Capsaicin inhibits jurkat T-cell activation by blocking calcium entry current ICRAC

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 1, 2001, Pages 238-246

  Fischer, Bruce S ^a   Qin, Danmei ^a   Kim, Kami ^a   Mcdonald, Thomas V ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM CHANNEL; CAPSAICIN; CAPSAZEPINE; IMMUNOMODULATING AGENT; INTERLEUKIN 2; MUSCARINIC M1 RECEPTOR; POTASSIUM CHANNEL; RESINIFERATOXIN; T LYMPHOCYTE RECEPTOR; THAPSIGARGIN;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG MECHANISM; HUMAN; HUMAN CELL; IC 50; IMMUNOMODULATION; LEUKEMIA CELL LINE; LYMPHOCYTE ACTIVATION; MEMBRANE POTENTIAL; PATCH CLAMP; PRIORITY JOURNAL; T LYMPHOCYTE;

CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CAPSAICIN; HUMANS; INDICATORS AND REAGENTS; INTERLEUKIN-2; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MEMBRANE POTENTIALS; MICROSCOPY, FLUORESCENCE; PATCH-CLAMP TECHNIQUES; T-LYMPHOCYTES;

EID: 0034802334     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Use of mutant Jurkat T cell lines to define human natural killer cell surface receptor signaling pathways
2. Characterization of functional vanilloid receptors expressed by mast cells
3. The vanilloid receptor: A molecular gateway to the pain pathway
4. The capsaicin receptor: A heat-activated ion channel in the pain pathway
5. Capsaicin inhibits phospholipase C-mediated Ca(2+) increase by blocking thapsigargin-sensitive store-operated Ca(2+) entry in PC12 cells
6. Inhibition by SK&F 96365 of Ca2+ current, IL-2 production and activation in T lymphocytes
7. Generic signals and specific outcomes: Signaling through Ca2+, calcineurin, and NF-AT
8. Selective antagonism of capsaicin by capsazepine: Evidence for a spinal receptor site in capsaicin-induced antinociception
9. i oscillations in T lymphocytes
10. Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels
11. Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences
12. Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants
13. Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines
14. A new generation of Ca2+ indicators with greatly improved fluorescence properties
15. Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
16. Molecular identification of the apical Ca2+ channel in 1, 25- dihydroxyvitamin D3-responsive epithelia
17. Depletion of intracellular calcium stores activates a calcium current in mast cells
18. Ion channels, Ca2+ signaling, and reporter gene expression in antigen-specific mouse T cells
19. Human lymphocytes express substance P and its receptor
20. Diverse K+ channels in primary human T lymphocytes
21. Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells
22. A non-pungent resiniferatoxin analogue, phorbol 12-phenylacetate 13 acetate 20-homovanillate, reveals vanilloid receptor subtypes on rat trigeminal ganglion neurons
23. Flash photolysis of caged-inositol 1,4,5-trisphosphate activates plasma membrane calcium current in human T cells
24. Capsaicin effects on non-neuronal plasma membranes
25. Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human
26. Local immune response and bronchial reactivity in rats after capsaicin treatment
27. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption
28. Multiple capsaicin-evoked currents in isolated rat sensory neurons
29. Activation of Ca current following depletion of Ca stores by microsomal Ca-ATPase inhibitors
30. Molecular cloning of an N-terminal splice variant of the capsaicin receptor. Loss of N-terminal domain suggests functional divergence among capsaicin receptor subtypes
31. Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
32. Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper
33. Vanilloid (Capsaicin) receptors and mechanisms
34. T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes
35. Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 1. The aromatic "A-region"
36. CaT1 manifests the pore properties of the calcium-release-activated calcium channel
37. Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores