Insulin-dependent diabetes induced by pancreatic beta cell expression of IL-15 and IL-15R?

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 33, 2013, Pages 13534-13539

  Chen, Jing ^a   Feigenbaum, Lionel ^b   Awasthi, Parirokh ^b   Butcher, Donna O ^b   Anver, Miriam R ^b   Golubeva, Yelena G ^b   Bamford, Richard ^c   Zhang, Xiaojie ^d   St Claire, Mark B ^d   Thomas, Craig J ^e   Discepolo, Valentina ^f,g   Jabri, Bana ^f   Waldmann, Thomas A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c Transponics   (United States)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^e NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF CHICAGO   (United States)

^g UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; TOFACITINIB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MONONUCLEAR CELL; MOUSE; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; HUMANS; INSULIN-SECRETING CELLS; INTERLEUKIN-15; INTERLEUKIN-15 RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, TRANSGENIC; PIPERIDINES; PYRIMIDINES; PYRROLES; SIGNAL TRANSDUCTION;

EID: 84882319996     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1312911110     Document Type: Article

References (39)

1. Delovitch TL, Singh B (1997) The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD. Immunity 7(6):727-738.
2. Kikutani H, Makino S (1992) The murine autoimmune diabetes model: NOD and related strains. Adv Immunol 51:285-322.
3. Lodolce JP, et al. (1998) IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9(5):669-676.
4. Schluns KS, Williams K, Ma A, Zheng XX, Lefrançois L (2002) Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol 168(10):4827-4831.
5. Burkett PR, et al. (2004) Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis. J Exp Med 200(7):825-834.
6. Dubois S, Mariner J, Waldmann TA, Tagaya Y (2002) IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 17(5):537-547.
7. Mortier E, Woo T, Advincula R, Gozalo S, Ma A (2008) IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J Exp Med 205(5):1213-1225.
8. Sandau MM, Schluns KS, Lefrancois L, Jameson SC (2004) Cutting edge: Transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells. J Immunol 173(11):6537-6541.
9. Verbist KC, Rose DL, Cole CJ, Field MB, Klonowski KD (2012) IL-15 participates in the respiratory innate immune response to influenza virus infection. PLoS ONE 7(5):e37539.
10. Ylipaasto P, et al. (2005) Global profiling of coxsackievirus-and cytokine-induced gene expression in human pancreatic islets. Diabetologia 48(8):1510-1522.
11. Waldmann TA (2004) Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases. Arthritis Res Ther 6(4):174-177.
12. Kuczynski S, et al. (2005) IL-15 is elevated in serum patients with type 1 diabetes mellitus. Diabetes Res Clin Pract 69(3):231-236.
13. Chen J, et al. (2011) Increased serum soluble interleukin-15 receptor alpha (sIL-15R?) levels in T cell large granular lymphocyte leukemia. Blood 119(1):137-143.
14. Dotta F, et al. (2007) Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci USA 104(12):5115-5120.
15. Foulis AK, Farquharson MA, Meager A (1987) Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus. Lancet 2(8573):1423-1427.
16. Huang X, et al. (1995) Interferon expression in the pancreases of patients with type I diabetes. Diabetes 44(6):658-664.
17. Dubois SP, Waldmann TA, Müller JR (2005) Survival adjustment of mature dendritic cells by IL-15. Proc Natl Acad Sci USA 102(24):8662-8667.
18. Zhang X, Sun S, Hwang I, Tough DF, Sprent J (1998) Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 8(5):591-599.
19. Azimi N, Shiramizu KM, Tagaya Y, Mariner J, Waldmann TA (2000) Viral activation of interleukin-15 (IL-15): Characterization of a virus-inducible element in the IL-15 promoter region. J Virol 74(16):7338-7348.
20. Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009) The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 52(6):1143-1151.
21. Smith SJ, et al. (2006) In vivo monitoring of pancreatic beta-cells in a transgenic mouse model. Mol Imaging 5(2):65-75.
22. Miller BJ, Appel MC, O'Neil JJ, Wicker LS (1988) Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J Immunol 140(1):52-58.
23. Herold KC, et al. (2002) Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 346(22):1692-1698.
24. Gur C, et al. (2010) The activating receptor NKp46 is essential for the development of type 1 diabetes. Nat Immunol 11(2):121-128.
25. Pescovitz MD, et al.; Type 1 Diabetes TrialNet Anti-CD20 Study Group (2009) Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N Engl J Med 361(22):2143-2152.
26. Bamford RN, et al. (1994) The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 91(11): 4940-4944.
27. Cardozo AK, et al. (2003) IL-1? and IFN-? induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice. Diabetologia 46(2):255-266.
28. Kochs G, Haller O (1999) GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae). J Biol Chem 274(7):4370-4376.
29. Golubeva Y, Salcedo R, Mueller C, Liotta LA, Espina V (2013) Laser capture microdissection for protein and NanoString RNA analysis. Methods Mol Biol 931:213-257.
30. Yeung WC, Rawlinson WD, Craig ME (2011) Enterovirus infection and type 1 diabetes mellitus: Systematic review and meta-analysis of observational molecular studies. BMJ 342:d35.
31. Nejentsev S, Walker N, Riches D, Egholm M, Todd JA (2009) Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324 (5925):387-389.
32. Stene LC, et al. (2010) Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: The Diabetes and Autoimmunity Study in the Young (DAISY). Diabetes 59(12):3174-3180.
33. Oikarinen S, et al. (2011) Enterovirus RNA in blood is linked to the development of type 1 diabetes. Diabetes 60(1):276-279.
34. Itoh N, et al. (1993) Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest 92(5):2313-2322.
35. Bottazzo GF, et al. (1985) In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 313(6): 353-360.
36. Coppieters KT, et al. (2012) Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med 209(1): 51-60.
37. Waldmann TA (2006) The biology of interleukin-2 and interleukin-15: Implications for cancer therapy and vaccine design. Nat Rev Immunol 6(8):595-601.
38. Flodström M, Shi FD, Sarvetnick N, Ljunggren HG (2002) The natural killer cell-friend or foe in autoimmune disease? Scand J Immunol 55(5):432-441.
39. Waldmann TA, et al. (2011) Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques. Blood 117(18):4787-4795.