메뉴 건너뛰기




Volumn 22, Issue 4, 2015, Pages 290-295

A run on the biobank: What have we learned about type 1 diabetes from the nPOD tissue repository?

Author keywords

atrophy; immunity; infiltration; pancreas; regeneration

Indexed keywords

COMPLEMENT; CYTOKINE;

EID: 84937797996     PISSN: 1752296X     EISSN: 17522978     Source Type: Journal    
DOI: 10.1097/MED.0000000000000171     Document Type: Review
Times cited : (37)

References (62)
  • 2
    • 57749176852 scopus 로고    scopus 로고
    • Type 1 diabetes trialnet: An international collaborative clinical trials network
    • Skyler JS, Greenbaum CJ, Lachin JM, et al. Type 1 Diabetes TrialNet: an international collaborative clinical trials network. Ann N Y Acad Sci. 2008; 1150: 14-24
    • (2008) Ann N y Acad Sci , vol.1150 , pp. 14-24
    • Skyler, J.S.1    Greenbaum, C.J.2    Lachin, J.M.3
  • 3
    • 84860484176 scopus 로고    scopus 로고
    • Overview of the type i diabetes genetics consortium
    • Rich SS, Akolkar B, Concannon P, et al. Overview of the type I diabetes genetics consortium. Genes Immun. 2009; 10: S1-S4
    • (2009) Genes Immun , vol.10 , pp. S1-S4
    • Rich, S.S.1    Akolkar, B.2    Concannon, P.3
  • 4
    • 57749178141 scopus 로고    scopus 로고
    • The environmental determinants of diabetes in the young (teddy) study
    • Group TS. The Environmental Determinants of Diabetes in the Young (TEDDY) Study. Ann N Y Acad Sci. 2008; 1150: 1-13
    • (2008) Ann N y Acad Sci , vol.1150 , pp. 1-13
    • Group, T.S.1
  • 5
    • 64749084813 scopus 로고    scopus 로고
    • Human pancreatic islets and diabetes research
    • Kaddis JS, Olack BJ, Sowinski J, et al. Human pancreatic islets and diabetes research. JAMA. 2009; 301: 1580-1587
    • (2009) JAMA , vol.301 , pp. 1580-1587
    • Kaddis, J.S.1    Olack, B.J.2    Sowinski, J.3
  • 7
    • 84875432419 scopus 로고    scopus 로고
    • Type 1 diabetes: Translating mechanistic observations into effective clinical outcomes
    • Herold KC, Vignali DAA, Cooke A, Bluestone JA. Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nat Rev Immunol. 2013; 13: 243-256
    • (2013) Nat Rev Immunol , vol.13 , pp. 243-256
    • Herold, K.C.1    Vignali, D.A.A.2    Cooke, A.3    Bluestone, J.A.4
  • 8
    • 84897052535 scopus 로고    scopus 로고
    • Immune modulation in humans: Implications for type 1 diabetes mellitus
    • Roep BO, Tree TIM. Immune modulation in humans: implications for type 1 diabetes mellitus. Nat Rev Endocrinol. 2014; 10: 229-242
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 229-242
    • Roep, B.O.1    Tree, T.I.M.2
  • 10
    • 84870936276 scopus 로고    scopus 로고
    • Environmental triggers of type 1 diabetes
    • Knip M, Simell O. Environmental triggers of type 1 diabetes. Cold Spring Harb Perspect Med. 2012; 2: a007690
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. a007690
    • Knip, M.1    Simell, O.2
  • 12
    • 84930791607 scopus 로고    scopus 로고
    • Insulitis in human type 1 diabetes: A comparison between patients and animal models
    • Int Veld P. Insulitis in human type 1 diabetes: a comparison between patients and animal models. Semin Immunopathol. 2014; 36: 569-579
    • (2014) Semin Immunopathol , vol.36 , pp. 569-579
    • Int Veld, P.1
  • 13
    • 84867041203 scopus 로고    scopus 로고
    • Network for pancreatic organ donors with diabetes (npod): Developing a tissue biobank for type 1 diabetes
    • Campbell-Thompson M, Wasserfall C, Kaddis J, et al. Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes. Diabetes/Metab Res Rev. 2012; 28: 608-617
    • (2012) Diabetes/Metab Res Rev , vol.28 , pp. 608-617
    • Campbell-Thompson, M.1    Wasserfall, C.2    Kaddis, J.3
  • 14
    • 77957012972 scopus 로고    scopus 로고
    • Global gene expression changes in type 1 diabetes: Insights into autoimmune response in the target organ and in the periphery
