Dietary ganglioside reduces proinflammatory signaling in the intestine

Journal of Nutrition and Metabolism

Volumn 2012, Issue , 2012, Pages

  Miklavcic, John Janez ^a   Schnabl, Kareena Leanne ^b   Mazurak, Vera Christine ^a   Thomson, Alan Bryan Robert ^c   Clandinin, Michael Thomas ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b DynaLIFE   (Canada)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84873865301     PISSN: 20900724     EISSN: 20900732     Source Type: Journal    
DOI: 10.1155/2012/280286     Document Type: Review

References (82)

1. Nakano J., Yasui H., Lloyd K. O., Muto M., Biologic roles of gangliosides G(M3) and G(D3) in the attachment of human melanoma cells to extracellular matrix proteins. Journal of Investigative Dermatology Symposium Proceedings 1999 4 2 173 176 2-s2.0-0032880312 (Pubitemid 29489044)
2. Wang X. Q., Yan Q., Sun P., Liu J. W., Go L., McDaniel S. M., Paller A. S., Suppression of epidermal growth factor receptor signaling by protein kinase C- α activation requires CD82, caveolin-1, and ganglioside. Cancer Research 2007 67 20 9986 9995 2-s2.0-35448931927 10.1158/0008-5472.CAN-07-1300 (Pubitemid 47621249)
3. Ohkubo S., Nakahata N., The role of lipid rafts in trimeric G protein-mediated signal transduction. Yakugaku Zasshi 2007 127 1 27 40 2-s2.0-33846126919 10.1248/yakushi.127.27 (Pubitemid 46089903)
4. Vyas K. A., Patel H. V., Vyas A. A., Schnaar R. L., Segregation of gangliosides GM1 and GD3 on cell membranes, isolated membrane rafts, and defined supported lipid monolayers. Biological Chemistry 2001 382 2 241 250 2-s2.0-0035082123 10.1515/BC.2001.031 (Pubitemid 32243932)
5. Drozdowski L. A., Clandinin M. T., Thomson A. B., Morphological, kinetic, membrane biochemical and genetic aspects of intestinal enteroplasticity. World Journal of Gastroenterology 2009 15 7 774 787 2-s2.0-65649092518 10.3748/wjg.15.774
6. Malisan F., Testi R., GD3 ganglioside and apoptosis. Biochimica et Biophysica Acta 2002 1585 2-3 179 187 2-s2.0-0037203318 10.1016/S1388-1981(02) 00339-6 (Pubitemid 36092083)
7. Fukasawa M., Nishijima M., Hanada K., Genetic evidence for ATP-dependent endoplasmic reticulum-to-Golgi apparatus trafficking of ceramide for sphingomyelin synthesis in Chinese hamster ovary cells. Journal of Cell Biology 1999 144 4 673 685 2-s2.0-0033593788 10.1083/jcb.144.4.673 (Pubitemid 29234546)
8. Yasuda S., Kitagawa H., Ueno M., Ishitani H., Fukasawa M., Nishijima M., Kobayashi S., Hanada K., A novel inhibitor of ceramide trafficking from the endoplasmic reticulum to the site of sphingomyelin synthesis. Journal of Biological Chemistry 2001 276 47 43994 44002 2-s2.0-0035941303 10.1074/jbc.M104884200
9. Kolter T., Proia R. L., Sandhoff K., Combinatorial ganglioside biosynthesis. Journal of Biological Chemistry 2002 277 29 25859 25862 2-s2.0-0037135608 10.1074/jbc.R200001200 (Pubitemid 34967063)
10. Birklé S., Zeng G., Gao L., Yu R. K., Aubry J., Role of tumor-associated gangliosides in cancer progression. Biochimie 2003 85 3-4 455 463 2-s2.0-0038532523 10.1016/S0300-9084(03)00006-3 (Pubitemid 36626016)
11. Devlin T. M., Textbook of Biochemistry with Clinical Correlations 1992 3rd New York, NY, USA Wiley Liss
12. Iwamori M., Shimomura J., Tsuyuhara S., Nagai Y., Gangliosides of various rat tissues: distribution of ganglio-N-tetraose-containing gangliosides and tissue-characteristic composition of gangliosides. Journal of Biochemistry 1984 95 3 761 770 2-s2.0-0021262589 (Pubitemid 14130537)
