Global gene expression changes in type 1 diabetes: Insights into autoimmune response in the target organ and in the periphery

Immunology Letters

Volumn 133, Issue 2, 2010, Pages 55-61

  Planas, Raquel ^a   Pujol Borrell, Ricardo ^a,b   Vives Pi, Marta ^a,b  

^a Blood and Tissue Bank   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Autoimmunity; Transcriptomics; Type 1 diabetes

Indexed keywords

INTERFERON; INTERLEUKIN 1BETA;

ACUTE PANCREATITIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BIOINFORMATICS; DIABETOGENESIS; GENE EXPRESSION PROFILING; HUMAN; IMMUNOPATHOGENESIS; INFLAMMATION; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOID ORGAN; MICROARRAY ANALYSIS; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS; PANCREAS ISLET; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TARGET ORGAN; TRANSCRIPTION REGULATION; TRANSCRIPTOMICS;

ANIMALS; AUTOIMMUNITY; BIOLOGICAL MARKERS; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INSULIN-SECRETING CELLS; MICE; MICE, INBRED NOD;

EID: 77957012972     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2010.08.001     Document Type: Review

References (60)

1. Atkinson M.A., Mclaren N.K. The pathogenesis of insulin dependent diabetes. N Engl J Med 1994, 331:1428-1436.
2. Eisenbarth G.S. Update in type 1 diabetes. J Clin Endocrinol Metab 2007, 92(7):2403-2407.
3. Onegut-Gumuscu S., Concannon P. Mapping genes for autoimmunity in humans: type 1 diabetes as a model. Immunol Rev 2002, 190:182-194.
4. Ounissi-Benkalha H., Polychronakos C. The molecular genetics of type 1 diabetes: new genes and emerging mechanisms. Trends Mol Med 2008, 14(6):268-275.
5. Barrett J.C., Clayton D.G., Concannon P., Akolkar B., Cooper J.D., Erlich H.A., et al. Genome-wide association study and metaanalysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 2009, 41:703-707.
6. Dotta F., Censini S., van Halteren A.G.S., Marselli L., Masini M., Dionisi S., et al. Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci USA 2007, 104:5115-5120.
7. Gagnerault M.C., Luan J.J., Lotton C., Lepault F. Pancreatic lymph nodes are required for priming of beta cell reactive T cells in NOD mice. J Exp Med 2002, 196(3):369-377.
8. Pinkse G.G., Boitard C., Tree T.I., Peakman M., Roep B.O. Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci USA 2005, 102(51):18425-18430.
9. Serreze D.V., Fleming S.A., Chapman H.D., Richard S.D., Leiter E.H., Tisch R.M. B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol 1998, 161(8):3912-3918.
10. Achenbach P., Warncke K., Reiter J., Naserke A.E., Williams A.J., Bingley P.J., et al. Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 2004, 53(2):384-392.
11. Makino S., Kunimoto K., Muraoka Y., Mizushima Y., Katagiri K., Tochino Y. Breeding of a non-obese diabetic strain of mice. Exp Anim 1980, 29:1-13.
12. Anderson M.S., Bluestone J.A. The NOD mouse: a model of immunedysregulation. Annu Rev Immunol 2005, 23:447-485.
13. Tsai S., Shameli A., Yamanouchi J., Clemente-Casares X., Wang J., Serra P., et al. Reversal of autoimmunity by boosting memory-like autoregulatory T cells. Immunity 2010, 32(4):568-580.
14. Herold K.C., Brooks-Worrell B., Palmer J., Dosch H.M., Peakman M., Gottlieb P., et al. Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes. Diabetes 2009, 58(11):2588-2595.
15. Wenzlau J.M., Juhl K., Yu L., Moua L., Sarkar S.A., Gottlieb P., et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 2007, 104(43):17040-17045.
16. Lockhart D.J., Dong H., Byrne M.C., Follettie M.T., Gallo M.V., Chee M.S., et al. Expression monitoring by hybridization to high density oligonucleotide arrays. Nat Biotechnol 1996, 14(13):1675-1680.
17. Hyatt G., Melamed R., Park R., Seguritan R., Laplace C., Poirot L., et al. Gene expression microarrays: glimpses of the immunological genome. Nat Immunol 2006, 7(7):686-691.
