Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 26, 2015, Pages E3421-E3430

  Rai, Prashant ^a,b   Parrish, Marcus ^c   Tay, Ian Jun Jie ^c   Li, Na ^a,b   Ackerman, Shelley ^c   He, Fang ^d   Kwang, Jimmy ^d   Chow, Vincent T ^a,b   Engelward, Bevin P ^a,c  

^a SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c Massachusetts Institute of Technology Cambridge   (United States)

^d Animal Health Biotechnology   (Singapore)

Author keywords

Dna damage; Hydrogen peroxide; Ku80; Streptococcus pneumoniae; H2ax

Indexed keywords

2 MORPHOLINO 6 (1 THIANTHRENYL) 4 PYRANONE; ATM PROTEIN; BACTERIAL ENZYME; DOUBLE STRANDED DNA; HISTONE H2AX; HYDROGEN PEROXIDE; PROTEIN P53; PYRUVATE OXIDASE; STREPTOCOCCUS PYRUVATE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; BACTERIAL VIRULENCE; CONTROLLED STUDY; DISEASE SEVERITY; DNA DAMAGE; DNA END JOINING REPAIR; DNA REPAIR; FEMALE; GENOTOXICITY; LOBAR PNEUMONIA; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; SYNTHESIS; ANIMAL; BAGG ALBINO MOUSE; CYTOLOGY; EPITHELIUM CELL; LUNG ALVEOLUS; METABOLISM; PATHOGENICITY; PATHOLOGY; VIRULENCE;

ANIMALIA; BACTERIA (MICROORGANISMS); STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; APOPTOSIS; DNA DAMAGE; DNA REPAIR; EPITHELIAL CELLS; FEMALE; HYDROGEN PEROXIDE; MICE; MICE, INBRED BALB C; PULMONARY ALVEOLI; STREPTOCOCCUS PNEUMONIAE; VIRULENCE;

EID: 84937922697     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424144112     Document Type: Article

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