Melittin inhibits TGF-β-induced pro-fibrotic gene expression through the suppression of the TGFβRII-Smad, ERK1/2 and JNK-mediated signaling pathway

American Journal of Chinese Medicine

Volumn 42, Issue 5, 2014, Pages 1139-1152

  Park, Su Hyun ^a   Cho, Hyun Ji ^a   Jeong, Yun Jeong ^a   Shin, Jae Moon ^a,b   Kang, Jeong Han ^a,g   Park, Kwan Kyu ^a   Choe, Jung Yoon ^a   Park, Yoon Yub ^a   Bae, Young Seuk ^b   Han, Sang Mi ^c   Moon, Sung Kwon ^d   Kim, Wun Jae ^e   Choi, Yung Hyun ^f   Chang, Young Chae ^a  

^a Catholic University of Daegu   (South Korea)

^b Kyungpook National University   (South Korea)

^c National Institute of Animal Science   (South Korea)

^d Chung Ang University   (South Korea)

^e Chungbuk National University   (South Korea)

^f Dong Eui University   (South Korea)

^g MAYO CLINIC   (United States)

Author keywords

Bee Venom; Melittin; Pro Fibrotic Factor; Renal Fibrosis; Transforming Growth Factor

Indexed keywords

APAMIN; BEE VENOM; COLLAGEN TYPE 1; FIBRONECTIN; MELITTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN KINASE B; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL CELL; ANTIFIBROTIC ACTIVITY; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; FIBROBLAST; FIBROGENESIS; GENE EXPRESSION; IN VITRO STUDY; KIDNEY CELL; KIDNEY FIBROBLAST; KIDNEY FIBROSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMICAL PHENOMENA; CYTOLOGY; DRUG EFFECTS; FIBROSIS; GENETICS; KIDNEY; KIDNEY DISEASES; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; BEE VENOMS; CELLS, CULTURED; COLLAGEN TYPE I; DEPRESSION, CHEMICAL; FIBROBLASTS; FIBRONECTINS; FIBROSIS; GENE EXPRESSION; KIDNEY; KIDNEY DISEASES; MAP KINASE SIGNALING SYSTEM; MELITTEN; PHOSPHORYLATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84926079137     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X14500712     Document Type: Article

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