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Volumn 33, Issue 4, 2015, Pages 508-514

Pathophysiology and a Rational Basis of Therapy

Author keywords

Chronic liver disease; Hepatic vascular resistance; Portal hypertension

Indexed keywords

ANGIOTENSIN II; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; ENDOTHELIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEUKOTRIENE; MONTELUKAST; NITRIC OXIDE; NORADRENALIN; OBETICHOLIC ACID; PROPRANOLOL; RESVERATROL; SIMVASTATIN; SOMATOSTATIN DERIVATIVE; SORAFENIB; TERUTROBAN; THROMBOXANE A2; VASOPRESSIN; VASOPRESSIN DERIVATIVE; ANGIOGENESIS INHIBITOR;

EID: 84937418322     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000374099     Document Type: Article
Times cited : (15)

References (63)
  • 3
    • 33644553509 scopus 로고    scopus 로고
    • The hyperdynamic circulation of chronic liver diseases: From the patient to the molecule
    • Iwakiri Y, Groszmann RJ: The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule. Hepatology 2006; 43:S121-S131.
    • (2006) Hepatology , vol.43 , pp. S121-S131
    • Iwakiri, Y.1    Groszmann, R.J.2
  • 4
    • 84863981483 scopus 로고    scopus 로고
    • Functional aspects on the pathophysiology of portal hypertension in cirrhosis
    • Garcia-Pagan JC, Gracia-Sancho J, Bosch J: Functional aspects on the pathophysiology of portal hypertension in cirrhosis. J Hepatol 2012; 57: 458-461.
    • (2012) J Hepatol , vol.57 , pp. 458-461
    • Garcia-Pagan, J.C.1    Gracia-Sancho, J.2    Bosch, J.3
  • 5
    • 84881558364 scopus 로고    scopus 로고
    • Beyond scoring: A modern interpretation of disease progression in chronic liver disease
    • Rosselli M, MacNaughtan J, Jalan R, Pinzani M: Beyond scoring: a modern interpretation of disease progression in chronic liver disease. Gut 2013; 62: 1234-1241.
    • (2013) Gut , vol.62 , pp. 1234-1241
    • Rosselli, M.1    Macnaughtan, J.2    Jalan, R.3    Pinzani, M.4
  • 6
    • 0036096420 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Diagnosis and treatment
    • Befeler AS, Di Bisceglie AM: Hepatocellular carcinoma: diagnosis and treatment. Gastroenterology 2002; 122: 1609-1619.
    • (2002) Gastroenterology , vol.122 , pp. 1609-1619
    • Befeler, A.S.1    Di Bisceglie, A.M.2
  • 8
    • 0021816284 scopus 로고
    • Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators
    • Bhathal PS, Grossmann HJ: Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators. J Hepatol 1985; 1: 325-329.
    • (1985) J Hepatol , vol.1 , pp. 325-329
    • Bhathal, P.S.1    Grossmann, H.J.2
  • 9
    • 35948931882 scopus 로고    scopus 로고
    • Hepatic microvasculature in liver injury
    • DeLeve LD: Hepatic microvasculature in liver injury. Semin Liver Dis 2007; 27: 390-400.
    • (2007) Semin Liver Dis , vol.27 , pp. 390-400
    • Deleve, L.D.1
  • 10
    • 0033450924 scopus 로고    scopus 로고
    • Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis
    • Pinzani M, Gentilini P: Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis. Semin Liver Dis 1999; 19: 397-410.
    • (1999) Semin Liver Dis , vol.19 , pp. 397-410
    • Pinzani, M.1    Gentilini, P.2
  • 11
    • 62749148283 scopus 로고    scopus 로고
    • Hepatic sinusoidal cells in health and disease: Update from the 14th International Symposium
    • Smedsrod B, Le Couteur D, Ikejima K, Jaeschke H, Kawada N, Naito M, et al: Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium. Liver Int 2009; 29: 490-501.
    • (2009) Liver Int , vol.29 , pp. 490-501
    • Smedsrod, B.1    Le Couteur, D.2    Ikejima, K.3    Jaeschke, H.4    Kawada, N.5    Naito, M.6
  • 12
    • 34447102726 scopus 로고    scopus 로고
    • Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers
    • Gracia-Sancho J, Lavina B, Rodriguez-Vilarrupla A, Garcia-Caldero H, Bosch J, Garcia-Pagan JC: Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers. J Hepatol 2007; 47: 220-227.
