Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease

Free Radical Biology and Medicine

Volumn 86, Issue , 2015, Pages 374-381

  Vaziri, Nosratola D ^a   Liu, Shuman ^a   Farzaneh, Seyed H ^a   Nazertehrani, Sohrab ^a   Khazaeli, Mahyar ^a   Zhao, Ying Yong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antioxidant system; Chronic kidney disease; CKD progression; Fibrosis; Free radicals; Inflammation; Nrf2; Oxidative stress

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; DH 404; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MALONALDEHYDE; PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UREA; DH404 COMPOUND; KEAP1 PROTEIN, RAT; NFE2L2 PROTEIN, RAT; OLEANOLIC ACID; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTERIAL PRESSURE; ARTICLE; BODY WEIGHT; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE COURSE; DISEASE EXACERBATION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; GENE EXPRESSION; GLOMERULOSCLEROSIS; KIDNEY FIBROSIS; LOW DRUG DOSE; MALE; NEPHRECTOMY; NEPHRITIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; RAT; UPREGULATION; UREA BLOOD LEVEL; URINE VOLUME; ZUCKER RAT; ANALOGS AND DERIVATIVES; ANIMAL; KIDNEY; METABOLISM; PATHOLOGY; PRECLINICAL STUDY; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; MALE; NF-E2-RELATED FACTOR 2; OLEANOLIC ACID; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION;

EID: 84938393155     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.04.022     Document Type: Article

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