Molecular and cellular basis of microvascular perfusion deficits induced by Clostridium perfringens and Clostridium septicum

PLoS Pathogens

Volumn 4, Issue 4, 2008, Pages

  Hickey, Michael J ^a   Kwan, Rain Y Q ^a   Awad, Milena M ^a   Kennedy, Catherine L ^a   Young, Lauren F ^b   Hall, Pam ^a   Cordner, Leanne M ^a   Lyras, Dena ^a   Emmins, John J ^b   Rood, Julian I ^a  

^a MONASH UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CLOSTRIDIUM PERFRINGENS TOXIN; CLOSTRIDIUM TOXIN; PROPIDIUM IODIDE; ALPHA TOXIN, CLOSTRIDIUM PERFRINGENS; BACTERIAL TOXIN; CALCIUM BINDING PROTEIN; CLOSTRIDIUM PERFRINGENS THETA TOXIN; CLOSTRIDIUM PERFRINGENS THETA-TOXIN; HEMOLYSIN; PHOSPHOLIPASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL VIRULENCE; CAPILLARY DENSITY; CELL DAMAGE; CELL DEATH; CLOSTRIDIUM PERFRINGENS; CLOSTRIDIUM SEPTICUM; CONTROLLED STUDY; FUNGUS CULTURE; GENETIC COMPLEMENTATION; IN VIVO STUDY; MALE; MICROCIRCULATION; MICROSCOPY; MOLECULAR DYNAMICS; MOUSE; MUSCLE NECROSIS; NONHUMAN; PATHOGENESIS; STRUCTURAL GENE; SUPERNATANT; TISSUE PERFUSION; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; BLOOD FLOW; DRUG EFFECT; GAS GANGRENE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PATHOLOGY; PATHOPHYSIOLOGY; PERFUSION; PHYSIOLOGY; SKELETAL MUSCLE; VASCULARIZATION;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM PERFRINGENS; CLOSTRIDIUM SEPTICUM;

ANIMALS; BACTERIAL TOXINS; CALCIUM-BINDING PROTEINS; CELL DEATH; CLOSTRIDIUM PERFRINGENS; CLOSTRIDIUM SEPTICUM; GAS GANGRENE; GENE EXPRESSION REGULATION, FUNGAL; HEMOLYSIN PROTEINS; MALE; MICE; MICE, INBRED BALB C; MICROCIRCULATION; MICROSCOPY, VIDEO; MUSCLE, SKELETAL; MUTAGENESIS, INSERTIONAL; PERFUSION; REGIONAL BLOOD FLOW; TYPE C PHOSPHOLIPASES;

EID: 43049083378     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000045     Document Type: Article

References (37)