18. Maas K., Chan S., Parker J., Slater A., Moore J., Olsen N., et al. Cutting edge: molecular portrait of human autoimmune disease. J Immunol 2002, 169(1):5-9.
19. Kaizer E.C., Glaser C.L., Chaussabel D., Banchereau J., Pascual V., White P.C. Gene expression in peripheral blood mononuclear cells from children with diabetes. J Clin Endocrinol Metab 2007, 92(9):3705-3711.
20. Reynier F., Pachot A., Paye M., Xu Q., Turrel-Davin F., Petit F., et al. Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis. Genes Immun 2010, 11(3):269-278.
21. Baechler E.C., Batliwalla F.M., Karypis G., Gaffney P.M., Ortmann W.A., Espe K.J., et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 2003, 100(5):2610-2615.
22. Emamian E.S., Leon J.M., Lessard C.J., Grandits M., Baechler E.C., Gaffney P.M., et al. Peripheral blood gene expression profiling in Sjogren's syndrome. Genes Immun 2009, 10(4):285-296.
23. Padmos R.C., Schloot N.C., Beyan H., Ruwhof C., Staal F.J., de Ridder D., et al. Distinct monocyte gene-expression profiles in autoimmune diabetes. Diabetes 2008, 57(10):2768-2773.
24. Wang X., Jia S., Geoffrey R., Alemzadeh R., Ghosh S., Hessner M.J. Identification of a molecular signature in human type 1 diabetes mellitus using serum and functional genomics. J Immunol 2008, 180(3):1929-1937.
25. Planas R., Carrillo J., Sanchez A., de Villa M.C., Nuñez F., Verdaguer J., et al. Gene expression profiles for the human pancreas and purified islets in type 1 diabetes: new findings at clinical onset and in long-standing diabetes. Clin Exp Immunol 2010, 159(1):23-44.
26. Li L., He Q., Garland A., Yi Z., Aybar L.T., Kepler T.B., et al. Beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct. J Immunol 2009, 183(11):7585-7591.
27. Eckenrode S.E., Ruan Q., Yang P., Zheng W., McIndoe R.A., She J.X. Gene expression profiles define a key checkpoint for type 1 diabetes in NOD mice. Diabetes 2004, 53(2):366-375.
28. Kodama K., Butte A.J., Creusot R.J., Su L., Sheng D., Hartnett M. Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice. Clin Immunol 2008, 129(2):195-201.
29. Regnault B., Osorio Y., Fortea J., Miao D., Eisenbarth G., Melanitou E. Early over expression of messenger RNA for multiple genes, including insulin, in the pancreatic lymph nodes of NOD mice is associated with islet autoimmunity. BMC Med Genomics 2009, 2:63.
30. Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965, 14(10):619-633.
31. Foulis A.K., Liddle C., Farquharson M.A. The histopathology of the pancreas of type 1 diabetes: a 25 year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 1986, 29:267-274.
32. Somoza N., Vargas F., Roura-Mir C., Vives-Pi M., Fernández-Figueras M.T., Ariza A., et al. Pancreas in recent onset insulin-dependent diabetes mellitus: changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor Vβ usage, and cytokine profile. J Immunol 1994, 153:1360-1377.
33. Willcox A., Richardson S.J., Bone A.J., Foulis A.K., Morgan N.G. Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol 2008, 155:173-181.
34. Hänninen A., Jalkanen S., Salmi M., Toikkanen S., Nikolakaros G., Simell O. Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus. J Clin Invest 1992, 90:1901-1910.
35. Aspord C., Rome S., Thivolet C. Early events in islets and pancreatic lymph nodes in autoimmune diabetes. J Autoimmun 2004, 23(1):27-35.
36. Matos M., Park R., Mathis D., Benoist C. Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview. Diabetes 2004, 53(9):2310-2321.
37. Vukkadapu S.S., Belli J.M., Ishii K., Jegga A.G., Hutton J.J., Aronow B.J., et al. Dynamic interaction between T cell-mediated beta-cell damage and beta-cell repair in the run up to autoimmune diabetes of the NOD mouse. Physiol Genomics 2005, 21(2):201-211.
38. Poirot L., Benoist C., Mathis D. Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity. Proc Natl Acad Sci USA 2004, 101(21):8102-8107.
39. von Herrath M.G., Nepom G.T. Remodeling rodent models to mimic human type 1 diabetes. Eur J Immunol 2009, 39(8):2049-2054.