    • Planas R, Pujol-Borrell R, Vives-Pi M. Global gene expression changes in type 1 diabetes: insights into autoimmune response in the target organ and in the periphery. Immunol Lett. 2010; 133: 55-61
    • (2010) Immunol Lett , vol.133 , pp. 55-61
    • Planas, R.1    Pujol-Borrell, R.2    Vives-Pi, M.3
  • 15
    • 84893708638 scopus 로고    scopus 로고
    • The juvenile diabetes research foundation network for pancreatic organ donors with diabetes (npod) program: Goals, operational model and emerging findings
    • Pugliese A, Yang M, Kusmarteva I, et al. The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings. Pediatr Diabetes. 2014; 15: 1-9
    • (2014) Pediatr Diabetes , vol.15 , pp. 1-9
    • Pugliese, A.1    Yang, M.2    Kusmarteva, I.3
  • 16
    • 84908635248 scopus 로고    scopus 로고
    • Increased immune cell infiltration of the exocrine pancreas: A possible contribution to the pathogenesis of type 1 diabetes
    • Rodriguez-Calvo T, Ekwall O, Amirian N, et al. Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes. Diabetes. 2014; 63: 3880-3890
    • (2014) Diabetes , vol.63 , pp. 3880-3890
    • Rodriguez-Calvo, T.1    Ekwall, O.2    Amirian, N.3
  • 17
    • 84900337050 scopus 로고    scopus 로고
    • Maternal microchimerism: Increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells
    • Ye J, Vives-Pi M, Gillespie KM. Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells. PLoS One. 2014; 9: e86985
    • (2014) PLoS One , vol.9 , pp. e86985
    • Ye, J.1    Vives-Pi, M.2    Gillespie, K.M.3
  • 18
    • 84891872943 scopus 로고    scopus 로고
    • Increased complement activation in human type 1 diabetes pancreata
    • Rowe P, Wasserfall C, Croker B, et al. Increased complement activation in human type 1 diabetes pancreata. Diabetes Care. 2013; 36: 3815-3817
    • (2013) Diabetes Care , vol.36 , pp. 3815-3817
    • Rowe, P.1    Wasserfall, C.2    Croker, B.3
  • 19
    • 84908632192 scopus 로고    scopus 로고
    • Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes
    • Arif S, Leete P, Nguyen V, et al. Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes. 2014; 63: 3835-3845
    • (2014) Diabetes , vol.63 , pp. 3835-3845
    • Arif, S.1    Leete, P.2    Nguyen, V.3
  • 20
    • 84882319996 scopus 로고    scopus 로고
    • Insulin-dependent diabetes induced by pancreatic beta cell expression of il-15 and il-15ralpha
    • Chen J, Feigenbaum L, Awasthi P, et al. Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15Ralpha. Proc Natl Acad Sci USA. 2013; 110: 13534-13539
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 13534-13539
    • Chen, J.1    Feigenbaum, L.2    Awasthi, P.3
  • 21
    • 84884332897 scopus 로고    scopus 로고
    • Extrathymic aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of cd4() t cells
    • Gardner JM, Metzger TC, McMahon EJ, et al. Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4() T cells. Immunity. 2013; 39: 560-572
    • (2013) Immunity , vol.39 , pp. 560-572
    • Gardner, J.M.1    Metzger, T.C.2    McMahon, E.J.3
  • 22
    • 84891552936 scopus 로고    scopus 로고
    • B7-h4 expression in normal and diseased human islet beta cells
    • Cheung SS, Ou D, Metzger DL, et al. B7-H4 expression in normal and diseased human islet beta cells. Pancreas. 2014; 43: 128-134
    • (2014) Pancreas , vol.43 , pp. 128-134
    • Cheung, S.S.1    Ou, D.2    Metzger, D.L.3
  • 23
    • 84905018256 scopus 로고    scopus 로고
    • Hyaluronan and hyaluronanbinding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis
    • Bogdani M, Johnson PY, Potter-Perigo S, et al. Hyaluronan and hyaluronanbinding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis. Diabetes. 2014; 63: 2727-2743
    • (2014) Diabetes , vol.63 , pp. 2727-2743