    • (2007) J Hepatol , vol.47 , pp. 220-227
    • Gracia-Sancho, J.1    Lavina, B.2    Rodriguez-Vilarrupla, A.3    Garcia-Caldero, H.4    Bosch, J.5    Garcia-Pagan, J.C.6
  • 13
    • 34347397134 scopus 로고    scopus 로고
    • Kupffer cell activation in normal and fibrotic livers increases portal pressure via thromboxane A 2
    • Steib CJ, Gerbes AL, Bystron M, op den Winkel M, Hartl J, Roggel F, et al: Kupffer cell activation in normal and fibrotic livers increases portal pressure via thromboxane A 2. J Hepatol 2007; 47: 228-238.
    • (2007) J Hepatol , vol.47 , pp. 228-238
    • Steib, C.J.1    Gerbes, A.L.2    Bystron, M.3    Winkel, M.4    Hartl, J.5    Roggel, F.6
  • 14
    • 0029011135 scopus 로고
    • Hepatic stellate (ITO) cells-Expanding roles for a liver-specific pericyte
    • Pinzani M: Hepatic stellate (ITO) cells-expanding roles for a liver-specific pericyte. J Hepatol 1995; 22: 700-706.
    • (1995) J Hepatol , vol.22 , pp. 700-706
    • Pinzani, M.1
  • 15
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis-From bench to bedside
    • Friedman SL: Liver fibrosis-from bench to bedside. J Hepatol 2003; 38(suppl 1):S38-S53.
    • (2003) J Hepatol , vol.38 , pp. S38-S53
    • Friedman, S.L.1
  • 16
    • 51349168307 scopus 로고    scopus 로고
    • Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence
    • DeLeve LD, Wang X, Guo Y: Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology 2008; 48: 920-930.
    • (2008) Hepatology , vol.48 , pp. 920-930
    • Deleve, L.D.1    Wang, X.2    Guo, Y.3
  • 17
    • 33845642594 scopus 로고    scopus 로고
    • Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells
    • Nieto N: Oxidative-stress and IL-6 mediate the fibrogenic effects of [corrected] Kupffer cells on stellate cells. Hepatology 2006; 44: 1487-1501.
    • (2006) Hepatology , vol.44 , pp. 1487-1501
    • Nieto, N.1
  • 18
    • 0029891589 scopus 로고    scopus 로고
    • Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: Implications for regulation of portal pressure and resistance
    • Rockey DC, Weisiger RA: Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance. Hepatology 1996; 24: 233-240.
    • (1996) Hepatology , vol.24 , pp. 233-240
    • Rockey, D.C.1    Weisiger, R.A.2
  • 19
    • 0018915843 scopus 로고
    • Hepatic hemodynamics and the renin-angiotensin-aldosterone system in cirrhosis
    • Bosch J, Arroyo V, Betriu A, Mas A, Carrilho F, Rivera F, et al: Hepatic hemodynamics and the renin-angiotensin-aldosterone system in cirrhosis. Gastroenterology 1980; 78: 92-99.
    • (1980) Gastroenterology , vol.78 , pp. 92-99
    • Bosch, J.1    Arroyo, V.2    Betriu, A.3    Mas, A.4    Carrilho, F.5    Rivera, F.6
  • 21
    • 0037221217 scopus 로고    scopus 로고
    • Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers
    • Graupera M, Garcia-Pagan JC, Abraldes JG, Peralta C, Bragulat M, Corominola H, et al: Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers. Hepatology 2003; 37: 172-181.
    • (2003) Hepatology , vol.37 , pp. 172-181
    • Graupera, M.1    Garcia-Pagan, J.C.2    Abraldes, J.G.3    Peralta, C.4    Bragulat, M.5    Corominola, H.6
  • 22
    • 42249111199 scopus 로고    scopus 로고
    • Increased oxidative stress in cirrhotic rat livers: A potential mechanism contributing to reduced nitric oxide bioavailability
    • Gracia-Sancho J, Lavina B, Rodriguez-Vilarupla A, Garcia-Caldero H, Fernandez M, Bosch J, et al: Increased oxidative stress in cirrhotic rat livers: a potential mechanism contributing to reduced nitric oxide bioavailability. Hepatology 2008; 47: 1248-1256.
