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Volumn 6, Issue JUL, 2015, Pages

Complement in the homeostatic and ischemic brain

Author keywords

Brain ischemia; Complement; Innate immunity; Neuroprotection; Reperfusion injury; Stroke

Indexed keywords

CASPASE 3; CASPASE 9; CD59 ANTIGEN; COBROTOXIN; COMPLEMENT COMPONENT C3B RECEPTOR; DECAY ACCELERATING FACTOR; MANNOSE BINDING LECTIN; MEMBRANE COFACTOR PROTEIN; MESSENGER RNA; MICRORNA; N METHYL DEXTRO ASPARTIC ACID; TISSUE PLASMINOGEN ACTIVATOR; VESICULAR GLUTAMATE TRANSPORTER 1;

EID: 84938518494     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00417     Document Type: Review
Times cited : (72)

References (131)
  • 3
    • 55849114955 scopus 로고    scopus 로고
    • The complement cascade: Yin-Yang in neuroinflammation-neuro-protection and-degeneration
    • Alexander, J.J., Anderson, A.J., Barnum, S.R., Stevens, B., and Tenner, A.J. (2008). The complement cascade: Yin-Yang in neuroinflammation-neuro-protection and-degeneration. J Neurochem 107, 1169-1187.
    • (2008) J Neurochem , vol.107 , pp. 1169-1187
    • Alexander, J.J.1    Anderson, A.J.2    Barnum, S.R.3    Stevens, B.4    Tenner, A.J.5
  • 6
    • 24644487357 scopus 로고    scopus 로고
    • Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection
    • Atkinson, C., Song, H., Lu, B., Qiao, F., Burns, T.A., Holers, V.M., Tsokos, G.C., and Tomlinson, S. (2005). Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection. J Clin Invest 115, 2444-2453.
    • (2005) J Clin Invest , vol.115 , pp. 2444-2453
    • Atkinson, C.1    Song, H.2    Lu, B.3    Qiao, F.4    Burns, T.A.5    Holers, V.M.6    Tsokos, G.C.7    Tomlinson, S.8
  • 7
    • 3843129808 scopus 로고    scopus 로고
    • Murine hindlimb reperfusion injury can be initiated by a self-reactive monoclonal IgM
    • Austen, W.G., Jr., Zhang, M., Chan, R., Friend, D., Hechtman, H.B., Carroll, M.C., and Moore, F.D., Jr. (2004). Murine hindlimb reperfusion injury can be initiated by a self-reactive monoclonal IgM. Surgery 136, 401-406.
    • (2004) Surgery , vol.136 , pp. 401-406
    • Austen, W.G.1    Zhang, M.2    Chan, R.3    Friend, D.4    Hechtman, H.B.5    Carroll, M.C.6    Moore, F.D.7
  • 9
    • 0035942340 scopus 로고    scopus 로고
    • Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility
    • Barber, P.A., Zhang, J., Demchuk, A.M., Hill, M.D., and Buchan, A.M. (2001). Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility. Neurology 56, 1015-1020.
    • (2001) Neurology , vol.56 , pp. 1015-1020
    • Barber, P.A.1    Zhang, J.2    Demchuk, A.M.3    Hill, M.D.4    Buchan, A.M.5
  • 10
    • 0031036287 scopus 로고    scopus 로고
    • Activation of complement by tissue plasminogen activator, but not acute cerebral ischemia, in a rabbit model of thromboembolic stroke
    • Bednar, M.M., Gross, C.E., Russell, S.R., Short, D., and Giclas, P.C. (1997). Activation of complement by tissue plasminogen activator, but not acute cerebral ischemia, in a rabbit model of thromboembolic stroke. J Neurosurg 86, 139-142.
    • (1997) J Neurosurg , vol.86 , pp. 139-142
    • Bednar, M.M.1    Gross, C.E.2    Russell, S.R.3    Short, D.4    Giclas, P.C.5
  • 13
    • 6344241861 scopus 로고    scopus 로고
    • Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death
    • Benard, M., Gonzalez, B.J., Schouft, M.T., Falluel-Morel, A., Vaudry, D., Chan, P., Vaudry, H., and Fontaine, M. (2004). Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death. J Biol Chem 279, 43487-43496.
    • (2004) J Biol Chem , vol.279 , pp. 43487-43496
    • Benard, M.1    Gonzalez, B.J.2    Schouft, M.T.3    Falluel-Morel, A.4    Vaudry, D.5    Chan, P.6    Vaudry, H.7    Fontaine, M.8
  • 15
    • 79952273376 scopus 로고    scopus 로고
    • Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression
    • Benoit, M.E., and Tenner, A.J. (2011). Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression. J Neurosci 31, 3459-3469.
    • (2011) J Neurosci , vol.31 , pp. 3459-3469
    • Benoit, M.E.1    Tenner, A.J.2
  • 16
    • 23644456320 scopus 로고    scopus 로고
    • C3a expressed in the central nervous system protects against LPS-induced shock
    • Boos, L., Szalai, A.J., and Barnum, S.R. (2005). C3a expressed in the central nervous system protects against LPS-induced shock. Neurosci Lett 387, 68-71.
