Protein kinase C protects from DNA damage-induced necrotic cell death by inhibiting poly(ADP-ribose) polymerase-1

FEBS Letters

Volumn 582, Issue 12, 2008, Pages 1672-1678

  Hegedus, Csaba ^a   Lakatos, Petra ^a   Oláh, Gábor ^b   Tóth, Balázs I ^a   Gergely, Szabolcs ^a   Szabó, Éva ^a   Bíró, Tamás ^a   Szabó, Csaba ^b   Virág, László ^a,c  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b University of Medicine and Dentistry of New Jersey   (United States)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

1 Methyl 3 nitro 1 nitrosoguanidine; Apoptosis; Cytotoxicity; Necrosis; Poly(ADP ribose) polymerase 1; Protein kinase C

Indexed keywords

METHYLNITRONITROSOGUANIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHORBOL ESTER; PROTEIN KINASE C;

ARTICLE; CELL DEATH; CELL ISOLATION; CELL STIMULATION; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; THYMOCYTE;

ANIMALS; APOPTOSIS; CARBAZOLES; CYTOPROTECTION; DNA DAMAGE; ENZYME ACTIVATION; INDOLES; MALEIMIDES; METHYLNITRONITROSOGUANIDINE; MICE; NECROSIS; PHORBOL ESTERS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; THYMUS GLAND;

EID: 43749109381     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2008.04.023     Document Type: Article

References (38)

