A validated hybrid computational fluid dynamics-physiologically based pharmacokinetic model for respiratory tract vapor absorption in the human and rat and its application to inhalation dosimetry of diacetyl

Toxicological Sciences

Volumn 123, Issue 1, 2011, Pages 231-246

  Gloede, Eric ^a   Cichocki, Joseph A ^a   Baldino, Joshua B ^a   Morris, John B ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Diacetyl; Inhalation dosimetry; PBPK model

Indexed keywords

2,3 BUTANEDIONE; ACETONE; ALCOHOL; HALOTHANE;

ABSORPTION; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; DIFFUSION; DOSIMETRY; HUMAN; IN VITRO STUDY; INSPIRED VAPOR DOSIMETRY; MALE; METABOLISM; MODEL; NONHUMAN; PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL; RAT; RESPIRATORY SYSTEM; VAPOR;

ANIMALS; COMPUTER SIMULATION; DIACETYL; DOSE-RESPONSE RELATIONSHIP, DRUG; GASES; HUMANS; INHALATION EXPOSURE; MALE; MODELS, BIOLOGICAL; RATS; RATS, INBRED F344; RESPIRATORY MUCOSA; VOLATILIZATION;

RATTUS;

EID: 80052506015     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr165     Document Type: Article

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