13. Bieberich E., Integration of glycosphingolipid metabolism and cell-fate decisions in cancer and stem cells: review and hypothesis. Glycoconjugate Journal 2004 21 6 315 327 2-s2.0-7244257698 10.1023/B:GLYC.0000046274.35732.47 (Pubitemid 39434560)
14. Ledeen R., The chemistry of gangliosides: a review. Journal of the American Oil Chemists Society 1966 43 2 57 66 2-s2.0-0013880186 10.1007/BF02641015
15. Sorensen L. K., A liquid chromatography/tandem mass spectrometric approach for the determination of gangliosides GD3 and GM3 in bovine milk and infant formulae. Rapid Communications in Mass Spectrometry 2006 20 24 3625 3633 10.1002/rcm.2775 (Pubitemid 44935312)
16. Prinetti A., Basso L., Appierto V., Villani M. G., Valsecchi M., Loberto N., Prioni S., Chigorno V., Cavadini E., Formelli F., Sonnino S., Altered sphingolipid metabolism in N-(4-hydroxyphenyl)-retinamide-resistant A2780 human ovarian carcinoma cells. Journal of Biological Chemistry 2003 278 8 5574 5583 2-s2.0-0037458741 10.1074/jbc.M207269200 (Pubitemid 36800799)
17. Müthing J., Maurer U., Neumann U., Kniep B., Weber-Schürholz S., Glycosphingolipids of skeletal muscle: I. Subcellular distribution of neutral glycosphingolipids and gangliosides in rabbit skeletal muscle. Carbohydrate Research 1998 307 1-2 135 145 2-s2.0-0032004159 10.1016/S0008-6215(98)00027-5 (Pubitemid 28282856)
18. 2+-flux in triad membranes by gangliosides. Carbohydrate Research 1998 307 1-2 147 157 2-s2.0-0032004252 10.1016/S0008-6215(98)00028-7 (Pubitemid 28282857)
19. Chiantia S., Ries J., Chwastek G., Carrer D., Li Z., Bittman R., Schwille P., Role of ceramide in membrane protein organization investigated by combined AFM and FCS. Biochimica et Biophysica Acta 2008 1778 5 1356 1364 2-s2.0-43049117446 10.1016/j.bbamem.2008.02.008
20. Park E. J., Suh M., Clandinin M. T., Dietary ganglioside and long-chain polyunsaturated fatty acids increase ganglioside GD3 content and alter the phospholipid profile in neonatal rat retina. Investigative Ophthalmology and Visual Science 2005 46 7 2571 2575 2-s2.0-23244440802 10.1167/iovs.04-1439 (Pubitemid 43119508)
21. Vanderghem C., Bodson P., Danthine S., Paquot M., Deroanne C., Blecker C., Milk fat globule membrane and buttermilks: from composition to valorization. Biotechnology, Agronomy and Society and Environment 2010 14 3 485 500 2-s2.0-78049348370
22. Schnabl K. L., Larcelet M., Thomson A. B. R., Clandinin M. T., Uptake and fate of ganglioside GD3 in human intestinal Caco-2 cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 2009 297 1 G52 G59 2-s2.0-67650069645 10.1152/ajpgi.90599.2008
23. Bode L., Beermann C., Mank M., Kohn G., Boehm G., Human and bovine milk gangliosides differ in their fatty acid composition. Journal of Nutrition 2004 134 11 3016 3020 2-s2.0-7944236169 (Pubitemid 39470078)
24. Park E. J., Suh M., Thomson B., Thomson A. B. R., Ramanujam K. S., Clandinin M. T., Dietary ganglioside decreases cholesterol content, caveolin expression and inflammatory mediators in rat intestinal microdomains. Glycobiology 2005 15 10 935 942 2-s2.0-27244449003 10.1093/glycob/cwi078 (Pubitemid 41511489)
25. Pham P. H., Duffy T. L., Dmytrash A. L., Lien V. W., Thomson A. B., Clandinin M. T., Estimate of dietary ganglioside intake in a group of healthy edmontonians based on selected foods. Journal of Food Composition and Analysis 2011 24 7 1032 1037 10.1016/j.jfca.2011.01.011
26. Park E. J., Suh M., Ramanujam K., Steiner K., Begg D., Clandinin M. T., Diet-induced changes in membrane gangliosides in rat intestinal mucosa, plasma and brain. Journal of Pediatric Gastroenterology and Nutrition 2005 40 4 487 495 2-s2.0-16844364569 10.1097/01.MPG.0000157199.25923.64 (Pubitemid 40489579)