    • (2005) Neurosci Lett , vol.387 , pp. 68-71
    • Boos, L.1    Szalai, A.J.2    Barnum, S.R.3
  • 17
    • 70350447381 scopus 로고    scopus 로고
    • Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin
    • Busche, M.N., Pavlov, V., Takahashi, K., and Stahl, G.L. (2009). Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin. Am J Physiol Heart Circ Physiol 297, H1853-1859.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297 , pp. H1853-H1859
    • Busche, M.N.1    Pavlov, V.2    Takahashi, K.3    Stahl, G.L.4
  • 18
    • 0037307933 scopus 로고    scopus 로고
    • Plasticity of cortical projections after stroke
    • Carmichael, S.T. (2003). Plasticity of cortical projections after stroke. Neuroscientist 9, 64-75.
    • (2003) Neuroscientist , vol.9 , pp. 64-75
    • Carmichael, S.T.1
  • 19
    • 18144416945 scopus 로고    scopus 로고
    • Growthassociated gene expression after stroke: evidence for a growth-promoting region in periinfarct cortex
    • Carmichael, S.T., Archibeque, I., Luke, L., Nolan, T., Momiy, J., and Li, S. (2005). Growthassociated gene expression after stroke: evidence for a growth-promoting region in periinfarct cortex. Exp Neurol 193, 291-311.
    • (2005) Exp Neurol , vol.193 , pp. 291-311
    • Carmichael, S.T.1    Archibeque, I.2    Luke, L.3    Nolan, T.4    Momiy, J.5    Li, S.6
  • 20
    • 0035173635 scopus 로고    scopus 로고
    • New patterns of intracortical projections after focal cortical stroke
    • Carmichael, S.T., Wei, L., Rovainen, C.M., and Woolsey, T.A. (2001). New patterns of intracortical projections after focal cortical stroke. Neurobiol Dis 8, 910-922.
    • (2001) Neurobiol Dis , vol.8 , pp. 910-922
    • Carmichael, S.T.1    Wei, L.2    Rovainen, C.M.3    Woolsey, T.A.4
  • 21
    • 34447262543 scopus 로고    scopus 로고
    • Usefulness of the serum complement component C4 as a predictor of stroke in patients with known or suspected coronary artery disease referred for coronary angiography
    • Cavusoglu, E., Eng, C., Chopra, V., Ruwende, C., Yanamadala, S., Clark, L.T., Pinsky, D.J., and Marmur, J.D. (2007). Usefulness of the serum complement component C4 as a predictor of stroke in patients with known or suspected coronary artery disease referred for coronary angiography. Amer J Cardiol. 100, 164-168.
    • (2007) Amer J Cardiol , vol.100 , pp. 164-168
    • Cavusoglu, E.1    Eng, C.2    Chopra, V.3    Ruwende, C.4    Yanamadala, S.5    Clark, L.T.6    Pinsky, D.J.7    Marmur, J.D.8
  • 22
    • 77949417477 scopus 로고    scopus 로고
    • Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke
    • Cervera, A., Planas, A.M., Justicia, C., Urra, X., Jensenius, J.C., Torres, F., Lozano, F., and Chamorro, A. (2010). Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke. PLoS One 5, e8433.
    • (2010) PLoS One , vol.5
    • Cervera, A.1    Planas, A.M.2    Justicia, C.3    Urra, X.4    Jensenius, J.C.5    Torres, F.6    Lozano, F.7    Chamorro, A.8
  • 25
    • 33746025371 scopus 로고    scopus 로고
    • Role of complement component C5 in cerebral ischemia/reperfusion injury
    • Costa, Cristina, et al. Role of complement component C5 in cerebral ischemia/reperfusion injury. (2006). Brain Res, 1100, 142-151.
    • (2006) Brain Res , vol.1100 , pp. 142-151
    • Costa, C.1
  • 26
    • 0142250820 scopus 로고    scopus 로고
    • Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats
    • Cowell, R.M., Plane, J.M., and Silverstein, F.S. (2003). Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats. J Neurosci 23, 9459-9468.
    • (2003) J Neurosci , vol.23 , pp. 9459-9468
    • Cowell, R.M.1    Plane, J.M.2    Silverstein, F.S.3
  • 28
    • 33644516274 scopus 로고    scopus 로고
    • C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP
    • Cudrici, C., Niculescu, F., Jensen, T., Zafranskaia, E., Fosbrink, M., Rus, V., Shin, M.L., and Rus, H. (2006). C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. J Immunol 176, 3173-3180.
    • (2006) J Immunol , vol.176 , pp. 3173-3180
    • Cudrici, C.1    Niculescu, F.2    Jensen, T.3    Zafranskaia, E.4    Fosbrink, M.5    Rus, V.6    Shin, M.L.7    Rus, H.8
  • 29
    • 0033134789 scopus 로고    scopus 로고
    • Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells
    • Davoust, N., Jones, J., Stahel, P.F., Ames, R.S., and Barnum, S.R. (1999). Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells. Glia 26, 201-211.
    • (1999) Glia , vol.26 , pp. 201-211
    • Davoust, N.1    Jones, J.2    Stahel, P.F.3    Ames, R.S.4    Barnum, S.R.5
  • 31
    • 1942437373 scopus 로고    scopus 로고
    • The powerful neuroprotective action of C1-inhibitor on brain ischemia-reperfusion injury does not require C1q
    • De Simoni, M.G., Rossi, E., Storini, C., Pizzimenti, S., Echart, C., and Bergamaschini, L. (2004). The powerful neuroprotective action of C1-inhibitor on brain ischemia-reperfusion injury does not require C1q. Amer J Pathol, 164, 1857-1863.
