Micronuclei and cell proliferation as early biological markers of ortho-phenylphenol-induced changes in the bladder of male F344 rats

Food and Chemical Toxicology

Volumn 44, Issue 8, 2006, Pages 1340-1347

  Balakrishnan, S ^a   Eastmond, D A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aneuploidy; Bladder; Micronucleus cell proliferation; ortho Phenylphenol; Sodium ortho phenylphenate

Indexed keywords

2 HYDROXYBIPHENYL; 2 PHENYLPHENATE; BIOLOGICAL MARKER; BROXURIDINE; CARCINOGEN; CENTROMERE ANTIBODY; FUNGICIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY LABELING; ARTICLE; BLADDER CANCER; BONE MARROW; CARCINOGENESIS; CELL PROLIFERATION; CHEMICAL ANALYSIS; CHROMOSOME BREAKAGE; CHROMOSOME LOSS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENOTOXICITY; LINEAR SYSTEM; MALE; MICRONUCLEUS; NONHUMAN; RAT; TARGET ORGAN;

AGROCHEMICALS; ANIMALS; BIPHENYL COMPOUNDS; BROMODEOXYURIDINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MUTAGENICITY TESTS; RATS; RATS, INBRED F344; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 33745186199     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.02.011     Document Type: Article

References (44)

