Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2- yl)-4-([1,2,4triazolo[1,5-apyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 20, 2011, Pages 6049-6053

  Jin, Cheng Hua ^a   Krishnaiah, Maddeboina ^a   Sreenu, Domalapally ^a   Subrahmanyam, Vura Bala ^a   Rao, Kota Sudhakar ^a   Mohan, Annaji Venkata Nagendra ^a   Park, Chul Yong ^a   Son, Jee Yeon ^a   Sheen, Yhun Yhong ^a   Kim, Dae Kee ^a  

^a Ewha Womans University   (South Korea)

Author keywords

ALK5 inhibitor; Cancer; Cell based luciferase reporter assay; Fibrosis; Kinase assay; TGF

Indexed keywords

3 (6 METHYLPYRIDIN 2 YL) 4 ([1,2,4]TRIAZOLO[1,5 A]PYRIDIN 6 YL)PYRAZOLE DERIVATIVE; 4 ([1,2,4]TRIAZOLO[1,5 A]PYRIDIN 6 YL) N (4 METHOXYPHENYL) 3 (6 METHYLPYRIDIN 2 YL) 1H PYRAZOLE 1 CARBOTHIOAMIDE; PHOSPHOTRANSFERASE INHIBITOR; PYRAZOLE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; IC 50; REACTION ANALYSIS;

ANIMALS; CELL LINE; HUMANS; INSECTS; LUCIFERASES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRAZOLES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT FUSION PROTEINS;

EID: 80052927702     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.064     Document Type: Article

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