27. Pagano R. E., Lipid traffic in eukaryotic cells: mechanisms for intracellular transport and organelle-specific enrichment of lipids. Current Opinion in Cell Biology 1990 2 4 652 663 2-s2.0-0025064559
28. Park E. J., Suh M., Thomson B., Ma D. W. L., Ramanujam K., Thomson A. B. R., Clandinin M. T., Dietary ganglioside inhibits acute inflammatory signals in intestinal mucosa and blood induced by systemic inflammation of Escherichia coli lipopolysaccharide. Shock 2007 28 1 112 117 2-s2.0-34250692041 10.1097/SHK.0b013e3180310fec (Pubitemid 46956472)
29. Schnabl K. L., Larsen B., Van Aerde J. E., Lees G., Evans M., Belosevic M., Field C., Thomson A. B. R., Clandinin M. T., Gangliosides protect bowel in an infant model of necrotizing enterocolitis by suppressing proinflammatory signals. Journal of Pediatric Gastroenterology and Nutrition 2009 49 4 382 392 2-s2.0-70349742795 10.1097/MPG.0b013e3181b6456d
30. Park E. J., Thomson A. B., Clandinin M. T., Protection of intestinal occludin tight junction protein by dietary gangliosides in lipopolysaccharide- induced acute inflammation. Journal of Pediatric Gastroenterology and Nutrition 2010 50 3 321 328 2-s2.0-77649313855 10.1097/MPG.0b013e3181ae2ba0
31. Schnoor M., Betanzos A., Weber D. A., Parkos C. A., Guanylate-binding protein-1 is expressed at tight junctions of intestinal epithelial cells in response to interferon- γ and regulates barrier function through effects on apoptosis. Mucosal Immunology 2009 2 1 33 42 2-s2.0-58049152410 10.1038/mi.2008.62
32. Agace W., Generation of gut-homing T cells and their localization to the small intestinal mucosa. Immunology Letters 2010 128 1 21 23 2-s2.0-74649087060 10.1016/j.imlet.2009.09.012
33. Rott L. S., Rosé J. R., Bass D., Williams M. B., Greenberg H. B., Butcher E. C., Expression of mucosal homing receptor α 4 β 7 by circulating CD4+ cells with memory for intestinal rotavirus. Journal of Clinical Investigation 1997 100 5 1204 1208 2-s2.0-0030983938 (Pubitemid 27386306)
34. Cheresh D. A., Pytela R., Pierschbacher M. D., Klier F. G., Ruoslahti E., Reisfeld R. A., An Arg-Gly-Asp-directed receptor on the surface of human melanoma cells exists in a divalent cation-dependent functional complex with the disialoganglioside GD2. Journal of Cell Biology 1987 105 3 1163 1173 2-s2.0-0023601045 (Pubitemid 18029841)
35. Ohkawa Y., Miyazaki S., Miyata M., Hamamura K., Furukawa K., Furukawa K., Essential roles of integrin-mediated signaling for the enhancement of malignant properties of melanomas based on the expression of GD3. Biochemical and Biophysical Research Communications 2008 373 1 14 19 2-s2.0-45849105540 10.1016/j.bbrc.2008.05.149
36. Simons K., Ehehalt R., Cholesterol, lipid rafts, and disease. Journal of Clinical Investigation 2002 110 5 597 603 2-s2.0-0036733578 10.1172/JCI200216390 (Pubitemid 34988781)
37. Brown D. A., London E., Functions of lipid rafts in biological membranes. Annual Review of Cell and Developmental Biology 1998 14 111 136 2-s2.0-0032421354 10.1146/annurev.cellbio.14.1.111 (Pubitemid 29001451)
38. Korade Z., Kenworthy A. K., Lipid rafts, cholesterol, and the brain. Neuropharmacology 2008 55 8 1265 1273 2-s2.0-56249124005 10.1016/j.neuropharm. 2008.02.019
39. Janes P. W., Ley S. C., Magee A. I., Kabouridis P. S., The role of lipid rafts in T cell antigen receptor (TCR) signalling. Seminars in Immunology 2000 12 1 23 34 2-s2.0-0033998793 10.1006/smim.2000.0204 (Pubitemid 30114013)
40. Simons K., Toomre D., Lipid rafts and signal transduction. Nature Reviews Molecular Cell Biology 2000 1 1 31 39 2-s2.0-0034304851
