Lipid Quality in Infant Nutrition: Current Knowledge and Future Opportunities

Journal of Pediatric Gastroenterology and Nutrition

Volumn 61, Issue 1, 2015, Pages 8-17

  Delplanque, Bernadette ^a   Gibson, Robert ^b   Koletzko, Berthold ^c   Lapillonne, Alexandre ^d   Strandvik, Birgitta ^e  

^a CNRS   (France)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

^e KAROLINSKA INSTITUTE   (Sweden)

Author keywords

breast milk; cholesterol; complex lipids; fatty acids; infant formulae

Indexed keywords

ARACHIDONIC ACID; CHOLESTEROL; DOCOSAHEXAENOIC ACID; LIPID; MONOUNSATURATED FATTY ACID; PALMITIC ACID; POLYUNSATURATED FATTY ACID; SATURATED FATTY ACID;

ARTIFICIAL MILK; BREAST MILK; CHOLESTEROL SYNTHESIS; FAT INTAKE; HUMAN; INFANT; INFANT NUTRITION; LIPID ANALYSIS; LIPID COMPOSITION; MATERNAL NUTRITION; PRIORITY JOURNAL; REVIEW; CHEMISTRY; COMPARATIVE STUDY; DIET; NEWBORN; NUTRITIONAL REQUIREMENT;

DIET; HUMANS; INFANT; INFANT FORMULA; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; LIPIDS; MILK, HUMAN; NUTRITIONAL REQUIREMENTS;

EID: 84937688448     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000000818     Document Type: Review

References (104)

