메뉴 건너뛰기




Volumn 26, Issue 5, 2014, Pages 622-626

Targets and molecular mechanisms of triptolide in cancer therapy

Author keywords

Antineoplastic; Cancer; Neoplasms; Triptolide (TPL TL)

Indexed keywords

CARBOPLATIN; CASPASE; CISPLATIN; DEXAMETHASONE; DNA; FLUOROURACIL; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OXALIPLATIN; TRIPTOLIDE;

EID: 84937440147     PISSN: 10009604     EISSN: 19930631     Source Type: Journal    
DOI: 10.3978/j.issn.1000-9604.2014.09.01     Document Type: Review
Times cited : (77)

References (34)
  • 1
    • 0141576565 scopus 로고    scopus 로고
    • Triptolide inhibits the growth and metastasis of solid tumors
    • Yang S, Chen J, Guo Z, et al. Triptolide inhibits the growth and metastasis of solid tumors. Mol Cancer Ther 2003;2:65-72.
    • (2003) Mol Cancer Ther , vol.2 , pp. 65-72
    • Yang, S.1    Chen, J.2    Guo, Z.3
  • 2
    • 84872824063 scopus 로고    scopus 로고
    • Triptolide induces S phase arrest via the inhibition of cyclin E and CDC25A and triggers apoptosis via caspase- and mitochondrial-dependent signaling pathways in A375.S2 human melanoma cells
    • Hung FM, Chen YL, Huang AC, et al. Triptolide induces S phase arrest via the inhibition of cyclin E and CDC25A and triggers apoptosis via caspase- and mitochondrial-dependent signaling pathways in A375.S2 human melanoma cells. Oncol Rep 2013;29:1053-60.
    • (2013) Oncol Rep , vol.29 , pp. 1053-1060
    • Hung, F.M.1    Chen, Y.L.2    Huang, A.C.3
  • 3
    • 79955831016 scopus 로고    scopus 로고
    • Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors
    • Johnson SM, Wang X, Evers BM. Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors. J Surg Res 2011;168:197-205.
    • (2011) J Surg Res , vol.168 , pp. 197-205
    • Johnson, S.M.1    Wang, X.2    Evers, B.M.3
  • 4
    • 84901579887 scopus 로고    scopus 로고
    • Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas
    • Wu J, Li QQ, Zhou H, et al. Selective tumor cell killing by triptolide in p53 wild-type and p53 mutant ovarian carcinomas. Med Oncol 2014;31:14.
    • (2014) Med Oncol , vol.31
    • Wu, J.1    Li, Q.Q.2    Zhou, H.3
  • 5
    • 84894638878 scopus 로고    scopus 로고
    • Triptolide induces s phase arrest and apoptosis in gallbladder cancer cells
    • Hu YP, Tan ZJ, Wu XS, et al. Triptolide induces s phase arrest and apoptosis in gallbladder cancer cells. Molecules 2014;19:2612-28.
    • (2014) Molecules , vol.19 , pp. 2612-2628
    • Hu, Y.P.1    Tan, Z.J.2    Wu, X.S.3
  • 6
    • 84893857199 scopus 로고    scopus 로고
    • Triptolide induces apoptosis in endometrial cancer via a p53‑independent mitochondrial pathway
    • Wang XF, Zhao YB, Wu Q, et al. Triptolide induces apoptosis in endometrial cancer via a p53‑independent mitochondrial pathway. Mol Med Rep 2014;9:39-44.
    • (2014) Mol Med Rep , vol.9 , pp. 39-44
    • Wang, X.F.1    Zhao, Y.B.2    Wu, Q.3
  • 7
    • 84894419903 scopus 로고    scopus 로고
    • Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1
    • Nakazato T, Sagawa M, Kizaki M. Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1. Int J Oncol 2014;44:1131-8.
    • (2014) Int J Oncol , vol.44 , pp. 1131-1138
    • Nakazato, T.1    Sagawa, M.2    Kizaki, M.3
  • 8
    • 84899489352 scopus 로고    scopus 로고
    • Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1
    • Ding X, Zhang B, Pei Q, et al. Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1. BMC Cancer 2014;14:271.
    • (2014) BMC Cancer , vol.14