    • (2008) Hepatology , vol.47 , pp. 1248-1256
    • Gracia-Sancho, J.1    Lavina, B.2    Rodriguez-Vilarupla, A.3    Garcia-Caldero, H.4    Fernandez, M.5    Bosch, J.6
  • 26
    • 79952538496 scopus 로고    scopus 로고
    • Endothelial expression of transcription factor Kruppel-like factor 2. And its vasoprotective target genes in the normal and cirrhotic rat liver
    • Gracia-Sancho J, Russo L, Garcia-Caldero H, Garcia-Pagan JC, Garcia-Cardena G, Bosch J: Endothelial expression of transcription factor Kruppel-like factor 2. And its vasoprotective target genes in the normal and cirrhotic rat liver. Gut 2011; 60: 517-524.
    • (2011) Gut , vol.60 , pp. 517-524
    • Gracia-Sancho, J.1    Russo, L.2    Garcia-Caldero, H.3    Garcia-Pagan, J.C.4    Garcia-Cardena, G.5    Bosch, J.6
  • 27
    • 0032738990 scopus 로고    scopus 로고
    • Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat
    • Shah V, Toruner M, Haddad F, Cadelina G, Papapetropoulos A, Choo K, et al: Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology 1999; 117: 1222-1228.
    • (1999) Gastroenterology , vol.117 , pp. 1222-1228
    • Shah, V.1    Toruner, M.2    Haddad, F.3    Cadelina, G.4    Papapetropoulos, A.5    Choo, K.6
  • 28
    • 0032883956 scopus 로고    scopus 로고
    • Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension
    • Shah V, Wiest R, Garcia-Cardena G, Cadelina G, Groszmann RJ, Sessa WC: Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension. Am J Physiol 1999; 277:G463-G468.
    • (1999) Am J Physiol , vol.277 , pp. G463-G468
    • Shah, V.1    Wiest, R.2    Garcia-Cardena, G.3    Cadelina, G.4    Groszmann, R.J.5    Sessa, W.C.6
  • 30
    • 32944479991 scopus 로고    scopus 로고
    • A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis
    • Laleman W, Omasta A, van de Casteele M, Zeegers M, Vander E, I, Van LL, et al: A role for asymmetric dimethylarginine in the pathophysiology of portal hypertension in rats with biliary cirrhosis. Hepatology 2005; 42: 1382-1390.
    • (2005) Hepatology , vol.42 , pp. 1382-1390
    • Laleman, W.1    Omasta, A.2    Van De Casteele, M.3    Zeegers, M.4    Vander, E.I.5    Van, L.L.6
  • 31
    • 33745941120 scopus 로고    scopus 로고
    • The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis
    • Matei V, Rodriguez-Vilarrupla A, Deulofeu R, Colomer D, Fernandez M, Bosch J, et al: The eNOS cofactor tetrahydrobiopterin improves endothelial dysfunction in livers of rats with CCl4 cirrhosis. Hepatology 2006; 44: 44-52.
    • (2006) Hepatology , vol.44 , pp. 44-52
    • Matei, V.1    Rodriguez-Vilarrupla, A.2    Deulofeu, R.3    Colomer, D.4    Fernandez, M.5    Bosch, J.6
  • 32
    • 24744444714 scopus 로고    scopus 로고
    • A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension
    • Liu SL, Premont RT, Kontos CD, Zhu SK, Rockey DC: A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat Med 2005; 11: 952-958.
    • (2005) Nat Med , vol.11 , pp. 952-958
    • Liu, S.L.1    Premont, R.T.2    Kontos, C.D.3    Zhu, S.K.4    Rockey, D.C.5
  • 35
    • 0027938229 scopus 로고
    • Hyperdynamic circulation of liver disease 40. Years later: Pathophysiology and clinical consequences
    • Groszmann RJ: Hyperdynamic circulation of liver disease 40. Years later: pathophysiology and clinical consequences. Hepatology 1994; 20: 1359-1363.
    • (1994) Hepatology , vol.20 , pp. 1359-1363
    • Groszmann, R.J.1
  • 36
    • 0032938259 scopus 로고    scopus 로고
    • NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats
    • Wiest R, Shah V, Sessa WC, Groszmann RJ: NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. Am J Physiol 1999; 276:G1043-G1051.
    • (1999) Am J Physiol , vol.276 , pp. G1043-G1051
    • Wiest, R.1    Shah, V.2    Sessa, W.C.3    Groszmann, R.J.4
  • 38
    • 33644870801 scopus 로고    scopus 로고
    • Defective RhoA/ Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats
    • Hennenberg M, Biecker E, Trebicka J, Jochem K, Zhou Q, Schmidt M, et al: Defective RhoA/ Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats. Gastroenterology 2006; 130: 838-854.
    • (2006) Gastroenterology , vol.130 , pp. 838-854
    • Hennenberg, M.1    Biecker, E.2    Trebicka, J.3    Jochem, K.4    Zhou, Q.5    Schmidt, M.6
  • 39
    • 20444367984 scopus 로고    scopus 로고
    • Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats
    • Fernandez M, Mejias M, Angermayr B, Garcia-Pagan JC, Rodes J, Bosch J: Inhibition of VEGF receptor-2 decreases the development of hyperdynamic splanchnic circulation and portal-systemic collateral vessels in portal hypertensive rats. J Hepatol 2005; 43: 98-103.
    • (2005) J Hepatol , vol.43 , pp. 98-103
    • Fernandez, M.1    Mejias, M.2    Angermayr, B.3    Garcia-Pagan, J.C.4    Rodes, J.5    Bosch, J.6
  • 40
    • 36348935694 scopus 로고    scopus 로고
    • Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats
    • Fernandez M, Mejias M, Garcia-Pras E, Mendez R, Garcia-Pagan JC, Bosch J: Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats. Hepatology 2007; 46: 1208-1217.
    • (2007) Hepatology , vol.46 , pp. 1208-1217
    • Fernandez, M.1    Mejias, M.2    Garcia-Pras, E.3    Mendez, R.4    Garcia-Pagan, J.C.5    Bosch, J.6
  • 41
    • 65449130742 scopus 로고    scopus 로고
    • Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats
    • Mejias M, Garcia-Pras E, Tiani C, Miquel R, Bosch J, Fernandez M: Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats. Hepatology 2009; 49: 1245-1256.
    • (2009) Hepatology , vol.49 , pp. 1245-1256
    • Mejias, M.1    Garcia-Pras, E.2    Tiani, C.3    Miquel, R.4    Bosch, J.5    Fernandez, M.6
  • 42
    • 84876286546 scopus 로고    scopus 로고
    • Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats
    • Di Pascoli M, Divi M, Rodriguez-Vilarrupla A, Rosado E, Gracia-Sancho J, Vilaseca M, et al: Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. J Hepatol 2013; 58: 904-910.
    • (2013) J Hepatol , vol.58 , pp. 904-910
    • Di Pascoli, M.1    Divi, M.2    Rodriguez-Vilarrupla, A.3    Rosado, E.4    Gracia-Sancho, J.5    Vilaseca, M.6
  • 43
    • 84872385637 scopus 로고    scopus 로고
    • Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats
    • Guillaume M, Rodriguez-Vilarrupla A, Gracia-Sancho J, Rosado E, Mancini A, Bosch J, et al: Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats. J Hepatol 2013; 58: 240-246.
    • (2013) J Hepatol , vol.58 , pp. 240-246
    • Guillaume, M.1    Rodriguez-Vilarrupla, A.2    Gracia-Sancho, J.3    Rosado, E.4    Mancini, A.5    Bosch, J.6
  • 44
    • 84893901321 scopus 로고    scopus 로고
    • Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis
    • Hsu SJ, Wang SS, Hsin IF, Lee FY, Huang HC, Huo TI, et al: Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis. Clin Sci (Lond) 2014; 126: 633-644.
    • (2014) Clin Sci (Lond , vol.126 , pp. 633-644
    • Hsu, S.J.1    Wang, S.S.2    Hsin, I.F.3    Lee, F.Y.4    Huang, H.C.5    Huo, T.I.6
  • 45
    • 77956268976 scopus 로고    scopus 로고
    • Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells
    • Trebicka J, Hennenberg M, Odenthal M, Shir K, Klein S, Granzow M, et al: Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells. J Hepatol 2010; 53: 702-712.
    • (2010) J Hepatol , vol.53 , pp. 702-712
    • Trebicka, J.1    Hennenberg, M.2    Odenthal, M.3    Shir, K.4    Klein, S.5    Granzow, M.6
  • 46
    • 84941281919 scopus 로고    scopus 로고
    • KLF2 exerts anti-fibrotic and vasoprotective effects in cirrhotic rat livers: Behind the molecular mechanisms of statins
    • in press
    • Marrone G, Maeso-Diaz R, Garcia-Cardena G, Garcia-Pagan JC, Bosch J, Gracia-Sancho J: KLF2 exerts anti-fibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins. Gut 2014; in press: doi: 10.1136/gutjnl-2014-308338.