1. WHO. Global Strategy for Infant and Young Child Feeding. Geneva: WHO; 2003.
2. Koletzko B, Shamir R, Ashwell M. Quality and safety aspects of infant nutrition. Ann Nutr Metab 2012;60:179-84.
3. Koletzko B, Agostoni C, Bergmann R, et al. Physiological aspects of human milk lipids and implications for infant feeding: a workshop report. Acta Paediatr 2011;100:1405-15.
4. Krohn K, Demmelmair H, Koletzko B. Macronutrient requirements for growth: fats and fatty acids. In: Duggan C, Watkins JB, Walker WA, eds. Nutrition in Pediatrics: Basic Science, Clinical, Applications. Toronto: BC Decker; 2008.
5. Keating EM, Curtis BA, Slusher TM. Maternal milk volume and breast milk expression: implications for diet and nutrition in infants. In: Zibadi S, Watson RR, Preedy VR, eds. Handbook of Dietary and Nutritional Aspects of Human Breast Milk. Wageningen: Wageningen Academic Publishers; 2013:193-213.
6. Michalski MC. Lipids and milk fat globule properties in human milk. In: Zibadi S, Watson RR, Preedy VR, eds. Handbook of dietary and nutritional aspects of human breast milk. Wageningen: Wageningen Academic Publishers; 2013:315-34.
7. Giuffrida F, Cruz-Hernandez C, Fluck B, et al. Quantification of phospholipids classes in human milk. Lipids 2013;48:1051-8.
8. Kamelska AM, Pietrzak-Fiecko R, Bryl K. Determination of cholesterol concentration in human milk samples using attenuated total reflectance Fourier transform infrared spectroscopy. J Appl Spectrosc 2013;80:148-52.
9. Innis SM. Dietary triacylglycerol structure and its role in infant nutrition. Adv Nutr 2011;2:275-83.
10. Bracco U. Effect of triglyceride structure on fat absorption. Am J Clin Nutr 1994;60 (6 suppl):1002S-9.
11. Gonzalez HF, Vicentin D, Giumelli O, et al. Profile of triacylglycerols and percentage of palmitic acid at the sn-2 in breast milk substitutes [Article in Spanish]. Arch Argent Pediatr 2012;110:227-30.
12. Ailhaud G, Massiera F, Weill P, et al. Temporal changes indietaryfats: role of n-6 poly unsaturated fatty acids in excessive a diposet issue development and relationship to obesity. Prog Lipid Res 2006;45:203-36.
13. Brenna JT, Lapillonne A. Background paper on fat and fatty acid requirements during pregnancy and lactation. Ann Nutr Metab 2009; 55:97-122.
14. Lattka E, Rzehak P, Szabo E, et al. Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the duration of lactation. Am J Clin Nutr 2011;93:382-91.
15. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr 2007;85:1457-64.
16. Weseler AR, Dirix CE, Bruins MJ, et al. Dietary arachidonic acid dose-dependently increases the arachidonic acid concentration in human milk. J Nutr 2008;138:2190-7.
17. Del Prado M, Villalpando S, Elizondo A, et al. Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet. Am J Clin Nutr 2001;74:242-7.
18. Koletzko B, Rodriguez-Palmero M, Demmelmair H, et al. Physiological aspects of human milk lipids. Early Hum Dev 2001;65 (suppl): S3-18.
19. Lapillonne A, Groh-Wargo S, Gonzalez CH, et al. Lipid needs of preterm infants: updated recommendations. J Pediatr 2013;162 (3 suppl):S37-47.
20. Flatt JP. Use and storage of carbohydrate and fat. Am J Clin Nutr 1995;61 (4 suppl):952S-9S.
21. Gale C, Logan KM, Santhakumaran S, et al. Effect of breastfeeding compared with formula feeding on infant body composition: a systematic review and meta-analysis. Am J Clin Nutr 2012;95:656-69.
22. Arenz S, Ruckerl R, Koletzko B, et al. Breast-feeding and childhood obesity-a systematic review. Int J Obes Relat Metab Disord 2004; 28:1247-56.
23. Weng SF, Redsell SA, Swift JA, et al. Systematic review and meta-analyses of risk factors for childhood overweight identifiable during infancy. Arch Dis Child 2012;97:1019-26.
24. Koletzko B, von Kries R, Monasterolo RC, et al. Infant feeding and later obesity risk. Adv Exp Med Biol 2009;646:15-29.
25. Brenna JT. Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man. Curr Opin Clin Nutr Metab Care 2002; 5:127-32.
26. Lapillonne A. Lipids. In: Koletzko B, Poindexter B, Uauy R, eds. Nutritional Care of Preterm Infants. Scientific Basis and Practical Guidelines. Basel: Karger; 2014:82-98.
27. Lehner F, Demmelmair H, Roschinger W, et al. Metabolic effects of intravenous LCT or MCT/LCT lipid emulsions in preterm infants. J Lipid Res 2006;47:404-11.
28. Rodriguez M, Funke S, Fink M, et al. Plasma fatty acids and [13C]li-noleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides. J Lipid Res 2003;44:41-8.
29. Lapillonne A. Enteral and parenteral lipid requirements of preterm infants. World Rev Nutr Diet 2014;110:82-98.
