Differences in virulence for mice among Streptococcus pneumoniae strains of capsular types 2, 3, 4, 5, and 6 are not attributable to differences in pneumolysin production

Infection and Immunity

Volumn 65, Issue 4, 1997, Pages 1237-1244

  Benton, Kimberly A ^a,e   Paton, James C ^b   Briles, David E ^a,c,d  

^a University of Alabama at Birmingham   (United States)

^b WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^c University of Alabama at Birmingham   (United States)

^d UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PNEUMOLYSIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERIAL MEMBRANE; BACTERIAL VIRULENCE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; STREPTOCOCCUS PNEUMONIAE;

EID: 0030911920     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.4.1237-1244.1997     Document Type: Article

References (28)

1. Alexander, J. E., R. A. Lock, C. C. A. M. Peeters, J. T. Poolman, P. W. Andrew, T. J. Mitchell, D. Hansman, and J. C. Paton. 1994. Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infect. Immun. 62:5683-5688.
2. AlonsoDeVelasco, E., A. F. M. Verheul, J. Verhoef, and H. Snippe. 1995. Streptococcus pneumoniae: virulence factors, pathogenesis, and vaccines. Microbiol. Rev. 59:591-603.
3. Amsbaugh, D. F., C. T. Hansen, B. Prescott, P. W. Stashak, D. R. Barthold, and P. J. Baker. 1972. Genetic control of the antibody response to type III pneumococcal polysaccharide in mice. I. Evidence that an X-linked gene plays a decisive role in determining responsiveness. J. Exp. Med. 136:931-949.
4. Avery, O. T., C. M. MacLeod, and M. McCarty. 1944. Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a deoxyribonucleic acid fraction isolated from pneumococcus type III. J. Exp. Med. 79:137-158.
5. Banks, S. D., and C. J. Lee. 1991. Analysis of pneumolysin in Streptococcus pneumoniae group 29 strains, p. 97. In Abstracts of the 1991 General Meeting of the American Society for Microbiology 1991. American Society for Microbiology, Washington, D.C.
6. Benton, K. A., M. P. Everson, and D. E. Briles. 1995. A pneumolysin-negative mutant of Streptococcus pneumonia? causes chronic bacteremia rather than acute sepsis in mice. Infect. Immun. 63:448-455.
7. Bernheimer, A. W. 1976. Sulphydryl activated toxins, p. 85-97. In A. W. Bernheimer (ed.). Mechanisms in bacterial toxicology. John Wiley & Sons, New York, N.Y. 85-97.
8. Berry, A. M., J. E. Alexander, T. J. Mitchell, P. W. Andrew, D. Hansman, and J. C. Paton. 1995. Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae. Infect. Immun. 63:1969-1974.
9. Berry, A. M., R. A. Lock, D. Hansman, and J. C. Paton. 1989. Contribution of autolysin to virulence of Streptococcus pneumoniae. Infect. Immun. 57:2324-2330.
10. Berry, A. M., J. C. Paton, and D. Hansman. 1992. Effect of insertional inactivation of the genes encoding pneumolysin and autolysin on the virulence of Streptococcus pneumoniae type 3. Microb. Pathog. 12:87-93.
11. Berry, A. M., J. Yother, D. E. Briles, D. Hansman, and J. C. Paton. 1989. Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infect. Immun. 57:2037-2042.
12. Boulnois, G. J. 1992. Pneumococcal proteins and the pathogenesis of disease caused by Streptococcus pneumoniae. J. Gen. Microbiol. 138:249-259.
13. Boulnois, G. J., J. C. Paton, T. J. Mitchell, and P. W. Andrew. 1991. Structure and function of pneumolysin, the multifunctional, thiol-activated toxin of Streptococcus pneumoniae. Mol. Microbiol. 5:2611-2616.
14. Briles, D. E., M. J. Grain, B. M. Gray, C. Forman, and J. Yother. 1992. A strong association between capsular type and mouse virulence among human isolates of Streptococcus pneumoniae. Infect. Immun. 60:111-116.
15. Briles, D. E., M. Nahm, K. Schroer, J. Davie, P. Baker, J. Kearney, and R. Barletta. 1981. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniae. J. Exp. Med. 153:694-705.
16. Eddy, B. E. 1944. Diplococcus pneumoniae. Public Health Rep. 59:449-468 and 485-499.
17. Gray, B. M. 1995. Pneumococcal infections in an era of multiple antibiotic resistance. Adv. Pediatr. Infect. Dis. 11:55-100.
18. Johnson, M. K. 1977. Cellular location of pneumolysin. FEMS Microbiol. Lett. 2:243-245.
19. Kanclerski, K., and R. Mollby. 1987. Production and purification of Streptococcus pneumoniae hemolysin (pneumolysin). J. Clin. Microbiol. 25:222-225.
20. Lock, R. A., Q. Y. Zhang, A. M. Berry, and J. C. Paton. 1996. Sequence variation in the Streptococcus pneumoniae pneumolysin gene affecting haemolytic activity and electrophoretic mobility of the toxin. Microb. Pathog. 21:71-83.
21. Mitchell, T. J., F. Mendez, J. C. Palon, P. W. Andrew, and G. J. Boulnois. 1990. Comparison of pneumolysin genes and proteins from Streptococcus pneumoniae types 1 and 2. Nucleic Acids Res. 18:4010.
22. Mond, J. J., J. R. Lieberman, J. K. Inman, D. E. Moiser, and W. E. Paul. 1977. Inability of mice with defect in B-lymphocyte maturation to respond to phosphocholine on immunogenic carriers. J. Exp. Med. 146:1138-1142.
23. Paton, J. C. 1996. The contribution of pneumolysin to the pathogenicity of Streptococcus pneumoniae. Trends Microbiol. 4:103-106.
24. Paton, J. C., P. W. Andrew, G. J. Boulnois, and T. J. Mitchell. 1993. Molecular analysis of the pathogenicity of Streptococcus pneumoniae: the role of pneumococcal proteins. Annu. Rev. Microbiol. 47:89-115.
25. Szu, S. C., S. Clark, and J. B. Robbins. 1983. Protection against pneumococcal infection in mice conferred by phosphocholine antibodies: specificity of the phosphocholine binding in relation to several types. Infect. Immun. 39:993-999.
26. Tomasz, A., P. Moreillon, and G. Pozzi. 1988. Insertional inactivation of the major autolysin gene of Streptococcus pneumoniae. J. Bacteriol. 170:5931-5934.
27. Walker, J. A., R. L. Allen, P. Falmagne, M. K. Johnson, and G. J. Boulnois. 1987. Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniae. Infect. Immun. 55:1184-1189.
28. Yother, J., C. Forman, B. M. Gray, and D. E. Briles. 1982. Protection of mice from infection with Streptococcus pneumoniae by anti-phosphocholine antibody. Infect. Immun. 36:184-188.