Triptolide sensitizes liver cancer cell lines to chemotherapy in vitro and in vivo

Panminerva Medica

Volumn 56, Issue 3, 2014, Pages 211-220

  Li, Y ^a   Hu, S ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Apoptosis; Cisplatin; Liver neoplasms; Triptolide

Indexed keywords

ALKYLATING AGENT; BAX PROTEIN, HUMAN; CASPASE 3; DITERPENE; EPOXIDE; FLUOROURACIL; HERBACEOUS AGENT; PHENANTHRENE DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; TRIPTOLIDE;

ANIMAL; APOPTOSIS; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG POTENTIATION; FEMALE; FLOW CYTOMETRY; HEPG2 CELL LINE; HUMAN; LIVER NEOPLASMS; METABOLISM; MOUSE; NUDE MOUSE; OXIDATIVE STRESS; TRIPTERYGIUM; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUGS, CHINESE HERBAL; EPOXY COMPOUNDS; FEMALE; FLOW CYTOMETRY; FLUOROURACIL; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MICE; MICE, NUDE; OXIDATIVE STRESS; PHENANTHRENES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; TRIPTERYGIUM;

EID: 84906717933     PISSN: 00310808     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Sangiovanni A, Del Ninno E, Fasani P, De Fazio C, Ronchi G Romeo R et al. Increased survival of cirrhotic patients with a Hepatocellular carcinoma detected during surveillance. Gastroenterology 2004;126:1005-14.
2. Tang YH, Wen TF, Chen X. Resection margin in hepatectomy for hepatocellular carcinoma: a systematic review. Hepatogastroenterology 2012;59:1393-7.
3. Kluger MD, Cherqui D. Laparoscopic resection of hepatocellular carcinoma. Cancer Res 2013;190:111-26.
4. Brouquet A, Andreou A, Shindoh J, Vauthey JN. Methods to improve resectability of hepatocellular carcinoma. Cancer Res 2013;190:57-67.
5. Geier A, Schadde E, Miillhaupt B. Current therapeutic strategies for hepatocellular carcinoma. MMW Fortschr Med 2012;154:63-7.
6. Limtrakul P. Curcumin as chemosensitizer. Adv Exp Med Biol 2007;595:269-300.
7. Han R, Rostami-Yazdi M, Gerdes S, Mrowietz U. Triptolide in the treatment of psoriasis and other immune-mediated inflammatory diseases. Br J Clin Pharmacol 2012;74:424-36.
8. Grzegorzewska AE, Frankiewicz D, Breborowicz D, Matlawska I, Bylka W. Disseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritis. Med Sci Monit2012;18:CS67-71.
9. Ma J, Dey M, Yang H, lev A, Pouleva R, Dorn R et al. Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii. Phytochemistry 2007;68:1172-8.
10. Cui Y, Brosnan JA, Blackford AL, Sur S, Hruban RH, Kinzier KW et al. Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity. Clin Cancer Res 2012;18:6519-30.
11. Yang S, Chen J, Guo Z, Xu XM, Wang L, Pei XF et al. Triptolide inhibits the growth and metastasis of solid tumors. Mol Cancer Ther 2003;2:65-72.
12. Kiviharju TM, Lecane PS, Sellers RG, Peehl DM. Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells. Clin Cancer Res 2002;8:2666-74.
13. Phillips PA, Dudeja V, McCarroll JA, Borja-Cacho D, Dawra RK, Grizzle WE et al. Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70. Cancer Res 2007;67:9407-16.
14. Zhou GX, Ding XL, Huang JF, Zhang H, Wu SB, Cheng JP et al. Apoptosis of human pancreatic cancer cells induced by Triptolide. World J Gastroenterol 2008;14:1504-9.
15. Carter BZ, Mak DH, Schober WD, McQueen T, Harris D, Estrov Z et al. Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells. Blood 2006;108:630-7.
16. Park B, Sung B, Yadav VR, Chaturvedi MM, Aggarwal BB Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway. Biochem Pharmacol 2011;82:1134-44.
17. Li CJ, Chu CY, Huang LH, Wang MH, Sheu LF, Yeh JI et al. Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo. Cancer Lett 2012;319:203-13.
18. Lee KY, Park JS, Jee YK, Rosen GD. Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation. Exp Mol Med 2002;34:462-8.
19. Chang WT, Kang JJ, Lee KY, Wei K, Anderson E, Gotmare S et al. Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway. J Biol Chem 2001;276:2221-7.
20. Carter BZ, Mak DH, Schober WD, Dietrich MF, Pinilla C, Vassilev LT et al. Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. Blood 2008;111:3742-50.
21. Xu B, Guo X, Mathew S, Armesilla AL, Armesilla AL, Cassidy J, Darling JL et al. Triptolide simultaneously induces reactive oxygen species, inhibits NF-κB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines. Cancer Letters 2010;28:200-8.
22. Yang M, Huang J, Pan HZ, Jin J. Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-κB pathways in human multiple myeloma cells. Int J Mol Med 2008;22:489-96.
23. Wang W, Yang S, Su Y, Xiao Z, Xiao Z, Wang C, Li X et al. Enhanced antitumor effect of combined triptolide and ionizing radiation. Clin Cancer Res 2007;13:4891-9.
24. Pigneux A, Mahon FX, Uhalde M, Jeanneteau M, eteau M, Lacombe F, Milpied N et al. Triptolide cooperates with chemotherapy to induce apoptosis in acute myeloid leukemia cells. Exp Hematol 2008;36:1648-59.
25. Tan BJ, Tan BH, Chiu GN. Effect of triptolide on focal adhesion kinase and survival in MCF-7 breast cancer cells. Lee KY, Oncol Rep 2011;26:1315-21.
26. Messina ME Jr, Halaby R. Does triptolide induce lysosomal-mediated apoptosis in human breast cancer cells? Med Hypotheses 2011;77:91-3.
27. Hennig R, Ventura J, Segersvard R, Ward E, Ding XZ, Rao SM et al. LY293111 improves efficacy of gemcitabine therapy on pancreatic cancer in a fluorescent orthotopic model in athymic mice. Neoplasia 2005;7:417-25.
28. Brunelle JK, Letai A. Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci 2009;122:437-41.
29. Chen YW, Lin GJ, Chia WT, Lin CK, Chuang YP, Sytwu HK. Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo. Oral Oncol 2009;45:562-8.
30. Antonoff MB, Chugh R, Borja-Cacho D, Dudeja V, Clawson KA, Skube SJ et al. Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo. Surgery 2009;146:282-90.
31. Wang X, Matta R, Shen G, Nelin LD, Pei D, Liu Y. Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide. J Mol Med 2006;84:405-15.
32. Wang H, Ao M, Wu J, Yu L. TNFα and Fas/FasL pathways are involved in 9-Methoxycamptothecin-induced apoptosis in cancer cells with oxidative stress and G(2)/M cell cycle arrest. Food Chem Toxicol 2013;55:396-410.
33. Xu B, Guo X, Mathew S, Armesilla AL, Cassidy J, Darling JL et al. Triptolide simultaneously induces reactive oxygen species, inhibits NF-κB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines. Cancer Lett 2010;291:200-8.