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Volumn 14, Issue 12, 2014, Pages 1-11

Extracellular Matrix Components in the Pathogenesis of Type 1 Diabetes

Author keywords

Cathepsins; Diabetes; Extracellular matrix; Heparan sulfate; Heparanase; Hyaladherins; Hyaluronan; Immune regulation; Islet; Islet infiltration; Laminin

Indexed keywords

COLLAGEN TYPE 4; HEPARAN SULFATE; HYALURONIC ACID; LAMININ; PANCRELIPASE; PROTEOHEPARAN SULFATE; PROTEOGLYCAN;

EID: 84910120838     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-014-0552-7     Document Type: Review
Times cited : (71)

References (95)
  • 1
    • 84878214358 scopus 로고    scopus 로고
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor: Excellent up-to-date coverage of different ECM components
    • Hynes RO, Yamada KM. Extracellular matrix biology. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 2012. Excellent up-to-date coverage of different ECM components.
    • (2012) Extracellular matrix biology
    • Hynes, R.O.1    Yamada, K.M.2
  • 2
    • 85054519143 scopus 로고    scopus 로고
    • Walter de Gruyter, Berlin/Boston: Outstanding collection of chapters covering information on how different components of ECM impact cellular signaling and cell phenotype
    • Karamanos N. Extracellular matrix: pathobiology and signaling. Berlin/Boston: Walter de Gruyter; 2012. Outstanding collection of chapters covering information on how different components of ECM impact cellular signaling and cell phenotype.
    • (2012) Extracellular matrix: pathobiology and signaling
    • Karamanos, N.1
  • 5
    • 77957221743 scopus 로고    scopus 로고
    • The impact of the extracellular matrix on inflammation
    • PID: 20865019, COI: 1:CAS:528:DC%2BC3cXht1SltbbO
    • Sorokin L. The impact of the extracellular matrix on inflammation. Nat Rev Immunol. 2010;10:712–23. doi:10.1038/nri2852.
    • (2010) Nat Rev Immunol , vol.10 , pp. 712-723
    • Sorokin, L.1
  • 6
    • 84893708638 scopus 로고    scopus 로고
    • The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings
    • PID: 24325575
    • Pugliese A, Yang M, Kusmarteva I, Heiple T, Vendrame F, Wasserfall C, et al. The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: goals, operational model and emerging findings. Pediatr Diabetes. 2014;15:1–9. doi:10.1111/pedi.12097.
    • (2014) Pediatr Diabetes , vol.15 , pp. 1-9
    • Pugliese, A.1    Yang, M.2    Kusmarteva, I.3    Heiple, T.4    Vendrame, F.5    Wasserfall, C.6
  • 7
    • 0037002547 scopus 로고    scopus 로고
    • Extracellular signals and pancreatic beta-cell development: a brief review
    • PID: 12606811, COI: 1:CAS:528:DC%2BD3sXhslWnsbk%3D
    • Jiang FX, Harrison LC. Extracellular signals and pancreatic beta-cell development: a brief review. Mol Med. 2002;8:763–70.
    • (2002) Mol Med , vol.8 , pp. 763-770
    • Jiang, F.X.1    Harrison, L.C.2
  • 8
    • 84895748980 scopus 로고    scopus 로고
    • Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding
    • PID: 24574008, COI: 1:CAS:528:DC%2BC2cXotV2kurc%3D, This study shows the interconnection between the vascular and neuronal system in pancreatic islet development
    • Reinert RB, Cai Q, Hong JY, Plank JL, Aamodt K, Prasad N, et al. Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development. 2014;141:1480–91. doi:10.1242/dev.098657. This study shows the interconnection between the vascular and neuronal system in pancreatic islet development.
    • (2014) Development , vol.141 , pp. 1480-1491
    • Reinert, R.B.1    Cai, Q.2    Hong, J.Y.3    Plank, J.L.4    Aamodt, K.5    Prasad, N.6
  • 9
    • 33644537403 scopus 로고    scopus 로고
    • The vascular basement membrane: a niche for insulin gene expression and beta cell proliferation
    • PID: 16516842, COI: 1:CAS:528:DC%2BD28Xislyhsbo%3D, This study shows how laminins can impact on islet development and insulin production, an area with enormous potential for improved islet transfer
    • Nikolova G, Jabs N, Konstantinova I, Domogatskaya A, Tryggvason K, Sorokin L, et al. The vascular basement membrane: a niche for insulin gene expression and beta cell proliferation. Dev Cell. 2006;10:397–405. doi:10.1016/j.devcel.2006.01.015. This study shows how laminins can impact on islet development and insulin production, an area with enormous potential for improved islet transfer.
    • (2006) Dev Cell , vol.10 , pp. 397-405
    • Nikolova, G.1    Jabs, N.2    Konstantinova, I.3    Domogatskaya, A.4    Tryggvason, K.5    Sorokin, L.6
  • 10
    • 44749086106 scopus 로고    scopus 로고
    • Blood vessels of human islets of Langerhans are surrounded by a double basement membrane
    • PID: 18438639, COI: 1:STN:280:DC%2BD1czlt12gsA%3D%3D
    • Virtanen I, Banerjee M, Palgi J, Korsgren O, Lukinius A, Thornell LE, et al. Blood vessels of human islets of Langerhans are surrounded by a double basement membrane. Diabetologia. 2008;51:1181–91. doi:10.1007/s00125-008-0997-9.
    • (2008) Diabetologia , vol.51 , pp. 1181-1191
    • Virtanen, I.1    Banerjee, M.2    Palgi, J.3    Korsgren, O.4    Lukinius, A.5    Thornell, L.E.6
  • 11
    • 53549130682 scopus 로고    scopus 로고
    • Unique basement membrane structure of human pancreatic islets: implications for beta-cell growth and differentiation
    • PID: 18834439
    • Otonkoski T, Banerjee M, Korsgren O, Thornell LE, Virtanen I. Unique basement membrane structure of human pancreatic islets: implications for beta-cell growth and differentiation. Diabetes Obes Metab. 2008;10 Suppl 4:119–27. doi:10.1111/j.1463-1326.2008.00955.x.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 119-127
    • Otonkoski, T.1    Banerjee, M.2    Korsgren, O.3    Thornell, L.E.4    Virtanen, I.5
  • 12
    • 0642272492 scopus 로고    scopus 로고
    • Immunohistochemical study of the pancreatic basement membrane in non obese diabetic mice (NOD) with spontaneous autoimmune insulitis
    • PID: 12762648, COI: 1:STN:280:DC%2BD3s3ktVahtA%3D%3D
    • Pavin EJ, Pinto GA, Zollner RL, Vassallo J. Immunohistochemical study of the pancreatic basement membrane in non obese diabetic mice (NOD) with spontaneous autoimmune insulitis. J Submicrosc Cytol Pathol. 2003;35:25–7.
