Genetic variation in complement component C3 shows association with ischaemic stroke

European Journal of Neurology

Volumn 18, Issue 10, 2011, Pages 1272-1274

  Olsson, S ^a   Stokowska, A ^a   Holmegaard, L ^a   Jood, K ^a   Blomstrand, C ^a   Pekna, M ^a   Jern, C ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Complement; Functional outcome; Genetics; Ischaemic stroke; Single nucleotide polymorphism; TOAST

Indexed keywords

COMPLEMENT COMPONENT C3;

AGED; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DIABETES MELLITUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; STROKE;

BRAIN ISCHEMIA; COMPLEMENT C3; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; STROKE;

EID: 80052787372     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2011.03377.x     Document Type: Article

References (12)

1. McColl BW, Allan SM, Rothwell NJ. Systemic infection, inflammation and acute ischemic stroke. Neuroscience 2009; 158: 1049-1061.
2. Pedersen ED, Løberg EM, Vege E, Daha MR, Maehlen J, Mollnes TE. In situ deposition of complement in human acute brain ischaemia. Scand J Immunol 2009; 69: 555-562.
3. Lindsberg PJ, Ohman J, Lehto T, et al. Complement activation in the central nervous system following blood-brain barrier damage in man. Ann Neurol 1996; 40: 587-596.
4. Rahpeymai Y, Hietala MA, Wilhelmsson U, et al. Complement: a novel factor in basal and ischemia-induced neurogenesis. EMBO J 2006; 25: 1364-1374.
5. Sahu A, Lambris JD. Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunol Rev 2001; 180: 35-48.
6. Jood K, Ladenvall C, Rosengren A, Blomstrand C, Jern C. Family history in ischemic stroke before 70years of age: the Sahlgrenska Academy Study on Ischemic Stroke. Stroke 2005; 36: 1383-1387.
7. Olsson S, Jood K, Blomstrand C, Jern C. Genetic variation on chromosome 9p21 shows association with the ischaemic stroke subtype large-vessel disease in a Swedish sample aged ≤70. Eur J Neurol 2011; 18: 365-367.
8. Flossmann E, Schulz UG, Rothwell PM. Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke. Stroke 2004; 35: 212-227.
9. Rhodes B, Hunnangkul S, Morris DL, et al. The heritability and genetics of complement C3 expression in UK SLE families. Genes Immun 2009; 10: 525-530.
10. Greisenegger S, Zehetmayer S, Bauer P, et al. Polymorphisms in inflammatory genes and the risk of ischemic stroke and transient ischemic attack: results of a multilocus genotyping assay. Clin Chem 2009; 55: 134-138.
11. Berger K, Stogbauer F, Stoll M, et al. The Glu298Asp polymorphism in the nitric oxide synthase 3 gene is associated with the risk of ischemic stroke in two large independent case-control studies. Hum Genet 2007; 121: 169-178.
12. Kramer J, Harcos P, Prohaszka Z, et al. Frequencies of certain complement protein alleles and serum levels of anti-heat-shock protein antibodies in cerebrovascular diseases. Stroke 2000; 31: 2648-2652.