    • Ding, X.1    Zhang, B.2    Pei, Q.3
  • 9
    • 84887549941 scopus 로고    scopus 로고
    • Triptolide inhibits the multidrug resistance in prostate cancer cells via the downregulation of MDR1 expression
    • Guo Q, Nan XX, Yang JR, et al. Triptolide inhibits the multidrug resistance in prostate cancer cells via the downregulation of MDR1 expression. Neoplasma 2013;60:598-604.
    • (2013) Neoplasma , vol.60 , pp. 598-604
    • Guo, Q.1    Nan, X.X.2    Yang, J.R.3
  • 10
    • 84875994002 scopus 로고    scopus 로고
    • Role of oxidative stress, endoplasmic reticulum stress and ERK activation in triptolide-induced apoptosis
    • Tan BJ, Chiu GN. Role of oxidative stress, endoplasmic reticulum stress and ERK activation in triptolide-induced apoptosis. Int J Oncol 2013;42:1605-12.
    • (2013) Int J Oncol , vol.42 , pp. 1605-1612
    • Tan, B.J.1    Chiu, G.N.2
  • 11
    • 84865862229 scopus 로고    scopus 로고
    • Triptolide cooperates with Cisplatin to induce apoptosis in gemcitabine-resistant pancreatic cancer
    • Zhu W, Li J, Wu S, et al. Triptolide cooperates with Cisplatin to induce apoptosis in gemcitabine-resistant pancreatic cancer. Pancreas 2012;41:1029-38.
    • (2012) Pancreas , vol.41 , pp. 1029-1038
    • Zhu, W.1    Li, J.2    Wu, S.3
  • 12
    • 33646900838 scopus 로고    scopus 로고
    • Triptolide, an inhibitor of the human heat shockresponse that enhances stress-induced cell death
    • Erratum in: J Biol Chem 2006;281:21575
    • Westerheide SD, Kawahara TL, Orton K, et al. Triptolide, an inhibitor of the human heat shockresponse that enhances stress-induced cell death. J Biol Chem 2006;281:9616-22. Erratum in: J Biol Chem 2006;281:21575.
    • (2006) J Biol Chem , vol.281 , pp. 9616-9622
    • Westerheide, S.D.1    Kawahara, T.L.2    Orton, K.3
  • 13
    • 84888367596 scopus 로고    scopus 로고
    • Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1
    • Banerjee S, Sangwan V, McGinn O, et al. Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1. J Biol Chem 2013;288:33927-38.
    • (2013) J Biol Chem , vol.288 , pp. 33927-33938
    • Banerjee, S.1    Sangwan, V.2    McGinn, O.3
  • 14
    • 84882431139 scopus 로고    scopus 로고
    • Triptolide induces apoptosis of PMA-treated THP-1 cells through activation of caspases, inhibition of NF-κB and activation of MAPKs
    • Park SW, Kim YI. Triptolide induces apoptosis of PMA-treated THP-1 cells through activation of caspases, inhibition of NF-κB and activation of MAPKs. Int J Oncol 2013;43:1169-75.
    • (2013) Int J Oncol , vol.43 , pp. 1169-1175
    • Park, S.W.1    Kim, Y.I.2
  • 15
    • 84905157730 scopus 로고    scopus 로고
    • NF-κB signaling inhibition and anticancer activities of LLDT-246 on human colorectal cancer HCT-116 cells in vitro
    • Li M, Wang X, Liu M, et al. NF-κB signaling inhibition and anticancer activities of LLDT-246 on human colorectal cancer HCT-116 cells in vitro. Biomed Pharmacother 2014;68:527-35.
    • (2014) Biomed Pharmacother , vol.68 , pp. 527-535
    • Li, M.1    Wang, X.2    Liu, M.3
  • 16
    • 84872825262 scopus 로고    scopus 로고
    • Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κB
    • Ou CC, Chen YW, Hsu SC, et al. Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κB. Evid Based Complement Alternat Med 2012;2012:350239.
    • (2012) Evid Based Complement Alternat Med , vol.2012
    • Ou, C.C.1    Chen, Y.W.2    Hsu, S.C.3
  • 17
    • 84881582988 scopus 로고    scopus 로고