1. Robb-Smith AHT (1945) Tissue changes induced by Cl. welchii type A filtrates. Lancet. pp 362-368.
2. Flores-Diaz M, Alape-Giron A (2003) Role of Clostridium perfringens phospholipase C in the pathogenesis of gas gangrene. Toxicon 42: 979-986.
3. Ellemor DM, Baird RN, Awad MM, Boyd RL, Rood JI, et al. (1999) Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene. Infect Immun 67: 4902-4907.
4. Awad MM, Bryant AE, Stevens DL, Rood JI (1995) Virulence studies on chromosomal alpha-toxin and theta-toxin mutants constructed by allelic exchange provide genetic evidence for the essential role of alpha-toxin in Clostridium perfringens-mediated gas gangrene. Mol Microbiol 15: 191-202.
5. Awad MM, Ellemor DM, Boyd RL, Emmins JJ, Rood JI (2001) Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene. Infect Immun 69: 7904-7910.
6. Bryant AE, Chen RY, Nagata Y, Wang Y, Lee CH, et al. (2000) Clostridial gas gangrene. I. Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens. J Infect Dis 182: 799-807.
7. Bryant AE, Chen RY, Nagata Y, Wang Y, Lee CH, et al. (2000) Clostridial gas gangrene. II. Phospholipase C-induced activation of platelet gpIIbIIIa mediates vascular occlusion and myonecrosis in Clostridium perfringens gas gangrene. J Infect Dis 182: 808-815.
8. Shimizu T, Ohtani K, Hirakawa H, Ohshima K, Yamashita A, et al. (2002) Complete genome sequence of Clostridium perfringens, an anaerobic flesheater. Proc Natl Acad Sci U S A 99: 996-1001.
9. Rood JI (1998) Virulence genes of Clostridium perfringens. Annu Rev Microbiol 52: 333-360.
10. Titball RW, Rood JI (2000) Bacterial phospholipases. In: Aktories K, Just I, eds (2000) Bacterial protein toxins. Berlin: Springer Verlag. pp 529-556.
11. Rossjohn J, Tweten R, Rood JI, Parker M (1999) Perfringolysin O. In: Alouf J, Freer J, eds (1999) Bacterial toxins: a comprehensive sourcebook. London: Academic Press.
12. Alape-Giron A, Flores-Diaz M, Guillouard I, Naylor CE, Titball RW, et al. (2000) Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene. Eur J Biochem 267: 5191-5197.
13. Bunting M, Lorant DE, Bryant AE, Zimmerman GA, McIntyre TM, et al. (1997) Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells. J Clin Invest 100: 565-574.
14. O'Brien DK, Melville SB (2004) Effects of Clostridium perfringens alpha-toxin (PLC) and perfringolysin O (PFO) on cytotoxicity to macrophages, on escape from the phagosomes of macrophages, and on persistence of C. perfringens in host tissues. Infect Immun 72: 5204-5215.
15. Hatheway CL (1990) Toxigenic clostridia. Clin Microbiol Rev 3: 66-98.
16. Abella BS, Kuchinic P, Hiraoka T, Howes DS (2003) Atraumatic Clostridial myonecrosis: case report and literature review. J Emerg Med 24: 401-405.
17. Kennedy CL, Krejany EO, Young LF, O'Connor JR, Awad MM, et al. (2005) The alpha-toxin of Clostridium septicum is essential for virulence. Mol Microbiol 57: 1357-1366.
18. O'Brien DK, Therit BH, Woodman ME, Melville SB (2007) The role of neutrophils and monocytic cells in controlling the initiation of Clostridium perfringens gas gangrene. FEMS Immunol Med Microbiol 50: 86-93.
19. Kuligowski MP, Kitching AR, Hickey MJ (2006) Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling. J Immunol 176: 6991-6999.
20. Tweten RK (2001) Clostridium perfringens beta toxin and Clostridium septicum alpha toxin: their mechanisms and possible role in pathogenesis. Vet Microbiol 82: 1-9.
21. Stevens DL, Musher DM, Watson DA, Eddy H, Hamill RJ, et al. (1990) Spontaneous, nontraumatic gangrene due to Clostridium septicum. Rev Infect Dis 12: 286-296.
22. Morinaga N, Kato I, Noda M (1994) Differentiation of HL-60 cells is promoted by H-toxin of Clostridium septicum. FEBS Lett 351: 317-320.
23. Rothe B, Roggentin P, Schauer R (1991) The sialidase gene from Clostridium septicum: cloning, sequencing, expression in Escherichia coli and identification of conserved sequences in sialidases and other proteins. Mol Gen Genet 226: 190-197.
24. Swiatek PJ, Allen SD, Siders JA, Lee CH (1987) DNase production by Clostridium septicum. J Clin Microbiol 25: 437-438.
25. Bryant AE, Bayer CR, Hayes-Schroer SM, Stevens DL (2003) Activation of platelet gpIIbIIIa by phospholipase C from Clostridium perfringens involves store-operated calcium entry. J Infect Dis 187: 408-417.
26. Bryant AE, Bayer CR, Aldape MJ, Wallace RJ, Titball RW, et al. (2006) Clostridium perfringens phospholipase C-induced platelet/leukocyte interactions impede neutrophil diapedesis. J Med Microbiol 55: 495-504.
27. Strock PE, Majno G (1969) Microvascular changes in acutely ischemic rat muscle. Surg Gynecol Obstet 129: 1213-1224.
28. Jerome SN, Smith CW, Korthuis RJ (1993) CD18-dependent adherence reactions play an important role in the development of the no-reflow phenomenon. Am J Physiol 264: H479-H483.
29. Jerome SN, Akimitsu T, Korthuis RJ (1994) Leukocyte adhesion, edema, and development of postischemic capillary no-reflow. Am J Physiol 267: H1329-H1336.
30. Williamson ED, Titball RW (1993) A genetically engineered vaccine against the alpha-toxin of Clostridium perfringens protects mice against experimental gas gangrene. Vaccine 11: 1253-1258.
31. Park JM, Ng VH, Maeda S, Rest RF, Karin M (2004) Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med 200: 1647-1655.
32. Huang AJ, Manning JE, Bandak TM, Ratau MC, Hanser KR, et al. (1993) Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells. J Cell Biol 120: 1371-1380.
33. Millan J, Ridley AJ (2005) Rho GTPases and leucocyte-induced endothelial remodelling. Biochem J 385: 329-337.
34. Lyristis M, Bryant AE, Sloan J, Awad MM, Nisbet IT, et al. (1994) Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens. Mol Microbiol 12: 761-777.
35. Norman MU, Lister KJ, Yang YH, Issekutz A, Hickey MJ (2005) TNF regulates leukocyte-endothelial cell interactions and microvascular dysfunction during immune complex-mediated inflammation. Br J Pharmacol 144: 265-274.
36. Brunner J, Krummenauer F, Lehr HA (2000) Quantification of video-taped images in microcirculation research using inexpensive imaging software (Adobe Photoshop). Microcirculation 7: 103-107.
37. Suematsu M, Delano FA, Poole D, Engler RL, Miyasaka M, et al. (1994) Spatial and temporal correlation between leukocyte behavior and cell injury in postischemic rat skeletal muscle microcirculation. Lab Invest 70: 684-695.