    • (2003) J Submicrosc Cytol Pathol , vol.35 , pp. 25-27
    • Pavin, E.J.1    Pinto, G.A.2    Zollner, R.L.3    Vassallo, J.4
  • 13
    • 49249124898 scopus 로고    scopus 로고
    • Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis
    • PID: 18633594, COI: 1:CAS:528:DC%2BD1cXpsVGitbo%3D
    • Irving-Rodgers HF, Ziolkowski AF, Parish CR, Sado Y, Ninomiya Y, Simeonovic CJ, et al. Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis. Diabetologia. 2008;51:1680–8. doi:10.1007/s00125-008-1085-x.
    • (2008) Diabetologia , vol.51 , pp. 1680-1688
    • Irving-Rodgers, H.F.1    Ziolkowski, A.F.2    Parish, C.R.3    Sado, Y.4    Ninomiya, Y.5    Simeonovic, C.J.6
  • 14
    • 84855460360 scopus 로고    scopus 로고
    • Heparan sulfate and heparanase play key roles in mouse beta cell survival and autoimmune diabetes
    • PID: 22182841, COI: 1:CAS:528:DC%2BC38XkvFClsQ%3D%3D, Hallmark study identifies heparan sulfate (HS) to be critical for islet beta cell survival and HS-degrading heparanase as a novel mechanism of beta cell death in T1D
    • Ziolkowski AF, Popp SK, Freeman C, Parish CR, Simeonovic CJ. Heparan sulfate and heparanase play key roles in mouse beta cell survival and autoimmune diabetes. J Clin Invest. 2012;122:132–41. doi:10.1172/JCI46177. Hallmark study identifies heparan sulfate (HS) to be critical for islet beta cell survival and HS-degrading heparanase as a novel mechanism of beta cell death in T1D.
    • (2012) J Clin Invest , vol.122 , pp. 132-141
    • Ziolkowski, A.F.1    Popp, S.K.2    Freeman, C.3    Parish, C.R.4    Simeonovic, C.J.5
  • 15
    • 84873051300 scopus 로고    scopus 로고
    • The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human
    • PID: 23139348, COI: 1:CAS:528:DC%2BC3sXhvFOns7s%3D, This work shows that the peri-islet basement membrane is a barrier in front of pancreatic islet infiltrating leukocyte not only in NOD mice but also in human type 1 diabetic pancreases
    • Korpos E, Kadri N, Kappelhoff R, Wegner J, Overall CM, Weber E, et al. The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes. 2013;62:531–42. doi:10.2337/db12-0432. This work shows that the peri-islet basement membrane is a barrier in front of pancreatic islet infiltrating leukocyte not only in NOD mice but also in human type 1 diabetic pancreases.
    • (2013) Diabetes , vol.62 , pp. 531-542
    • Korpos, E.1    Kadri, N.2    Kappelhoff, R.3    Wegner, J.4    Overall, C.M.5    Weber, E.6
  • 16
    • 33744493940 scopus 로고    scopus 로고
    • Current concepts of extracellular matrix
    • PID: 16721539
    • Tanzer ML. Current concepts of extracellular matrix. J Orthop Sci. 2006;11:326–31. doi:10.1007/s00776-006-1012-2.
    • (2006) J Orthop Sci , vol.11 , pp. 326-331
    • Tanzer, M.L.1
  • 17
    • 70849099495 scopus 로고    scopus 로고
    • The extracellular matrix: not just pretty fibrils
    • PID: 19965464, COI: 1:CAS:528:DC%2BD1MXhsVKhur%2FM, An excellent overview of what the ECM is and how it can impact cellular behavior
    • Hynes RO. The extracellular matrix: not just pretty fibrils. Science. 2009;326:1216–9. doi:10.1126/science.1176009. An excellent overview of what the ECM is and how it can impact cellular behavior.
    • (2009) Science , vol.326 , pp. 1216-1219
    • Hynes, R.O.1
  • 18
    • 78649737455 scopus 로고    scopus 로고
    • The extracellular matrix at a glance
    • PID: 21123617, COI: 1:CAS:528:DC%2BC3MXhtV2qsr4%3D
    • Frantz C, Stewart KM, Weaver VM. The extracellular matrix at a glance. J Cell Sci. 2010;123:4195–200. doi:10.1242/jcs.023820.
    • (2010) J Cell Sci , vol.123 , pp. 4195-4200
    • Frantz, C.1    Stewart, K.M.2    Weaver, V.M.3
  • 19
    • 72049133263 scopus 로고    scopus 로고
    • Biological effects of hyaluronan in connective tissues, eye, skin, venous wall
    • COI: 1:CAS:528:DC%2BC3cXmvVWnt7c%3D
    • Robert L, Robert AM, Renard G. Biological effects of hyaluronan in connective tissues, eye, skin, venous wall. Role in aging Pathol Biol (Paris). 2010;58:187–98. doi:10.1016/j.patbio.2009.09.010.
    • (2010) Role in aging Pathol Biol (Paris) , vol.58 , pp. 187-198
    • Robert, L.1    Robert, A.M.2    Renard, G.3
  • 20
    • 84905018256 scopus 로고    scopus 로고
    • Bogdani M, Johnson PY, Potter-Perigo S, Nagy N, Day AJ, Bollyky PL, et al. Hyaluronan and hyaluronan binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis. Diabetes. 2014;63:2727–43. doi:. A thorough investigation of the involvement of hyaluronan and associated molecules in the pathogenesis of T1D
    • Bogdani M, Johnson PY, Potter-Perigo S, Nagy N, Day AJ, Bollyky PL, et al. Hyaluronan and hyaluronan binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis. Diabetes. 2014;63:2727–43. doi:10.2337/db13-1658. A thorough investigation of the involvement of hyaluronan and associated molecules in the pathogenesis of T1D.
  • 21
    • 84861537861 scopus 로고    scopus 로고
    • The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens
    • PID: 22493504, COI: 1:CAS:528:DC%2BC38XnsF2msrg%3D
    • Behrens DT, Villone D, Koch M, Brunner G, Sorokin L, Robenek H, et al. The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens. J Biol Chem. 2012;287:18700–9. doi:10.1074/jbc.M111.336073.
    • (2012) J Biol Chem , vol.287 , pp. 18700-18709
    • Behrens, D.T.1    Villone, D.2    Koch, M.3    Brunner, G.4    Sorokin, L.5    Robenek, H.6
  • 22
    • 0026006388 scopus 로고
    • Recombinant nidogen consists of three globular domains and mediates binding of laminin to collagen type IV
    • PID: 1717261, COI: 1:CAS:528:DyaK3MXmt1KmsL8%3D
    • Fox JW, Mayer U, Nischt R, Aumailley M, Reinhardt D, Wiedemann H, et al. Recombinant nidogen consists of three globular domains and mediates binding of laminin to collagen type IV. EMBO J. 1991;10:3137–46.