    • Triptolide avoids cisplatin resistance and induces apoptosis via the reactive oxygen species/nuclear factor-κB pathway in SKOV3PT platinum-resistant human ovarian cancer cells
    • Zhong YY, Chen HP, Tan BZ, et al. Triptolide avoids cisplatin resistance and induces apoptosis via the reactive oxygen species/nuclear factor-κB pathway in SKOV3PT platinum-resistant human ovarian cancer cells. Oncol Lett 2013;6:1084-92.
    • (2013) Oncol Lett , vol.6 , pp. 1084-1092
    • Zhong, Y.Y.1    Chen, H.P.2    Tan, B.Z.3
  • 18
    • 70449339746 scopus 로고    scopus 로고
    • Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-kappaB-related mechanism
    • Zhu W, Hu H, Qiu P, et al. Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-kappaB-related mechanism. Oncol Rep 2009;22:1397-401.
    • (2009) Oncol Rep , vol.22 , pp. 1397-1401
    • Zhu, W.1    Hu, H.2    Qiu, P.3
  • 19
    • 31444445458 scopus 로고    scopus 로고
    • A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery
    • Keogh MC, Kim JA, Downey M, et al. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 2006;439:497-501.
    • (2006) Nature , vol.439 , pp. 497-501
    • Keogh, M.C.1    Kim, J.A.2    Downey, M.3
  • 20
    • 84872777084 scopus 로고    scopus 로고
    • Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes
    • Chueh FS, Chen YL, Hsu SC, et al. Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes. Oncol Rep 2013;29:613-8.
    • (2013) Oncol Rep , vol.29 , pp. 613-618
    • Chueh, F.S.1    Chen, Y.L.2    Hsu, S.C.3
  • 21
    • 84884405576 scopus 로고    scopus 로고
    • Triptolide induces lysosomal-mediated programmed cell death in MCF-7 breast cancer cells
    • Owa C, Messina ME Jr, Halaby R. Triptolide induces lysosomal-mediated programmed cell death in MCF-7 breast cancer cells. Int J Womens Health 2013;5:557-69.
    • (2013) Int J Womens Health , vol.5 , pp. 557-569
    • Owa, C.1    Messina, M.E.2    Halaby, R.3
  • 22
    • 73449089468 scopus 로고    scopus 로고
    • Triptolide functions as a potent angiogenesis inhibitor
    • He MF, Huang YH, Wu LW, et al. Triptolide functions as a potent angiogenesis inhibitor. Int J Cancer 2010;126:266-78.
    • (2010) Int J Cancer , vol.126 , pp. 266-278
    • He, M.F.1    Huang, Y.H.2    Wu, L.W.3
  • 23
    • 84879670401 scopus 로고    scopus 로고
    • Triptolide induces apoptosis and inhibits the growth and angiogenesis of human pancreatic cancer cells by downregulating COX-2 and VEGF
    • Ma JX, Sun YL, Wang YQ, et al. Triptolide induces apoptosis and inhibits the growth and angiogenesis of human pancreatic cancer cells by downregulating COX-2 and VEGF. Oncol Res 2013;20:359-68.
    • (2013) Oncol Res , vol.20 , pp. 359-368
    • Ma, J.X.1    Sun, Y.L.2    Wang, Y.Q.3
  • 24
    • 84906717933 scopus 로고    scopus 로고
    • Triptolide sensitizes liver cancer cell lines to chemotherapy in vitro and in vivo
    • Li Y, Hu S. Triptolide sensitizes liver cancer cell lines to chemotherapy in vitro and in vivo. Panminerva Med 2014;56:211-20.
    • (2014) Panminerva Med , vol.56 , pp. 211-220
    • Li, Y.1    Hu, S.2
  • 25
    • 37349127480 scopus 로고    scopus 로고
    • Role of triptolide as an adjunct chemotherapy for ovarian cancer
    • Westfall SD, Nilsson EE, Skinner MK. Role of triptolide as an adjunct chemotherapy for ovarian cancer. Chemotherapy 2008;54:67-76.
    • (2008) Chemotherapy , vol.54 , pp. 67-76
    • Westfall, S.D.1    Nilsson, E.E.2    Skinner, M.K.3
  • 26
    • 84904251521 scopus 로고    scopus 로고
