Tissue sensitivity of the rat upper and lower extrapulmonary airways to the inhaled electrophilic air pollutants diacetyl and acrolein

Toxicological Sciences

Volumn 142, Issue 1, 2014, Pages 126-136

  Cichocki, Joseph A ^a   Smith, Gregory J ^a   Morris, John B ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Electrophilic stress; Inhalation toxicology; Physiologically based pharmacokinetic modeling

Indexed keywords

2,3 BUTANEDIONE; ACROLEIN; ANTIOXIDANT; ELECTROPHILE; GLUTATHIONE; MESSENGER RNA; TRANSCRIPTION FACTOR NRF2; AIR POLLUTANT; BIOLOGICAL MARKER;

AIR POLLUTANT; AIRWAY; ANIMAL EXPERIMENT; ARTICLE; BRONCHUS MUCOSA; CELL NUCLEUS; COMPUTATIONAL FLUID DYNAMICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROPHILICITY; MALE; NONHUMAN; PROTEIN LOCALIZATION; RAT; ANIMAL; BIOLOGICAL MODEL; BRONCHUS; CHEMICALLY INDUCED; DOSE RESPONSE; DRUG EFFECTS; EXPOSURE; FISCHER 344 RAT; GENETICS; IMMUNOLOGY; METABOLISM; NOSE CAVITY; PHARMACOKINETICS; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT MUCOSA; TOXICITY; TRACHEA;

ACROLEIN; AIR POLLUTANTS; ANIMALS; BIOLOGICAL MARKERS; BRONCHI; DIACETYL; DOSE-RESPONSE RELATIONSHIP, DRUG; INHALATION EXPOSURE; MALE; MODELS, BIOLOGICAL; NASAL CAVITY; RATS, INBRED F344; RESPIRATORY HYPERSENSITIVITY; RESPIRATORY MUCOSA; RNA, MESSENGER; TRACHEA;

EID: 84937569403     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu165     Document Type: Article

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