A stereoselective approach to peptidomimetic BACE1 inhibitors

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 233-247

  Butini, Stefania ^a   Gabellieri, Emanuele ^a   Brindisi, Margherita ^a   Giovani, Simone ^a   Maramai, Samuele ^a   Kshirsagar, Giridhar ^a   Guarino, Egeria ^a   Brogi, Simone ^a   La Pietra, Valeria ^a,b   Giustiniano, Mariateresa ^a,b   Marinelli, Luciana ^a,b   Novellino, Ettore ^a,b   Campiani, Giuseppe ^a   Cappelli, Andrea ^a   Gemma, Sandra ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Alzheimer's disease; BACE1; Benzodiazepines; Inhibitors; Peptidomimetics

Indexed keywords

2 (BENZYLOXYCARBONYLAMINO) N (2 BENZOYL 5 (( 1 HYDROXY) 2 (BENZYL(TERT BUTOXYCARBONYLAMINO))ETHYL)PHENYL) 2 PHENYLACETAMIDE; 2 (BENZYLOXYCARBONYLAMINO) N (3 (( 1 HYDROXY) 2 ( 1 BENZYL 2 HYDROXYETHYL)AMINOETHYL)PHENYL) 2 PHENYLACETAMIDE; 2 (BENZYLOXYCARBONYLAMINO) N (3 (( 1 HYDROXY) 2 (( 1 PHENYL 2 HYDROXYETHYL)(TERT BUTOXYCARBONYLAMINO))ETHYL)PHENYL) 2 PHENYLACETAMIDE; 2 (BENZYLOXYCARBONYLAMINO) N(3 (( 1 HYDROXY) 2 (BENZYL(TERT BUTOXYCARBONYLAMINO))ETHYL)PHENYL) 2 PHENYLACETAMIDE; 3 PHENYL 9 (4 TERT BUTOXYCARBONYLPIPERAZIN 1 YL) 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3,6 DIPHENYL 9 (4 TERT BUTOXYCARBONYLPIPERAZIN 1 YL) 1,3 DIHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3,6 DIPHENYL 9 (4 TERT BUTOXYCARBONYLPIPERAZIN 1 YL) 1,3,4,5 TETRAHYDROBENZO[E][1,4]DIAZEPIN 2 ONE; 3,6 DIPHENYL 9 (PIPERAZIN 1 YL) 1,3 DIHYDROBENZO[E] [1,4]DIAZEPIN 2 ONE; BENZODIAZEPINE DERIVATIVE; BETA SECRETASE INHIBITOR; LIGAND; N (3 (( 1 HYDROXY) 2 (BENZYL(TERT BUTOXYCARBONYLAMINO)) ETHYL)PHENYL) 1 NAPHTHAMIDE; UNCLASSIFIED DRUG; [2 ((9H FLUOREN 9 YLMETHOXYCARBONYLAMINO) 2 PHENYLACETAMIDO) 3 (4 TERT BUTOXYCARBONYLPIPERAZIN 1 YL) 6 PHENYL]BENZALDEHYDE; [2 (BENZYLOXYCARBONYLAMINO 2 PHENYLACETAMIDO) 3 (4 TERT BUTOXYCARBONYLPIPERAZIN 1 YL)]BENZALDEHYDE;

ARTICLE; BINDING ASSAY; DRUG SYNTHESIS; ENANTIOSELECTIVITY; ENZYMATIC ASSAY; ENZYME ISOLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; MOLECULAR WEIGHT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; WHOLE CELL;

1,4-BENZODIAZEPINE; AD; ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEIN; APP; BACE1; BDZ; BENZODIAZEPINES; HEA; HYDROXYETHYLAMINE; INHIBITORS; PEPTIDOMIMETICS; Β-SECRETASE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDOMIMETICS; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84886039061     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.056     Document Type: Article

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