Repeated topical challenge with chemical antigen elicits sustained dermatitis in NC/Nga mice in specific-pathogen-free condition

Journal of Investigative Dermatology

Volumn 124, Issue 1, 2005, Pages 119-124

  Tomimori, Yoshiaki ^a   Tanaka, Yoshitaka ^a   Goto, Megumi ^a   Fukuda, Yoshiaki ^a  

^a SUNTORY LTD   (Japan)

Author keywords

Atopic dermatitis; Cytokine; Hapten

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4;

ANIMAL CELL; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; GERMFREE ANIMAL; HELPER CELL; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN MANIFESTATION; SKINFOLD THICKNESS;

EID: 11944250162     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23516.x     Document Type: Article

References (23)

1. Akdis CA, Akdis M, Trautmann A, Blaser K: Immune regulation in atopic dermatitis. Curr Opin Immunol 12:641-646, 2000
2. Grewe M, Gyufko K, Schopf E, Krutmann J: Lesional expression of interferon-gamma in atopic eczema. Lancet 343:25-26, 1994
3. Grewe M, Walther S, Gyufko K, Czech W, Schopf E, Krutmann J: Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients. J Invest Dermatol 105:407-410, 1995
4. Habu Y, Seki S, Takayama E, et al: The mechanism of a defective IFN-gamma response to bacterial toxins in an atopic dermatitis model, NC/Nga mice, and the therapeutic effect of IFN-gamma, IL-12, or IL-18 on dermatitis. J Immunol 166:5439-5447, 2001
5. Hamid Q, Naseer T, Minshall EM, Song YL, Boguniewicz M, Leung DY: In vivo expression of IL-12 and IL-13 in atopic dermatitis. J Allergy Clin Immunol 98:225-231, 1996
6. Higa S, Kotani M, Matsumoto M, et al: Administration of anti-interleukin 18 antibody fails to inhibit development of dermatitis in atopic dermatitis-model mice NC/Nga. Br J Dermatol 149:39-45, 2003
7. Kitagaki H, Fujisawa S, Watanabe K, Hayakawa K, Shiohara T: Immediate-type hypersensitivity response followed by a late reaction is induced by repeated epicutaneous application of contact sensitizing agents in mice. J Invest Dermatol 105:749-755, 1995
8. Kitagaki H, Ono N, Hayakawa K, Kitazawa T, Watanabe K, Shiohara T: Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile. J Immunol 159:2484-2491, 1997
9. Konishi H, Tsutsui H, Murakami T, et al: IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions. Proc Natl Acad Sci USA 99:11340-11345, 2002
10. Kuhn R, Rajewsky K, Muller W: Generation and analysis of interleukin-4 deficient mice. Science 254:707-710, 1991
11. Matsuda H, Watanabe N, Geba GP, et al: Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int Immunol 9: 461-466, 1997
12. Matsumoto M, Ra C, Kawamoto K, et al: IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis. J Immunol 162:1056-1063, 1999
13. Nagai H, Matsuo A, Hiyama H, Inagaki N, Kawada K: Immunoglobulin E production in mice by means of contact sensitization with a simple chemical, hapten. J Allergy Clin Immunol 100:339-344, 1997
14. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H: Interleukin-18 regulates both Th1 and Th2 responses. Annu Rev Immunol 19:423-474, 2001
15. Paludan SR: Interleukin-4 and interferon-gamma: The quintessence of a mutual antagonistic relationship. Scand J Immunol 48:459-468, 1998
16. Punnonen J, Aversa G, Cocks BG, et al: Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci USA 90:3730-3734, 1993
17. Tanaka T, Tsutsui H, Yoshimoto T, et al: Interleukin-18 is elevated in the sera from patients with atopic dermatitis and from atopic dermatitis model mice, NC/Nga. Int Arch Allergy Immunol 125:236-240, 2001
18. Tomimori Y, Muto T, Fukami H, et al: Chymase participates in chronic dermatitis by inducing eosinophil infiltration. Lab Invest 82:789-794, 2002
19. Trinchieri G: Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3:133-146, 2003
20. Watanabe N, Tomimori Y, Saito K, Miura K, Wada A, Tsudzuki M, Fukuda Y: Chymase inhibitor improves dermatitis in NC/Nga mice. Int Arch Allergy Immunol 128:229-234, 2002
21. Werfel T, Morita A, Grewe M, Renz H, Wahn U, Krutmann J, Kapp A: Allergen specificity of skin-infiltrating T cells is not restricted to a type-2 cytokine pattern in chronic skin lesions of atopic dermatitis. J Invest Dermatol 107: 871-876, 1996
22. Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, Ihle JN: Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153-157, 1994
23. Yamada N, Wakugawa M, Kuwata S, Yoshida T, Nakagawa H: Chronologic analysis of in situ cytokine expression in mite allergen-induced dermatitis in atopic subjects. J Allergy Clin Immunol 96:1069-1075, 1995