Stochastic modeling indicates that aging and somatic evolution in the hematopoietic system are driven by non-cell-autonomous processes

Aging

Volumn 6, Issue 12, 2014, Pages 1033-1048

  Rozhok, Andrii I ^a   Salstrom, Jennifer L ^a,b   DeGregori, James ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b University of Colorado Denver and Children s Hospital Colorado   (United States)

Author keywords

Carcinogenesis; Driver mutation; Fitness; Hematopoiesis; Leukemogenesis somatic evolution; Microenvironment and adaptation

Indexed keywords

AGING; ANIMAL; BIOLOGICAL MODEL; CANCER STEM CELL; CELL AGING; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; COMPUTER SIMULATION; EVOLUTION; GENETICS; GENOTYPE; HEMATOPOIETIC STEM CELL; HUMAN; METABOLISM; MUTATION; NEOPLASM; PATHOLOGY; PHENOTYPE; SIGNAL TRANSDUCTION; STATISTICS; STEM CELL NICHE;

AGING; ANIMALS; BIOLOGICAL EVOLUTION; CELL AGING; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; COMPUTER SIMULATION; GENOTYPE; HEMATOPOIETIC STEM CELLS; HUMANS; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; NEOPLASTIC STEM CELLS; PHENOTYPE; SIGNAL TRANSDUCTION; STEM CELL NICHE; STOCHASTIC PROCESSES;

EID: 84920889720     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100707     Document Type: Article

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