Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: In vivo and in vitro evidence

Annals of the Rheumatic Diseases

Volumn 73, Issue 7, 2014, Pages 1405-1413

  Poulsen, Raewyn C ^a   Watts, Anna C ^a   Murphy, Richard J ^a   Snelling, Sarah J ^a   Carr, Andrew J ^a   Hulley, Philippa A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; DEXAMETHASONE; GLUCOCORTICOID; GLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; METHYLPREDNISOLONE ACETATE; PROTEIN P21; PROTEIN P53; RESVERATROL; RNA; S6 KINASE; SIRTUIN 1;

ACETYLATION; ADULT; AGED; ARTICLE; BIOPSY; CELL AGING; CELL CYCLE ARREST; CELL FATE; CELL TYPE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; TENDINITIS; TENDON BIOPSY; TENOCYTE;

CHONDROCYTES; CORTICOSTEROIDS; FIBROBLASTS; INFLAMMATION; TENDINITIS;

ADULT; AGED; BETA-GALACTOSIDASE; CELL AGING; CELL CYCLE; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DEXAMETHASONE; FEMALE; GENE KNOCKDOWN TECHNIQUES; GLUCOCORTICOIDS; HUMANS; MALE; MIDDLE AGED; ROTATOR CUFF; SIGNAL TRANSDUCTION; SIRTUIN 1; TENDINOPATHY; TENDONS; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84902283529     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-203146     Document Type: Article

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