1. Balakrishnan S., and Eastmond D.A. Evaluation of hyperdiploidy in the bladder epithelial cells of male F344 rats treated with ortho-phenylphenol. Mutation Research 537 (2003) 11-20
2. Balakrishnan S., Uppala P.T., Rupa D.S., Hasegawa L., and Eastmond D.A. Detection of micronuclei, cell proliferation and hyperdiploidy in bladder epithelial cells of rats treated with o-phenylphenol. Mutagenesis 17 (2002) 89-93
3. Brusick D. Analysis of genotoxicity and the carcinogenic mode of action for ortho-phenylphenol. Environmental and Molecular Mutagenesis 45 (2005) 460-481
4. Chen H., and Eastmond D.A. Topoisomerase inhibition by phenolic metabolites: a potential mechanism for benzene's clastogenic effects. Carcinogenesis 16 (1995) 2301-2307
5. Eastmond D.A., Schuler M., Frantz C., Chen H., Parks R., Wang L., and Hasegawa L. Characterization and mechanisms of chromosomal alterations induced by benzene in mice and humans. Research Report of the Health Effects Institute (2001) 1-68 discussion 69-80
6. Eastmond D.A., and Tucker J.D. Identification of aneuploidy-inducing agents using cytokinesis-blocked human lymphocytes and an antikinetochore antibody. Environmental and Molecular Mutagenesis 13 (1989) 34-43
7. Eastmond D.A., and Tucker J.D. Kinetochore localization in micronucleated cytokinesis-blocked Chinese hamster ovary cells: a new and rapid assay for identifying aneuploidy-inducing agents. Mutation Research 224 (1989) 517-526
8. Epe B., Harttig U., Stopper H., and Metzler M. Covalent binding of reactive estrogen metabolites to microtubular protein as a possible mechanism of aneuploidy induction and neoplastic cell transformation. Environmental Health Perspectives 88 (1990) 123-127
9. Frantz C.E., Chen H., and Eastmond D.A. Inhibition of human topoisomerase II in vitro by bioactive benzene metabolites. Environmental Health Perspectives 104 Suppl. 6 (1996) 1319-1323
10. Fujii T., Nakamura K., and Hiraga K. Effects of pH on the carcinogenicity of o-phenylphenol and sodium o-phenylphenate in the rat urinary bladder. Food and Chemical Toxicology 25 (1987) 359-362
11. Galloway S.M., Deasy D.A., Bean C.L., Kraynak A.R., Armstrong M.J., and Bradley M.O. Effects of high osmotic strength on chromosome aberrations, sister-chromatid exchanges and DNA strand breaks, and the relation to toxicity. Mutation Research 189 (1987) 15-25
12. Grossman J. What's hiding under the sink: dangers of household pesticides. Environmental Health Perspectives 103 (1995) 550-554
13. Hasegawa R., Furukawa F., Toyoda K., Sato H., Takahashi M., and Hayashi Y. Urothelial damage and tumor initiation by urinary metabolites of sodium o-phenylphenate in the urinary bladder of female rats. Japanese Journal of Cancer Research 81 (1990) 483-488
14. Hayashi M., Sofuni T., and Ishidate Jr. M. An application of Acridine Orange fluorescent staining to the micronucleus test. Mutation Research 120 (1983) 241-247
15. Hiraga K., and Fujii T. Induction of tumours of the urinary system in F344 rats by dietary administration of sodium o-phenylphenate. Food and Cosmetics Toxicology 19 (1981) 303-310
16. Hiraga K., and Fujii T. Induction of tumours of the urinary bladder in F344 rats by dietary administration of o-phenylphenol. Food and Chemical Toxicology 22 (1984) 865-870
17. IARC. ortho-Phenylphenol and its sodium salt. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans 30 (1983) 329-344
18. IARC. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs (1987), IARC scientific publications, Lyon
19. IARC. ortho-Phenylphenol and its sodium salt. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans 73 (1999) 451-480
20. Irons R.D., and Neptun D.A. Effects of the principal hydroxy-metabolites of benzene on microtubule polymerization. Archives of Toxicology 45 (1980) 297-305
21. Irons R.D., and Sawahata T. Phenols, Catechols, and Quinones. In: Anders M.W. (Ed). Bioactivation of Foreign Compounds (1985), Academic Press, Orlando 259-284
22. Kolachana P., Subrahmanyam V.V., Eastmond D.A., and Smith M.T. Metabolism of phenylhydroquinone by prostaglandin (H) synthase: possible implications in o-phenylphenol carcinogenesis. Carcinogenesis 12 (1991) 145-149
23. Kwok E.S., Buchholz B.A., Vogel J.S., Turteltaub K.W., and Eastmond D.A. Dose-dependent binding of ortho-phenylphenol to protein but not DNA in the urinary bladder of male F344 rats. Toxicology and Applied Pharmacology 159 (1999) 18-24