    • Sorafenib and triptolide as combination therapy for hepatocellular carcinoma
    • Alsaied OA, Sangwan V, Banerjee S, et al. Sorafenib and triptolide as combination therapy for hepatocellular carcinoma. Surgery 2014;156:270-9.
    • (2014) Surgery , vol.156 , pp. 270-279
    • Alsaied, O.A.1    Sangwan, V.2    Banerjee, S.3
  • 27
    • 84903278893 scopus 로고    scopus 로고
    • Triptolide synergistically enhances antitumor activity of oxaliplatin in colon carcinoma in vitro and in vivo
    • Liu Y, Xiao E, Yuan L, et al. Triptolide synergistically enhances antitumor activity of oxaliplatin in colon carcinoma in vitro and in vivo. DNA Cell Biol 2014;33:418-25.
    • (2014) DNA Cell Biol , vol.33 , pp. 418-425
    • Liu, Y.1    Xiao, E.2    Yuan, L.3
  • 28
    • 84897843737 scopus 로고    scopus 로고
    • Triptolide synergistically enhances temozolomide-induced apoptosis and potentiates inhibition of NF-κB signaling in glioma initiating cells
    • Sai K, Li WY, Chen YS, et al. Triptolide synergistically enhances temozolomide-induced apoptosis and potentiates inhibition of NF-κB signaling in glioma initiating cells. Am J Chin Med 2014;42:485-503.
    • (2014) Am J Chin Med , vol.42 , pp. 485-503
    • Sai, K.1    Li, W.Y.2    Chen, Y.S.3
  • 29
    • 84861416979 scopus 로고    scopus 로고
    • Triptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs
    • Huang X, Yang M, Jin J. Triptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs. Leuk Lymphoma 2012;53:1188-95.
    • (2012) Leuk Lymphoma , vol.53 , pp. 1188-1195
    • Huang, X.1    Yang, M.2    Jin, J.3
  • 30
    • 84891798669 scopus 로고    scopus 로고
    • Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors
    • Liu Y, Chen F, Wang S, et al. Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors. Cell Death Dis 2013;4:e948.
    • (2013) Cell Death Dis , vol.4
    • Liu, Y.1    Chen, F.2    Wang, S.3
  • 31
    • 84880349109 scopus 로고    scopus 로고
    • Enhanced anti-tumor efficacy of aspirin combined with triptolide in cervical cancer cells
    • Chen RH, Tian YJ. Enhanced anti-tumor efficacy of aspirin combined with triptolide in cervical cancer cells. Asian Pac J Cancer Prev 2013;14:3041-4.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 3041-3044
    • Chen, R.H.1    Tian, Y.J.2
  • 32
    • 34548061783 scopus 로고    scopus 로고
    • Enhanced antitumor effect of combined triptolide and ionizing radiation
    • Wang W, Yang S, Su Y, et al. Enhanced antitumor effect of combined triptolide and ionizing radiation. Clin Cancer Res 2007;13:4891-9.
    • (2007) Clin Cancer Res , vol.13 , pp. 4891-4899
    • Wang, W.1    Yang, S.2    Su, Y.3
  • 33
    • 84896067383 scopus 로고    scopus 로고
    • Enhanced anti-tumor activity of triptolide in combination with irradiation for the treatment of oral cancer
    • Chen YW, Lin GJ, Hueng DY, et al. Enhanced anti-tumor activity of triptolide in combination with irradiation for the treatment of oral cancer. Planta Med 2014;80:255-61.
    • (2014) Planta Med , vol.80 , pp. 255-261
    • Chen, Y.W.1    Lin, G.J.2    Hueng, D.Y.3
  • 34
    • 67049110419 scopus 로고    scopus 로고
    • Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours
    • Kitzen JJ, de Jonge MJ, Lamers CH, et al. Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours. Eur J Cancer 2009;45:1764-72.
    • (2009) Eur J Cancer , vol.45 , pp. 1764-1772
    • Kitzen, J.J.1    De Jonge, M.J.2    Lamers, C.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.