    • (2014) Gut
    • Marrone, G.1    Maeso-Diaz, R.2    Garcia-Cardena, G.3    Garcia-Pagan, J.C.4    Bosch, J.5    Gracia-Sancho, J.6
  • 47
    • 84871211218 scopus 로고    scopus 로고
    • The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins
    • Marrone G, Russo L, Rosado E, Hide D, Garcia-Cardena G, Garcia-Pagan JC, et al: The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins. J Hepatol 2013; 58: 98-103.
    • (2013) J Hepatol , vol.58 , pp. 98-103
    • Marrone, G.1    Russo, L.2    Rosado, E.3    Hide, D.4    Garcia-Cardena, G.5    Garcia-Pagan, J.C.6
  • 48
    • 84901605121 scopus 로고    scopus 로고
    • Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats
    • Verbeke L, Farre R, Trebicka J, Komuta M, Roskams T, Klein S, et al: Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats. Hepatology 2014; 59: 2286-2298.
    • (2014) Hepatology , vol.59 , pp. 2286-2298
    • Verbeke, L.1    Farre, R.2    Trebicka, J.3    Komuta, M.4    Roskams, T.5    Klein, S.6
  • 49
    • 77952732092 scopus 로고    scopus 로고
    • Treatment with the leukotriene inhibitor montelukast for 10. Days attenuates portal hypertension in rat liver cirrhosis
    • Steib CJ, Bilzer M, op den Winkel M, Pfeiler S, Hartmann AC, Hennenberg M, et al: Treatment with the leukotriene inhibitor montelukast for 10. Days attenuates portal hypertension in rat liver cirrhosis. Hepatology 2010; 51: 2086-2096.
    • (2010) Hepatology , vol.51 , pp. 2086-2096
    • Steib, C.J.1    Bilzer, M.2    Winkel, M.3    Pfeiler, S.4    Hartmann, A.C.5    Hennenberg, M.6
  • 50
    • 84869222173 scopus 로고    scopus 로고
    • HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects
    • Klein S, van Beuge MM, Granzow M, Beljaars L, Schierwagen R, Kilic S, et al: HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects. J Hepatol 2012; 57: 1220-1227.
    • (2012) J Hepatol , vol.57 , pp. 1220-1227
    • Klein, S.1    Van Beuge, M.M.2    Granzow, M.3    Beljaars, L.4    Schierwagen, R.5    Kilic, S.6
  • 51
    • 0034829351 scopus 로고    scopus 로고
    • Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo
    • Williams EJ, Benyon RC, Trim N, Hadwin R, Grove BH, Arthur MJ, et al: Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 2001; 49: 577-583.
    • (2001) Gut , vol.49 , pp. 577-583
    • Williams, E.J.1    Benyon, R.C.2    Trim, N.3    Hadwin, R.4    Grove, B.H.5    Arthur, M.J.6
  • 52
    • 33645240442 scopus 로고    scopus 로고
    • Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension
    • Hernandez-Guerra M, Garcia-Pagan JC, Turnes J, Bellot P, Deulofeu R, Abraldes JG, et al: Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension. Hepatology 2006; 43: 485-491.
    • (2006) Hepatology , vol.43 , pp. 485-491
    • Hernandez-Guerra, M.1    Garcia-Pagan, J.C.2    Turnes, J.3    Bellot, P.4    Deulofeu, R.5    Abraldes, J.G.6
  • 53
    • 83255164277 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin e in cirrhotic rats
    • Yang YY, Lee TY, Huang YT, Chan CC, Yeh YC, Lee FY, et al: Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin E in cirrhotic rats. Liver Int 2012; 32: 48-57.
    • (2012) Liver Int , vol.32 , pp. 48-57
    • Yang, Y.Y.1    Lee, T.Y.2    Huang, Y.T.3    Chan, C.C.4    Yeh, Y.C.5    Lee, F.Y.6
  • 54
    • 84865324219 scopus 로고    scopus 로고
    • Postprandial effects of dark chocolate on portal hypertension in patients with cirrhosis: Results of a phase 2, double-blind, randomized controlled trial
    • De Gottardi A, Berzigotti A, Seijo S, D'Amico M, Thormann W, Abraldes JG, et al: Postprandial effects of dark chocolate on portal hypertension in patients with cirrhosis: results of a phase 2, double-blind, randomized controlled trial. Am J Clin Nutr 2012; 96: 584-590.
