Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1

International Journal of Oncology

Volumn 44, Issue 4, 2014, Pages 1131-1138

  Nakazato, Tomonori ^a,b   Sagawa, Morihiko ^b,c   Kizaki, Masahiro ^c  

^a YOKOHAMA MUNICIPAL CITIZEN'S HOSPITAL   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Cell death; Mcl 1; Myeloma cells; Transcription; Triptolide

Indexed keywords

ALKYLATING AGENT; CASPASE 3; CASPASE 9; CYTOCHROME C; DIABLO PROTEIN, HUMAN; DITERPENE; EPOXIDE; MCL1 PROTEIN, HUMAN; MITOCHONDRIAL PROTEIN; MYELOID LEUKEMIA FACTOR 1; PHENANTHRENE DERIVATIVE; SIGNAL PEPTIDE; TRIPTOLIDE;

APOPTOSIS; BIOSYNTHESIS; CELL PROLIFERATION; CHINESE MEDICINE; DRUG EFFECTS; G1 PHASE CELL CYCLE CHECKPOINT; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MULTIPLE MYELOMA; SECRETION (PROCESS); TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, ALKYLATING; APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DITERPENES; EPOXY COMPOUNDS; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEDICINE, CHINESE TRADITIONAL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MULTIPLE MYELOMA; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PHENANTHRENES; TRANSCRIPTION, GENETIC;

EID: 84894419903     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2280     Document Type: Article

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