    • Bogdani, M.1    Johnson, P.Y.2    Potter-Perigo, S.3
  • 24
    • 84904353328 scopus 로고    scopus 로고
    • Ctsh regulates beta-cell function and disease progression in newly diagnosed type 1 diabetes patients
    • Floyel T, Brorsson C, Nielsen LB, et al. CTSH regulates beta-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci USA. 2014; 111: 10305-10310
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 10305-10310
    • Floyel, T.1    Brorsson, C.2    Nielsen, L.B.3
  • 25
    • 84933544989 scopus 로고    scopus 로고
    • Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes
    • Krogvold L, Edwin B, Buanes T, et al. Detection of a low-grade enteroviral infection in the islets of Langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes. 2015; 64: 1682-1687
    • (2015) Diabetes , vol.64 , pp. 1682-1687
    • Krogvold, L.1    Edwin, B.2    Buanes, T.3
  • 26
    • 84937788636 scopus 로고    scopus 로고
    • Expression pattern of 12-lipoxygenases in human islets with type 1 diabetes and type 2 diabetes
    • Grzesik WJ, Nadler JL, Machida Y, et al. Expression pattern of 12-lipoxygenases in human islets with type 1 diabetes and type 2 diabetes. J Clin Endocrinol Metab 2014
    • (2014) J Clin Endocrinol Metab
    • Grzesik, W.J.1    Nadler, J.L.2    Machida, Y.3
  • 27
    • 84907679203 scopus 로고    scopus 로고
    • Repurposing camp-modulating medications to promote beta-cell replication
    • Zhao Z, Low YS, Armstrong NA, et al. Repurposing cAMP-modulating medications to promote beta-cell replication. Mol Endocrinol. 2014; 28: 1682-1697
    • (2014) Mol Endocrinol , vol.28 , pp. 1682-1697
    • Zhao, Z.1    Low, Y.S.2    Armstrong, N.A.3
  • 28
    • 84891758721 scopus 로고    scopus 로고
    • Diminished adenosine a1 receptor expression in pancreatic alpha-cells may contribute to the pathology of type 1 diabetes
    • Yip L, Taylor C, Whiting CC, Fathman CG. Diminished adenosine A1 receptor expression in pancreatic alpha-cells may contribute to the pathology of type 1 diabetes. Diabetes. 2013; 62: 4208-4219
    • (2013) Diabetes , vol.62 , pp. 4208-4219
    • Yip, L.1    Taylor, C.2    Whiting, C.C.3    Fathman, C.G.4
  • 29
    • 84905500227 scopus 로고    scopus 로고
    • Pharmacological induction of pancreatic islet cell transdifferentiation: Relevance to type i diabetes
    • Piran R, Lee SH, Li CR, et al. Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes. Cell Death Dis. 2014; 5: e1357
    • (2014) Cell Death Dis , vol.5 , pp. e1357
    • Piran, R.1    Lee, S.H.2    Li, C.R.3
  • 30
    • 84888376674 scopus 로고    scopus 로고
    • Sphingomyelin patches on pancreatic beta-cells are indicative of insulin secretory capacity
    • Kavishwar A, Moore A. Sphingomyelin patches on pancreatic beta-cells are indicative of insulin secretory capacity. J Histochem Cytochem. 2013; 61: 910-919
    • (2013) J Histochem Cytochem , vol.61 , pp. 910-919
    • Kavishwar, A.1    Moore, A.2
  • 31
    • 84870909023 scopus 로고    scopus 로고
    • Pancreas organ weight in individuals with disease-Associated autoantibodies at risk for type 1 diabetes
    • Campbell-Thompson M, Wasserfall C, Montgomery EL, et al. PAncreas organ weight in individuals with disease-Associated autoantibodies at risk for type 1 diabetes. JAMA. 2012; 308: 2337-2339
    • (2012) JAMA , vol.308 , pp. 2337-2339
    • Campbell-Thompson, M.1    Wasserfall, C.2    Montgomery, E.L.3
  • 32
    • 78650967712 scopus 로고    scopus 로고
    • Noninvasive imaging of pancreatic islet inflammation in type 1a diabetes patients
    • Gaglia JL, Guimaraes AR, Harisinghani M, et al. Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. J Clin Investig. 2011; 121: 442-445
    • (2011) J Clin Investig , vol.121 , pp. 442-445
    • Gaglia, J.L.1    Guimaraes, A.R.2    Harisinghani, M.3
  • 33
