NF-κB signaling inhibition and anticancer activities of LLDT-246 on human colorectal cancer HCT-116 cells in vitro

Biomedicine and Pharmacotherapy

Volumn 68, Issue 5, 2014, Pages 527-535

  Li, Meng ^a   Wang, Xiu'e ^a   Liu, Ming ^a   Qi, Xin ^a   Li, Jing ^a  

^a Laboratory for Marine Science and Technology   (China)

Author keywords

Derivative; NF B; Tripotolide; Tripterygium wilfordii Hook F

Indexed keywords

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK PROTEIN 70; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LLDT 246; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TRIPTOLIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; DITERPENE; EPOXIDE; I KAPPA B; LLDT-246; NF-KAPPAB INHIBITOR ALPHA; PHENANTHRENE DERIVATIVE; PROTEIN P53; STAT3 PROTEIN; TRANSCRIPTION FACTOR RELA; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CHEMOLUMINESCENCE; COLORECTAL CANCER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HCT116 CELL LINE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; APOPTOSIS; CELL NUCLEUS; CELL SURVIVAL; CHEMISTRY; COLORECTAL TUMOR; DOWN REGULATION; DRUG EFFECTS; DRUG POTENTIATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; IC50; METABOLISM; MITOCHONDRION; MOUSE; PATHOLOGY; PHOSPHORYLATION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL NUCLEUS; CELL SURVIVAL; COLORECTAL NEOPLASMS; DITERPENES; DOWN-REGULATION; DRUG SYNERGISM; EPOXY COMPOUNDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; I-KAPPA B PROTEINS; INHIBITORY CONCENTRATION 50; MICE; MITOCHONDRIA; NEOPLASM PROTEINS; NF-KAPPA B; PHENANTHRENES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84905157730     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2014.05.002     Document Type: Article

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