41. Kabouridis P. S., Janzen J., Magee A. L., Ley S. C., Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes. European Journal of Immunology 2000 30 3 954 963 2-s2.0-0033993454 (Pubitemid 30216271)
42. Kabouridis P. S., Magee A. I., Ley S. C., S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes. EMBO Journal 1997 16 16 4983 4998 2-s2.0-0030746106 10.1093/emboj/16.16.4983 (Pubitemid 27348407)
43. Zhang W., Trible R. P., Samelson L. E., LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 1998 9 2 239 246 2-s2.0-0032142953 (Pubitemid 28400037)
44. Kasahara K., Sanai Y., Possible roles of glycosphingolipids in lipid rafts. Biophysical Chemistry 1999 82 2-3 121 127 2-s2.0-0033552678 10.1016/S0301-4622(99)00111-8
45. Schnabl K. L., Field C., Clandinin M. T., Ganglioside composition of differentiated Caco-2 cells resembles human colostrum and neonatal rat intestine. British Journal of Nutrition 2009 101 5 694 700 2-s2.0-67649449990 10.1017/S0007114508048289
46. Samuel B. U., Mohandas N., Harrison T., McManus H., Rosse W., Reid M., Haldar K., The role of cholesterol and glycosylphosphatidylinositol-anchored proteins of erythrocyte rafts in regulating raft protein content and malarial infection. Journal of Biological Chemistry 2001 276 31 29319 29329 2-s2.0-0035800734 10.1074/jbc.M101268200
47. Wolf A. A., Fujinaga Y., Lencer W. I., Uncoupling of the cholera toxin-GM1 ganglioside receptor complex from endocytosis, retrograde golgi trafficking, and downstream signal transduction by depletion of membrane cholesterol. Journal of Biological Chemistry 2002 277 18 16249 16256 2-s2.0-0037013269 10.1074/jbc.M109834200 (Pubitemid 34967913)
48. Serhan C. N., Novel chemical mediators in the resolution of inflammation: resolvins and protectins. Anesthesiology Clinics of North America 2006 24 2 341 364 2-s2.0-33646404335 10.1016/j.atc.2006.01.003
49. Hudert C. A., Weylandt K. H., Lu Y., Wang J., Hong S., Dignass A., Serhan C. N., Kang J. X., Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proceedings of the National Academy of Sciences of the United States of America 2006 103 30 11276 11281 2-s2.0-33746625086 10.1073/pnas.0601280103 (Pubitemid 44156509)
50. Weylandt K. H., Kang J. X., Wiedenmann B., Baumgart D. C., Lipoxins and resolvins in inflammatory bowel disease. Inflammatory Bowel Diseases 2007 13 6 797 799 2-s2.0-34250373637 10.1002/ibd.20109 (Pubitemid 46909995)
51. Park E. J., Suh M., Thomson A. B., Ramanujam K. S., Clandinin M. T., Dietary gangliosides increase the content and molecular percentage of ether phospholipids containing 20: 4 n-6 and 22: 6 n-3 in weanling rat intestine. Journal of Nutritional Biochemistry 2006 17 5 337 344 2-s2.0-33646109806 10.1016/j.jnutbio.2005.08.005
52. Rodemann J. F., Dubberke E. R., Reske K. A., Seo D. H., Stone C. D., Incidence of clostridium difficile infection in inflammatory bowel disease. Clinical Gastroenterology and Hepatology 2007 5 3 339 344 2-s2.0-33947105999 10.1016/j.cgh.2006.12.027 (Pubitemid 46401530)
53. Marquez A., Nunez C., Martinez A., Mendoza J. L., Taxonera C., Fernandez-Arquero M., Diaz-Rubio M., De La Concha E. G., Urcelay E., Role of ATG16L1 Thr300Ala polymorphism in inflammatory bowel disease: a study in the spanish population and a meta-analysis. Inflammatory Bowel Diseases 2009 15 11 1697 1704 10.1002/ibd.21001
54. Cooney R., Jewell D., The genetic basis of inflammatory bowel disease. Digestive Diseases 2009 27 4 428 442 2-s2.0-70449479014 10.1159/000234909
55. Szebeni B., Veres G., Dezsõfi A., Rusai K., Vannay A.., Mraz M., Majorova E., Arató A., Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease. Clinical and Experimental Immunology 2008 151 1 34 41 2-s2.0-36849077704 10.1111/j.1365-2249.2007.03531.x (Pubitemid 350230984)