    • (2004) Amer J Pathol , vol.164 , pp. 1857-1863
    • De Simoni, M.G.1    Rossi, E.2    Storini, C.3    Pizzimenti, S.4    Echart, C.5    Bergamaschini, L.6
  • 33
    • 0035377582 scopus 로고    scopus 로고
    • Systemic complement activation in ischemic stroke
    • Di Napoli, M. (2001). Systemic complement activation in ischemic stroke. Stroke 32, 1443-1448.
    • (2001) Stroke , vol.32 , pp. 1443-1448
    • Di Napoli, M.1
  • 35
    • 35748936795 scopus 로고    scopus 로고
    • Pre-clinical evaluation of an sLe xglycosylated complement inhibitory protein in a non-human primate model of reperfused stroke
    • Ducruet, A.F., Mocco, J., Mack, W.J., Coon, A.L., Marsh, H.C., Pinsky, D.J., Hickman, Z.L., Kim, G.H., and Connolly, E.S., Jr. (2007). Pre-clinical evaluation of an sLe xglycosylated complement inhibitory protein in a non-human primate model of reperfused stroke. J Med Primatol 36, 375-380.
    • (2007) J Med Primatol , vol.36 , pp. 375-380
    • Ducruet, A.F.1    Mocco, J.2    Mack, W.J.3    Coon, A.L.4    Marsh, H.C.5    Pinsky, D.J.6    Hickman, Z.L.7    Kim, G.H.8    Connolly, E.S.9
  • 38
    • 84863011135 scopus 로고    scopus 로고
    • Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice
    • Elvington, A., Atkinson, C., Kulik, L., Zhu, H., Yu, J., Kindy, M.S., Holers, V.M., and Tomlinson, S. (2012a). Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice. J Immunol 188, 1460-1468.
    • (2012) J Immunol , vol.188 , pp. 1460-1468
    • Elvington, A.1    Atkinson, C.2    Kulik, L.3    Zhu, H.4    Yu, J.5    Kindy, M.S.6    Holers, V.M.7    Tomlinson, S.8
  • 39
    • 84867910274 scopus 로고    scopus 로고
    • The alternative complement pathway propagates inflammation and injury in murine ischemic stroke
    • Elvington, A., Atkinson, C., Zhu, H., Yu, J., Takahashi, K., Stahl, G.L., Kindy, M.S., and Tomlinson, S. (2012b). The alternative complement pathway propagates inflammation and injury in murine ischemic stroke. J Immunol 189, 4640-4647.
    • (2012) J Immunol , vol.189 , pp. 4640-4647
    • Elvington, A.1    Atkinson, C.2    Zhu, H.3    Yu, J.4    Takahashi, K.5    Stahl, G.L.6    Kindy, M.S.7    Tomlinson, S.8
  • 40
    • 34250649678 scopus 로고    scopus 로고
    • Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study
    • Engstrom, G., Hedblad, B., Janzon, L., and Lindgarde, F. (2007). Complement C3 and C4 in plasma and incidence of myocardial infarction and stroke: a population-based cohort study. Eur J Cardiovasc Prev Rehabil 14, 392-397.
    • (2007) Eur J Cardiovasc Prev Rehabil , vol.14 , pp. 392-397
    • Engstrom, G.1    Hedblad, B.2    Janzon, L.3    Lindgarde, F.4
  • 41
    • 18044383749 scopus 로고    scopus 로고
    • The administration of cobra venom factor reduces post-ischemic cerebral injury in adult and neonatal rats
    • Figueroa, E., Gordon, L.E., Feldhoff, P.W., and Lassiter, H.A. (2005). The administration of cobra venom factor reduces post-ischemic cerebral injury in adult and neonatal rats. Neurosci Lett 380, 48-53.
    • (2005) Neurosci Lett , vol.380 , pp. 48-53
    • Figueroa, E.1    Gordon, L.E.2    Feldhoff, P.W.3    Lassiter, H.A.4
  • 42
    • 66849097996 scopus 로고    scopus 로고
    • Update of the stroke therapy academic industry roundtable preclinical recommendations
    • Fisher, M., Feuerstein, G., Howells, D.W., Hurn, P.D., Kent, T.A., Savitz, S.I., and Lo, E.H. (2009). Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 40, 2244-2250.
    • (2009) Stroke , vol.40 , pp. 2244-2250
    • Fisher, M.1    Feuerstein, G.2    Howells, D.W.3    Hurn, P.D.4    Kent, T.A.5    Savitz, S.I.6    Lo, E.H.7
  • 43
    • 84878797556 scopus 로고    scopus 로고
    • Plasma levels of mannan-binding lectin (MBL)-associated serine proteases (MASPs) and MBL-associated protein in cardio-and cerebrovascular diseases
    • Frauenknecht, V., Thiel, S., Storm, L., Meier, N., Arnold, M., Schmid, J.P., Saner, H., and Schroeder, V. (2013). Plasma levels of mannan-binding lectin (MBL)-associated serine proteases (MASPs) and MBL-associated protein in cardio-and cerebrovascular diseases. Clin Exp Immunol 173, 112-120.