    • (1991) EMBO J , vol.10 , pp. 3137-3146
    • Fox, J.W.1    Mayer, U.2    Nischt, R.3    Aumailley, M.4    Reinhardt, D.5    Wiedemann, H.6
  • 23
    • 0031729185 scopus 로고    scopus 로고
    • Structural and genetic analysis of laminin-nidogen interaction
    • PID: 9917838, COI: 1:CAS:528:DyaK1cXns1Gquro%3D
    • Mayer U, Kohfeldt E, Timpl R. Structural and genetic analysis of laminin-nidogen interaction. Ann NY Acad Sci. 1998;857:130–42.
    • (1998) Ann NY Acad Sci , vol.857 , pp. 130-142
    • Mayer, U.1    Kohfeldt, E.2    Timpl, R.3
  • 24
    • 0027489337 scopus 로고
    • Sites of nidogen cleavage by proteases involved in tissue homeostasis and remodelling
    • PID: 8223643, COI: 1:CAS:528:DyaK3sXmt1Shu7g%3D
    • Mayer U, Mann K, Timpl R, Murphy G. Sites of nidogen cleavage by proteases involved in tissue homeostasis and remodelling. Eur J Biochem. 1993;217:877–84.
    • (1993) Eur J Biochem , vol.217 , pp. 877-884
    • Mayer, U.1    Mann, K.2    Timpl, R.3    Murphy, G.4
  • 25
    • 0027263329 scopus 로고
    • Nidogen mediates the formation of ternary complexes of basement membrane components
    • PID: 8433572, COI: 1:CAS:528:DyaK3sXlsFCgu70%3D
    • Aumailley M, Battaglia C, Mayer U, Reinhardt D, Nischt R, Timpl R, et al. Nidogen mediates the formation of ternary complexes of basement membrane components. Kidney Int. 1993;43:7–12.
    • (1993) Kidney Int , vol.43 , pp. 7-12
    • Aumailley, M.1    Battaglia, C.2    Mayer, U.3    Reinhardt, D.4    Nischt, R.5    Timpl, R.6
  • 26
    • 1842482987 scopus 로고    scopus 로고
    • Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development
    • PID: 14998921
    • Poschl E, Schlotzer-Schrehardt U, Brachvogel B, Saito K, Ninomiya Y, Mayer U. Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development. 2004;131:1619–28. doi:10.1242/dev.01037.
    • (2004) Development , vol.131 , pp. 1619-1628
    • Poschl, E.1    Schlotzer-Schrehardt, U.2    Brachvogel, B.3    Saito, K.4    Ninomiya, Y.5    Mayer, U.6
  • 27
    • 72449128021 scopus 로고    scopus 로고
    • COI: 1:CAS:528:DC%2BD1MXhsVymtrbO
    • Durbeej M. Laminins Cell Tissue Res. 2010;339:259–68. doi:10.1007/s00441-009-0838-2.
    • (2010) Laminins Cell Tissue Res , vol.339 , pp. 259-268
    • Durbeej, M.1
  • 28
    • 33748048179 scopus 로고    scopus 로고
    • The role of heparan sulphate in inflammation
    • PID: 16917509, COI: 1:CAS:528:DC%2BD28Xos12gt78%3D
    • Parish CR. The role of heparan sulphate in inflammation. Nat Rev Immunol. 2006;6:633–43.
    • (2006) Nat Rev Immunol , vol.6 , pp. 633-643
    • Parish, C.R.1
  • 29
    • 0036942123 scopus 로고    scopus 로고
    • Distinct distribution of laminin and its integrin receptors in the pancreas
    • PID: 12486084, COI: 1:CAS:528:DC%2BD3sXkvVCntg%3D%3D
    • Jiang FX, Naselli G, Harrison LC. Distinct distribution of laminin and its integrin receptors in the pancreas. J Histochem Cytochem. 2002;50:1625–32.
    • (2002) J Histochem Cytochem , vol.50 , pp. 1625-1632
    • Jiang, F.X.1    Naselli, G.2    Harrison, L.C.3
  • 30
    • 84858749440 scopus 로고    scopus 로고
    • Proliferation and plasticity of human beta cells on physiologically occurring laminin isoforms
    • PID: 22314207, COI: 1:CAS:528:DC%2BC38XisFyjtrk%3D
    • Banerjee M, Virtanen I, Palgi J, Korsgren O, Otonkoski T. Proliferation and plasticity of human beta cells on physiologically occurring laminin isoforms. Mol Cell Endocrinol. 2012;355:78–86. doi:10.1016/j.mce.2012.01.020.
    • (2012) Mol Cell Endocrinol , vol.355 , pp. 78-86
    • Banerjee, M.1    Virtanen, I.2    Palgi, J.3    Korsgren, O.4    Otonkoski, T.5
  • 31
    • 0028276507 scopus 로고
    • Distribution of collagens type I, type III and type V in the pancreas of rat, dog, pig and man
    • PID: 8055531
    • Van Deijnen JH, Van Suylichem PT, Wolters GH, Van Schilfgaarde R. Distribution of collagens type I, type III and type V in the pancreas of rat, dog, pig and man. Cell Tissue Res. 1994;277:115–21.
    • (1994) Cell Tissue Res , vol.277 , pp. 115-121
    • Van Deijnen, J.H.1    Van Suylichem, P.T.2    Wolters, G.H.3    Van Schilfgaarde, R.4
  • 32
    • 0037378123 scopus 로고    scopus 로고
    • Unique structural features that influence neutrophil emigration into the lung
    • PID: 12663861, COI: 1:CAS:528:DC%2BD3sXjtVagtr4%3D
    • Burns AR, Smith CW, Walker DC. Unique structural features that influence neutrophil emigration into the lung. Physiol Rev. 2003;83:309–36. doi:10.1152/physrev.00023.2002.
    • (2003) Physiol Rev , vol.83 , pp. 309-336
    • Burns, A.R.1    Smith, C.W.2    Walker, D.C.3
  • 33
    • 34548230927 scopus 로고    scopus 로고
    • Getting to the site of inflammation: the leukocyte adhesion cascade updated
    • PID: 17717539, COI: 1:CAS:528:DC%2BD2sXpsV2qtb0%3D
    • Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7:678–89. doi:10.1038/nri2156.
    • (2007) Nat Rev Immunol , vol.7 , pp. 678-689
    • Ley, K.1    Laudanna, C.2    Cybulsky, M.I.3    Nourshargh, S.4
  • 34
    • 0004808355 scopus 로고    scopus 로고
    • Microcirculation of the islets of Langerhans. Long Beach Veterans Administration Regional Medical Education Center Symposium
    • PID: 8603757, COI: 1:CAS:528:DyaK28Xjs1GjtLs%3D
    • Brunicardi FC, Stagner J, Bonner-Weir S, Wayland H, Kleinman R, Livingston E, et al. Microcirculation of the islets of Langerhans. Long Beach Veterans Administration Regional Medical Education Center Symposium. Diabetes. 1996;45:385–92.
