In situ deposition of complement in human acute brain ischaemia

Scandinavian Journal of Immunology

Volumn 69, Issue 6, 2009, Pages 555-562

  Pedersen, E D ^a   Loberg E M ^b   Vege, E ^b   Daha, M R ^c   Maehlen J ^b   Mollnes, T E ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; C REACTIVE PROTEIN; CD59 ANTIGEN; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C3C; COMPLEMENT COMPONENT C4D; COMPLEMENT COMPONENT C9; DECAY ACCELERATING FACTOR; IMMUNOGLOBULIN M; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNOSE BINDING LECTIN; PARAFFIN;

ADULT; AGED; ARTICLE; BRAIN ISCHEMIA; COMPLEMENT ACTIVATION; COMPLEMENT BLOOD LEVEL; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT DEPOSITION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROKE; TISSUE FIXATION; TISSUE INJURY;

ADULT; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED;

EID: 65349162764     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2009.02253.x     Document Type: Article

References (41)

1. Khalil AA, Aziz FA, Hall JC. Reperfusion injury. Plast Reconstr Surg 2006 117 : 1024 33. (Pubitemid 44324547)
2. Riedemann NC, Ward PA. Complement in ischemia reperfusion injury. Am J Pathol 2003 162 : 363 7. (Pubitemid 36267843)
3. Lucas SM, Rothwell NJ, Gibson RM. The role of inflammation in CNS injury and disease. Br J Pharmacol 2006 147 (Suppl. 1 S232 40. (Pubitemid 43077281)
4. Huang J, Kim LJ, Mealey R et al. Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. Science 1999 285 : 595 9. (Pubitemid 129515299)
5. Mack WJ, Sughrue ME, Ducruet AF et al. Temporal pattern of C1q deposition after transient focal cerebral ischemia. J Neurosci Res 2006 83 : 883 9.
6. Schafer MK, Schwaeble WJ, Post C et al. Complement C1q is dramatically up-regulated in brain microglia in response to transient global cerebral ischemia. J Immunol 2000 164 : 5446 52. (Pubitemid 30305228)
7. Mocco J, Mack WJ, Ducruet AF et al. Complement component C3 mediates inflammatory injury following focal cerebral ischemia. Circ Res 2006 99 : 209 17. (Pubitemid 44297045)
8. Imm MD, Feldhoff PW, Feldhoff RC, Lassiter HA. The administration of complement component C9 augments post-ischemic cerebral infarction volume in neonatal rats. Neurosci Lett 2002 325 : 175 8. (Pubitemid 34603523)
9. Lindsberg PJ, Ohman J, Lehto T et al. Complement activation in the central nervous system following blood-brain barrier damage in man. Ann Neurol 1996 40 : 587 96. (Pubitemid 26357883)
10. Buerke M, Prufer D, Dahm M, Oelert H, Meyer J, Darius H. Blocking of classical complement pathway inhibits endothelial adhesion molecule expression and preserves ischemic myocardium from reperfusion injury. J Pharmacol Exp Ther 1998 286 : 429 38. (Pubitemid 28318019)
11. Chan RK, Ibrahim SI, Takahashi K et al. The differing roles of the classical and mannose-binding lectin complement pathways in the events following skeletal muscle ischemia-reperfusion. J Immunol 2006 177 : 8080 5.
12. Leinhase I, Holers VM, Thurman JM et al. Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation. BMC Neurosci 2006 7 : 55. (Pubitemid 46277111)
13. Harboe M, Ulvund G, Vien L, Fung M, Mollnes TE. The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation. Clin Exp Immunol 2004 138 : 439 46. (Pubitemid 39573623)
14. Chan RK, Ibrahim SI, Verna N, Carroll M, Moore FD Jr., Hechtman HB. Ischaemia-reperfusion is an event triggered by immune complexes and complement. Br J Surg 2003 90 : 1470 8. (Pubitemid 37533162)
15. Nijmeijer R, Krijnen PA, Assink J et al. C-reactive protein and complement depositions in human infarcted myocardium are more extensive in patients with reinfarction or upon treatment with reperfusion. Eur J Clin Invest 2004 34 : 803 10. (Pubitemid 39657927)
16. Heijnen BH, Straatsburg IH, Padilla ND, van Mierlo GJ, Hack CE, van Gulik TM. Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model. Clin Exp Immunol 2006 143 : 15 23.
17. Chan RK, Ding G, Verna N et al. IgM binding to injured tissue precedes complement activation during skeletal muscle ischemia-reperfusion. J Surg Res 2004 122 : 29 35. (Pubitemid 39441229)
18. Williams JP, Pechet TT, Weiser MR et al. Intestinal reperfusion injury is mediated by IgM and complement. J Appl Physiol 1999 86 : 938 42. (Pubitemid 29118016)