    • 33846236337 scopus 로고    scopus 로고
    • Magnetic resonance imaging: A reliable method for measuring pancreatic volume in type 1 diabetes
    • Williams AJK, Chau W, Callaway MP, Dayan CM. Magnetic resonance imaging: a reliable method for measuring pancreatic volume in type 1 diabetes. Diabetic Med. 2007; 24: 35-40
    • (2007) Diabetic Med , vol.24 , pp. 35-40
    • Williams, A.J.K.1    Chau, W.2    Callaway, M.P.3    Dayan, C.M.4
  • 34
    • 84868619304 scopus 로고    scopus 로고
    • Pancreatic volume is reduced in adult patients with recently diagnosed type 1 diabetes
    • Williams AJK, Thrower SL, Sequeiros IM, et al. Pancreatic volume is reduced in adult patients with recently diagnosed type 1 diabetes. J Clin Endocrinol Metab. 2012; 97: E2109-E2113
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. E2109-E2113
    • Williams, A.J.K.1    Thrower, S.L.2    Sequeiros, I.M.3
  • 35
    • 0022386662 scopus 로고
    • Size of pancreas in diabetes mellitus: A study based on ultrasound
    • Fonseca V, Berger LA, Beckett AG, Dandona P. Size of pancreas in diabetes mellitus: a study based on ultrasound. Br Med J. 1985; 291: 1240-1241
    • (1985) Br Med J , vol.291 , pp. 1240-1241
    • Fonseca, V.1    Berger, L.A.2    Beckett, A.G.3    Dandona, P.4
  • 36
    • 0023618080 scopus 로고
    • Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy
    • Lö hr M, Klö ppel G. Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy. Diabetologia. 1987; 30: 757-762
    • (1987) Diabetologia , vol.30 , pp. 757-762
    • Löhr, M.1    Klöppel, G.2
  • 37
    • 0031661092 scopus 로고    scopus 로고
    • Size of pancreas in children and adolescents with type i (insulin-dependent) diabetes
    • Altobelli E, Blasetti A, Verrotti A, et al. Size of pancreas in children and adolescents with type I (insulin-dependent) diabetes. J Clin Ultrasound. 1998; 26: 391-395
    • (1998) J Clin Ultrasound , vol.26 , pp. 391-395
    • Altobelli, E.1    Blasetti, A.2    Verrotti, A.3
  • 38
    • 0035673881 scopus 로고    scopus 로고
    • Pancreatic volume in type 1 und type 2 diabetes mellitus
    • Goda K, Sasaki E, Nagata K, et al. Pancreatic volume in type 1 und type 2 diabetes mellitus. Acta Diabetol. 2001; 38: 145-149
    • (2001) Acta Diabetol , vol.38 , pp. 145-149
    • Goda, K.1    Sasaki, E.2    Nagata, K.3
  • 39
    • 0026667763 scopus 로고
    • The density, contour, and thickness of the pancreas in diabetics: Ct findings in 57 patients
    • Gilbeau JP, Poncelet V, Libon E, et al. The density, contour, and thickness of the pancreas in diabetics: CT findings in 57 patients. Am J Roentgenol. 1992; 159: 527-531
    • (1992) Am J Roentgenol , vol.159 , pp. 527-531
    • Gilbeau, J.P.1    Poncelet, V.2    Libon, E.3
  • 40
    • 77953920802 scopus 로고    scopus 로고
    • Microscopic anatomy of the human islet of langerhans
    • Islam MS editor Springer Netherlands: Berlin
    • Int Veld P, Marichal M. Microscopic anatomy of the human islet of langerhans. In: Islam MS, editor. The islets of Langerhans. Springer Netherlands: Berlin; 2010. pp. 1-19
    • (2010) The Islets of Langerhans , pp. 1-19
    • Int Veld, P.1    Marichal, M.2
  • 41
    • 0021252607 scopus 로고
    • The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: Insulin content of islets, insulitis and associated changes in the exocrine acinar tissue
    • Foulis AK, Stewart JA. The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue. Diabetologia. 1984; 26: 456-461
    • (1984) Diabetologia , vol.26 , pp. 456-461
    • Foulis, A.K.1    Stewart, J.A.2
  • 42
    • 66049112916 scopus 로고    scopus 로고
    • Interactions between the endocrine and exocrine pancreas and their clinical relevance
    • Czako L, Hegyi P, Rakonczay Z Jr, et al. Interactions between the endocrine and exocrine pancreas and their clinical relevance. Pancreatology. 2009; 9: 351-359