    • (1996) Diabetes , vol.45 , pp. 385-392
    • Brunicardi, F.C.1    Stagner, J.2    Bonner-Weir, S.3    Wayland, H.4    Kleinman, R.5    Livingston, E.6
  • 35
    • 0035947768 scopus 로고    scopus 로고
    • Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood–brain barrier in experimental autoimmune encephalomyelitis
    • PID: 11381080, COI: 1:CAS:528:DC%2BD3MXktVahu7w%3D
    • Sixt M, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin LM. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood–brain barrier in experimental autoimmune encephalomyelitis. J Cell Biol. 2001;153:933–46.
    • (2001) J Cell Biol , vol.153 , pp. 933-946
    • Sixt, M.1    Engelhardt, B.2    Pausch, F.3    Hallmann, R.4    Wendler, O.5    Sorokin, L.M.6
  • 36
    • 33745029732 scopus 로고    scopus 로고
    • Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils
    • PID: 16754715, COI: 1:CAS:528:DC%2BD28XmtVantrs%3D
    • Wang S, Voisin MB, Larbi KY, Dangerfield J, Scheiermann C, Tran M, et al. Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. J Exp Med. 2006;203:1519–32.
    • (2006) J Exp Med , vol.203 , pp. 1519-1532
    • Wang, S.1    Voisin, M.B.2    Larbi, K.Y.3    Dangerfield, J.4    Scheiermann, C.5    Tran, M.6
  • 37
    • 67349162632 scopus 로고    scopus 로고
    • Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain
    • PID: 19396173, COI: 1:CAS:528:DC%2BD1MXltValt78%3D
    • Wu C, Ivars F, Anderson P, Hallmann R, Vestweber D, Nilsson P, et al. Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain. Nat Med. 2009;15:519–27. doi:10.1038/nm.1957.
    • (2009) Nat Med , vol.15 , pp. 519-527
    • Wu, C.1    Ivars, F.2    Anderson, P.3    Hallmann, R.4    Vestweber, D.5    Nilsson, P.6
  • 38
    • 77957148462 scopus 로고    scopus 로고
    • Immune cell recruitment to inflammatory loci is impaired in mice deficient in basement membrane protein laminin alpha4
    • PID: 20483922, COI: 1:CAS:528:DC%2BC3cXhtFertrbI
    • Kenne E, Soehnlein O, Genove G, Rotzius P, Eriksson EE, Lindbom L. Immune cell recruitment to inflammatory loci is impaired in mice deficient in basement membrane protein laminin alpha4. J Leukoc Biol. 2010;88:523–8. doi:10.1189/jlb.0110043.
    • (2010) J Leukoc Biol , vol.88 , pp. 523-528
    • Kenne, E.1    Soehnlein, O.2    Genove, G.3    Rotzius, P.4    Eriksson, E.E.5    Lindbom, L.6
  • 39
    • 49149107616 scopus 로고    scopus 로고
    • The CLIP-CHIP oligonucleotide microarray: dedicated array for analysis of all protease, nonproteolytic homolog, and inhibitor gene transcripts in human and mouse. Curr Protoc Protein Sci 2007. p
    • Kappelhoff R, Overall C. The CLIP-CHIP oligonucleotide microarray: dedicated array for analysis of all protease, nonproteolytic homolog, and inhibitor gene transcripts in human and mouse. Curr Protoc Protein Sci 2007. p. Unit 21 19.
    • Unit , vol.21 , pp. 19
    • Kappelhoff, R.1    Overall, C.2
  • 40
    • 76149146398 scopus 로고    scopus 로고
    • IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
    • PID: 20080943, COI: 1:CAS:528:DC%2BC3cXhsFeitrY%3D
    • Gocheva V, Wang HW, Gadea BB, Shree T, Hunter KE, Garfall AL, et al. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes Dev. 2010;24:241–55. doi:10.1101/gad.1874010.
    • (2010) Genes Dev , vol.24 , pp. 241-255
    • Gocheva, V.1    Wang, H.W.2    Gadea, B.B.3    Shree, T.4    Hunter, K.E.5    Garfall, A.L.6
  • 41
    • 33646827205 scopus 로고    scopus 로고
    • Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors
    • PID: 16365041, COI: 1:CAS:528:DC%2BD28XhvVeju7Y%3D
    • Wang B, Sun J, Kitamoto S, Yang M, Grubb A, Chapman HA, et al. Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. J Biol Chem. 2006;281:6020–9. doi:10.1074/jbc.M509134200.
    • (2006) J Biol Chem , vol.281 , pp. 6020-6029
    • Wang, B.1    Sun, J.2    Kitamoto, S.3    Yang, M.4    Grubb, A.5    Chapman, H.A.6
  • 42
    • 34247868280 scopus 로고    scopus 로고
    • Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine collagenases
    • PID: 17322367, COI: 1:CAS:528:DC%2BD2sXjs1Wls70%3D
    • Abdul-Hussien H, Soekhoe RG, Weber E, von der Thusen JH, Kleemann R, Mulder A, et al. Collagen degradation in the abdominal aneurysm: a conspiracy of matrix metalloproteinase and cysteine collagenases. Am J Pathol. 2007;170:809–17. doi:10.2353/ajpath.2007.060522.
    • (2007) Am J Pathol , vol.170 , pp. 809-817
    • Abdul-Hussien, H.1    Soekhoe, R.G.2    Weber, E.3    von der Thusen, J.H.4    Kleemann, R.5    Mulder, A.6
  • 43
    • 66249098899 scopus 로고    scopus 로고
    • VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation
    • PID: 19435903, COI: 1:CAS:528:DC%2BD1MXlvFWlu7s%3D
    • Chang SH, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, et al. VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Res. 2009;69:4537–44. doi:10.1158/0008-5472.
    • (2009) Cancer Res , vol.69 , pp. 4537-4544
    • Chang, S.H.1    Kanasaki, K.2    Gocheva, V.3    Blum, G.4    Harper, J.5    Moses, M.A.6
  • 44
    • 70349335653 scopus 로고    scopus 로고
    • Matrix metalloproteinase proteomics: substrates, targets, and therapy
    • PID: 19616423, COI: 1:CAS:528:DC%2BD1MXhtFyqt7rI
    • Morrison CJ, Butler GS, Rodriguez D, Overall CM. Matrix metalloproteinase proteomics: substrates, targets, and therapy. Curr Opin Cell Biol. 2009;21:645–53. doi:10.1016/j.ceb.2009.06.006.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 645-653
    • Morrison, C.J.1    Butler, G.S.2    Rodriguez, D.3    Overall, C.M.4
  • 45
    • 84876019734 scopus 로고    scopus 로고
    • Missing the target: matrix metalloproteinase antitargets in inflammation and cancer
    • PID: 23541335, COI: 1:CAS:528:DC%2BC3sXkslantro%3D, This review summarizes the novel substrates of matrix metalloproteinases in inflammation and cancer
    • Dufour A, Overall CM. Missing the target: matrix metalloproteinase antitargets in inflammation and cancer. Trends Pharmacol Sci. 2013;34:233–42. doi:10.1016/j.tips.2013.02.004. This review summarizes the novel substrates of matrix metalloproteinases in inflammation and cancer.