19. Monaco S, Bonetti B, Ferrari S et al. Complement-mediated demyelination in patients with IgM monoclonal gammopathy and polyneuropathy. N Engl J Med 1990 322 : 649 52. (Pubitemid 20089530)
20. Zhang M, Alicot EM, Carroll MC. Human natural IgM can induce ischemia/reperfusion injury in a murine intestinal model. Mol Immunol 2008 45 : 4036 9.
21. Dheen ST, Kaur C, Ling EA. Microglial activation and its implications in the brain diseases. Curr Med Chem 2007 14 : 1189 97. (Pubitemid 46739320)
22. van Beek J, van Meurs M, Hart BA et al. Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation. J Immunol 2005 174 : 2353 65. (Pubitemid 40223985)
23. Iwata F, Joh T, Tada T et al. Role of complement regulatory membrane proteins in ischaemia-reperfusion injury of rat gastric mucosa. J Gastroenterol Hepatol 1999 14 : 967 72. (Pubitemid 29487291)
24. Turnberg D, Botto M, Lewis M et al. CD59a deficiency exacerbates ischemia-reperfusion injury in mice. Am J Pathol 2004 165 : 825 32. (Pubitemid 39129290)
25. Pedersen ED, Aass HC, Rootwelt T, Fung M, Lambris JD, Mollnes TE. CD59 efficiently protects human NT2-N neurons against complement-mediated damage. Scand J Immunol 2007 66 : 345 51. (Pubitemid 47063191)
26. Vakeva A, Laurila P, Meri S. Loss of expression of protectin (CD59) is associated with complement membrane attack complex deposition in myocardial infarction. Lab Invest 1992 67 : 608 16.
27. Mocco J, Sughrue ME, Ducruet AF, Komotar RJ, Sosunov SA, Connolly ES Jr. The complement system: a potential target for stroke therapy. Adv Exp Med Biol 2006 586 : 189 201.
28. Arumugam TV, Tang SC, Lathia JD et al. Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proc Natl Acad Sci U S A 2007 104 : 14104 9. (Pubitemid 350003342)
29. Ten VS, Sosunov SA, Mazer SP et al. C1q-deficiency is neuroprotective against hypoxic-ischemic brain injury in neonatal mice. Stroke 2005 36 : 2244 50. (Pubitemid 41429254)
30. Gehrmann J, Banati RB, Wiessner C, Hossmann KA, Kreutzberg GW. Reactive microglia in cerebral ischaemia: an early mediator of tissue damage? Neuropathol Appl Neurobiol 1995 21 : 277 89.
31. Gehrmann J, Bonnekoh P, Miyazawa T, Hossmann KA, Kreutzberg GW. Immunocytochemical study of an early microglial activation in ischemia. J Cereb Blood Flow Metab 1992 12 : 257 69.
32. Bazan NG, Marcheselli VL, Cole-Edwards K. Brain response to injury and neurodegeneration: endogenous neuroprotective signaling. Ann N Y Acad Sci 2005 1053 : 137 47. (Pubitemid 43031090)
33. Danton GH, Dietrich WD. Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol 2003 62 : 127 36. (Pubitemid 36176947)
34. Bonifati DM, Kishore U. Role of complement in neurodegeneration and neuroinflammation. Mol Immunol 2007 44 : 999 1010. (Pubitemid 44414994)
35. Susuki K, Rasband MN, Tohyama K et al. Anti-GM1 antibodies cause complement-mediated disruption of sodium channel clusters in peripheral motor nerve fibers. J Neurosci 2007 27 : 3956 67. (Pubitemid 46597169)
36. Paparounas K, O'Hanlon GM, O'Leary CP, Rowan EG, Willison HJ. Anti-ganglioside antibodies can bind peripheral nerve nodes of Ranvier and activate the complement cascade without inducing acute conduction block in vitro. Brain 1999 122 (Pt 5 807 16. (Pubitemid 29219256)
37. Kaur C, Sivakumar V, Zhang Y, Ling EA. Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellum. Glia 2006 54 : 826 39. (Pubitemid 44671988)
38. Arai N. The role of swollen astrocytes in human brain lesions after edema - an immunohistochemical study using formalin-fixed paraffin-embedded sections. Neurosci Lett 1992 138 : 56 8.
39. Singhrao SK, Neal JW, Rushmere NK, Morgan BP, Gasque P. Spontaneous classical pathway activation and deficiency of membrane regulators render human neurons susceptible to complement lysis. Am J Pathol 2000 157 : 905 18. (Pubitemid 32109383)
40. Pedersen ED, Froyland E, Kvissel AK et al. Expression of complement regulators and receptors on human NT2-N neurons - effect of hypoxia and reoxygenation. Mol Immunol 2007 44 : 2459 68. (Pubitemid 46097099)
41. Ward NS. Future perspectives in functional neuroimaging in stroke recovery. Eura Medicophys 2007 43 : 285 94.