Evolutionary triage governs fitness in driver and passenger mutations and suggests targeting never mutations

Nature Communications

Volumn 5, Issue , 2014, Pages

  Gatenby, R A ^a   Cunningham, J J ^a   Brown, J S ^b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELL ORGANELLE; FECUNDITY; FITNESS; GENETIC ANALYSIS; GENOTYPE; HETEROGENEITY; MOLECULAR ANALYSIS; MUTATION; NUMERICAL MODEL; PHENOTYPE; TRADE-OFF;

ARTICLE; BLOOD FLOW; CANCER CELL; CANCER THERAPY; CELL DIVISION; FERTILITY; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENETIC VARIABILITY; SURVIVAL; TUMOR MICROENVIRONMENT; TUMOR VOLUME; UPREGULATION; BIOLOGICAL MODEL; COMPUTER SIMULATION; GENETIC EPIGENESIS; GENETICS; HUMAN; MOLECULAR EVOLUTION; MUTATION; NEOPLASM; REPRODUCTIVE FITNESS;

COMPUTER SIMULATION; EPIGENESIS, GENETIC; EVOLUTION, MOLECULAR; GENETIC FITNESS; HUMANS; MODELS, GENETIC; MUTATION; NEOPLASMS;

EID: 84923300669     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6499     Document Type: Article

References (41)

1. Nowell, P. C. The clonal evolution of tumor cell populations. Science 194, 23-28 (1976).
2. Merlo, L. M., Pepper, J. W., Reid, B. J. & Maley, C. C. Cancer as an evolutionary and ecological process. Nat. Rev.. Cancer 812, 924-935 (2006).
3. Greaves, M. & Maley, C. C. Clonal evolution in cancer. Nature 481, 306-313 (2012).
4. Komarova, N. L., Sengupta, A. & Nowak, M. A. Mutation-selection networks in cancer initiation: tumor suppressor genes and chromosomal instability. J. Theor. Biol. 223, 433-450 (2003).
5. Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
6. Bozic, I., Antal, T., Ohtsuki, H., Carter, H. & Kim, D. Accumulation of driver and passenger mutations during tumor progression. Proc. Natl Acad. Sci. USA 107, 18545-18550 (2010).
7. McFarland, C. D., Korolev, K. S., Kryukov, G. V., Sunyaev, S. R. & Mirny, L. A. Impact of deleterious passenger mutations on cancer progression. Proc. Natl Acad. Sci. USA 110, 2910-2915 (2013).
8. Diaz, L. A., Williams, R. T., Wu, J. & Kinde, I. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancer. Nature 486, 537-540 (2012).
9. Crespi, B. & Summers, K. Evolutionary biology of cancer. Trends Ecol. Evol. 20, 545-552 (2005).
10. Gatenby, R. A. & Gillies, R. J. A microenvironmental model of carcinogenesis. Nat. Rev. Cancer 8, 56-61 (2008).
11. Gerlinger, M. & Swanton, C. How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine. Br. J. Cancer 103, 1139-1143 (2010).
12. Wilkinson, L. Systat. Wiley Interdiscip. Rev. Comput. Stat. 2, 256-257 (2010).
13. Zhou, M. et al. Radiologically defined ecological dynamics and clinical outcomes in glioblastoma multiforme: preliminary results. Transl. Oncol. 7, 5-13 (2014).
14. Stratton, M. R., Campbell, P. J. & Futreal, P. A. The cancer genome. Nature 458, 719-724 (2009).
15. Jackson, A. L. & Loeb, L. A. The mutation rate and cancer. Genetics 148, 1483-1490 (1998).
16. Gatenby, R. A., Gillies, R. J. & Brown, J. S. Of cancer and cave fish. Nat. Rev. Cancer 11, 237-238 (2011).
17. Kudchadkar, R. R., Smalley, K. S., Glass, L. F., Trimble, J. S. & Sondak, V. K. Targeted therapy in melanoma. Clin. Dermatol. 31, 200-208 (2013).
18. Maemondo, M. et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. New Engl. J. Med. 362, 2380-2388 (2010).
19. Cunningham, J. J., Gatenby, R. A. & Brown, J. S. Evolutionary dynamics in cancer therapy. Mol. Pharm. 8, 2094-2100 (2011).
20. Weinberg, R. Coming full circle-from endless complexity to simplicity and back again. Cell 157, 267-271 (2014).
21. Gatenby, R. Finding cancer's first principles. Nature 491, 55 (2012).
22. Bellamy, W. T. & Dalton, W. S. Multidrug resistance in the laboratory and clinic. Adv. Clin. Chem. 31, 1-61 (1994).
23. Haldane, J. B. S. A mathematical theory of natural and artificial selection, Part V: selection and mutation. Math. Proc. Cambridge Philos. Soc. 23, 838-844 (1927).
24. Roach, J. C. et al. Analysis of genetic inheritance in a family quartet of wholegenome sequencing. Science 328, 636-639 (2010).
25. Gatenby, R. A. & Frieden, B. R. Application of information theory and extreme physical information to carcinogenesis. Cancer Res. 62, 3675-3684 (2002).
26. Tohsato, Y. et al. Environmental dependency of gene knockouts on phenotype microarray analysis in Escherichia coli. J. Bioinform. Comput. Biol. 1, 83-99 (2010).
27. Joyce, A. R. et al. Experimental and computational assessment of conditionally essential genes in Escherichia coli. J. Bacteriol. 188, 8259-8271 (2006).
28. Salama, A. K. & Kim, K. B. The evolution of melanoma resistance reveals therapeutic opportunities. Cancer Res. 73, 6106-6110 (2013).
29. Wong, D. J. et al. Antitumor activity of the ERK inhibitor SCH722984 against BRAF mutant, NRAS mutant and wild-type melanoma. Mol. Cancer 13, 194-201 (2014).
30. Gatenby, R. A., Brown, J. & Vincent, T. Lessons from applied ecology: cancer control using an evolutionary double bind. Cancer Res. 59, 7499-7502 (2009).
31. Stearns, S. C. Trade-offs in life-history evolution. Funct. Ecol. 3, 259-268 (1989).
32. Atkipis, A., Boddy, A. M., Gatenby, R. A., Brown, J. S. & Maley, C. C. Life history trade-offs in cancer evolution. Nat. Rev. Cancer 13, 883-892 (2013).
33. Mukhopadhvav, A. & Tissenbaum, H. A. Reproduction and longevity: secrets revealed by C. Elegans. Trends Cell Biol. 17, 65-71 (2007).
34. Marden, J. H., Rogina, B., Montooth, K. L. & Helfand, S. L. Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. Proc. Natl Acad. Sci. USA 18, 3369-3373 (2003).
35. Case, T. J. An illustrated guide to theoretical ecology (Oxford Press, 2001).
36. Kandoth, C. et al. Mutational landscape and significance across 12 major cancer types. Nature 502, 333-339 (2013).
37. Yang, L., Han, Y., Suarez Saiz, F. & Minden, M. D. A tumor suppressor and oncogene: the WT1 story. Leukemia 21, 868-876 (2007).
38. Smith, M. J. & Price, G. R. The logic of animal conflict. Nature 246, 15-18 (1973).
39. Pintor, L. M., Brown, J. S. & Vincent, T. L. Evolutionary game theory as a framework for studying biological invasions. Am. Nat. 177, 410-423 (2011).
40. Muller, H. J. Reversibility in evolution considered from the standpoint of genetics. Biol. Rev. 14, 261-280 (1939).
41. Loeb, L. A. A mutator phenotype in cancer. Cancer Res. 61, 3230-3239 (2001).