    • (2013) Trends Pharmacol Sci , vol.34 , pp. 233-242
    • Dufour, A.1    Overall, C.M.2
  • 46
    • 33644828187 scopus 로고    scopus 로고
    • A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation
    • PID: 16474398, COI: 1:CAS:528:DC%2BD28XitVGnt70%3D
    • Weathington NM, van Houwelingen AH, Noerager BD, Jackson PL, Kraneveld AD, Galin FS, et al. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nat Med. 2006;12:317–23. doi:10.1038/nm1361.
    • (2006) Nat Med , vol.12 , pp. 317-323
    • Weathington, N.M.1    van Houwelingen, A.H.2    Noerager, B.D.3    Jackson, P.L.4    Kraneveld, A.D.5    Galin, F.S.6
  • 47
    • 84904393259 scopus 로고    scopus 로고
    • Matricryptins and matrikines: biologically active fragments of the extracellular matrix
    • PID: 24815015
    • Ricard-Blum S, Salza R. Matricryptins and matrikines: biologically active fragments of the extracellular matrix. Exp Dermatol. 2014. doi:10.1111/exd.12435.
    • (2014) Exp Dermatol
    • Ricard-Blum, S.1    Salza, R.2
  • 49
    • 0035997376 scopus 로고    scopus 로고
    • Order out of chaos: assembly of ligand binding sites in heparan sulfate
    • PID: 12045103, COI: 1:CAS:528:DC%2BD38Xos1Cltrk%3D
    • Esko JD, Selleck SB. Order out of chaos: assembly of ligand binding sites in heparan sulfate. Annu Rev Biochem. 2002;71:435–71. doi:10.1146/annurev.biochem.71.110601.135458.
    • (2002) Annu Rev Biochem , vol.71 , pp. 435-471
    • Esko, J.D.1    Selleck, S.B.2
  • 50
    • 84877919950 scopus 로고    scopus 로고
    • Pathophysiology of heparan sulphate: many diseases, few drugs
    • PID: 23432337, COI: 1:CAS:528:DC%2BC3sXnvV2nu7s%3D
    • Lindahl U, Kjellen L. Pathophysiology of heparan sulphate: many diseases, few drugs. J Intern Med. 2013;273:555–71. doi:10.1111/joim.12061.
    • (2013) J Intern Med , vol.273 , pp. 555-571
    • Lindahl, U.1    Kjellen, L.2
  • 52
    • 84873024385 scopus 로고    scopus 로고
    • Heparan sulfate biosynthesis: regulation and variability
    • PID: 23042481
    • Kreuger J, Kjellen L. Heparan sulfate biosynthesis: regulation and variability. J Histochem Cytochem. 2012;60:898–907. doi:10.1369/0022155412464972.
    • (2012) J Histochem Cytochem , vol.60 , pp. 898-907
    • Kreuger, J.1    Kjellen, L.2
  • 53
    • 77956485588 scopus 로고    scopus 로고
    • Heparin-derived heparan sulfate mimics that modulate inflammation and cancer
    • Casu B, Naggi A, Torri G. Heparin-derived heparan sulfate mimics that modulate inflammation and cancer. Matrix Biol 2010;29:442–52. doi:10.1016/j.matbio.2010.04.003.
    • (2010) Matrix Biol , vol.29 , pp. 442-452
    • Casu, B.1    Naggi, A.2    Torri, G.3
  • 54
    • 84872176915 scopus 로고    scopus 로고
    • Laminins in basement membrane assembly
    • PID: 23076216
    • Hohenester E, Yurchenco PD. Laminins in basement membrane assembly. Cell Adh Migr. 2013;7:56–63. doi:10.4161/cam.21831.
    • (2013) Cell Adh Migr , vol.7 , pp. 56-63
    • Hohenester, E.1    Yurchenco, P.D.2
  • 55
    • 0033055992 scopus 로고    scopus 로고
    • Autoimmune diabetes: the involvement of benign and malignant autoimmunity
    • PID: 10330293, COI: 1:STN:280:DyaK1M3msValsQ%3D%3D
    • Dilts SM, Lafferty KJ. Autoimmune diabetes: the involvement of benign and malignant autoimmunity. J Autoimmun. 1999;12:229–32. doi:10.1006/jaut.1999.0284.
    • (1999) J Autoimmun , vol.12 , pp. 229-232
    • Dilts, S.M.1    Lafferty, K.J.2
  • 56
    • 3042731121 scopus 로고    scopus 로고
    • The pathogenesis of diabetes in the NOD mouse
    • PID: 15246255, COI: 1:CAS:528:DC%2BD2cXnvVWju7Y%3D
    • Solomon M, Sarvetnick N. The pathogenesis of diabetes in the NOD mouse. Adv Immunol. 2004;84:239–64. doi:10.1016/S0065-2776(04)84007-0.
    • (2004) Adv Immunol , vol.84 , pp. 239-264
    • Solomon, M.1    Sarvetnick, N.2
  • 58
    • 64949095247 scopus 로고    scopus 로고
    • Important role of heparan sulfate in postnatal islet growth and insulin secretion
    • PID: 19336225, COI: 1:CAS:528:DC%2BD1MXltFWgs7o%3D
    • Takahashi I, Noguchi N, Nata K, Yamada S, Kaneiwa T, Mizumoto S, et al. Important role of heparan sulfate in postnatal islet growth and insulin secretion. Biochem Biophys Res Commun. 2009;383:113–8. doi:10.1016/j.bbrc.2009.03.140.
    • (2009) Biochem Biophys Res Commun , vol.383 , pp. 113-118
    • Takahashi, I.1    Noguchi, N.2    Nata, K.3    Yamada, S.4    Kaneiwa, T.5    Mizumoto, S.6
  • 59
    • 0034904048 scopus 로고    scopus 로고
    • Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
    • PID: 11489924, COI: 1:CAS:528:DC%2BD3MXlvVGlt7o%3D
    • Vlodavsky I, Friedmann Y. Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest. 2001;108:341–7. doi:10.1172/JCI13662.
    • (2001) J Clin Invest , vol.108 , pp. 341-347
    • Vlodavsky, I.1    Friedmann, Y.2
  • 60
    • 80051650851 scopus 로고    scopus 로고
    • Clinical studies. Trying to reset the clock on type 1 diabetes
    • Couzin-Frankel J. Clinical studies. Trying to reset the clock on type 1 diabetes. Science. 2011;333:819–21. doi:10.1126/science.333.6044.819.
    • (2011) Science , vol.333 , pp. 819-821
    • Couzin-Frankel, J.1
  • 61
    • 84861397054 scopus 로고    scopus 로고
    • Immunomodulators: cell savers
    • PID: 22616095, COI: 1:CAS:528:DC%2BC38XntlWju7Y%3D
    • DeWeerdt S. Immunomodulators: cell savers. Nature. 2012;485:S4–5.