40. Mestas J., Hughes C.C. Of mice and not men: differences between mouse and human immunology. J Immunol 2004, 172(5):2731-2738.
41. Ylipaasto P., Kutlu B., Rasilainen S., Rasschaert J., Salmela K., Teerijoki, et al. Global profile of coxcackievirus- and cytokine-induced expression in human pancreatic islets. Diabetologia 2005, 48:1510-1522.
42. Ortis F., Naamane N., Flamez D., Ladrière L., Moore F., Cunha D.A., et al. Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes 2010, 59(2):358-374.
43. Mutlu G.M., Mutlu E.A., Factor P. GI complications in patients receiving mechanical ventilation. Chest 2001, 119(4):1222-1241.
44. von Herrath M.G., Sanda S., Herold K.C. Type 1 diabetes as a relapsing-remitting disease?. Nat Rev Immunol 2007, 7(12):988-994.
45. Cirulli V., Zalatan J., McMaster M., Prinsen R., Salomon D.R., Ricordi C., et al. The class I HLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G. Diabetes 2006, 55(5):1214-1222.
46. Roep B.O., Atkinson M. Animal models have little to teach us about type 1 diabetes: 1. In support of this proposal. Diabetologia 2004, 47(10):1650-1656.
47. Roep B.O., Kleijwegt F.S., van Halteren A.G., Bonato V., Boggi U., Vendrame, et al. Islet inflammation and CXCL10 in recent-onset type 1 diabetes. Clin Exp Immunol 2010, 159(3):338-343.
48. Chaussabel D., Quinn C., Shen J., Patel P., Glaser C., Baldwin N., et al. A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. Immunity 2008, 29(1):150-164.
49. McKinney E.F., Lyons P.A., Carr E.J., Hollis J.L., Jayne D.R., Willcocks L.C., et al. A CD8(+) T cell transcription signature predicts prognosis in autoimmune disease. Nat Med 2010, 16(5):586-591.
50. Zhou X., Dimachkie M.M., Xiong M., Tan F.K., Arnett F.C. cDNA microarrays reveal distinct gene expression clusters in idiopathic inflammatory myopathies. Med Sci Monit 2004, 10(7):BR191-BR197.
51. Peterson K.S., Huang J.F., Zhu J., D'Agati V., Liu X., Miller N., et al. Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli. J Clin Invest 2004, 113(12):1722-1733.
52. Hjelmervik T.O., Petersen K., Jonassen I., Jonsson R., Bolstad A.I. Gene expression profiling of minor salivary glands clearly distinguishes primary Sjogren's syndrome patients from healthy control subjects. Arthritis Rheum 2005, 52(5):1534-1544.
53. van der Pouw Kraan T.C., van Gaalen F.A., Huizinga T.W., Pieterman E., Breedveld F.C., Verweij C.L. Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair. Genes Immun 2003, 4(3):187-196.
54. Aust G., Krohn K., Morgenthaler N.G. Graves' disease and Hashimoto's thyroiditis in monozygotic twins: case study as well as transcriptomic and immunohistological analysis of thyroid tissues. Eur J Endocrinol 2006, 154(1):13-20.
55. Zhou X., Krueger J.G., Kao M.C., Lee E., Du F., Menter A., et al. Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array. Physiol Genomics 2003, 13(1):69-78.
56. Lock C., Hermans G., Pedotti R., Brendolan A., Schadt E., Garren H., et al. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 2002, 8(5):500-508.
57. Juuti-Uusitalo K., Mäki M., Kaukinen K., Collin P., Visakorpi T., Vihinen M., et al. cDNA microarray analysis of gene expression in coeliac disease jejunal biopsy samples. J Autoimmun 2004, 22(3):249-265.
58. Costello C.M., Mah N., Häsler R., Rosenstiel P., Waetzig G.H., Hahn A., et al. Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. PLoS Med 2005, 2(8):e199.
59. Baechler E.C., Batliwalla F.M., Reed A.M., Peterson E.J., Gaffney P.M., Moser K.L., et al. Gene expression profiling in human autoimmunity. Immunol Rev 2006, 210:120-137.
60. Castellanos-Rubio A., Martin-Pagola A., Santín I., Hualde I., Aransay A.M., Castaño L., et al. Combined functional and positional gene information for the identification of susceptibility variants in celiac disease. Gastroenterology 2008, 134(3):738-746.