The cholesterol-dependent cytolysin membrane-binding interface discriminates lipid environments of cholesterol to support β-barrel pore insertion

Journal of Biological Chemistry

Volumn 290, Issue 29, 2015, Pages 17733-17744

  Farrand, Allison J ^a   Hotze, Eileen M ^a   Sato, Takehiro K ^b   Wade, Kristin R ^a   Wimley, William C ^c   Johnson, Arthur E ^b   Tweten, Rodney K ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; MOBILE SECURITY;

BINDING AFFINITIES; BINDING MOTIF; BINDING PARAMETER; MEMBRANE BINDING; MEMBRANE CHOLESTEROL; MEMBRANE INTERACTIONS; PORE FORMING;

CHOLESTEROL;

BACTERIAL TOXIN; CYTOLYSIN; PERFRINGOLYSIN O; STREPTOLYSIN O; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CHOLESTEROL; CLOSTRIDIUM PERFRINGENS THETA-TOXIN; CYTOTOXIN; HEMOLYSIN; LIPOSOME; PROTEIN BINDING; STREPTOLYSIN;

ARTICLE; BETA BARREL PORE; BINDING AFFINITY; COMPETITIVE BINDING ASSAY; CONTROLLED STUDY; EUKARYOTIC CELL; MEMBRANE BINDING; MEMBRANE STRUCTURE; MOLECULAR INTERACTION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; BACTERIAL PHENOMENA AND FUNCTIONS; CELL LINE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MICROBIOLOGY; MOUSE; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PHYSIOLOGICAL PHENOMENA; BACTERIAL PROTEINS; BACTERIAL TOXINS; CELL LINE; CELL MEMBRANE; CHOLESTEROL; CYTOTOXINS; HEMOLYSIN PROTEINS; LIPOSOMES; MICE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; STREPTOLYSINS;

EID: 84937469189     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.656769     Document Type: Article

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