Evidence that hematopoiesis may be a stochastic process in vivo

Nature Medicine

Volumn 2, Issue 2, 1996, Pages 190-197

  Abkowitz, Janis L ^a   Catlin, Sandra N ^a   Guttorp, Peter ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE 6 PHOSPHATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CAT; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; GENE THERAPY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; NONHUMAN; PRIORITY JOURNAL; STOCHASTIC MODEL;

ANIMALS; BONE MARROW TRANSPLANTATION; CATS; CELL DIFFERENTIATION; CELL DIVISION; COMPUTER SIMULATION; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; MARKOV CHAINS;

ANIMALIA; FELIDAE; FELIS CATUS;

EID: 0030065744     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0296-190     Document Type: Article

References (15)

1. Till, J.E., McCulloch, E.A. & Siminovitch, L. A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells. Proc. Natl. Acad. Sci. USA 51, 29-36 (1964).
2. Ogawa, M., Porter, P.N. & Nakahata, T. Renewal and commitment to differentiation of hematopoietic stem cells (an interpretive review). Blood 61, 823-829 (1983).
3. Gordon, M.Y. & Amos, T.A.S. Stochastic effects in hematopoiesis. Stem Cells 12, 175-179 (1994).
4. Fairbairn, L.J., Cowling, G.J., Reipert, B.M. & Dexter, T.M. Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 74, 823-832 (1993).
5. Jordan, C.T., McKearn, J.P. & Lemischka, I.R. Cellular and developmental properties of fetal hematopoietic stem cells. Cell 61, 952-963 (1990).
6. Jones, R.J., Wagner, J.E., Celano, P., Zicha, M.S. & Sharkis, S.J. Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells. Nature 347, 188-189 (1990).
7. - progenitor cells. Blood 77, 1218-1227 (1991).
8. Keifer, F., Wagner, E.F. & Keller, G. Fractionation of mouse bone marrow by adherence separates primitive hematopoietic stem cells from in vitro colony-forming cells. Blood 78, 2577-2582 (1991).
9. Ogata, H. et al. Separation of hematopoietic stem cells into two populations and their characterization. Blood 80, 91-95 (1992).
10. + cells are the only stem cells in C7SBL/Ka-Thy-1.1 bone marrow. J. Exp. Med. 175, 175-184 (1992).
11. Baum, C.M., Weissman, I.L., Tsukamoto, A.S., Buckle, A.-M. & Peault, B. Isolation of a candidate human hematopoietic stem cell population. Proc. Natl. Acad. Sci. USA 89, 2804-2808 (1992).
12. Spain, L.M. & Mulligan, R.C. Purification and characterization of retrovirally transduced hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 89, 3790-3794 (1992).
13. dull+ hematopoietic progenitor cells in murine bone marrow. Blood 81, 3217-3225 (1993).
14. Wolf, N.S., Kona, A., Priestley, G.V. & Bartalmez, S.H. In vivo and in vitro characterization of long-term repopulating primitive hematopoietic stem cells isolated by sequential Hoechst 33342-rhodamine 123 FACS selections. Exp. Hematol. 21, S14-22 (1993).
15. + hematopoietic stem cells. Blood 83, 3358-3379 (1994).