    • (2013) Clin Exp Immunol , vol.173 , pp. 112-120
    • Frauenknecht, V.1    Thiel, S.2    Storm, L.3    Meier, N.4    Arnold, M.5    Schmid, J.P.6    Saner, H.7    Schroeder, V.8
  • 45
    • 0033921540 scopus 로고    scopus 로고
    • Complement components of the innate immune system in health and disease in the CNS
    • Gasque, P., Dean, Y., Mcgreal, E., Vanbeek, J., and Morgan, B. (2000). Complement components of the innate immune system in health and disease in the CNS. Immunopharmacology 49, 171-186.
    • (2000) Immunopharmacology , vol.49 , pp. 171-186
    • Gasque, P.1    Dean, Y.2    Mcgreal, E.3    Vanbeek, J.4    Morgan, B.5
  • 46
    • 0029053689 scopus 로고
    • Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines
    • Gasque, P., Fontaine, M., and Morgan, B.P. (1995). Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines. J Immunol, 154, 4726-4733.
    • (1995) J Immunol , vol.154 , pp. 4726-4733
    • Gasque, P.1    Fontaine, M.2    Morgan, B.P.3
  • 48
    • 8344247671 scopus 로고    scopus 로고
    • Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats
    • Gill, R., Kemp, J.A., Sabin, C., and Pepys, M.B. (2004). Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats. J Cereb Blood Flow Metab 24, 1214-1218.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 1214-1218
    • Gill, R.1    Kemp, J.A.2    Sabin, C.3    Pepys, M.B.4
  • 49
    • 9644280856 scopus 로고    scopus 로고
    • The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation
    • Harboe, M., Ulvund, G., Vien, L., Fung, M., and Mollnes, T.E. (2004). The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation. Clin Exp Immunol 138, 439-446.
    • (2004) Clin Exp Immunol , vol.138 , pp. 439-446
    • Harboe, M.1    Ulvund, G.2    Vien, L.3    Fung, M.4    Mollnes, T.E.5
  • 51
    • 0031913982 scopus 로고    scopus 로고
    • Inflammatory signals induce neurotrophin expression in human microglial cells
    • Heese, K., Hock, C., and Otten, U. (1998). Inflammatory signals induce neurotrophin expression in human microglial cells. J Neurochem 70, 699-707.
    • (1998) J Neurochem , vol.70 , pp. 699-707
    • Heese, K.1    Hock, C.2    Otten, U.3
  • 52
    • 0033554228 scopus 로고    scopus 로고
    • C1-esterase inhibitor reduces infarct volume after cortical vein occlusion
    • Heimann, A., Takeshima, T., Horstick, G., and Kempski, O. (1999). C1-esterase inhibitor reduces infarct volume after cortical vein occlusion. Brain Res 838, 210-213.
    • (1999) Brain Res , vol.838 , pp. 210-213
    • Heimann, A.1    Takeshima, T.2    Horstick, G.3    Kempski, O.4
  • 54
    • 2442667974 scopus 로고    scopus 로고
    • The alternative pathway of complement in disease: opportunities for therapeutic targeting
    • Holers, V.M., and Thurman, J.M. (2004). The alternative pathway of complement in disease: opportunities for therapeutic targeting. Mol Immunol 41, 147-152.
    • (2004) Mol Immunol , vol.41 , pp. 147-152
    • Holers, V.M.1    Thurman, J.M.2
  • 57
    • 78349305772 scopus 로고    scopus 로고
    • Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model
    • Hurtado, O., Serrano, J., Sobrado, M., Fernández, A., Lizasoain, I., Martínez-Murillo, R., Moro, M., and Martínez, A. (2010). Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model. Neuroscience 171, 885-892.
    • (2010) Neuroscience , vol.171 , pp. 885-892
    • Hurtado, O.1    Serrano, J.2    Sobrado, M.3    Fernández, A.4    Lizasoain, I.5    Martínez-Murillo, R.6    Moro, M.7    Martínez, A.8
  • 58
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: from mechanisms to translation
    • Iadecola, C., and Anrather, J. (2011). The immunology of stroke: from mechanisms to translation. Nat Med 17, 796-808.
    • (2011) Nat Med , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 59
    • 0037076863 scopus 로고    scopus 로고
    • The administration of complement component C9 augments post-ischemic cerebral infarction volume in neonatal rats
    • Imm, M.D., Feldhoff, P.W., Feldhoff, R.C., and Lassiter, H.A. (2002). The administration of complement component C9 augments post-ischemic cerebral infarction volume in neonatal rats. Neurosci Lett 325, 175-178.
    • (2002) Neurosci Lett , vol.325 , pp. 175-178
    • Imm, M.D.1    Feldhoff, P.W.2    Feldhoff, R.C.3    Lassiter, H.A.4
  • 63
    • 0033766746 scopus 로고    scopus 로고
    • Frequencies of certain complement protein alleles and serum levels of anti-heat-shock protein antibodies in cerebrovascular diseases
    • Kramer, J., Harcos, P., Prohaszka, Z., Horvath, L., Karadi, I., Singh, M., Csaszar, A., Romics, L., and Fust, G. (2000). Frequencies of certain complement protein alleles and serum levels of anti-heat-shock protein antibodies in cerebrovascular diseases. Stroke 31, 2648-2652.