    • (2012) Nature , vol.485 , pp. S4-S5
    • DeWeerdt, S.1
  • 62
    • 33846975880 scopus 로고
    • The structure of hyalobiuronic acid and of hyaluronic acid from umbilical cord
    • COI: 1:CAS:528:DyaG2MXjt1Wksg%3D%3D
    • Weissmann B, Meyer K. The structure of hyalobiuronic acid and of hyaluronic acid from umbilical cord. J Am Chem Soc. 1954;76:1753–7.
    • (1954) J Am Chem Soc , vol.76 , pp. 1753-1757
    • Weissmann, B.1    Meyer, K.2
  • 63
    • 0029989042 scopus 로고    scopus 로고
    • The structure and function of hyaluronan: an overview
    • PID: 8724014, COI: 1:CAS:528:DyaK28XjsVekurc%3D
    • Laurent TC, Laurent UB, Fraser JR. The structure and function of hyaluronan: an overview. Immunol Cell Biol. 1996;74:A1–7. doi:10.1038/icb.1996.32.
    • (1996) Immunol Cell Biol , vol.74 , pp. A1-A7
    • Laurent, T.C.1    Laurent, U.B.2    Fraser, J.R.3
  • 64
    • 3042697038 scopus 로고    scopus 로고
    • Hyaluronan: from extracellular glue to pericellular cue
    • PID: 15229478, COI: 1:CAS:528:DC%2BD2cXlt1OktrY%3D
    • Toole BP. Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer. 2004;4:528–39.
    • (2004) Nat Rev Cancer , vol.4 , pp. 528-539
    • Toole, B.P.1
  • 65
    • 67651049960 scopus 로고    scopus 로고
    • Role, metabolism, chemical modifications and applications of hyaluronan
    • PID: 19442142, COI: 1:CAS:528:DC%2BD1MXmslagtbg%3D
    • Volpi N, Schiller J, Stern R, Soltes L. Role, metabolism, chemical modifications and applications of hyaluronan. Curr Med Chem. 2009;16:1718–45.
    • (2009) Curr Med Chem , vol.16 , pp. 1718-1745
    • Volpi, N.1    Schiller, J.2    Stern, R.3    Soltes, L.4
  • 66
    • 0037085372 scopus 로고    scopus 로고
    • Hyaluronan-binding proteins: tying up the giant
    • PID: 11717315, COI: 1:CAS:528:DC%2BD38XhsFeqsb0%3D
    • Day AJ, Prestwich GD. Hyaluronan-binding proteins: tying up the giant. J Biol Chem. 2002;277:4585–8.
    • (2002) J Biol Chem , vol.277 , pp. 4585-4588
    • Day, A.J.1    Prestwich, G.D.2
  • 67
    • 78751670809 scopus 로고    scopus 로고
    • Hyaluronan as an immune regulator in human diseases
    • PID: 21248167, COI: 1:CAS:528:DC%2BC3MXisVCht70%3D
    • Jiang D, Liang J, Noble PW. Hyaluronan as an immune regulator in human diseases. Physiol Rev. 2011;91:221–64. doi:10.1152/physrev.00052.2009.
    • (2011) Physiol Rev , vol.91 , pp. 221-264
    • Jiang, D.1    Liang, J.2    Noble, P.W.3
  • 68
    • 84874745402 scopus 로고    scopus 로고
    • Hypotheses on the evolution of hyaluronan: a highly ironic acid
    • PID: 23315448, COI: 1:CAS:528:DC%2BC3sXjtlymtrY%3D, Outstanding review of functional aspects of hyaluronan biology—thought provoking
    • Csoka AB, Stern R. Hypotheses on the evolution of hyaluronan: a highly ironic acid. Glycobiology. 2013;23:398–411. doi:10.1093/glycob/cws218. Outstanding review of functional aspects of hyaluronan biology—thought provoking.
    • (2013) Glycobiology , vol.23 , pp. 398-411
    • Csoka, A.B.1    Stern, R.2
  • 69
    • 84880508209 scopus 로고    scopus 로고
    • High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
    • PID: 23783513, COI: 1:CAS:528:DC%2BC3sXps1Ghu7Y%3D
    • Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, et al. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature. 2013;499:346–9. doi:10.1038/nature12234.
    • (2013) Nature , vol.499 , pp. 346-349
    • Tian, X.1    Azpurua, J.2    Hine, C.3    Vaidya, A.4    Myakishev-Rempel, M.5    Ablaeva, J.6
  • 70
    • 33746040501 scopus 로고    scopus 로고
    • Hyaluronan fragments: an information-rich system
    • PID: 16822580, COI: 1:CAS:528:DC%2BD28XptlSnt7c%3D
    • Stern R, Asari AA, Sugahara KN. Hyaluronan fragments: an information-rich system. Eur J Cell Biol. 2006;85:699–715.
    • (2006) Eur J Cell Biol , vol.85 , pp. 699-715
    • Stern, R.1    Asari, A.A.2    Sugahara, K.N.3
  • 71
    • 0030820092 scopus 로고    scopus 로고
    • Hyaluronan: its nature, distribution, functions and turnover
    • PID: 9260563, COI: 1:CAS:528:DyaK2sXls1Wgurs%3D
    • Fraser JR, Laurent TC, Laurent UB. Hyaluronan: its nature, distribution, functions and turnover. J Intern Med. 1997;242:27–33.
    • (1997) J Intern Med , vol.242 , pp. 27-33
    • Fraser, J.R.1    Laurent, T.C.2    Laurent, U.B.3
  • 72
    • 27744571610 scopus 로고    scopus 로고
    • Hyaluronan cross-linking: a protective mechanism in inflammation?
    • PID: 16214414, COI: 1:CAS:528:DC%2BD2MXht1egurjK
    • Day AJ, de la Motte CA. Hyaluronan cross-linking: a protective mechanism in inflammation? Trends Immunol. 2005;26:637–43.
    • (2005) Trends Immunol , vol.26 , pp. 637-643
    • Day, A.J.1    de la Motte, C.A.2
  • 73
    • 84870776864 scopus 로고    scopus 로고
    • The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation
    • PID: 22810951, COI: 1:CAS:528:DC%2BC38XhtlSksbnO, An excellent review of how hyaluronan regulates innate and adaptive immunity
    • Bollyky PL, Bogdani M, Bollyky JB, Hull RL, Wight TN. The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation. Curr Diab Rep. 2012;12:471–80. doi:10.1007/s11892-012-0297-0. An excellent review of how hyaluronan regulates innate and adaptive immunity.
