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Bioorganic and Medicinal Chemistry

Volumn 23, Issue 9, 2015, Pages 1963-1974

Design, synthesis and biological evaluation of tasiamide B derivatives as BACE1 inhibitors

(6) Liu, Jian a Chen, Wuyan b Xu, Yechun b Ren, Sumei a Zhang, Wei a Li, Yingxia a

a FUDAN UNIVERSITY (China)

b National Center for Drug Screening (China)

Author keywords

Alzheimer's disease; BACE1 inhibitor; Docking; Synthesis; Secretase

Indexed keywords

ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; OLIGOPEPTIDE; PROTEINASE INHIBITOR; SECRETASE; TASIAMIDE B;

ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DESIGN; HUMAN; METABOLISM; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937757914 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2015.03.034 Document Type: Article

Times cited : (36)

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