    • (2000) Stroke , vol.31 , pp. 2648-2652
    • Kramer, J.1    Harcos, P.2    Prohaszka, Z.3    Horvath, L.4    Karadi, I.5    Singh, M.6    Csaszar, A.7    Romics, L.8    Fust, G.9
  • 65
    • 0023226359 scopus 로고
    • Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation
    • Levi-Strauss, M., and Mallat, M. (1987). Primary cultures of murine astrocytes produce C3 and factor B, two components of the alternative pathway of complement activation. J Immunol, 139, 2361-2366.
    • (1987) J Immunol , vol.139 , pp. 2361-2366
    • Levi-Strauss, M.1    Mallat, M.2
  • 67
    • 84891600918 scopus 로고    scopus 로고
    • Neuroprotective effects of Argatroban and C5a receptor antagonist (PMX53) following intracerebral hemorrhage
    • Li, G., Fan, R.M., Chen, J.L., Wang, C.M., Zeng, Y.C., Han, C., Jiao, S., Xia, X.P., Chen, W., and Yao, S.T. (2013). Neuroprotective effects of Argatroban and C5a receptor antagonist (PMX53) following intracerebral hemorrhage. Clin Exp Immunol 175, 285-295.
    • (2013) Clin Exp Immunol , vol.175 , pp. 285-295
    • Li, G.1    Fan, R.M.2    Chen, J.L.3    Wang, C.M.4    Zeng, Y.C.5    Han, C.6    Jiao, S.7    Xia, X.P.8    Chen, W.9    Yao, S.T.10
  • 68
    • 80855164480 scopus 로고    scopus 로고
    • The protective effect of SCR(15-18) on cerebral ischemia-reperfusion injury
    • Li, S., Xian, J., He, L., Luo, X., Tan, B., Yang, Y., Liu, G., and Wang, Z. (2011). The protective effect of SCR(15-18) on cerebral ischemia-reperfusion injury. Neurol Res 33, 866-874.
    • (2011) Neurol Res , vol.33 , pp. 866-874
    • Li, S.1    Xian, J.2    He, L.3    Luo, X.4    Tan, B.5    Yang, Y.6    Liu, G.7    Wang, Z.8
  • 70
    • 84887776829 scopus 로고    scopus 로고
    • Expressions of complement C1q and C3c in rat brain tissues with cerebral ischemia/reperfusion injury
    • Luo, H., Li, W., Yang, F., Zhou, L., Wen, P., and Zhou, J. (2013). Expressions of complement C1q and C3c in rat brain tissues with cerebral ischemia/reperfusion injury. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 29, 897-900.
    • (2013) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi , vol.29 , pp. 897-900
    • Luo, H.1    Li, W.2    Yang, F.3    Zhou, L.4    Wen, P.5    Zhou, J.6
  • 72
    • 33751106657 scopus 로고    scopus 로고
    • Mannose-binding lectin binds IgM to activate the lectin complement pathway in vitro and in vivo
    • Mcmullen, M.E., Hart, M.L., Walsh, M.C., Buras, J., Takahashi, K., and Stahl, G.L. (2006). Mannose-binding lectin binds IgM to activate the lectin complement pathway in vitro and in vivo. Immunobiology 211, 759-766.
    • (2006) Immunobiology , vol.211 , pp. 759-766
    • Mcmullen, M.E.1    Hart, M.L.2    Walsh, M.C.3    Buras, J.4    Takahashi, K.5    Stahl, G.L.6
  • 73
    • 0036135588 scopus 로고    scopus 로고
    • The membrane attack complex of complement causes severe demyelination associated with acute axonal injury
    • Mead, R.J., Singhrao, S.K., Neal, J.W., Lassmann, H., and Morgan, B.P. (2002). The membrane attack complex of complement causes severe demyelination associated with acute axonal injury. J Immunol 168, 458-465.
    • (2002) J Immunol , vol.168 , pp. 458-465
    • Mead, R.J.1    Singhrao, S.K.2    Neal, J.W.3    Lassmann, H.4    Morgan, B.P.5
  • 80
    • 0035076597 scopus 로고    scopus 로고
    • Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinase-dependent inhibition of caspase 3
    • Mukherjee, P., and Pasinetti, G.M. (2001). Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinase-dependent inhibition of caspase 3. J Neurochem 77, 43-49.
    • (2001) J Neurochem , vol.77 , pp. 43-49
    • Mukherjee, P.1    Pasinetti, G.M.2
  • 81
    • 39649121460 scopus 로고    scopus 로고
    • Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo
    • Mukherjee, P., Thomas, S., and Pasinetti, G.M. (2008). Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo. J Neuroinflam, 5, 5.
    • (2008) J Neuroinflam , vol.5 , pp. 5
    • Mukherjee, P.1    Thomas, S.2    Pasinetti, G.M.3
  • 82
    • 70450267518 scopus 로고    scopus 로고
    • Plasticity during stroke recovery: from synapse to behaviour
    • Murphy, T.H., and Corbett, D. (2009). Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci 10, 861-872.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 861-872
    • Murphy, T.H.1    Corbett, D.2
  • 83
    • 80052787372 scopus 로고    scopus 로고
    • Genetic variation in complement component C3 shows association with ischaemic stroke
    • Olsson, S., Stokowska, A., Holmegaard, L., Jood, K., Blomstrand, C., Pekna, M., and Jern, C. (2011). Genetic variation in complement component C3 shows association with ischaemic stroke. Eur J Neurol, 18, 1272-1274.
