Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 29, 2015, Pages 8914-8921

  Rozhok, Andrii I ^a   DeGregori, James ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Children's Hospital Colorado   (United States)

Author keywords

Aging; Cancer; Fitness; Oncogenic mutations; Somatic evolution

Indexed keywords

ARTICLE; CANCER INCIDENCE; CANCER MODEL; CARCINOGENESIS; CELL DIVISION; CELL FATE; CELL RENEWAL; CELL SURVIVAL; ENVIRONMENTAL FACTOR; GENETIC DRIFT; GENETIC SELECTION; HUMAN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REPRODUCTIVE FITNESS; SOMATIC CELL; SOMATIC MUTATION; STEM CELL; ANIMAL; BIOLOGICAL MODEL; EVOLUTION; GENETICS; METABOLISM; MUTATION; NEOPLASM; NONLINEAR SYSTEM; TIME;

MAMMALIA;

ANIMALS; BIOLOGICAL EVOLUTION; GENETIC DRIFT; GENETIC FITNESS; HUMANS; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; NONLINEAR DYNAMICS; SELECTION, GENETIC; STEM CELLS; TIME FACTORS;

EID: 84937457954     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1501713112     Document Type: Article

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