Design, synthesis and anticancer activity of Michael-type thiol adducts of α-santonin analogue with exocyclic methylene

European Journal of Medicinal Chemistry

Volumn 101, Issue , 2015, Pages 769-779

  Khazir, Jabeena ^a   Riley, Darren L ^a   Chashoo, Gousia ^b   Mir, Bilal Ahmad ^a   Liles, David ^a   Islam, Md Ataul ^c   Singh, Shashank K ^b   Vishwakarma, Ram A ^b   Pilcher, Lynne A ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^c UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Anticancer; Michael adducts; Santonin; Sesquiterpenoid lactones; Thiols

Indexed keywords

3 [(1 METHYL 1H BENZO[D]IMIDAZOL 2 YLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(1H IMIDAZOL 2 YLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(2 AMINOPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(2 BROMOPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(2 CHLOROPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(2 FLUOROPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(2 METHOXYPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(2 METHYLPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(3 BROMO 4 METHYLPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(3, 4 DIFLUOROPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1, 2 B]FURAN 2,8 DIONE; 3 [(3,4 DIHYDRO 4 OXOQUINAZOLIN 2 YLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPH THO [1,2 B]FURAN 2,8 DIONE; 3 [(4 BROMO 2 METHYLPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(4 BROMOPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(4 CHLOROPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(4 FLUOROPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(4 METHOXYPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(4 METHYLPHENYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(CYCLOHEXYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN 2,8 DIONE; 3 [(ETHYLTHIO)METHYL] 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYLNAPHTHO[1,2 B]FURAN2,8 DIONE; 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYL 3 [(PHENYLTHIO)METHYL]NAPHTHO[1,2 B]FURAN 2,8 DIONE; 3A,4,5,5A TETRAHYDRO 5A,9 DIMETHYL 3 [(PYRIDIN 2 YLTHIO)METHYL]NAPHTHO[1,2 B]FURAN 2,8 DIONE; ALPHA SANTONIN; CARBENE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SYNAPTOTAGMIN I; THIOL; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; SANTONIN; THIOL DERIVATIVE;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE G1 PHASE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; FLOW CYTOMETRY; HCT116 CELL LINE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MCF 7 CELL LINE; MICHAEL ADDITION; ANALOGS AND DERIVATIVES; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SANTONIN; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 84938098509     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.07.022     Document Type: Article

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