Sonic Hedgehog signaling protects human hepatocellular carcinoma cells against ionizing radiation in an autocrine manner

International Journal of Radiation Oncology Biology Physics

Volumn 80, Issue 3, 2011, Pages 851-859

  Chen, Yu Jen ^a   Lin, Chin Ping ^a   Hsu, Ming Ling ^a   Shieh, Hui Ru ^a   Chao, Nicholas K ^a   Chao, K S Clifford ^b  

^a MACKAY MEMORIAL HOSPITAL   (Taiwan)

^b Columbia University ^*  (United States)

Author keywords

Hepatoma; Radiation; Sonic hedgehog

Indexed keywords

AUTOCRINE MANNERS; CLONOGENIC ASSAYS; CONDITIONED MEDIUM; CULTURING CELLS; CYTOSOLIC; DNA DAMAGES; DNA DOUBLE STRAND BREAKS; DNA DSB; HEPATOCELLULAR CARCINOMA; HEPATOCELLULAR CARCINOMA CELL; HEPATOMA; IMMUNOPRECIPITATIONS; NOVEL STRATEGIES; NUCLEAR TRANSLOCATIONS; RADIATION RESISTANCE; RADIOPROTECTION; RADIORESISTANCE; RNA INTERFERENCE; SIGNALING PATHWAYS; SONIC HEDGEHOGS; UP-REGULATION; WESTERN BLOTTING;

ANTIBODIES; CHEMOTHERAPY; DAMAGE DETECTION; DNA; IONIZING RADIATION; LIGANDS; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; RADIATION SHIELDING; RADIOACTIVITY; RATING; REPAIR; RNA; SIGNALING;

CELLS;

CHECKPOINT KINASE 1; HISTONE H2AX; PROTEIN H2AX GAMMA; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; DNA DAMAGE; DNA HELIX; DNA REPAIR; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IONIZING RADIATION; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIATION PROTECTION; RNA INTERFERENCE; WESTERN BLOTTING;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CULTURE MEDIA, CONDITIONED; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; HEDGEHOG PROTEINS; HISTONES; HUMANS; LIVER NEOPLASMS; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN KINASES; RADIATION TOLERANCE; RECEPTORS, CELL SURFACE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 79957566966     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.01.003     Document Type: Article

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