Dairy fat blends high in α-linolenic acid are superior to n-3 fatty-acid-enriched palm oil blends for increasing DHA levels in the brains of young rats

Journal of Nutritional Biochemistry

Volumn 23, Issue 12, 2012, Pages 1573-1582

  Du, Qin ^a,b,d   Martin, Jean Charles ^a,b   Agnani, Genevieve ^c   Pages, Nicole ^c   Leruyet, Pascale ^d   Carayon, Pierre ^e   Delplanque, Bernadette ^c  

^a INSERM   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c CNRS   (France)

^d LRD   (France)

^e TIMONE HOSPITAL   (France)

Author keywords

Linolenic acid; Brain; Dairy fat; Docosahexaenoic acid; Palm oil; Rat neonates

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; LINOLENIC ACID; OMEGA 3 FATTY ACID; PALM OIL;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; DAIRY PRODUCT; ERYTHROCYTE; FAT INTAKE; FATTY ACID BLOOD LEVEL; FEMALE; GENE EXPRESSION; LACTATION; MALE; NEWBORN; NONHUMAN; PREGNANCY; RAT; SEX DIFFERENCE; WEANING;

ACETYLTRANSFERASES; ALPHA-LINOLENIC ACID; ANIMALS; BRAIN; BUTTER; DAIRY PRODUCTS; DIETARY FATS; DOCOSAHEXAENOIC ACIDS; ERYTHROCYTES; FATTY ACID DESATURASES; FATTY ACIDS; FATTY ACIDS, OMEGA-3; FEMALE; GENE EXPRESSION; LIVER; MALE; MODELS, THEORETICAL; PLANT OILS; RATS; STEAROYL-COA DESATURASE; WEANING;

RATTUS;

EID: 84869080788     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2011.10.011     Document Type: Article

References (47)