    • (2012) Curr Diab Rep , vol.12 , pp. 471-480
    • Bollyky, P.L.1    Bogdani, M.2    Bollyky, J.B.3    Hull, R.L.4    Wight, T.N.5
  • 74
    • 82455175828 scopus 로고    scopus 로고
    • Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis
    • PID: 21852366
    • de la Motte CA. Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis. Am J Physiol Gastrointest Liver Physiol. 2011;301:G945–9. doi:10.1152/ajpgi.00063.2011.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , pp. G945-G949
    • de la Motte, C.A.1
  • 75
    • 2942530361 scopus 로고    scopus 로고
    • TSG-6 modulates the interaction between hyaluronan and cell surface CD44
    • PID: 15060082, COI: 1:CAS:528:DC%2BD2cXksFygtLo%3D
    • Lesley J, Gal I, Mahoney DJ, Cordell MR, Rugg MS, Hyman R, et al. TSG-6 modulates the interaction between hyaluronan and cell surface CD44. J Biol Chem. 2004;279:25745–54.
    • (2004) J Biol Chem , vol.279 , pp. 25745-25754
    • Lesley, J.1    Gal, I.2    Mahoney, D.J.3    Cordell, M.R.4    Rugg, M.S.5    Hyman, R.6
  • 76
    • 77956893098 scopus 로고    scopus 로고
    • Polyinosine-polycytidylic acid stimulates versican accumulation in the extracellular matrix promoting monocyte adhesion
    • PID: 19717812, COI: 1:CAS:528:DC%2BC3cXpt1ymtrw%3D
    • Potter-Perigo S, Johnson PY, Evanko SP, Chan CK, Braun KR, Wilkinson TS, et al. Polyinosine-polycytidylic acid stimulates versican accumulation in the extracellular matrix promoting monocyte adhesion. Am J Respir Cell Mol Biol. 2010;43:109–20. doi:10.1165/rcmb.2009-0081OC.
    • (2010) Am J Respir Cell Mol Biol , vol.43 , pp. 109-120
    • Potter-Perigo, S.1    Johnson, P.Y.2    Evanko, S.P.3    Chan, C.K.4    Braun, K.R.5    Wilkinson, T.S.6
  • 77
    • 84857033876 scopus 로고    scopus 로고
    • Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration
    • PID: 22155153, COI: 1:CAS:528:DC%2BC38XjtVOhsbs%3D, A nice demonstration of how these components affect T-cell phenotype
    • Evanko SP, Potter-Perigo S, Bollyky PL, Nepom GT, Wight TN. Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration. Matrix Biol. 2012;31:90–100. doi:10.1016/j.matbio.2011.10.004. A nice demonstration of how these components affect T-cell phenotype.
    • (2012) Matrix Biol , vol.31 , pp. 90-100
    • Evanko, S.P.1    Potter-Perigo, S.2    Bollyky, P.L.3    Nepom, G.T.4    Wight, T.N.5
  • 78
    • 84885635212 scopus 로고    scopus 로고
    • Inter-α-inhibitor impairs TSG-6 induced hyaluronan cross-linking
    • PID: 24005673, COI: 1:CAS:528:DC%2BC3sXhs1Shs7fO, Insightful study demonstrating key molecules in the generation of high molecular complexes of hyaluronan
    • Baranova NS, Foulcer SJ, Briggs DC, Tilakaratna V, Enghild JJ, Milner CM, et al. Inter-α-inhibitor impairs TSG-6 induced hyaluronan cross-linking. J Biol Chem. 2013;288:29642–53. doi:10.1074/jbc.M113.477422. Insightful study demonstrating key molecules in the generation of high molecular complexes of hyaluronan.
    • (2013) J Biol Chem , vol.288 , pp. 29642-29653
    • Baranova, N.S.1    Foulcer, S.J.2    Briggs, D.C.3    Tilakaratna, V.4    Enghild, J.J.5    Milner, C.M.6
  • 79
    • 79955063269 scopus 로고    scopus 로고
    • Hyaluronan matrices in pathobiological processes
    • PID: 21362136, COI: 1:CAS:528:DC%2BC3MXls1Oit74%3D
    • Wang A, de la Motte C, Lauer M, Hascall V. Hyaluronan matrices in pathobiological processes. FEBS J. 2011;278:1412–8. doi:10.1111/j.1742-4658.2011.08069.x.
    • (2011) FEBS J , vol.278 , pp. 1412-1418
    • Wang, A.1    de la Motte, C.2    Lauer, M.3    Hascall, V.4
  • 80
    • 79960431401 scopus 로고    scopus 로고
    • The inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers
    • PID: 21596748, COI: 1:CAS:528:DC%2BC3MXovFCktL0%3D
    • Baranova NS, Nileback E, Haller FM, Briggs DC, Svedhem S, Day AJ, et al. The inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers. J Biol Chem. 2011;286:25675–86. doi:10.1074/jbc.M111.247395.
    • (2011) J Biol Chem , vol.286 , pp. 25675-25686
    • Baranova, N.S.1    Nileback, E.2    Haller, F.M.3    Briggs, D.C.4    Svedhem, S.5    Day, A.J.6
  • 81
    • 33645372800 scopus 로고    scopus 로고
    • Hyaluronidases: their genomics, structures, and mechanisms of action
    • PID: 16522010, COI: 1:CAS:528:DC%2BD28XhtlOqs78%3D
    • Stern R, Jedrzejas MJ. Hyaluronidases: their genomics, structures, and mechanisms of action. Chem Rev. 2006;106:818–39. doi:10.1021/cr050247k.
    • (2006) Chem Rev , vol.106 , pp. 818-839
    • Stern, R.1    Jedrzejas, M.J.2
  • 82
    • 0037023364 scopus 로고    scopus 로고
    • Resolution of lung inflammation by CD44
    • PID: 11935029, COI: 1:CAS:528:DC%2BD38XivVWjsLs%3D
    • Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Pure E, et al. Resolution of lung inflammation by CD44. Science. 2002;296:155–8.
    • (2002) Science , vol.296 , pp. 155-158
    • Teder, P.1    Vandivier, R.W.2    Jiang, D.3    Liang, J.4    Cohn, L.5    Pure, E.6
  • 83
    • 18244390226 scopus 로고    scopus 로고
    • Threat matrix: low-molecular-weight hyaluronan (HA) as a danger signal
    • PID: 15888912, COI: 1:CAS:528:DC%2BD2MXkslymtbo%3D
    • Powell JD, Horton MR. Threat matrix: low-molecular-weight hyaluronan (HA) as a danger signal. Immunol Res. 2005;31:207–18.
    • (2005) Immunol Res , vol.31 , pp. 207-218
    • Powell, J.D.1    Horton, M.R.2
  • 84
    • 67651107348 scopus 로고    scopus 로고
    • The pancreas in human type 1 diabetes: providing new answers to age-old questions
    • PID: 19502978
    • Atkinson MA, Gianani R. The pancreas in human type 1 diabetes: providing new answers to age-old questions. Curr Opin Endocrinol Diabetes Obes. 2009;16:279–85. doi:10.1097/MED.0b013e32832e06ba.