56. Yagci A., Yagci T., Sener B., Suziki Y., Ahmed K., Sulfatide mediates attachment of Pseudomonas aeruginosa to human pharyngeal epithelial cells. New Microbiologica 2007 30 2 167 171 2-s2.0-34250821178 (Pubitemid 46984124)
57. Sanchez-Juanes F., Alonso J. M., Zancada L., Hueso P., Glycosphingolipids from bovine milk and milk fat globule membranes: a comparative study. Adhesion to enterotoxigenic Escherichia coli strains. Biological Chemistry 2009 390 1 31 40 2-s2.0-58249118728 10.1515/BC.2009.003
58. Weersma R. K., Stokkers P. C., van Bodegraven A. A., van Hogezand R. A., Verspaget H. W., de Jong D. J., van der Woude C. J., Oldenburg B., Linskens R. K., Festen E. A. M., van der Steege G., Hommes D. W., Crusius J. B. A., Wijmenga C., Nolte M., Dijkstra G., Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort. Gut 2009 58 3 388 395 2-s2.0-61649123125 10.1136/gut.2007.144865
59. Sventoraityte J., Zvirbliene A., Franke A., Kwiatkowski R., Kiudelis G., Kupcinskas L., Schreiber S., NOD2, IL23R and ATG16L1 polymorphisms in Lithuanian patients with inflammatory bowel disease. World Journal of Gastroenterology 2010 16 3 359 364 2-s2.0-75349104831 10.3748/wjg.v16.i3.359
60. Watanabe T., Kitani A., Murray P. J., Strober W., NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nature Immunology 2004 5 8 800 808 2-s2.0-4444253690 10.1038/ni1092 (Pubitemid 39172973)
61. Vasseur F., Sendid B., Jouault T., Standaert-Vitse A., Dubuquoy L., Francois N., Gower-Rousseau C., Desreumaux P., Broly F., Vermeire S., Colombel J. -F., Poulain D., Variants of NOD1 and NOD2 genes display opposite associations with familial risk of crohn's disease and anti-saccharomyces cerevisiae antibody levels. Bowel Diseases. In press 10.1002/ibd.21817
62. Irani D. N., Lin K. L., Griffin D. E., Brain-derived gangliosides regulate the cytokine production and proliferation ofactivated T cells. Journal of Immunology 1996 157 10 4333 4340 2-s2.0-0030588610 (Pubitemid 126449350)
63. Pahl H. L., Activators and target genes of Rel/NF- B transcription factors. Oncogene 1999 18 49 6853 6866 2-s2.0-0033596121
64. Colell A., García-Ruiz C., Roman J., Ballesta A., Fernández-Checa J. C., Ganglioside GD3 enhances apoptosis by suppressing the nuclear factor-kappa B-dependent survival pathway. The FASEB journal 2001 15 6 1068 1070 2-s2.0-0035319268
65. Khan K. J., Dubinsky M. C., Ford A. C., Ullman T. A., Talley N. J., Moayyedi P., Efficacy of immunosuppressive therapy for inflammatory bowel disease: a systematic review and meta-analysis. American Journal of Gastroenterology 2011 106 4 630 642 10.1038/ajg.2011.64
66. Khan K. J., Ullman T. A., Ford A. C., Abreu M. T., Abadir A., Marshall J. K., Talley N. J., Moayyedi P., Antibiotic therapy in inflammatory bowel disease:a systematic review and meta-analysis. American Journal of Gastroenterology 2011 106 4 661 673 10.1038/ajg.2011.72
67. Maser E. A., Deconda D., Lichtiger S., Ullman T., Present D. H., Kornbluth A., Cyclosporine and infliximab as rescue therapy for each other in patients with steroid-refractory ulcerative colitis. Clinical Gastroenterology and Hepatology 2008 6 10 1112 1116 2-s2.0-52949131525 10.1016/j.cgh.2008.04.035
68. Tsironi E., Hadjidakis D., Mallas E., Tzathas C., Karamanolis D. G., Ladas S. D., Comparison of T- and Z-score in identifying risk factors of osteoporosis in inflammatory bowel disease patients. Journal of Musculoskeletal Neuronal Interactions 2008 8 1 79 84 2-s2.0-51749111167