1. Jagtap P., and Szabo C. Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat. Rev. Drug Discov. 4 (2005) 421-440
2. Virag L., and Szabo C. The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol. Rev. 54 (2002) 375-429
3. Hassa P.O., and Hottiger M.O. The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci. 13 (2008) 3046-3082
4. Aguilar-Quesada R., Munoz-Gamez J.A., Martin-Oliva D., Peralta-Leal A., Quiles-Perez R., Rodriguez-Vargas J.M., de Almodovar M.R., Conde C., Ruiz-Extremera A., and Oliver F.J. Modulation of transcription by PARP-1: consequences in carcinogenesis and inflammation. Curr. Med. Chem. 14 (2007) 1179-1187
5. Szabo C., Pacher P., and Swanson R.A. Novel modulators of poly(ADP-ribose) polymerase. Trends Pharmacol. Sci. 27 (2006) 626-630
6. Bauer P.I., Farkas G., Buday L., Mikala G., Meszaros G., Kun E., and Farago A. Inhibition of DNA binding by the phosphorylation of poly ADP-ribose polymerase protein catalysed by protein kinase C. Biochem. Biophys. Res. Commun. 187 (1992) 730-736
7. Tanaka Y., Koide S.S., Yoshihara K., and Kamiya T. Poly (ADP-ribose) synthetase is phosphorylated by protein kinase C in vitro. Biochem. Biophys. Res. Commun. 148 (1987) 709-717
8. Jagtap P., Soriano F.G., Virag L., Liaudet L., Mabley J., Szabo E., Hasko G., Marton A., Lorigados C.B., Gallyas Jr. F., Sumegi B., Hoyt D.G., Baloglu E., VanDuzer J., Salzman A.L., Southan G.J., and Szabo C. Novel phenanthridinone inhibitors of poly (adenosine 5′-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents. Crit. Care Med. 30 (2002) 1071-1082
9. Bai P., Bakondi E., Szabo E., Gergely P., Szabo C., and Virag L. Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxicity in thymocytes. Free Radic. Biol. Med. 31 (2001) 1616-1623
10. Virag L., Scott G.S., Cuzzocrea S., Marmer D., Salzman A.L., and Szabo C. Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation. Immunology 94 (1998) 345-355
11. Virag L., Kerekgyarto C., and Fachet J. A simple, rapid and sensitive fluorimetric assay for the measurement of cell-mediated cytotoxicity. J. Immunol. Meth. 185 (1995) 199-208
12. Bai P., Hegedus C., Erdelyi K., Szabo E., Bakondi E., Gergely S., Szabo C., and Virag L. Protein tyrosine nitration and poly(ADP-ribose) polymerase activation in N-methyl-N-nitro-N-nitrosoguanidine-treated thymocytes: implication for cytotoxicity. Toxicol. Lett. 170 (2007) 203-213
13. Singh N.P., McCoy M.T., Tice R.R., and Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175 (1988) 184-191
14. Griger Z., Payer E., Kovacs I., Toth B.I., Kovacs L., Sipka S., and Biro T. Protein kinase C-beta and -delta isoenzymes promote arachidonic acid production and proliferation of MonoMac-6 cells. J. Mol. Med. 85 (2007) 1031-1042
15. Virag L., Salzman A.L., and Szabo C. Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death. J. Immunol. 161 (1998) 3753-3759
16. Ariumi Y., Masutani M., Copeland T.D., Mimori T., Sugimura T., Shimotohno K., Ueda K., Hatanaka M., and Noda M. Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro. Oncogene 18 (1999) 4616-4625
17. Ruscetti T., Lehnert B.E., Halbrook J., Le T.H., Hoekstra M.F., Chen D.J., and Peterson S.R. Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase. J. Biol. Chem. 273 (1998) 14461-14467
18. Byun H.S., Park K.A., Won M., Yang K.J., Shin S., Piao L., Kwak J.Y., Lee Z.W., Park J., Seok J.H., Liu Z.G., and Hur G.M. Phorbol 12-myristate 13-acetate protects against tumor necrosis factor (TNF)-induced necrotic cell death by modulating the recruitment of TNF receptor 1-associated death domain and receptor-interacting protein into the TNF receptor 1 signaling complex: implication for the regulatory role of protein kinase C. Mol. Pharmacol. 70 (2006) 1099-1108
19. Chihab R., Oillet J., Bossenmeyer C., and Daval J.L. Glutamate triggers cell death specifically in mature central neurons through a necrotic process. Mol. Genet. Metab. 63 (1998) 142-147
20. Kim C.H., Han S.I., Lee S.Y., Youk H.S., Moon J.Y., Duong H.Q., Park M.J., Joo Y.M., Park H.G., Kim Y.J., Yoo M.A., Lim S.C., and Kang H.S. Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells. J. Cell Physiol. 211 (2007) 371-385
21. Mansat V., Laurent G., Levade T., Bettaieb A., and Jaffrezou J.P. The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. Cancer Res. 57 (1997) 5300-5304
22. Yiang G.T., Yu Y.L., Hu S.C., Chen M.H., Wang J.J., and Wei C.W. PKC and MEK pathways inhibit caspase-9/-3-mediated cytotoxicity in differentiated cells. FEBS Lett. 582 (2008) 881-885
23. Gubina E., Rinaudo M.S., Szallasi Z., Blumberg P.M., and Mufson R.A. Overexpression of protein kinase C isoform epsilon but not delta in human interleukin-3-dependent cells suppresses apoptosis and induces bcl-2 expression. Blood 91 (1998) 823-829
24. Li P.F., Maasch C., Haller H., Dietz R., and von H.R. Requirement for protein kinase C in reactive oxygen species-induced apoptosis of vascular smooth muscle cells. Circulation 100 (1999) 967-973
25. Drew L., Kumar R., Bandyopadhyay D., and Gupta S. Inhibition of the protein kinase C pathway promotes anti-CD95-induced apoptosis in Jurkat T cells. Int. Immunol. 10 (1998) 877-889
26. Kobayashi D., Watanabe N., Yamauchi N., Tsuji N., Sato T., Sasaki H., Okamoto T., and Niitsu Y. Protein kinase C inhibitors augment tumor-necrosis-factor-induced apoptosis in normal human diploid cells. Chemotherapy 43 (1997) 415-423
27. Shen L., and Glazer R.I. Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3. Biochem. Pharmacol. 55 (1998) 1711-1719
28. Joyeux M., Baxter G.F., Thomas D.L., Ribuot C., and Yellon D.M. Protein kinase C is involved in resistance to myocardial infarction induced by heat stress. J. Mol. Cell Cardiol. 29 (1997) 3311-3319
29. Thiemermann C., Bowes J., Myint F.P., and Vane J.R. Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc. Natl. Acad. Sci. USA 94 (1997) 679-683
30. Zingarelli B., Salzman A.L., and Szabo C. Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ. Res. 83 (1998) 85-94
31. Pacher P., and Szabo C. Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. Cardiovasc. Drug Rev. 25 (2007) 235-260
32. Beckert S., Farrahi F., Perveen G.Q., Aslam R., Scheuenstuhl H., Coerper S., Konigsrainer A., Hunt T.K., and Hussain M.Z. IGF-I-induced VEGF expression in HUVEC involves phosphorylation and inhibition of poly(ADP-ribose)polymerase. Biochem. Biophys. Res. Commun. 341 (2006) 67-72
33. Singh N., Poirier G., and Cerutti P. Tumor promoter phorbol-12-myristate-13-acetate induces poly ADP-ribosylation in human monocytes. Biochem. Biophys. Res. Commun. 126 (1985) 1208-1214
34. Singh N., Poirier G., and Cerutti P. Tumor promoter phorbol-12-myristate-13-acetate induces poly(ADP)-ribosylation in fibroblasts. EMBO J. 4 (1985) 1491-1494
35. Ricciarelli R., Palomba L., Cantoni O., and Azzi A. 3-Aminobenzamide inhibition of protein kinase C at a cellular level. FEBS Lett. 431 (1998) 465-467
36. Schmitz A.A., Pleschke J.M., Kleczkowska H.E., Althaus F.R., and Vergeres G. Poly(ADP-ribose) modulates the properties of MARCKS proteins. Biochemistry 37 (1998) 9520-9527
37. Chao D., Severson D.L., Zwiers H., and Hollenberg M.D. Radiolabelling of bovine myristoylated alanine-rich protein kinase C substrate (MARCKS) in an ADP-ribosylation reaction. Biochem. Cell Biol. 72 (1994) 391-396
38. Du X., Matsumura T., Edelstein D., Rossetti L., Zsengeller Z., Szabo C., and Brownlee M. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J. Clin. Invest. 112 (2003) 1049-1057