    • (2011) Eur J Neurol , vol.18 , pp. 1272-1274
    • Olsson, S.1    Stokowska, A.2    Holmegaard, L.3    Jood, K.4    Blomstrand, C.5    Pekna, M.6    Jern, C.7
  • 85
    • 0033562337 scopus 로고    scopus 로고
    • Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity
    • Osaka, H., Mukherjee, P., Aisen, P.S., and Pasinetti, G.M. (1999). Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity. J Cell Biochem 73, 303-311.
    • (1999) J Cell Biochem , vol.73 , pp. 303-311
    • Osaka, H.1    Mukherjee, P.2    Aisen, P.S.3    Pasinetti, G.M.4
  • 87
    • 84872072202 scopus 로고    scopus 로고
    • Evolution of reperfusion therapies for acute brain and acute myocardial ischemia: a systematic, comparative analysis
    • Patel, R.D., and Saver, J.L. (2013). Evolution of reperfusion therapies for acute brain and acute myocardial ischemia: a systematic, comparative analysis. Stroke 44, 94-98.
    • (2013) Stroke , vol.44 , pp. 94-98
    • Patel, R.D.1    Saver, J.L.2
  • 88
    • 84865716916 scopus 로고    scopus 로고
    • Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis
    • Pavlovski, D., Thundyil, J., Monk, P.N., Wetsel, R.A., Taylor, S.M., and Woodruff, T.M. (2012). Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis. Faseb j 26, 3680-3690.
    • (2012) Faseb j , vol.26 , pp. 3680-3690
    • Pavlovski, D.1    Thundyil, J.2    Monk, P.N.3    Wetsel, R.A.4    Taylor, S.M.5    Woodruff, T.M.6
  • 89
    • 33846232316 scopus 로고    scopus 로고
    • Expression of complement regulators and receptors on human NT2-N neurons-effect of hypoxia and reoxygenation
    • Pedersen, E.D., Froyland, E., Kvissel, A.K., Pharo, A.M., Skalhegg, B.S., Rootwelt, T., and Mollnes, T.E. (2007). Expression of complement regulators and receptors on human NT2-N neurons-effect of hypoxia and reoxygenation. Mol Immunol 44, 2459-2468.
    • (2007) Mol Immunol , vol.44 , pp. 2459-2468
    • Pedersen, E.D.1    Froyland, E.2    Kvissel, A.K.3    Pharo, A.M.4    Skalhegg, B.S.5    Rootwelt, T.6    Mollnes, T.E.7
  • 92
    • 58449100948 scopus 로고    scopus 로고
    • The complement-derived anaphylatoxin C5a increases microglial GLT-1 expression and glutamate uptake in a TNF-alpha-independent manner
    • Persson, M., Pekna, M., Hansson, E., and Ronnback, L. (2009). The complement-derived anaphylatoxin C5a increases microglial GLT-1 expression and glutamate uptake in a TNF-alpha-independent manner. Eur J Neurosci 29, 267-274.
    • (2009) Eur J Neurosci , vol.29 , pp. 267-274
    • Persson, M.1    Pekna, M.2    Hansson, E.3    Ronnback, L.4
  • 93
    • 38049107388 scopus 로고    scopus 로고
    • Complement component C1q inhibits beta-amyloid-and serum amyloid P-induced neurotoxicity via caspase-and calpain-independent mechanisms
    • Pisalyaput, K., and Tenner, A.J. (2008). Complement component C1q inhibits beta-amyloid-and serum amyloid P-induced neurotoxicity via caspase-and calpain-independent mechanisms. J Neurochem 104, 696-707.
    • (2008) J Neurochem , vol.104 , pp. 696-707
    • Pisalyaput, K.1    Tenner, A.J.2
  • 95
    • 49449109634 scopus 로고    scopus 로고
    • The complement system in the peripheral nerve: Friend or foe?
    • Ramaglia, V., Daha, M., and Baas, F. (2008). The complement system in the peripheral nerve: Friend or foe? Mol Immunol, 45, 3865-3877.
    • (2008) Mol Immunol , vol.45 , pp. 3865-3877
    • Ramaglia, V.1    Daha, M.2    Baas, F.3
  • 96
    • 77955883153 scopus 로고    scopus 로고
    • Complement: a key system for immune surveillance and homeostasis
    • Ricklin, D., Hajishengallis, G., Yang, K., and Lambris, J.D. (2010). Complement: a key system for immune surveillance and homeostasis. Nat Immunol 11, 785-797.
    • (2010) Nat Immunol , vol.11 , pp. 785-797
    • Ricklin, D.1    Hajishengallis, G.2    Yang, K.3    Lambris, J.D.4
  • 97
    • 0036849021 scopus 로고    scopus 로고
    • Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide
    • Rogers, J., Strohmeyer, R., Kovelowski, C.J., and Li, R. (2002). Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia 40, 260-269.
    • (2002) Glia , vol.40 , pp. 260-269
    • Rogers, J.1    Strohmeyer, R.2    Kovelowski, C.J.3    Li, R.4
  • 98
    • 33846504078 scopus 로고    scopus 로고
    • Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system
    • Rupprecht, T.A., Angele, B., Klein, M., Heesemann, J., Pfister, H.W., Botto, M., and Koedel, U. (2007). Complement C1q and C3 are critical for the innate immune response to Streptococcus pneumoniae in the central nervous system. J Immunol 178, 1861-1869.