30. Goulet O, Olieman J, Ksiazyk J, et al. Neonatal short bowel syndrome as a model of intestinal failure: physiological background for enteral feeding. Clin Nutr 2013;32:162-71.
31. Koo WW, Hammami M, Margeson DP, et al. Reduced bone mineralization in infants fed palm olein-containing formula: a randomized, double-blinded, prospective trial. Pediatrics 2003;111 (5 pt 1):1017-23.
32. Leite ME, Lasekan J, Baggs G, et al. Calcium and fat metabolic balance, and gastrointestinal tolerance in term infants fed milk-based formulas with and without palm olein and palm kernel oils: a randomized blinded crossover study. BMC Pediatr 2013;13:215.
33. Carnielli VP, Luijendijk IH, van Beek RH, et al. Effect of dietary triacylglycerol fatty acid positional distribution on plasma lipid classes and their fatty acid composition in preterm infants. Am J Clin Nutr 1995;62:776-81.
34. Fewtrell MS, Kennedy K, Murgatroyd PR, et al. Breast-feeding and formula feeding in healthy term infants and bone health at age 10 years. Br J Nutr 2013;110:1061-7.
35. Schmidt R, Meier U, Markart P, et al. Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease. Am J Physiol Lung Cell Mol Physiol 2002;283:L1079-85.
36. Bergsson G, Arnfinnsson J, Steingrimsson O, et al. Killing of Gram-positive cocci by fatty acids and monoglycerides. APMIS 2001;109: 670-8.
37. Tollin M, Bergsson G, Kai-Larsen Y, et al. Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions. Cell Mol Life Sci 2005;62:2390-9.
38. Rioux V, Pedrono F, Legrand P. Regulation of mammalian desaturases by myristic acid: N-terminal myristoylation and other modulations. Biochim Biophys Acta 2011;1811:1-8.
39. Hostmark AT, Haug A. Percentages of oleic acid and arachidonic acid are inversely related in phospholipids of human sera. Lipids Health Dis 2013;12:106.
40. Cleland LG, Gibson RA, Neumann MA, et al. Dietary (n-9) eicosa-trienoic acid from a cultured fungus inhibits leukotriene B4 synthesis in rats and the effect is modified by dietary linoleic acid. J Nutr 1996;126:1534-40.
41. Martinez M, Mougan I. Fatty acid composition of human brain phospholipids during normal development. J Neurochem 1998;71: 2528-33.
42. Ntoumani E, Strandvik B, Sabel KG. Nervonic acid is much lower in donor milk than in milk from mothers delivering premature infants-of neglected importance? Prostaglandins Leukot Essent Fatty Acids 2013;89:241-4.
43. Jensen CL, Prager TC, Fraley JK, et al. Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. J Pediatr 1997;131:200-9.
44. Koletzko B, Bhutta ZA, Cai W, et al. Compositional requirements of follow-up formula for use in infancy: recommendations of an international expert group coordinated by the Early Nutrition Academy. Ann Nutr Metab 2013;62:44-54.
45. EFSA NDA Panel. Scientific Opinion on the essential composition of infant and follow-on formulae. EFSA J 2014;12:3760.
46. Innis SM. Dietary lipids in early development: relevance to obesity, immune and inflammatory disorders. Curr Opin Endocrinol Diabetes Obes 2007;14:359-64.
47. Ramsden CE, Ringel A, Feldstein AE, et al. Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. Prostaglandins Leukot Essent Fatty Acids 2012;87:135-41.
48. Sabel KG, Strandvik B, Petzold M, et al. Motor, mental and behavioral developments in infancy are associated with fatty acid pattern in breast milk and plasma of premature infants. Prostaglandins Leukot Essent Fatty Acids 2012;86:183-8.
49. Bernard JY, De Agostini M, Forhan A, et al. The dietary n6:n3 fatty acid ratio during pregnancy is inversely associated with child neuro-development in the EDEN mother-child cohort. J Nutr 2013;143: 1481-8.
50. Goyens PL, Spilker ME, Zock PL, et al. Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio. Am J Clin Nutr 2006;84:44-53.
51. Liou YA, King DJ, Zibrik D, et al. Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosa-pentaenoic acid in plasma phospholipids in healthy men. J Nutr 2007;137:945-52.
52. Makrides M, Neumann MA, Jeffrey B, et al. A randomized trial of different ratios of linoleic to alpha-linolenic acid in the diet of term infants: effects on visual function and growth. Am J Clin Nutr 2000;71:120-9.
53. Du Q, Martin JC, Agnani G, et al. Dairy fat blends high in alpha-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats. J Nutr Biochem 2012;23:1573-82.
54. Delplanque B, Du Q, Agnani G, et al. A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. Prostaglandins Leukot Essent Fatty Acids 2013;88:115-20.
