Therapeutic targeting of STAT3 (signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitis

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Yu, Cheng Rong ^a   Lee, Yun Song ^a   Mahdi, Rashid M ^a   Surendran, Narayanan ^b   Egwuagu, Charles E ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b Orchid Research Laboratories Limited   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4BETA7 INTEGRIN; CHEMOKINE RECEPTOR CCR6; CHEMOKINE RECEPTOR CXCR3; INTEGRIN; ORLL NIH001; PROTEIN INHIBITOR; RETINOID RELATED ORPHAN RECEPTOR ALPHA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; RETINOID RELATED ORPHAN RECEPTOR GAMMA T; STAT3 PROTEIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4; ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DOWN REGULATION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; EXPERIMENTAL AUTOIMMUNE UVEITIS; EYE PROTECTION; HUMAN; INFLAMMATORY CELL; LYMPHOCYTE PROLIFERATION; NONHUMAN; NORMAL HUMAN; PROTEIN EXPRESSION; RETINA; SIGNAL TRANSDUCTION; TH17 CELL; UVEITIS; WESTERN BLOTTING; ANIMAL; AUTOIMMUNE DISEASE; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULARLY TARGETED THERAPY; MOUSE; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

ANIMALIA; MUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AUTOIMMUNE DISEASES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR TARGETED THERAPY; RETINA; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TH17 CELLS; UVEITIS;

EID: 84855368621     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029742     Document Type: Article

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