Extracellular group A Streptococcus induces keratinocyte apoptosis by dysregulating calcium signalling

Cellular Microbiology

Volumn 7, Issue 7, 2005, Pages 945-955

  Cywes Bentley, Collete ^a,c   Hakansson, Anders ^b,c   Christianson, Jennifer ^a   Wessels, Michael R ^a,b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; HYALURONIC ACID; STREPTOLYSIN O;

APOPTOSIS; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL VIRULENCE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; CYTOSOL; DISEASE SEVERITY; ENDOPLASMIC RETICULUM; HOST CELL; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; KERATINOCYTE; NONHUMAN; OROPHARYNX; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN DEFECT; SKIN EPITHELIUM; STREPTOCOCCUS GROUP A; STREPTOCOCCUS INFECTION; WILD TYPE;

ANTIGENS, CD44; APOPTOSIS; BACTERIAL CAPSULES; BACTERIAL PROTEINS; BORON COMPOUNDS; CALCIUM; CALCIUM SIGNALING; CELL LINE; CYTOPLASM; DNA FRAGMENTATION; ENDOPLASMIC RETICULUM; HUMANS; IN SITU NICK-END LABELING; KERATINOCYTES; MITOCHONDRIA; PERMEABILITY; STREPTOCOCCUS PYOGENES; STREPTOLYSINS; VACUOLES;

STREPTOCOCCUS SP. 'GROUP A';

EID: 21344467496     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2005.00525.x     Document Type: Article

References (13)

1. Andreadis, S.T., Hamoen, K.E., Yarmush, M.L., and Morgan, J.R. (2001) Keratinocyte growth factor induces hyperproliferation and delays differentiation in a skin equivalent model system. FASEB J 15: 898-906.
2. Ashbaugh, C.D., Moser, T.J., Shearer, M.H., White, G.L., Kennedy, R.C., and Wessels, M.R. (2000) Bacterial determinants of persistent throat colonization and the associated immune response in a primate model of human group A streptococcal pharyngeal infection. Cell Microbiol 2: 283-292.
3. Bourguignon, L.Y., Singleton, P.A., and Diedrich, F. (2004) Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation. J Biol Chem 279: 29654-29669.
4. Bricker, A.L., Cywes, C., Ashbaugh, C.D., and Wessels, M.R. (2002) NAD+-glycohydrolase acts as an intracellular toxin to enhance the extracellular survival of group A streptococci. Mol Microbiol 44: 257-269.
5. Crowe, D.L., Hu, L., Gudas, L.J., and Rheinwald, J.G. (1991) Variable expression of retinoic acid receptor (RAR beta) mRNA in human oral and epidermal keratinocytes; relation to keratin 19 expression and keratinization potential. Differentiation 48: 199-208.
6. Cywes, C., and Wessels, M.R. (2001) Group A Streptococcus tissue invasion by CD44-mediated cell signalling. Nature 414: 648-652.
7. Davies, H.D., McGeer, A., Schwartz, B., Green, K., Cann, D., Simor, A.E., and Low, D.E. (1996) Invasive group A streptococcal infections in Ontario, Canada. Ontario group A streptococcal study group N Engl J Med 335: 547-554.
8. Demaurex, N., and Distelhorst, C. (2003) Cell biology. Apoptosis - the calcium connection. Science 300: 65-67.
9. Givner, L.B. (1998) Invasive disease due to group A beta-hemolytic streptococci: continued occurrence in children in North Carolina. South Med J 91: 333-337.
10. Nakagawa, I., Nakata, M., Kawabata, S., and Hamada, S. (2001) Cytochrome c-mediated caspase-9 activation triggers apoptosis in Streptococcus pyogenes-infected epithelial cells. Cell Microbiol 3: 395-405.
11. Nakagawa, I., Nakata, M., Kawabata, S., and Hamada, S. (2004) Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells. Cell Microbiol 6: 939-952.
12. Shimizu, A., and Yamanaka, N. (1993) Apoptosis and cell desquamation in repair process of ischemic tubular necrosis. Virchows Arch B Cell Pathol Incl Mol Pathol 64: 171-180.
13. Tsai, P.J., Lin, Y.S., Kuo, C.F., Lei, H.Y., and Wu, J.J. (1999) Group A Streptococcus induces apoptosis in human epithelial cells. Infect Immun 67: 4334-4339.