    • (2012) Am J Clin Nutr , vol.96 , pp. 584-590
    • De Gottardi, A.1    Berzigotti, A.2    Seijo, S.3    D'amico, M.4    Thormann, W.5    Abraldes, J.G.6
  • 56
    • 34547469050 scopus 로고    scopus 로고
    • Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
    • Trebicka J, Hennenberg M, Laleman W, Shelest N, Biecker E, Schepke M, et al: Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. Hepatology 2007; 46: 242-253.
    • (2007) Hepatology , vol.46 , pp. 242-253
    • Trebicka, J.1    Hennenberg, M.2    Laleman, W.3    Shelest, N.4    Biecker, E.5    Schepke, M.6
  • 57
    • 65349094504 scopus 로고    scopus 로고
    • Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: A randomized controlled trial
    • Abraldes JG, Albillos A, Banares R, Turnes J, Gonzalez R, Garcia-Pagan JC, et al: Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial. Gastroenterology 2009; 136: 1651-1658.
    • (2009) Gastroenterology , vol.136 , pp. 1651-1658
    • Abraldes, J.G.1    Albillos, A.2    Banares, R.3    Turnes, J.4    Gonzalez, R.5    Garcia-Pagan, J.C.6
  • 58
    • 84930475918 scopus 로고    scopus 로고
    • Addition of simvastatin to standard treatment improves survival after variceal bleeding in patients with cirrhosis: A double-blind randomized trial (NCT01095185
    • Abraldes JG, Villanueva C, Aracil C, Turnes J, Hernandez-Guerra M, Genesca J, et al: Addition of simvastatin to standard treatment improves survival after variceal bleeding in patients with cirrhosis: a double-blind randomized trial (NCT01095185). J Hepatol 2014; 60:S525.
    • (2014) J Hepatol , vol.60 , pp. S525
    • Abraldes, J.G.1    Villanueva, C.2    Aracil, C.3    Turnes, J.4    Hernandez-Guerra, M.5    Genesca, J.6
  • 59
    • 77955853856 scopus 로고    scopus 로고
    • Hepatic endothelial dysfunction and abnormal angiogenesis: New targets in the treatment of portal hypertension
    • Bosch J, Abraldes JG, Fernandez M, Garcia-Pagan JC: Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension. J Hepatol 2010; 53: 558-567.
    • (2010) J Hepatol , vol.53 , pp. 558-567
    • Bosch, J.1    Abraldes, J.G.2    Fernandez, M.3    Garcia-Pagan, J.C.4
  • 60
    • 85027908473 scopus 로고    scopus 로고
    • Antiangiogenic and antifibrogenic activity of pigment epitheliumderived factor (PEDF) in bile duct-ligated portal hypertensive rats
    • Epub ahead of print
    • Mejias M, Coch L, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, et al: Antiangiogenic and antifibrogenic activity of pigment epitheliumderived factor (PEDF) in bile duct-ligated portal hypertensive rats. Gut 2014, Epub ahead of print.
    • (2014) Gut
    • Mejias, M.1    Coch, L.2    Berzigotti, A.3    Garcia-Pras, E.4    Gallego, J.5    Bosch, J.6
  • 61
    • 84898987733 scopus 로고    scopus 로고
    • Vascular endothelial growth factor promotes fibrosis resolution and repair in mice
    • Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, et al: Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology 2014; 146: 1339-1350.
    • (2014) Gastroenterology , vol.146 , pp. 1339-1350
    • Yang, L.1    Kwon, J.2    Popov, Y.3    Gajdos, G.B.4    Ordog, T.5    Brekken, R.A.6
  • 62
    • 84904724134 scopus 로고    scopus 로고
    • Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats
    • Coch L, Mejias M, Berzigotti A, Garcia-Pras E, Gallego J, Bosch J, et al: Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats. Hepatology 2014; 60: 633-647.
    • (2014) Hepatology , vol.60 , pp. 633-647
    • Coch, L.1    Mejias, M.2    Berzigotti, A.3    Garcia-Pras, E.4    Gallego, J.5    Bosch, J.6


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