55. Courage ML, McCloy UR, Herzberg GR, et al. Visual acuity development and fatty acid composition of erythrocytes in full-term infants fed breast milk, commercial formula, or evaporated milk. J Dev Behav Pediatr 1998;19:9-17.
56. Carnielli VP, Simonato M, Verlato G, et al. Synthesis of long-chain polyunsaturated fatty acids in preterm newborns fed formula with long-chain polyunsaturated fatty acids. Am J Clin Nutr 2007;86:1323-30.
57. Makrides M, Neumann MA, Byard RW, et al. Fatty acid composition of brain, retina, and erythrocytes in breast-and formula-fed infants. Am J Clin Nutr 1994;60:189-94.
58. Campoy C, Escolano-Margarit MV, Anjos T, et al. Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. Br J Nutr 2012;107 (suppl 2):S85-106.
59. Makrides M, Gibson RA, McPhee AJ, et al. Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid: a randomized controlled trial. JAMA 2009;301:175-82.
60. Manley BJ, Makrides M, Collins CT, et al. High-dose docosahexaenoic acid supplementation of preterm infants: respiratory and allergy outcomes. Pediatrics 2011;128:e71-7.
61. Makrides M, Gibson RA, Udell T, et al. Supplementation of infant formula with long-chain polyunsaturated fatty acids does not influence the growth of term infants. Am J Clin Nutr 2005;81: 1094-101.
62. Pedersen L, Lauritzen L, Brasholt M, et al. Polyunsaturated fatty acid content of mother's milk is associated with childhood body composition. Pediatr Res 2012;72:631-6.
63. Carlson SE. Arachidonic acid status of human infants: influence of gestational age at birth and diets with very long chain n-3 and n-6 fatty acids. J Nutr 1996;126 (4 suppl):1092S-8.
64. Lapillonne A, Carlson SE. Polyunsaturated fatty acids and infant growth. Lipids 2001;36:901-11.
65. Collins CT, Makrides M, Gibson RA, et al. Pre-and post-term growth in pre-term infants supplemented with higher-dose DHA: a randomised controlled trial. Br J Nutr 2011;105:1635-43.
66. Standl M, Sausenthaler S, Lattka E, et al. FADS gene cluster modulates the effect of breastfeeding on asthma. Results from the GINIplus and LISAplus studies. Allergy 2012;67:83-90.
67. Steer CD, Davey Smith G, Emmett PM, et al. FADS2 polymorphisms modify the effect of breastfeeding on child IQ. PLoS One 2010;5: e11570.
68. Jensen CL, Voigt RG, Llorente AM, et al. Effects of early maternal docosahexaenoic acid intake on neuropsychological status and visual acuity at five years of age of breast-fed term infants. J Pediatr 2010;157:900-5.
69. Simmer K, Patole SK, Rao SC, et al. Long-chain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst Rev 2011:CD000376.
70. Schulzke SM, Patole SK, Simmer K, et al. Long-chain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst Rev 2011:CD000375.
71. FAO. Fats and fatty acids in human nutrition. Report of an expert consultation. FAO Food Nutr Pap 2008;91:63-76.
72. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). DHA and ARA and visual development: scientific substantiation of a health claim related to docosahexaenoic acid (DHA) and arachidonic acid (ARA) and visual development pursuant to Article14 of Regulation (EC) No 1924/2006. EFSA J 2009; 941: 1-14.
73. Noakes PS, Vlachava M, Kremmyda LS, et al. Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo. Am J Clin Nutr 2012;95:395-404.
74. Much D, Brunner S, Vollhardt C, et al. Breast milk fatty acid profile in relation to infant growth and body composition: results from the INFAT study. Pediatr Res 2013;74:230-7.
75. Liou AY, Innis SM. Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men. Prosta-glandins Leukot Essent Fatty Acids 2009;80:201-6.
76. Friesen RW, Innis SM. Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. Am J Clin Nutr 2010;91:23-31.
77. Koletzko B, Braun M. Arachidonic acid and early human growth: is there a relation? Ann Nutr Metab 1991;35:128-31.
78. Sellmayer A, Koletzko B. Long-chain polyunsaturated fatty acids and eicosanoids in infants-physiological and pathophysiological aspects and open questions. Lipids 1999;34:199-205.
79. Koletzko B, Boey C, Campoy C, et al. Current information and Asian perspectives on long-chain polyunsaturated fatty acids in pregnancy, lactation, and infancy: systematic review and practice recommendations from an early nutrition academy workshop. Ann Nutr Metab 2014;65:49-80.
80. Novak EM, Dyer RA, Innis SM. High dietary omega-6 fatty acids contribute to reduced docosahexaenoic acid in the developing brain and inhibit secondary neurite growth. Brain Res 2008;1237: 136-45.
81. Dalli J, Colas RA, Serhan CN. Novel n-3 immunoresolvents: structures and actions. Sci Rep 2013;3:1940.