    • (2007) J Immunol , vol.178 , pp. 1861-1869
    • Rupprecht, T.A.1    Angele, B.2    Klein, M.3    Heesemann, J.4    Pfister, H.W.5    Botto, M.6    Koedel, U.7
  • 101
    • 0343962980 scopus 로고    scopus 로고
    • Complement C1q is dramatically up-regulated in brain microglia in response to transient global cerebral ischemia
    • Schafer, M.K., Schwaeble, W.J., Post, C., Salvati, P., Calabresi, M., Sim, R.B., Petry, F., Loos, M., and Weihe, E. (2000). Complement C1q is dramatically up-regulated in brain microglia in response to transient global cerebral ischemia. J Immunol 164, 5446-5452.
    • (2000) J Immunol , vol.164 , pp. 5446-5452
    • Schafer, M.K.1    Schwaeble, W.J.2    Post, C.3    Salvati, P.4    Calabresi, M.5    Sim, R.B.6    Petry, F.7    Loos, M.8    Weihe, E.9
  • 102
    • 14844336965 scopus 로고    scopus 로고
    • Complement component 9 activation, consumption, and neuronal deposition in the post-hypoxic-ischemic central nervous system of human newborn infants
    • Schultz, S.J., Aly, H., Hasanen, B.M., Khashaba, M.T., Lear, S.C., Bendon, R.W., Gordon, L.E., Feldhoff, P.W., and Lassiter, H.A. (2005). Complement component 9 activation, consumption, and neuronal deposition in the post-hypoxic-ischemic central nervous system of human newborn infants. Neurosci Lett 378, 1-6.
    • (2005) Neurosci Lett , vol.378 , pp. 1-6
    • Schultz, S.J.1    Aly, H.2    Hasanen, B.M.3    Khashaba, M.T.4    Lear, S.C.5    Bendon, R.W.6    Gordon, L.E.7    Feldhoff, P.W.8    Lassiter, H.A.9
  • 103
    • 72849120050 scopus 로고    scopus 로고
    • Complementderived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells
    • Shinjyo, N., Stahlberg, A., Dragunow, M., Pekny, M., and Pekna, M. (2009). Complementderived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells. Stem Cells 27, 2824-2832.
    • (2009) Stem Cells , vol.27 , pp. 2824-2832
    • Shinjyo, N.1    Stahlberg, A.2    Dragunow, M.3    Pekny, M.4    Pekna, M.5
  • 104
    • 0033485393 scopus 로고    scopus 로고
    • Inhibition of oligodendrocyte apoptosis by sublytic C5b-9 is associated with enhanced synthesis of bcl-2 and mediated by inhibition of caspase-3 activation
    • Soane, L., Rus, H., Niculescu, F., and Shin, M.L. (1999). Inhibition of oligodendrocyte apoptosis by sublytic C5b-9 is associated with enhanced synthesis of bcl-2 and mediated by inhibition of caspase-3 activation. J Immunol 163, 6132-6138.
    • (1999) J Immunol , vol.163 , pp. 6132-6138
    • Soane, L.1    Rus, H.2    Niculescu, F.3    Shin, M.L.4
  • 105
    • 33747164229 scopus 로고    scopus 로고
    • Complement C3 and Creactive protein are elevated in South Asians independent of a family history of stroke
    • Somani, R., Grant, P.J., Kain, K., Catto, A.J., and Carter, A.M. (2006). Complement C3 and Creactive protein are elevated in South Asians independent of a family history of stroke. Stroke 37, 2001-2006.
    • (2006) Stroke , vol.37 , pp. 2001-2006
    • Somani, R.1    Grant, P.J.2    Kain, K.3    Catto, A.J.4    Carter, A.M.5
  • 107
    • 0031443978 scopus 로고    scopus 로고
    • Bacterial meningitis: complement gene expression in the central nervous system
    • Stahel, P.F., and Bamum, S.R. (1997). Bacterial meningitis: complement gene expression in the central nervous system. Immunopharmacology 38, 65-72.
    • (1997) Immunopharmacology , vol.38 , pp. 65-72
    • Stahel, P.F.1    Bamum, S.R.2
  • 108
    • 84860338445 scopus 로고    scopus 로고
    • The complement system: an unexpected role in synaptic pruning during development and disease
    • Stephan, A.H., Barres, B.A., and Stevens, B. (2012). The complement system: an unexpected role in synaptic pruning during development and disease. Annu Rev Neurosci 35, 369-389.
    • (2012) Annu Rev Neurosci , vol.35 , pp. 369-389
    • Stephan, A.H.1    Barres, B.A.2    Stevens, B.3
  • 110
    • 79959546271 scopus 로고    scopus 로고
    • Plasma C3 and C3a levels in cryptogenic and large-vessel disease stroke: associations with outcome
    • Stokowska, A., Olsson, S., Holmegaard, L., Jood, K., Blomstrand, C., Jern, C., and Pekna, M. (2011). Plasma C3 and C3a levels in cryptogenic and large-vessel disease stroke: associations with outcome. Cerebrovasc Dis 32, 114-122.
