4
Michel, L.S.5
-
29
-
-
34548833559
-
Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth
-
O'Neill CF, Urs S, Cinelli C, Lincoln A, Nadeau RJ, Leon R, Toher J, Mouta-Bellum C, Friesel RE, Liaw L: Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth. Am J Pathol. 2007, 171: 1023-1036. 10.2353/ajpath.2007.061029.
-
(2007)
Am J Pathol
, vol.171
, pp. 1023-1036
-
-
O'Neill, C.F.1
Urs, S.2
Cinelli, C.3
Lincoln, A.4
Nadeau, R.J.5
Leon, R.6
Toher, J.7
Mouta-Bellum, C.8
Friesel, R.E.9
Liaw, L.10
-
30
-
-
37249013019
-
Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients
-
Florena AM, Tripodo C, Guarnotta C, Ingrao S, Porcasi R, Martorana A, Lo Bosco G, Cabibi D, Franco V: Associations between Notch-2, Akt-1 and HER2/neu expression in invasive human breast cancer: a tissue microarray immunophenotypic analysis on 98 patients. Pathobiology. 2007, 74: 317-322. 10.1159/000110024.
-
(2007)
Pathobiology
, vol.74
, pp. 317-322
-
-
Florena, A.M.1
Tripodo, C.2
Guarnotta, C.3
Ingrao, S.4
Porcasi, R.5
Martorana, A.6
Lo Bosco, G.7
Cabibi, D.8
Franco, V.9
-
31
-
-
33644826798
-
The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila
-
Fuwa TJ, Hori K, Sasamura T, Higgs J, Baron M, Matsuno K: The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila. Mol Genet Genomics. 2006, 275: 251-263. 10.1007/s00438-005-0087-3.
-
(2006)
Mol Genet Genomics
, vol.275
, pp. 251-263
-
-
Fuwa, T.J.1
Hori, K.2
Sasamura, T.3
Higgs, J.4
Baron, M.5
Matsuno, K.6
-
32
-
-
48549085976
-
Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis
-
Lee CW, Raskett CM, Prudovsky I, Altieri DC: Molecular dependence of estrogen receptor-negative breast cancer on a notch-survivin signaling axis. Cancer Res. 2008, 68: 5273-5281. 10.1158/0008-5472.CAN-07-6673.
-
(2008)
Cancer Res
, vol.68
, pp. 5273-5281
-
-
Lee, C.W.1
Raskett, C.M.2
Prudovsky, I.3
Altieri, D.C.4
-
33
-
-
67149138004
-
Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells
-
Rasul S, Balasubramanian R, Filipovic A, Slade MJ, Yague E, Coombes RC: Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009, 100: 1879-1888. 10.1038/sj.bjc.6605034.
-
(2009)
Br J Cancer
, vol.100
, pp. 1879-1888
-
-
Rasul, S.1
Balasubramanian, R.2
Filipovic, A.3
Slade, M.J.4
Yague, E.5
Coombes, R.C.6
-
34
-
-
40349100486
-
Activity of gamma-secretase on substrates other than APP
-
Lleo A: Activity of gamma-secretase on substrates other than APP. Curr Top Med Chem. 2008, 8: 9-16. 10.2174/156802608783334060.
-
(2008)
Curr Top Med Chem
, vol.8
, pp. 9-16
-
-
Lleo, A.1
-
35
-
-
67449116604
-
Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells
-
Meurette O, Stylianou S, Rock R, Collu GM, Gilmore AP, Brennan K: Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer Res. 2009, 69: 5015-5022.
-
(2009)
Cancer Res
, vol.69
, pp. 5015-5022
-
-
Meurette, O.1
Stylianou, S.2
Rock, R.3
Collu, G.M.4
Gilmore, A.P.5
Brennan, K.6
-
36
-
-
77949457142
-
RNAi-mediated knockdown of Notch-1 leads to cell growth inhibition and enhanced chemosensitivity in human breast cancer
-
Zang S, Chen F, Dai J, Guo D, Tse W, Qu X, Ma D, Ji C: RNAi-mediated knockdown of Notch-1 leads to cell growth inhibition and enhanced chemosensitivity in human breast cancer. Oncol Rep. 2010, 23: 893-899.