69. Bernstein C. N., Singh S., Graff L. A., Walker J. R., Miller N., Cheang M., A prospective population-based study of triggers of symptomatic flares in IBD. American Journal of Gastroenterology 2010 105 9 1994 2002 2-s2.0-77956343420 10.1038/ajg.2010.140
70. Crohn's and Colitis Foundation of Canada Board, The burden of inflammatory bowel disease (IBD) in canada. 2008 Toronto, ON, Canada Crohn's and Colitis Foundation of Canada Board
71. Bernstein C. N., Wajda A., Svenson L. W., MacKenzie A., Koehoorn M., Jackson M., Fedorak R., Israel D., Blanchard J. F., The epidemiology of inflammatory bowel disease in Canada: a population-based study. American Journal of Gastroenterology 2006 101 7 1559 1568 2-s2.0-33745541232 10.1111/j.1572-0241.2006.00603.x (Pubitemid 43980630)
72. Loftus C. G., Loftus E. V. Jr, Harmsen W. S., Zinsmeister A. R., Tremaine W. J., Melton L. J., Sandborn W. J., Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940-2000. Inflammatory Bowel Diseases 2007 13 3 254 261 2-s2.0-33947546191 10.1002/ibd.20029 (Pubitemid 46465905)
73. Shivananda S., Lennard-Jones J., Logan R., Fear N., Price A., Carpenter L., Van Blankenstein M., Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? results of the European collaborative study on inflammatory bowel disease (EC-IBD). Gut 1996 39 5 690 697 2-s2.0-0030451868 (Pubitemid 26426470)
74. Gearry R. B., Richardson A., Frampton C. M. A., Collett J. A., Burt M. J., Chapman B. A., Barclay M. L., High incidence of Crohn's disease in Canterbury, New Zealand: results of an epidemiologic study. Inflammatory Bowel Diseases 2006 12 10 936 943 2-s2.0-33749316892 10.1097/01.mib.0000231572.88806. b9 (Pubitemid 44498282)
75. Yu A. P., Cabanilla L. A., Wu E. Q., Mulani P. M., Chao J., The costs of Crohn's disease in the United States and other Western countries: a systematic review. Current Medical Research and Opinion 2008 24 2 319 328 2-s2.0-39749169727 10.1185/030079908X260790 (Pubitemid 351294380)
76. Fedorak R. N., Thomson A. B. R., Thomson A. B. R., Shaffer E. A., Inflammatory bowel disease. First Principles of Gastroenterology 2000 4th Mississauga, ON, Canada AstraZeneca Canada 326 372
77. Yantiss R. K., Odze R. D., Diagnostic difficulties in inflammatory bowel disease pathology. Histopathology 2006 48 2 116 132 2-s2.0-33644862017 10.1111/j.1365-2559.2005.02248.x
78. Abraham C., Cho J. H., Inflammatory bowel disease. New England Journal of Medicine 2009 361 21 2066 2078 2-s2.0-70949107842 10.1056/NEJMra0804647
79. Molodecky N. A., Kaplan G. G., Environmental risk factors for inflammatory bowel disease. Gastroenterology and Hepatology 2010 6 5 339 346 2-s2.0-77953307288
80. Kolter T., Sandhoff K., Sphingolipid metabolism diseases. Biochimica et Biophysica Acta 2006 1758 12 2057 2079 2-s2.0-33845343984 10.1016/j.bbamem.2006. 05.027 (Pubitemid 44879358)
81. Costello C. M., Mah N., Häsler R., Rosenstiel P., Waetzig G. H., Hahn A., Lu T., Gurbuz Y., Nikolaus S., Albrecht M., Hampe J., Lucius R., Klöppel G., Eickhoff H., Lehrach H., Lengauer T., Schreiber S., Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. PLoS Medicine 2005 2 8 e199 2-s2.0-33644847555 10.1371/journal. pmed.0020199 (Pubitemid 46179249)
82. Lugering N., Kucharzik T., Stein H., Winde G., Lugering A., Hasilik A., Domschke W., Stoll R., IL-10 synergizes with IL-4 and IL-13 in inhibiting lysosomal enzyme secretion by human monocytes and lamina propria mononuclear cells from patients with inflammatory bowel disease. Digestive Diseases and Sciences 1998 43 4 706 714 2-s2.0-0031926406 10.1023/A:1018845526434 (Pubitemid 28176456)