    • (2009) Pancreatology , vol.9 , pp. 351-359
    • Czako, L.1    Hegyi, P.2    Rakonczay, Z.3
  • 43
    • 20944443596 scopus 로고    scopus 로고
    • Human pancreatic exocrine response to nutrients in health and disease
    • Keller J, Layer P. Human pancreatic exocrine response to nutrients in health and disease. Gut. 2005; 54: 1-28
    • (2005) Gut , vol.54 , pp. 1-28
    • Keller, J.1    Layer, P.2
  • 44
    • 79954416602 scopus 로고    scopus 로고
    • Pancreatic volume and endocrine and exocrine functions in patients with diabetes
    • Philippe MF, Benabadji S, Barbot-Trystram L, et al. Pancreatic volume and endocrine and exocrine functions in patients with diabetes. Pancreas. 2011; 40: 359-363
    • (2011) Pancreas , vol.40 , pp. 359-363
    • Philippe, M.F.1    Benabadji, S.2    Barbot-Trystram, L.3
  • 45
    • 84864010108 scopus 로고    scopus 로고
    • Pancreatic exocrine function in patients with diabetes
    • Larger E, Philippe MF, Barbot-Trystram L, et al. Pancreatic exocrine function in patients with diabetes. Diabetic Med. 2012; 29: 1047-1054
    • (2012) Diabetic Med , vol.29 , pp. 1047-1054
    • Larger, E.1    Philippe, M.F.2    Barbot-Trystram, L.3
  • 46
    • 84863053082 scopus 로고    scopus 로고
    • Expression and regulation of chemokines in murine and human type 1 diabetes
    • Sarkar SA, Lee CE, Victorino F, et al. Expression and regulation of chemokines in murine and human type 1 diabetes. Diabetes. 2012; 61: 436-446
    • (2012) Diabetes , vol.61 , pp. 436-446
    • Sarkar, S.A.1    Lee, C.E.2    Victorino, F.3
  • 47
    • 84921914093 scopus 로고    scopus 로고
    • Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors
    • Oram RA, McDonald TJ, Shields BM, et al. Most people with long-duration type 1 diabetes in a large population-based study are insulin microsecretors. Diabetes Care. 2015; 38: 323-328
    • (2015) Diabetes Care , vol.38 , pp. 323-328
    • Oram, R.A.1    McDonald, T.J.2    Shields, B.M.3
  • 48
    • 84856825977 scopus 로고    scopus 로고
    • Demonstration of islet-Autoreactive cd8 t cells in insulitic lesions from recent onset and long-Term type 1 diabetes patients
    • Coppieters KT, Dotta F, Amirian N, et al. Demonstration of islet-Autoreactive CD8 T cells in insulitic lesions from recent onset and long-Term type 1 diabetes patients. J Exp Med. 2012; 209: 51-60
    • (2012) J Exp Med , vol.209 , pp. 51-60
    • Coppieters, K.T.1    Dotta, F.2    Amirian, N.3
  • 49
    • 23844550325 scopus 로고    scopus 로고
    • Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets
    • Ylipaasto P, Kutlu B, Rasilainen S, et al. Global profiling of coxsackievirus- And cytokine-induced gene expression in human pancreatic islets. Diabetologia. 2005; 48: 1510-1522
    • (2005) Diabetologia , vol.48 , pp. 1510-1522
    • Ylipaasto, P.1    Kutlu, B.2    Rasilainen, S.3
  • 50
    • 84910120838 scopus 로고    scopus 로고
    • Extracellular matrix components in the pathogenesis of type 1 diabetes
    • Bogdani M, Korpos E, Simeonovic C, et al. Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr Diab Rep. 2014; 14: 1-11
    • (2014) Curr Diab Rep , vol.14 , pp. 1-11
    • Bogdani, M.1    Korpos, E.2    Simeonovic, C.3
  • 51
    • 77953943557 scopus 로고    scopus 로고
    • Basement membrane in pancreatic islet function
    • In: Islam MS editor Springer Netherlands: Dordrecht
    • Kragl M, Lammert E. Basement membrane in pancreatic islet function. In: Islam MS, editor. The islets of Langerhans. Springer Netherlands: Dordrecht; 2010. pp. 217-234
    • (2010) The Islets of Langerhans , pp. 217-234
    • Kragl, M.1    Lammert, E.2
  • 52
    • 34848889281 scopus 로고    scopus 로고
    • Structure and function of basement membranes
