Capsiate Inhibits DNFB-Induced Atopic Dermatitis in NC/Nga Mice through Mast Cell and CD4+ T-Cell Inactivation

Journal of Investigative Dermatology

Volumn 135, Issue 8, 2015, Pages 1977-1985

  Lee, Ji H ^a   Lee, Yun S ^a   Lee, Eun Jung ^a   Kim, Tae Yoon ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; ANTIALLERGIC AGENT; CAPSAICIN; CAPSIATE; EOTAXIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN E; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MACROPHAGE DERIVED CHEMOKINE; MITOGEN ACTIVATED PROTEIN KINASE; THYMIC STROMAL LYMPHOPOIETIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; BIOLOGICAL ACTIVITY; BONE MARROW DERIVED MAST CELL; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; IMMUNOGLOBULIN BLOOD LEVEL; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PASSIVE SKIN ANAPHYLAXIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL; TH2 CELL; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; DERMATITIS, ATOPIC; DISEASE MODEL; DRUG EFFECTS; MUTANT MOUSE STRAIN; PATHOLOGY; SKIN;

ANIMALS; CAPSAICIN; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; DERMATITIS, ATOPIC; DINITROFLUOROBENZENE; DISEASE MODELS, ANIMAL; MAP KINASE SIGNALING SYSTEM; MAST CELLS; MICE; MICE, MUTANT STRAINS; PASSIVE CUTANEOUS ANAPHYLAXIS; SKIN;

EID: 84937641586     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2015.117     Document Type: Article

References (36)

1. Amadi-Obi A, Yu C-R, Liu X et al. (2007) TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med 13:711-8
2. Barczyk A, Pierzchala W, Sozanska E (2003) Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med 97:534-7
3. Bullens DM, Truyen E, Coteur L et al. (2006) IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir Res 7:135
4. Chakir J, Shannon J, Molet S et al. (2003) Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol 111:1293-8
5. CRAC. J Pharacolm Exp Ther 299:238-46
6. Frossi B, Rivera J, Hirsch E et al. (2007) Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition. J Immunol 178:2549-55
7. Grewe M, Bruijnzeel-Koomen CA, Schopf E et al. (1998) A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today 19: 359-61
8. Hershey GK, Friedrich MF, Esswein LA et al. (1997) The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N Engl J Med 337:1720-5
9. Hirota K, Yoshitomi H, Hashimoto M et al. (2007) Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med 204:2803-12
10. Homey B, Steinfhff M, Ruzicka T et al. (2006) Cytokines and chemokines orchestrate atopic skin inflammation. J Allergy Clin Immunol 118:178-89
11. Hur S, Lee YS, Yoo H et al. (2010) Homoisoflavanone inhibits UVB-induced skin inflammation through reduced cyclooxygenase-2 expression and NF-kappaB nuclear localization. J Dermatol Sci 59:163-9
12. Jin H, He R, Oyoshi M et al. (2009) Animal models of atopic dermatitis. J Invest Dermatol 129:31-40
13. Kalesnikoff J, Galli SJ (2008) New developments in mast cell biology. Nat Immunol 9:1215-23
14. Kim SY, Sohn EJ, Kim DWet al. (2011) Transduced PEP-1-FK506BP ameliorates atopic dermatitis in NC/Nga mice. J Invest Dermatol 131:1477-85
15. Koga C, Kabashima K, Shiraishi N et al. (2008) Possible pathogenic role of Th17 cells for atopic dermatitis. J Invest Dermatol 128:2625-30
16. Kraft S, Kinet JP (2007) New development in FceRI regulaton, function and inhibition. Nat Rev Immunol 7:365-78
17. Lowes MA, Kikuch T, Fuentes-Duculan J et al. (2008) Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 128:1207-11
18. Lee EJ, Jeon MS, Kim BD et al. (2010) Capsiate inhibits ultraviolet B-induced skin inflammation b inhibiting Src family kinases and epidermal growth factor receptor signaling. Free Radic Biol Med 48:1133-43
19. Lee YS, Amadi-Obi A, Yu C-R et al. (2011) Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10. Immunology 132:492-502
20. Lee YS, Cheon IS, Kim BH et al. (2013) Loss of extracellular superoxide dismutase induces severe IL-23-mediated skin inflammation in mice. J Invest Dermatol 133:1134-44
21. Lee YS, Hur S, Kim TY (2014) Homoisoflavanone prevents mast cell activation and allergic responses by inhibition of Syk signaling pathway. Allergy 69: 453-63
22. Murakami K, Ito MHH, Tsubouchi R et al. (2001) Antioxidant effect of capsaici-noids on the metal-catalyzed lipid peroxidation. Biomed Res 22:15-7
23. Min JK, Han KY, Kim EC et al. (2004) Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res 64:644-51
24. Molet S, Hamid Q, Davoine F et al. (2001) IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol 108:430-8
25. Ngoc LP, Gold DR, Tzianabos AO et al. (2005) Cytokines, allergy and asthma. Curr Opin Allergy Clin Immunol 5:161-6
26. Pyun BJ, Choi S, Lee Y et al. (2008) Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activity. Cancer Res 68:227-35
27. Rivera J (2002) Molecular adapters in FceRI signaling and the allergic response. Curr Opin Immunol 14:688-93
28. Rivera J, Gilfillan AM (2006) Molecular regulation of mast cell activation. J Allergy Clin Immunol 117:1214-25
29. Sancho R, Lucena C, Macho A et al. (2002) Immunosuppressive activity of capsaicinoids: capsiate derived from sweet peppers inhibits NF-KB activation and is a potent anti-inflammatory compound in vivo. Eur J Immunol 32:1753-63
30. Sundelin K, Roberg K, Grenman R et al. (2005) Effects of cytokines on matrix metalloproteinases expression in oral squamous cell carcinoma in vitro. Acta Otolaryngol 125:765-73
31. Theoharides TC, Kempuraj D, Tagen M et al. (2007) Differential release of mast cell mediators and the pathogenesis of inflammation. Immunol Rev 217: 65-78
32. Tomimori Y, Tanaka Y, Goto M et al. (2005) Repeated topical challenge with chemical antigen elicits sustained dermatitis in NC/Nga mice in specific-pathogen-free condition. J Invest Dermatol 124:119-24
33. Tzartos JS, Friese MA, Craner MJ et al. (2008) Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol 172:146-55
34. Van Gerven L, Alpizar YA, Wouters MM et al. (2014) Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor (TRPV1) overexpression in patients with idiopathic rhinitis. J Allergy Clin Immunol 133:1332-9
35. Wong CK, Ho CY, Ko FWS et al. (2001) Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-y, IL-4, IL-10 and IL-13) in patients with allergic asthma. Clin Exp Immunol 125:177-83
36. Yu C-R, Lee YS, Mahdi RM et al. (2012) Therapeutic targeting of STAT3 (Signal Transducers and Activators of Transcription 3) Pathway inhibits experimental autoimmune uveitis. PLoS One 7:e29742