Melittin induces PTCH1 expression by down-regulating MeCP2 in human hepatocellular carcinoma SMMC-7721 cells

Toxicology and Applied Pharmacology

Volumn 288, Issue 1, 2015, Pages 74-83

  Wu, Xiaoqin ^a   Zhao, Bin ^a   Cheng, Yahui ^a   Yang, Yang ^a   Huang, Cheng ^a   Meng, Xiaoming ^a   Wu, Baoming ^a   Zhang, Lei ^a   Lv, Xiongwen ^a   Li, Jun ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

DNA methylation; Hepatocellular carcinoma (HCC); MeCP2; Melittin; Sonic hedgehog (Shh) signaling

Indexed keywords

MELITTIN; METHYL CPG BINDING PROTEIN 2; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; ANTINEOPLASTIC AGENT; CELL SURFACE RECEPTOR; GLI1 PROTEIN, HUMAN; MECP2 PROTEIN, HUMAN; PATCHED RECEPTORS; SHH PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL LINE; CELL CYCLE G0 PHASE; CELL CYCLE PROGRESSION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DEMETHYLATION; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; CARCINOMA, HEPATOCELLULAR; CELL CYCLE CHECKPOINT; DNA METHYLATION; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; LIVER NEOPLASMS; METABOLISM; PATHOLOGY; PROMOTER REGION; RNA INTERFERENCE; TIME; TUMOR CELL LINE;

APOIDEA; ERINACEIDAE;

ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, DRUG; G0 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HUMANS; LIVER NEOPLASMS; MELITTEN; METHYL-CPG-BINDING PROTEIN 2; PROMOTER REGIONS, GENETIC; RECEPTORS, CELL SURFACE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84938338074     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.07.010     Document Type: Article

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