1. Innis S.M. Dietary (n-3) fatty acids and brain development. J Nutr 2007, 137:855-859.
2. Jensen R.G. Lipids in human milk composition and fat soluble vitamins. Textbook of gastroenterology and nutrition in infancy 1989, 157-208. Raven Press, New York. 2nd ed. E. Lebenthal (Ed.).
3. Koletzko B., Demmelmair H., Socha P. Nutritional support of infants and children: supply and metabolism of lipids. Baillieres Clin Gastroenterol 1998, 12:671-696.
4. Innis S.M. Essential fatty acid transfer and fetal development. Placenta 2005, 26(Suppl A):S70-S75.
5. Innis S.M., Gilley J., Werker J. Are human milk long-chain polyunsaturated fatty acids related to visual and neural development in breast-fed term infants?. J Pediatr 2001, 139:532-538.
6. Malcolm C.A., McCulloch D.L., Montgomery C., Shepherd A., Weaver L.T. Maternal docosahexaenoic acid supplementation during pregnancy and visual evoked potential development in term infants: a double blind, prospective, randomised trial. Arch Dis Child Fetal Neonatal Ed 2003, 88:F383-F390.
7. Hoffman D.R., Birch E.E., Birch D.G., Uauy R., Castaneda Y.S., Lapus M.G., et al. Impact of early dietary intake and blood lipid composition of long-chain polyunsaturated fatty acids on later visual development. J Pediatr Gastroenterol Nutr 2000, 31:540-553.
8. Simmer K., Patole S. Long-chain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst Rev 2004, CD000375.
9. Uauy R., Mize C.E., Castillo-Duran C. Fat intake during childhood: metabolic responses and effects on growth. Am J Clin Nutr 2000, 72:1354S-1360S.
10. Nutrition during infancy: principles and practice 1997, 123-153. Digital Educational Publishing, Cincinnati. 1st ed. B. Koletzko, R. Tsang, S.H. Zlotkin, B. Nichols, J. Hansen (Eds.).
11. Mohrhauer H., Holman R.T. The effect of dose level of essential fatty acids upon fatty acid composition of the rat liver. J Lipid Res 1963, 4:151-159.
12. Clandinin M.T., Jumpsen J., Suh M. Relationship between fatty acid accretion, membrane composition, and biologic functions. J Pediatr 1994, 125:S25-S32.
13. Brenna J.T. Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man. Curr Opin Clin Nutr Metab Care 2002, 5:127-132.
14. Burdge G.C., Calder P.C. Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev 2005, 45:581-597.
15. Valenzuela A., Von Bernhardi R., Valenzuela V., Ramirez G., Alarcon R., Sanhueza J., et al. Supplementation of female rats with alpha-linolenic acid or docosahexaenoic acid leads to the same omega-6/omega-3 LC-PUFA accretion in mother tissues and in fetal and newborn brains. Ann Nutr Metab 2004, 48:28-35.
16. Poumes-Ballihaut C., Langelier B., Houlier F., Alessandri J.M., Durand G., Latge C., et al. Comparative bioavailability of dietary alpha-linolenic and docosahexaenoic acids in the growing rat. Lipids 2001, 36:793-800.
17. Bowen R.A., Clandinin M.T. Maternal dietary 22: 6n-3 is more effective than 18:3n-3 in increasing the 22:6n-3 content in phospholipids of glial cells from neonatal rat brain. Br J Nutr 2005, 93:601-611.
18. Lefkowitz W., Lim S.Y., Lin Y., Salem N. Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid, and body stores in the developing rat. Pediatr Res 2005, 57:157-165.
19. Plourde M., Cunnane S.C. Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. Appl Physiol Nutr Metab 2007, 32:619-634.
20. DIRECTIVE 2006/141/CE DE LA COMMISSION, du 22 décembre 2006 concernant les préparations pour nourrissons et les préparations de suite et modifiant la directive 1999/21/CE, Règlement (CE) n° 1243/2008 de la commission du 12 décembre 2008.
21. Alessandri J.M., Goustard B., Guesnet P., Durand G. Polyunsaturated fatty acids status in blood, heart, liver, intestine, retina and brain of newborn piglets fed either sow milk or a milk replacer diet. Reprod Nutr Dev 1996, 36:95-109.
22. Pugo-Gunsam P., Guesnet P., Subratty A.H., Rajcoomar D.A., Maurage C., Couet C. Fatty acid composition of white adipose tissue and breast milk of Mauritian and French mothers and erythrocyte phospholipids of their full-term breast-fed infants. Br J Nutr 1999, 82:263-271.
23. Bennett D.A., Waters M.D. Applying biomarker research. Environ Health Perspect 2000, 108:907-910.
24. Radbill S.X. Infant feeding through the ages. Clin Pediatr (Phila) 1981, 20:613-621.
25. Bach A.C., Babayan V.K. Medium-chain triglycerides: an update. Am J Clin Nutr 1982, 36:950-962.
26. Fomon S Infant feeding in the 20th century: formula and beikost. J Nutr 2001, 131:409S-420S.
27. Stevens E.E., Patrick T.E., Pickler R. A history of infant feeding. J Perinat Educ 2009, 18:32-39.
28. AFSSA. - saisine no 2006-SA-0359 de l'Agence française de sécurité sanitaire des aliments relatif à l'actualisation des apports nutritionnels conseillés pour les acides gras. Mars 2010.
29. Guesnet P., Alessandri J.M. Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) - implications for dietary recommendations. Biochimie 2010.
30. Schwarz E., Prabakaran S., Whitfield P., Major H., Leweke F.M., Koethe D., et al. High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides. J Proteome Res 2008, 7:4266-4277.
31. Lepage G., Roy C.C. Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 1986, 27:114-120.
32. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25:402-408.
33. Ni Y., Su M., Lin J., Wang X., Qiu Y., Zhao A., et al. Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress. FEBS Lett 2008, 582:2627-2636.
34. Wiklund S., Johansson E., Sjostrom L., Mellerowicz E.J., Edlund U., Shockcor J.P., et al. Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models. Anal Chem 2008, 80:115-122.
35. Shannon P., Markiel A., Ozier O., Baliga N.S., Wang J.T., Ramage D., et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 2003, 13:2498-2504.
36. Chavance M. Jackknife and bootstrap. Rev Epidemiol Sante Publique 1992, 40:209-218.
37. Wold S., Kettaneh N., Tjessem K. Hierarchical multiblock PLS and PC models for easier model interpretation and as an alternative to variable selection. J Chemometrics 1996, 10:463-482.
38. Tu W.C., Cook-Johnson R.J., James M.J., Muhlhausler B.S., Gibson R.A. Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression. Prostaglandins Leukot Essent Fatty Acids 2010, 83:61-68.
39. Jones P.J. Dietary linoleic, alpha-linolenic and oleic acids are oxidized at similar rates in rats fed a diet containing these acids in equal proportions. Lipids 1994, 29:491-495.
40. Rolland V., Roseau S., Fromentin G., Nicolaidis S., Tome D., Even P.C. Body weight, body composition, and energy metabolism in lean and obese Zucker rats fed soybean oil or butter. Am J Clin Nutr 2002, 75:21-30.
41. Bendixen H., Flint A., Raben A., Hoy C.E., Mu H., Xu X., et al. Effect of 3 modified fats and a conventional fat on appetite, energy intake, energy expenditure, and substrate oxidation in healthy men. Am J Clin Nutr 2002, 75:47-56.
42. Childs C.E., Romeu-Nadal M., Burdge G.C., Calder P.C. Gender differences in the n-3 fatty acid content of tissues. Proc Nutr Soc 2008, 67:19-27.
43. Kuratko C.N., Salem N. Biomarkers of DHA status. Prostaglandins Leukot Essent Fatty Acids 2009, 81:111-118.
44. Sarkadi-Nagy E., Wijendran V., Diau G.Y., Chao A.C., Hsieh A.T., Turpeinen A., et al. Formula feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm baboon neonates. J Lipid Res 2004, 45:71-80.
45. Ward G.R., Huang Y.S., Bobik E., Xing H.C., Mutsaers L., Auestad N., et al. Long-chain polyunsaturated fatty acid levels in formulae influence deposition of docosahexaenoic acid and arachidonic acid in brain and red blood cells of artificially reared neonatal rats. J Nutr 1998, 128:2473-2487.
46. Blank C., Neumann M.A., Makrides M., Gibson R.A. Optimizing DHA levels in piglets by lowering the linoleic acid to alpha-linolenic acid ratio. J Lipid Res 2002, 43:1537-1543.
47. Stark K.D. The percentage of n-3 highly unsaturated fatty acids in total HUFA as a biomarker for omega-3 fatty acid status in tissues. Lipids 2008, 43:45-53.