-
(2010)
Oncol Rep
, vol.23
, pp. 893-899
-
-
Zang, S.1
Chen, F.2
Dai, J.3
Guo, D.4
Tse, W.5
Qu, X.6
Ma, D.7
Ji, C.8
-
37
-
-
77950441537
-
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells
-
Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS: Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci USA. 2010, 107: 5012-5017. 10.1073/pnas.1000896107.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 5012-5017
-
-
Mazzone, M.1
Selfors, L.M.2
Albeck, J.3
Overholtzer, M.4
Sale, S.5
Carroll, D.L.6
Pandya, D.7
Lu, Y.8
Mills, G.B.9
Aster, J.C.10
Artavanis-Tsakonas, S.11
Brugge, J.S.12
-
38
-
-
33646415906
-
Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53
-
Mungamuri SK, Yang X, Thor AD, Somasundaram K: Survival signaling by Notch1: mammalian target of rapamycin (mTOR)-dependent inhibition of p53. Cancer Res. 2006, 66: 4715-4724. 10.1158/0008-5472.CAN-05-3830.
-
(2006)
Cancer Res
, vol.66
, pp. 4715-4724
-
-
Mungamuri, S.K.1
Yang, X.2
Thor, A.D.3
Somasundaram, K.4
-
39
-
-
43149113910
-
Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3
-
Li K, Li Y, Wu W, Gordon WR, Chang DW, Lu M, Scoggin S, Fu T, Vien L, Histen G, Zheng J, Martin-Hollister R, Duensing T, Singh S, Blacklow SC, Yao Z, Aster JC, Zhou BB: Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem. 2008, 283: 8046-8054. 10.1074/jbc.M800170200.
-
(2008)
J Biol Chem
, vol.283
, pp. 8046-8054
-
-
Li, K.1
Li, Y.2
Wu, W.3
Gordon, W.R.4
Chang, D.W.5
Lu, M.6
Scoggin, S.7
Fu, T.8
Vien, L.9
Histen, G.10
Zheng, J.11
Martin-Hollister, R.12
Duensing, T.13
Singh, S.14
Blacklow, S.C.15
Yao, Z.16
Aster, J.C.17
Zhou, B.B.18
-
40
-
-
77951139188
-
Therapeutic antibody targeting of individual Notch receptors
-
Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW: Therapeutic antibody targeting of individual Notch receptors. Nature. 2010, 464: 1052-1057. 10.1038/nature08878.
-
(2010)
Nature
, vol.464
, pp. 1052-1057
-
-
Wu, Y.1
Cain-Hom, C.2
Choy, L.3
Hagenbeek, T.J.4
de Leon, G.P.5
Chen, Y.6
Finkle, D.7
Venook, R.8
Wu, X.9
Ridgway, J.10
Schahin-Reed, D.11
Dow, G.J.12
Shelton, A.13
Stawicki, S.14
Watts, R.J.15
Zhang, J.16
Choy, R.17
Howard, P.18
Kadyk, L.19
Yan, M.20
Zha, J.21
Callahan, C.A.22
Hymowitz, S.G.23
Siebel, C.W.24
more..
-
41
-
-
34247581697
-
Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways
-
Farnie G, Clarke RB, Spence K, Pinnock N, Brennan K, Anderson NG, Bundred NJ: Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. J Natl Cancer Inst. 2007, 99: 616-627. 10.1093/jnci/djk133.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 616-627
-
-
Farnie, G.1
Clarke, R.B.2
Spence, K.3
Pinnock, N.4
Brennan, K.5
Anderson, N.G.6
Bundred, N.J.7
-
42
-
-
76549084826
-
Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor
-
Harrison H, Farnie G, Howell SJ, Rock RE, Stylianou S, Brennan KR, Bundred NJ, Clarke RB: Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res. 2010, 70: 709-718. 10.1158/0008-5472.CAN-09-1681.
-
(2010)
Cancer Res
, vol.70
, pp. 709-718
-
-
Harrison, H.1
Farnie, G.2
Howell, S.J.3
Rock, R.E.4
Stylianou, S.5
Brennan, K.R.6
Bundred, N.J.7
Clarke, R.B.8
-
43
-
-
3142702839
-
Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function
-
Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R, Weng AP, Kutok JL, Aster JC, Kitajewski J: Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function. J Biol Chem. 2004, 279: 30771-30780. 10.1074/jbc.M309252200.
-
(2004)
J Biol Chem
, vol.279
, pp. 30771-30780
-
-
Das, I.1
Craig, C.2
Funahashi, Y.3
Jung, K.M.4
Kim, T.W.5
Byers, R.6
Weng, A.P.7
Kutok, J.L.8
Aster, J.C.9
Kitajewski, J.10
-
44
-
-
0035955604
-
Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis
-
Saxena MT, Schroeter EH, Mumm JS, Kopan R: Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. J Biol Chem. 2001, 276: 40268-40273.
-
(2001)
J Biol Chem
, vol.276
, pp. 40268-40273
-
-
Saxena, M.T.1
Schroeter, E.H.2
Mumm, J.S.3
Kopan, R.4
-
45
-
-
77956328365
-
Biodiversity and noncanonical Notch signaling
-
Heitzler P: Biodiversity and noncanonical Notch signaling. Curr Top Dev Biol. 2010, 92: 457-481.
