Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins

Journal of Biological Chemistry

Volumn 287, Issue 29, 2012, Pages 24534-24543

  Hotze, Eileen M ^a   Wilson Kubalek, Elizabeth ^b   Farrand, Allison J ^a   Bentsen, Lori ^a   Parker, Michael W ^c   Johnson, Arthur E ^d,e   Tweten, Rodney K ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d TEXAS A AND M UNIVERSITY   (United States)

^e TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE-BOUND; MONOMER STRUCTURES; MONOMER-MONOMER INTERACTIONS; POINT MUTATIONS; PORE FORMATION; SELF-ASSEMBLING; STRUCTURAL CHANGE; STRUCTURAL INFORMATION; STRUCTURAL TRANSITIONS;

CHOLESTEROL; OLIGOMERS;

MONOMERS;

CHOLESTEROL; CHOLESTEROL DEPENDENT CYTOLYSIN; CLOSTRIDIUM PERFRINGENS TOXIN; CYTOLYSIN; MONOMER; UNCLASSIFIED DRUG;

ARTICLE; BETA SHEET; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOLYSIS; MEMBRANE BINDING; MOLECULAR INTERACTION; OLIGOMERIC PORE COMPLEX; OLIGOMERIZATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ANALYSIS;

CELLS, CULTURED; CHOLESTEROL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEMOLYSIS; HUMANS; MICROSCOPY, ELECTRON; PERFORIN; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84863799473     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.380139     Document Type: Article

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