The JaCVAM international validation study on the in vivo comet assay: Selection of test chemicals

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 786-788, Issue , 2015, Pages 14-44

  Morita, Takeshi ^a   Uno, Yoshifumi ^b   Honma, Masamitsu ^a   Kojima, Hajime ^a,c   Hayashi, Makoto ^d   Tice, Raymond R ^e   Corvi, Raffaella ^f   Schechtman, Leonard ^g  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^c Japanese Center for the Validation of Alternative Methods (JaCVAM)   (Japan)

^d Japan Council for Quality Health Care   (Japan)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^f JOINT RESEARCH CENTRE   (Italy)

^g Innovative Toxicology Consulting LLC   (United States)

Author keywords

Chemical selection; In vivo comet assay; JaCVAM; Validation study

Indexed keywords

1,2 DIMETHYLHYDRAZINE; 2,6 DIAMINOTOLUENE; 8 QUINOLINOL; ALCOHOL; AMINOACRIDINE; AMPICILLIN; CARCINOGEN; CHLOROFORM; ETHIONAMIDE; FLUOROURACIL; HYDROQUINONE; HYDROXYBIPHENYL; ISOBUTYRALDEHYDE; MESYLIC ACID METHYL ESTER; N (2 FLUORENYL)ACETAMIDE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; SODIUM CHLORIDE; THIOACETAMIDE; MUTAGENIC AGENT;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; COMET ASSAY; CONTROLLED STUDY; GENOTOXICITY; IN VIVO STUDY; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIVITY AND SPECIFICITY; UNSCHEDULED DNA SYNTHESIS; VALIDATION STUDY; ANIMAL; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECTS; FACTUAL DATABASE; FEMALE; MALE; PROCEDURES; REPRODUCIBILITY; STANDARDS; TOXICITY TESTING;

RATTUS;

ANIMALS; CARCINOGENS; COMET ASSAY; DATABASES, FACTUAL; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; MUTAGENS; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOXICITY TESTS, ACUTE;

EID: 84937974898     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2015.03.004     Document Type: Article

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