Plasma C3 and C3a levels in cryptogenic and large-vessel disease stroke: Associations with outcome

Cerebrovascular Diseases

Volumn 32, Issue 2, 2011, Pages 114-122

  Stokowska, Anna ^a   Olsson, Sandra ^a   Holmegaard, Lukas ^a   Jood, Katarina ^a   Blomstrand, Christian ^a   Jern, Christina ^a   Pekna, Marcela ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

C3; C3a; Complement system; Ischemic stroke; Outcome

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3A;

ADULT; ARTICLE; BLOOD LEVEL; BRAIN ISCHEMIA; COMPLEMENT SYSTEM; CONTROLLED STUDY; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RANKIN SCALE;

BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; COMPLEMENT C3; COMPLEMENT C3A; FEMALE; FOLLOW-UP STUDIES; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SEVERITY OF ILLNESS INDEX; STROKE;

EID: 79959546271     PISSN: 10159770     EISSN: 14219786     Source Type: Journal    
DOI: 10.1159/000328238     Document Type: Article

References (27)

1. Lindsberg PJ, Grau AJ: Inflammation and infections as risk factors for ischemic stroke. Stroke 2003; 34: 2518-2532. (Pubitemid 37221976)
2. Danton GH, Dietrich WD: Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol 2003; 62: 127-136. (Pubitemid 36176947)
3. Stoll G, Bendszus M: Inflammation and atherosclerosis: Novel insights into plaque formation and destabilization. Stroke 2006; 37: 1923-1932. (Pubitemid 44297753)
4. Wahlgren CM, Zheng W, Shaalan W, Tang J, Bassiouny HS: Human carotid plaque calcification and vulnerability. Relationship between degree of plaque calcification, fibrous cap inflammatory gene expression and symptomatology. Cerebrovasc Dis 2009; 27: 193-200.
5. Arenillas JF, Alvarez-Sabin J, Molina CA, Chacon P, Fernandez-Cadenas I, Ribo M, Delgado P, Rubiera M, Penalba A, Rovira A, Montaner J: Progression of symptomatic intracranial large artery atherosclerosis is associated with a proinflammatory state and impaired fibrinolysis. Stroke 2008; 39: 1456-1463.
6. Worthmann H, Tryc AB, Goldbecker A, Ma YT, Tountopoulou A, Hahn A, Dengler R, Lichtinghagen R, Weissenborn K: The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcome. Cerebrovasc Dis 2010; 30: 85-92.
7. Rahpeymai Y, Hietala MA, Wilhelmsson U, Fotheringham A, Davies I, Nilsson AK, Zwirner J, Wetsel RA, Gerard C, Pekny M, Pekna M: Complement: A novel factor in basal and ischemia-induced neurogenesis. EMBO J 2006; 25: 1364-1374.
8. van Beek J, Nicole O, Ali C, Ischenko A, MacKenzie ET, Buisson A, Fontaine M: Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death. Neuroreport 2001; 12: 289-293. (Pubitemid 32114367)
9. Mukherjee P, Pasinetti GM: Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinase-dependent inhibition of caspase 3. J Neurochem 2001; 77: 43-49. (Pubitemid 32245078)
10. De Simoni MG, Storini C, Barba M, Catapano L, Arabia AM, Rossi E, Bergamaschini L: Neuroprotection by complement (C1) inhibitor in mouse transient brain ischemia. J Cereb Blood Flow Metab 2003; 23: 232-239. (Pubitemid 36188461)
11. Mocco J, Mack WJ, Ducruet AF, Sosunov SA, Sughrue ME, Hassid BG, Nair MN, Laufer I, Komotar RJ, Claire M, Holland H, Pinsky DJ, Connolly ES, Jr: Complement component C3 mediates inflammatory injury following focal cerebral ischemia. Circ Res 2006; 99: 209-217. (Pubitemid 44297045)