    • (2009) Curr Opin Endocrinol Diabetes Obes , vol.16 , pp. 279-285
    • Atkinson, M.A.1    Gianani, R.2
  • 85
    • 67649364114 scopus 로고    scopus 로고
    • The role of inflammation in insulitis and beta-cell loss in type 1 diabetes
    • PID: 19352320, COI: 1:CAS:528:DC%2BD1MXjs1ymt7Y%3D
    • Eizirik DL, Colli ML, Ortis F. The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol. 2009;5:219–26. doi:10.1038/nrendo.2009.21.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 219-226
    • Eizirik, D.L.1    Colli, M.L.2    Ortis, F.3
  • 86
    • 0028233270 scopus 로고
    • Hyaluronate is costimulatory for human T cell effector functions and binds to CD44 on activated T cells
    • PID: 7515923, COI: 1:CAS:528:DyaK2cXltlait78%3D
    • Galandrini R, Galluzzo E, Albi N, Grossi CE, Velardi A. Hyaluronate is costimulatory for human T cell effector functions and binds to CD44 on activated T cells. J Immunol. 1994;153:21–31.
    • (1994) J Immunol , vol.153 , pp. 21-31
    • Galandrini, R.1    Galluzzo, E.2    Albi, N.3    Grossi, C.E.4    Velardi, A.5
  • 87
    • 0033806427 scopus 로고    scopus 로고
    • Development of a peptide inhibitor of hyaluronan-mediated leukocyte trafficking
    • PID: 10993908, COI: 1:CAS:528:DC%2BD3cXmslGmt7k%3D
    • Mummert ME, Mohamadzadeh M, Mummert DI, Mizumoto N, Takashima A. Development of a peptide inhibitor of hyaluronan-mediated leukocyte trafficking. J Exp Med. 2000;192:769–79.
    • (2000) J Exp Med , vol.192 , pp. 769-779
    • Mummert, M.E.1    Mohamadzadeh, M.2    Mummert, D.I.3    Mizumoto, N.4    Takashima, A.5
  • 88
    • 0037108377 scopus 로고    scopus 로고
    • Synthesis and surface expression of hyaluronan by dendritic cells and its potential role in antigen presentation
    • PID: 12370364, COI: 1:CAS:528:DC%2BD38XnvFGnur0%3D
    • Mummert ME, Mummert D, Edelbaum D, Hui F, Matsue H, Takashima A. Synthesis and surface expression of hyaluronan by dendritic cells and its potential role in antigen presentation. J Immunol. 2002;169:4322–31.
    • (2002) J Immunol , vol.169 , pp. 4322-4331
    • Mummert, M.E.1    Mummert, D.2    Edelbaum, D.3    Hui, F.4    Matsue, H.5    Takashima, A.6
  • 89
    • 18244402390 scopus 로고    scopus 로고
    • Immunologic roles of hyaluronan
    • PID: 15888911, COI: 1:CAS:528:DC%2BD2MXkslymtb0%3D
    • Mummert ME. Immunologic roles of hyaluronan. Immunol Res. 2005;31:189–206.
    • (2005) Immunol Res , vol.31 , pp. 189-206
    • Mummert, M.E.1
  • 90
    • 77953238460 scopus 로고    scopus 로고
    • TH1 cytokines promote hyaluronan production by antigen presenting cells and accumulation at the immune synapse
    • PID: 20228832, COI: 1:CAS:528:DC%2BC3cXlsFSmtLY%3D
    • Bollyky P, Evanko S, Wu R, Potter-Perigo S, Long S, Kinsella B, et al. TH1 cytokines promote hyaluronan production by antigen presenting cells and accumulation at the immune synapse. Cell Mol Immunol. 2010;7:211–20. doi:10.1038/cmi.2010.9.
    • (2010) Cell Mol Immunol , vol.7 , pp. 211-220
    • Bollyky, P.1    Evanko, S.2    Wu, R.3    Potter-Perigo, S.4    Long, S.5    Kinsella, B.6
  • 91
    • 12944331941 scopus 로고    scopus 로고
    • Induction of resistance to diabetes in non-obese diabetic mice by targeting CD44 with a specific monoclonal antibody
    • PID: 10618410, COI: 1:CAS:528:DC%2BD3cXjvVGjuw%3D%3D
    • Weiss L, Slavin S, Reich S, Cohen P, Shuster S, Stern R, et al. Induction of resistance to diabetes in non-obese diabetic mice by targeting CD44 with a specific monoclonal antibody. Proc Natl Acad Sci U S A. 2000;97:285–90.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 285-290
    • Weiss, L.1    Slavin, S.2    Reich, S.3    Cohen, P.4    Shuster, S.5    Stern, R.6
  • 92
    • 84878221854 scopus 로고    scopus 로고
    • TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity
    • PID: 23349496, COI: 1:CAS:528:DC%2BC3sXpt1OrsL0%3D, Interesting study implicating a hyaluronan binding protein as a possible therapeutic target to treat T1D
    • Kota DJ, Wiggins LL, Yoon N, Lee RH. TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity. Diabetes. 2013;62:2048–58. doi:10.2337/db12-0931. Interesting study implicating a hyaluronan binding protein as a possible therapeutic target to treat T1D.
    • (2013) Diabetes , vol.62 , pp. 2048-2058
    • Kota, D.J.1    Wiggins, L.L.2    Yoon, N.3    Lee, R.H.4
  • 93
    • 58149299735 scopus 로고    scopus 로고
    • Analysis of islet inflammation in human type 1 diabetes
    • PID: 19128359, COI: 1:STN:280:DC%2BD1M%2FlslKltw%3D%3D
    • Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG. Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol. 2009;155:173–81. doi:10.1111/j.1365-2249.2008.03860.x.
    • (2009) Clin Exp Immunol , vol.155 , pp. 173-181
    • Willcox, A.1    Richardson, S.J.2    Bone, A.J.3    Foulis, A.K.4    Morgan, N.G.5
  • 94
    • 84856825977 scopus 로고    scopus 로고
    • Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
    • PID: 22213807, COI: 1:CAS:528:DC%2BC38XhtFSqurk%3D
    • Coppieters KT, Dotta F, Amirian N, Campbell PD, Kay TW, Atkinson MA, et al. Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med. 2012;209:51–60. doi:10.1084/jem.20111187.
    • (2012) J Exp Med , vol.209 , pp. 51-60
    • Coppieters, K.T.1    Dotta, F.2    Amirian, N.3    Campbell, P.D.4    Kay, T.W.5    Atkinson, M.A.6
  • 95
    • 33845455093 scopus 로고    scopus 로고
    • Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes
    • PID: 17112751, COI: 1:CAS:528:DC%2BD2sXisFehsw%3D%3D
    • Bajenoff M, Egen JG, Koo LY, Laugier JP, Brau F, Glaichenhaus N, et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity. 2006;25:989–1001. doi:10.1016/j.immuni.2006.10.011.
    • (2006) Immunity , vol.25 , pp. 989-1001
    • Bajenoff, M.1    Egen, J.G.2    Koo, L.Y.3    Laugier, J.P.4    Brau, F.5    Glaichenhaus, N.6


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