-
(2010)
Curr Top Dev Biol
, vol.92
, pp. 457-481
-
-
Heitzler, P.1
-
46
-
-
33644992638
-
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C mediated transcription and is required for normal myogenesis
-
Shen H, McElhinny AS, Cao Y, Gao P, Liu J, Bronson R, Griffin JD, Wu L: The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C mediated transcription and is required for normal myogenesis. Genes Dev. 2006, 20: 675-688. 10.1101/gad.1383706.
-
(2006)
Genes Dev
, vol.20
, pp. 675-688
-
-
Shen, H.1
McElhinny, A.S.2
Cao, Y.3
Gao, P.4
Liu, J.5
Bronson, R.6
Griffin, J.D.7
Wu, L.8
-
47
-
-
34547603970
-
The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1
-
Liao WR, Hsieh RH, Hsu KW, Wu MZ, Tseng MJ, Mai RT, Wu Lee YH, Yeh TS: The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1. Carcinogenesis. 2007, 28: 1867-1876. 10.1093/carcin/bgm092.
-
(2007)
Carcinogenesis
, vol.28
, pp. 1867-1876
-
-
Liao, W.R.1
Hsieh, R.H.2
Hsu, K.W.3
Wu, M.Z.4
Tseng, M.J.5
Mai, R.T.6
Wu Lee, Y.H.7
Yeh, T.S.8
-
48
-
-
26444435322
-
Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway
-
Kim JW, Kim MJ, Kim KJ, Yun HJ, Chae JS, Hwang SG, Chang TS, Park HS, Lee KW, Han PL, Cho SG, Kim TW, Choi EJ: Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit the JNK signaling pathway. Proc Natl Acad Sci USA. 2005, 102: 14308-14313. 10.1073/pnas.0501600102.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 14308-14313
-
-
Kim, J.W.1
Kim, M.J.2
Kim, K.J.3
Yun, H.J.4
Chae, J.S.5
Hwang, S.G.6
Chang, T.S.7
Park, H.S.8
Lee, K.W.9
Han, P.L.10
Cho, S.G.11
Kim, T.W.12
Choi, E.J.13
-
49
-
-
0034719383
-
Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signalling
-
Dumont E, Fuchs KP, Bommer G, Christoph B, Kremmer E, Kempkes B: Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signalling. Oncogene. 2000, 19: 556-561. 10.1038/sj.onc.1203352.
-
(2000)
Oncogene
, vol.19
, pp. 556-561
-
-
Dumont, E.1
Fuchs, K.P.2
Bommer, G.3
Christoph, B.4
Kremmer, E.5
Kempkes, B.6
-
50
-
-
58249112360
-
Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis
-
Raafat A, Lawson S, Bargo S, Klauzinska M, Strizzi L, Goldhar AS, Buono K, Salomon D, Vonderhaar BK, Callahan R: Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis. Oncogene. 2009, 28: 219-230. 10.1038/onc.2008.379.
-
(2009)
Oncogene
, vol.28
, pp. 219-230
-
-
Raafat, A.1
Lawson, S.2
Bargo, S.3
Klauzinska, M.4
Strizzi, L.5
Goldhar, A.S.6
Buono, K.7
Salomon, D.8
Vonderhaar, B.K.9
Callahan, R.10
-
51
-
-
79954623907
-
Characterization and comparison of protein complexes initiated by the intracellular domain of individual Notch paralogs
-
Han J, Allalunis-Turner J, Hendzel MJ: Characterization and comparison of protein complexes initiated by the intracellular domain of individual Notch paralogs. Biochem Biophys Res Commun. 2011, 407: 479-485. 10.1016/j.bbrc.2011.03.042.
-
(2011)
Biochem Biophys Res Commun
, vol.407
, pp. 479-485
-
-
Han, J.1
Allalunis-Turner, J.2
Hendzel, M.J.3
-
52
-
-
33846048039
-
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
-
Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, Thompson B, Spaulding C, Macaroun S, Alegre ML, Kee BL, Ferrando A, Miele L, Aifantis I: Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med. 2007, 13: 70-77. 10.1038/nm1524.
-
(2007)
Nat Med
, vol.13
, pp. 70-77
-
-
Vilimas, T.1
Mascarenhas, J.2
Palomero, T.3
Mandal, M.4
Buonamici, S.5
Meng, F.6
Thompson, B.7
Spaulding, C.8
Macaroun, S.9
Alegre, M.L.10
Kee, B.L.11
Ferrando, A.12
Miele, L.13
Aifantis, I.14
|