    • (2011) Cerebrovasc Dis , vol.32 , pp. 114-122
    • Stokowska, A.1    Olsson, S.2    Holmegaard, L.3    Jood, K.4    Blomstrand, C.5    Jern, C.6    Pekna, M.7
  • 111
    • 84882627221 scopus 로고    scopus 로고
    • Cardioembolic and Small Vessel Disease Stroke Show Differences in Associations between Systemic C3 Levels and Outcome
    • Stokowska, A., Olsson, S., Holmegaard, L., Jood, K., Blomstrand, C., Jern, C., and Pekna, M. (2013). Cardioembolic and Small Vessel Disease Stroke Show Differences in Associations between Systemic C3 Levels and Outcome. PLoS One 8, e72133.
    • (2013) PLoS One , vol.8
    • Stokowska, A.1    Olsson, S.2    Holmegaard, L.3    Jood, K.4    Blomstrand, C.5    Jern, C.6    Pekna, M.7
  • 117
    • 31144460785 scopus 로고    scopus 로고
    • The central role of the alternative complement pathway in human disease
    • Thurman, J.M., and Holers, V.M. (2006). The central role of the alternative complement pathway in human disease. J Immunol 176, 1305-1310.
    • (2006) J Immunol , vol.176 , pp. 1305-1310
    • Thurman, J.M.1    Holers, V.M.2
  • 118
    • 0034703598 scopus 로고    scopus 로고
    • Hypoxia-induced expression of C1q, a subcomponent of the complement system, in cultured rat PC12 cells
    • Tohgi, H., Utsugisawa, K., and Nagane, Y. (2000). Hypoxia-induced expression of C1q, a subcomponent of the complement system, in cultured rat PC12 cells. Neurosci Lett 291, 151-154.
    • (2000) Neurosci Lett , vol.291 , pp. 151-154
    • Tohgi, H.1    Utsugisawa, K.2    Nagane, Y.3
  • 119
    • 0035847643 scopus 로고    scopus 로고
    • Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death
    • Van Beek, J., Nicole, O., Ali, C., Ischenko, A., Mackenzie, E.T., Buisson, A., and Fontaine, M. (2001). Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death. Neuroreport 12, 289-293.
    • (2001) Neuroreport , vol.12 , pp. 289-293
    • Van Beek, J.1    Nicole, O.2    Ali, C.3    Ischenko, A.4    Mackenzie, E.T.5    Buisson, A.6    Fontaine, M.7
  • 121
    • 33745478859 scopus 로고    scopus 로고
    • Mechanisms of neural plasticity following brain injury
    • Wieloch, T., and Nikolich, K. (2006a). Mechanisms of neural plasticity following brain injury. Curr Opin Neurobiol 16, 258-264.
    • (2006) Curr Opin Neurobiol , vol.16 , pp. 258-264
    • Wieloch, T.1    Nikolich, K.2
  • 122
    • 33745478859 scopus 로고    scopus 로고
    • Mechanisms of neural plasticity following brain injury
    • Wieloch, T., and Nikolich, K. (2006b). Mechanisms of neural plasticity following brain injury. Curr Opin Neurobiol 16, 258-264.
    • (2006) Curr Opin Neurobiol , vol.16 , pp. 258-264
    • Wieloch, T.1    Nikolich, K.2
  • 124
    • 84873302973 scopus 로고    scopus 로고
    • Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice
    • Yang, J., Ahn, H.N., Chang, M., Narasimhan, P., Chan, P.H., and Song, Y.S. (2013). Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice. J Neurochem,124, 523-535.
    • (2013) J Neurochem , vol.124 , pp. 523-535
    • Yang, J.1    Ahn, H.N.2    Chang, M.3    Narasimhan, P.4    Chan, P.H.5    Song, Y.S.6
  • 125
    • 33745506458 scopus 로고    scopus 로고
    • Complement factor H Y402H gene polymorphism, C-reactive protein, and risk of incident myocardial infarction, ischaemic stroke, and venous thromboembolism: a nested case-control study
    • Zee, R.Y., Diehl, K.A., and Ridker, P.M. (2006). Complement factor H Y402H gene polymorphism, C-reactive protein, and risk of incident myocardial infarction, ischaemic stroke, and venous thromboembolism: a nested case-control study. Atherosclerosis 187, 332-335.
    • (2006) Atherosclerosis , vol.187 , pp. 332-335
    • Zee, R.Y.1    Diehl, K.A.2    Ridker, P.M.3
  • 126
    • 84939885619 scopus 로고    scopus 로고
    • Is plasma C3 and C4 levels useful in young cerebral ischemic stroke patients? Associations with prognosis at 3 months
    • Zhang, B., Yang, N., and Gao, C. (2014a). Is plasma C3 and C4 levels useful in young cerebral ischemic stroke patients? Associations with prognosis at 3 months. J Thromb, 39, 209-214.
    • (2014) J Thromb , vol.39 , pp. 209-214
    • Zhang, B.1    Yang, N.2    Gao, C.3
  • 131
    • 70349437186 scopus 로고    scopus 로고
    • Complement regulators and inhibitory proteins
    • Zipfel, P.F., and Skerka, C. (2009). Complement regulators and inhibitory proteins. Nat Rev Immunol 9, 729-740.
    • (2009) Nat Rev Immunol , vol.9 , pp. 729-740
    • Zipfel, P.F.1    Skerka, C.2


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