12. Huang J, Kim LJ, Mealey R, Marsh HC, Jr, Zhang Y, Tenner AJ, Connolly ES, Jr, Pinsky DJ: Neuronal protection in stroke by an sLexglycosylated complement inhibitory protein. Science 1999; 285: 595-599.
13. Costa C, Zhao L, Shen Y, Su X, Hao L, Colgan SP, Stahl GL, Zhou T, Wang Y: Role of complement component C5 in cerebral ischemia/ reperfusion injury. Brain Res 2006; 1100: 142-151. (Pubitemid 44063494)
14. Pedersen ED, Loberg EM, Vege E, Daha MR, Maehlen J, Mollnes TE: In situ deposition of complement in human acute brain ischaemia. Scand J Immunol 2009; 69: 555-562.
15. Lindsberg PJ, Ohman J, Lehto T, Karjalainen-Lindsberg ML, Paetau A, Wuorimaa T, Carpen O, Kaste M, Meri S: Complement activation in the central nervous system following blood-brain barrier damage in man. Ann Neurol 1996; 40: 587-596. (Pubitemid 26357883)
16. Szeplaki G, Szegedi R, Hirschberg K, Gombos T, Varga L, Karadi I, Entz L, Szeplaki Z, Garred P, Prohaszka Z, Fust G: Strong complement activation after acute ischemic stroke is associated with unfavorable outcomes. Atherosclerosis 2009; 204: 315-320.
17. Tamam Y, Iltumur K, Apak I: Assessment of acute phase proteins in acute ischemic stroke. Tohoku J Exp Med 2005; 206: 91-98. (Pubitemid 40895037)
18. Mocco J, Wilson DA, Komotar RJ, Sughrue ME, Coates K, Sacco RL, Elkind MS, Connolly ES, Jr: Alterations in plasma complement levels after human ischemic stroke. Neurosurgery 2006; 59: 28-33; discussion 28-33.
19. Jood K, Ladenvall C, Rosengren A, Blomstrand C, Jern C: Family history in ischemic stroke before 70 years of age: The Sahlgrenska Academy Study on Ischemic Stroke. Stroke 2005; 36: 1383-1387. (Pubitemid 40967498)
20. Ladenvall C, Jood K, Blomstrand C, Nilsson S, Jern C, Ladenvall P: Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype. Stroke 2006; 37: 2018-2023. (Pubitemid 44309897)
21. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP: The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies. J Clin Epidemiol 2008; 61: 344-349. (Pubitemid 351289042)
22. Pedersen ED, Waje-Andreassen U, Vedeler CA, Aamodt G, Mollnes TE: Systemic complement activation following human acute ischaemic stroke. Clin Exp Immunol 2004; 137: 117-122. (Pubitemid 38869785)
23. Szeplaki G, Varga L, Fust G, Prohaszka Z: Role of complement in the pathomechanism of atherosclerotic vascular diseases. Mol Immunol 2009; 46: 2784-2793.
24. Bang OY, Lee PH, Joo SY, Lee JS, Joo IS, Huh K: Frequency and mechanisms of stroke recurrence after cryptogenic stroke. Ann Neurol 2003; 54: 227-234. (Pubitemid 36909621)
25. Bang OY, Lee PH, Yeo SH, Kim JW, Joo IS, Huh K: Non-cardioembolic mechanisms in cryptogenic stroke: Clinical and diffusionweighted imaging features. J Clin Neurol 2005; 1: 50-58.
26. Atkinson C, Zhu H, Qiao F, Varela JC, Yu J, Song H, Kindy MS, Tomlinson S: Complement-dependent P-selectin expression and injury following ischemic stroke. J Immunol 2006; 177: 7266-7274. (Pubitemid 44715096)
27. Ducruet AF, Hassid BG, Mack WJ, Sosunov SA, Otten ML, Fusco DJ, Hickman ZL, Kim GH, Komotar RJ, Mocco J, Connolly ES: C3a receptor modulation of granulocyte infiltration after murine focal cerebral ischemia is reperfusion dependent. J Cereb Blood Flow Metab 2008; 28: 1048-1058. (Pubitemid 351589644)