24. Kwok E.S., and Eastmond D.A. Effects of pH on nonenzymatic oxidation of phenylhydroquinone: potential role in urinary bladder carcinogenesis induced by o-phenylphenol in Fischer 344 rats. Chemical Research in Toxicology 10 (1997) 742-749
25. Lambert A.C., and Eastmond D.A. Genotoxic effects of the o-phenylphenol metabolites phenylhydroquinone and phenylbenzoquinone in V79 cells. Mutation Research 322 (1994) 243-256
26. Monks T.J., Hanzlik R.P., Cohen G.M., Ross D., and Graham D.G. Quinone chemistry and toxicity. Toxicology and Applied Pharmacology 112 (1992) 2-16
27. Morimoto K., Fukuoka M., Hasegawa R., Tanaka A., Takahashi A., and Hayashi Y. DNA damage in urinary bladder epithelium of male F344 rats treated with 2-phenyl-1,4-benzoquinone, one of the non-conjugated urinary metabolites of sodium o-phenylphenate. Japanese Journal of Cancer Research 78 (1987) 1027-1030
28. Morita T., Asano N., Awogi T., Sasaki Y.F., Sato S., Shimada H., Sutou S., Suzuki T., Wakata A., Sofuni T., and Hayashi M. Evaluation of the rodent micronucleus assay in the screening of IARC carcinogens (groups 1, 2 A and 2B). The summary report of the 6th collaborative study by CSGMT/JEMS MMS. Collaborative Study of the Micronucleus Group Test. Mammalian Mutagenicity Study Group. Mutation Research 389 (1997) 3-122
29. Qu Q., Shore R., Li G., Jin X., Chen L.C., Cohen B., Melikian A.A., Eastmond D., Rappaport S., Li H., Rupa D., Waidyanatha S., Yin S., Yan H., Meng M., Winnik W., Kwok E.S., Li Y., Mu R., Xu B., Zhang X., and Li K. Validation and evaluation of biomarkers in workers exposed to benzene in China. Research Report of the Health Effects Institute (2003) 1-72 discussion 73-87
30. Reid T.M., DeBord D.G., Cheever K.L., and Savage Jr. R.E. Mutagenicity of N-OH-MOCA (4-amino-4′-hydroxylamino-bis-3,3′-dichlorodiphenylmethane) and PBQ (2-phenyl-1,4-benzoquinone) in human lymphoblastoid cells. Toxicology letters 95 (1998) 205-210
31. Reitz R.H., Fox T.R., Quast J.F., Hermann E.A., and Watanabe P.G. Molecular mechanisms involved in the toxicity of ortho-phenylphenol and its sodium salt. Chemico-Biological Interactions 43 (1983) 99-119
32. Reitz R.H., Fox T.R., Quast J.F., Hermann E.A., and Watanabe P.G. Biochemical factors involved in the effects of ortho-phenylphenol (OPP) and sodium ortho-phenylphenate (SOPP) on the urinary tract of male F344 rats. Toxicology and Applied Pharmacology 73 (1984) 345-349
33. Roy D. Cytochrome P-450 catalyzed redox cycling of ortho-phenylphenol. Biochemistry International 22 (1990) 849-857
34. Sasaki Y.F., Nishidate E., Su Y.Q., Matsusaka N., Tsuda S., Susa N., Furukawa Y., and Ueno S. Organ-specific genotoxicity of the potent rodent bladder carcinogens o-anisidine and p-cresidine. Mutation Research 412 (1998) 155-160
35. Shirasu Y., Moriya M., Kato K., Tezuka H., Henmi R., Shingu A., Kaneda M., and Teramoto S. Mutagenicity testing on o-phenylphenol. Mutation Research 54 (1978) Abstract number 31
36. Smith R.A., Christenson W.R., Bartels M.J., Arnold L.L., St. John M.K., Cano M., Garland E.M., Lake S.G., Wahle B.S., McNett D.A., and Cohen S.M. Urinary physiologic and chemical metabolic effects on the urothelial cytotoxicity and potential DNA adducts of o-phenylphenol in male rats. Toxicology and Applied Pharmacology 150 (1998) 402-413
37. Solomon E., Borrow J., and Goddard A.D. Chromosome aberrations and cancer. Science (Washington DC) 254 (1991) 1153-1160
38. Stouten H. Toxicological profile for o-phenylphenol and its sodium salt. Journal of Applied Toxicology 18 (1998) 261-270
39. Tayama S., Kamiya N., and Nakagawa Y. Genotoxic effects of o-phenylphenol metabolites in CHO-K1 cells. Mutation Research 223 (1989) 23-33
40. Tayama S., and Nakagawa Y. Sulfhydryl compounds inhibit the cyto- and geno-toxicity of o-phenylphenol metabolites in CHO-K1 cells. Mutation Research 259 (1991) 1-12
41. Tayama-Nawai S., Yoshida S., Nakao T., and Hiraga K. Induction of chromosome aberrations and sister-chromatid exchanges in CHO-K1 cells by o-phenylphenol. Mutation Research 141 (1984) 95-99
42. Tsugane S. Salt, salted food intake, and risk of gastric cancer: Epidemiological evidence. Cancer Science 96 (2005) 1-6
43. Wahle B.S., and Christenson W.R. Technical grade ortho-phenylphenol: A Combined Chronic Toxicity/Oncogenicity Testing Study in the Rat (1996), Bayer Corporation, Agriculture Division, Toxicology, Stilwell, Kansas City, Missouri
44. WHO. Diet, Nutrition and the Prevention of Chronic Diseases. WHO Technical Report Series Vol. 916 (2003), World Health Organization