82. Lemke SL, Maki KC, Hughes G, et al. Consumption of stearidonic acid-rich oil in foods increases red blood cell eicosapentaenoic acid. J Acad Nutr Diet 2013;113:1044-56.
83. Palsdottir V, Wickman A, Andersson N, et al. Postnatal deficiency of essential fatty acids in mice results in resistance to diet-induced obesity and low plasma insulin during adulthood. Prostaglandins Leukot Essent Fatty Acids 2011;84:85-92.
84. de Vries PS, Gielen M, Rizopoulos D, et al. Association between polyunsaturated fatty acid concentrations in maternal plasma phos-pholipids during pregnancy and offspring adiposity at age 7: the MEFAB cohort. Prostaglandins Leukot Essent Fatty Acids 2014;91: 81-5.
85. Rump P, Popp-Snijders C, Heine RJ, et al. Components of the insulin resistance syndrome in seven-year-old children: relations with birth weight and the polyunsaturated fatty acid content of umbilical cord plasma phospholipids. Diabetologia 2002;45:349-55.
86. Bayley TM, Alasmi M, Thorkelson T, et al. Longer term effects of early dietary cholesterol level on synthesis and circulating cholesterol concentrations in human infants. Metabolism 2002;51:25-33.
87. Kinney HC, Karthigasan J, Borenshteyn NI, et al. Myelination in the developing human brain: biochemical correlates. Neurochem Res 1994;19:983-96.
88. Shamir R, Nganga A, Berkowitz D, et al. Serum levels of bile salt-stimulated lipase and breast feeding. J Pediatr Endocrinol Metab 2003;16:1289-94.
89. Wong WW, Hachey DL, Insull W, et al. Effect of dietary cholesterol on cholesterol synthesis in breast-fed and formula-fed infants. J Lipid Res 1993;34:1403-11.
90. Makrides M, Gibson RA. The role of fats in the lifecycle stages: pregnancy and the first year of life. Med J Aust 2002;176 (suppl): S111-2.
91. Demmers TA, Jones PJ, Wang Y, et al. Effects of early cholesterol intake on cholesterol biosynthesis and plasma lipids among infants until 18 months of age. Pediatrics 2005;115:1594-601.
92. Owen CG, Whincup PH, Kaye SJ, et al. Does initial breastfeeding lead to lower blood cholesterol in adult life? A quantitative review of the evidence. Am J Clin Nutr 2008;88:305-14.
93. Rich-Edwards JW, Stampfer MJ, Manson JE, et al. Breastfeeding during infancy and the risk of cardiovascular disease in adulthood. Epidemiology 2004;15:550-6.
94. Picaud JC, Boucher P, Lapillonne A, et al. Influence of dietary cholesterol on vitamin D metabolism in formula-fed preterm neonates. J Pediatr Gastroenterol Nutr 2002;35:180-4.
95. Katoku Y, Yamada M, Yonekubo A, et al. Effect of the cholesterol content of a formula on the lipid compositions of plasma lipoproteins and red blood cell membranes in early infancy. Am J Clin Nutr 1996;64:871-7.
96. Van Biervliet JP, Vinaimont N, Vercaemst R, et al. Serum cholesterol, cholesteryl ester, and high-density lipoprotein development in newborn infants: response to formulas supplemented with cholesterol and gamma-linolenic acid. J Pediatr 1992;120 (4 pt 2):S101-8.
97. Agostoni C, Riva E, Bellu R, et al. Effects of diet on the lipid and fatty acid status of full-term infants at 4 months. J Am Coll Nutr 1994; 13:658-64.
98. Rioux V, Catheline D, Bouriel M, et al. Dietary myristic acid at physiologically relevant levels increases the tissue content of C20:5 n-3 and C20:3 n-6 in the rat. Reprod Nutr Dev 2005;45:599-612.
99. Tanaka K, Hosozawa M, Kudo N, et al. The pilot study: sphingomye-lin-fortified milk has a positive association with the neurobehavioural development of very low birth weight infants during infancy, randomized control trial. Brain Dev 2013;35:45-52.
100. Miklavcic JJ, Schnabl KL, Mazurak VC, et al. Dietary ganglioside reduces proinflammatory signaling in the intestine. J Nutr Metab 2012: 2012(280-286).
101. Schnabl KL, Larsen B, Van Aerde JE, et al. Gangliosides protect bowel in an infant model of necrotizing enterocolitis by suppressing proin-flammatory signals. J Pediatr Gastroenterol Nutr 2009;49:382-92.
102. Billeaud C, Puccio G, Saliba E, et al. Safety and tolerance evaluation of milk fat globule membrane-enriched infant formulas: a randomized controlled multicenter non-inferiority trial in healthy term infants. Clin Med Insights Pediatr 2014;8:51-60.
103. Veereman-Wauters G, Staelens S, Rombaut R, et al. Milk fat globule membrane (INPULSE) enriched formula milk decreases febrile episodes and may improve behavioral regulation in young children. Nutrition 2012;28:749-52.
104. Timby N, Domellof E, Hernell O, et al. Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: a randomized controlled trial. Am J Clin Nutr 2014;99:860-8.