    • LeBleu VS, MacDonald B, Kalluri R. Structure and function of basement membranes. Exp Biol Med. 2007; 232: 1121-1129
    • (2007) Exp Biol Med , vol.232 , pp. 1121-1129
    • LeBleu, V.S.1    MacDonald, B.2    Kalluri, R.3
  • 54
    • 84873051300 scopus 로고    scopus 로고
    • The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human
    • Korpos É, Kadri N, Kappelhoff R, et al. The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes. 2013; 62: 531-542
    • (2013) Diabetes , vol.62 , pp. 531-542
    • Korpos E..1    Kadri, N.2    Kappelhoff, R.3
  • 55
    • 84920683669 scopus 로고    scopus 로고
    • Determinants of immunodominance for cd4 t cells
    • Kim A, Sadegh-Nasseri S. Determinants of immunodominance for CD4 T cells. Curr Opin Immunol. 2015; 34: 9-15
    • (2015) Curr Opin Immunol , vol.34 , pp. 9-15
    • Kim, A.1    Sadegh-Nasseri, S.2
  • 56
    • 84893693165 scopus 로고    scopus 로고
    • Evaluation of the fidelity of immunolabelling obtained with clone 5d8/1, a monoclonal antibody directed against the enteroviral capsid protein, vp1, in human pancreas
    • Richardson SJ, Leete P, Dhayal S, et al. Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia. 2014; 57: 392-401
    • (2014) Diabetologia , vol.57 , pp. 392-401
    • Richardson, S.J.1    Leete, P.2    Dhayal, S.3
  • 57
    • 35248864495 scopus 로고    scopus 로고
    • Human pancreatic islet endothelial cells express coxsackievirus and adenovirus receptor and are activated by coxsackie b virus infection
    • Zanone MM, Favaro E, Ferioli E, et al. Human pancreatic islet endothelial cells express coxsackievirus and adenovirus receptor and are activated by coxsackie B virus infection. FASEB J. 2007; 21: 3308-3317
    • (2007) FASEB J , vol.21 , pp. 3308-3317
    • Zanone, M.M.1    Favaro, E.2    Ferioli, E.3
  • 58
    • 84866389264 scopus 로고    scopus 로고
    • Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure
    • Talchai C, Xuan S, Lin HV, et al. Pancreatic beta cell dedifferentiation as a mechanism of diabetic beta cell failure. Cell. 2012; 150: 1223-1234
    • (2012) Cell , vol.150 , pp. 1223-1234
    • Talchai, C.1    Xuan, S.2    Lin, H.V.3
  • 59
    • 84886545834 scopus 로고    scopus 로고
    • A smad signaling network regulates islet cell proliferation
    • El-Gohary Y, Tulachan S, Wiersch J, et al A smad signaling network regulates islet cell proliferation. Diabetes. 2014; 63: 224-236
    • (2014) Diabetes , vol.63 , pp. 224-236
    • El-Gohary, Y.1    Tulachan, S.2    Wiersch, J.3
  • 60
    • 84925849428 scopus 로고    scopus 로고
    • Adenosine signalling in diabetes mellitus[mdash]pathophysiology and therapeutic considerations
    • Antonioli L, Blandizzi C, Csoka B, et al. Adenosine signalling in diabetes mellitus[mdash]pathophysiology and therapeutic considerations. Nat Rev Endocrinol. 2015; 11: 228-241
    • (2015) Nat Rev Endocrinol , vol.11 , pp. 228-241
    • Antonioli, L.1    Blandizzi, C.2    Csoka, B.3
  • 61
    • 84860498528 scopus 로고    scopus 로고
    • Novel pancreatic beta cell-specific proteins: Antibody-based proteomics for identification of new biomarker candidates
    • Lindskog C, Korsgren O, Ponten F, et al. Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates. J Proteomics. 2012; 75: 2611-2620
    • (2012) J Proteomics , vol.75 , pp. 2611-2620
    • Lindskog, C.1    Korsgren, O.2    Ponten, F.3
  • 62
    • 84879831638 scopus 로고    scopus 로고
    • Immunologic and metabolic biomarkers of (-cell destruction in the diagnosis of type 1 diabetes
    • Lebastchi J, Herold KC. Immunologic and Metabolic Biomarkers of (-Cell Destruction in the Diagnosis of Type 1 Diabetes. Cold Spring Harb Perspect Med. 2012; 2: a007708
    • (2012) Cold Spring Harb Perspect Med , vol.2 , pp. a007708
    • Lebastchi, J.1    Herold, K.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.