Design and synthesis of new potent anticancer pyrazoles with high FLT3 kinase inhibitory selectivity

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 11, 2010, Pages 3961-3973

  El Deeb, Ibrahim Mustafa ^a,b   Lee, So Ha ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

Author keywords

Anticancer; FLT3; Pyrazoles; Receptor tyrosine kinase

Indexed keywords

2 [3 (3 HYDROXY 5 METHYLPHENYL) 4 (2 PHENYLPYRIDIN 4 YL) 1H PYRAZOL 1 YL]ACETONITRILE; 2 [3 (3 HYDROXY 5 METHYLPHENYL) 4 [2 (4 PHENOXYPHENYL)PYRIDIN 4 YL] 1H PYRAZOL 1 YL]ACETONITRILE; 2 [3 (3 METHOXY 5 METHYLPHENYL) 4 [2 (4 PHENOXYPHENYL)PYRIDIN 4 YL] 1H PYRAZOL 1 YL]ACETONITRILE; 2 [4 [2 (4 ACETYLPHENYL)PYRIDIN 4 YL] 3 [3 METHOXY 5 METHYLPHENYL] 1H PYRAZOL 1 YL]ACETONITRILE; 2 [4 [2 (4 ACETYLPHENYL)PYRIDIN 4 YL] 5 (3 METHOXY-5-METHYLPHENYL) 1H PYRAZOL 1 YL]ACETONITRILE; 2 [4 [2 4 (DIMETHYLAMINO)PHENYL]PYRIDIN 4 YL] 3 (3 METHOXY 5 METHYLPHENYL) 1H PYRAZOL 1 YL]ACETONITRILE; 2 [4 [2 [4 (DIMETHYLAMINO)PHENYL]PYRIDIN 4 YL] 3 (3 HYDROXY 5 METHYLPHENYL) 1H PYRAZOL 1 YL]ACETONITRILE; 2 [4 [2 [4 (DIMETHYLAMINO)PHENYL]PYRIDIN 4 YL] 5 (3 METHOXY 5 METHYLPHENYL) 1H PYRAZOL 1 YL)ACETONITRILE; 2 [4 [6 (3 ACETYLPHENYL)PYRIDIN 3 YL] 3 (3 METHOXY 5 METHYLPHENYL) 1H PYRAZOL 1 YL]ACETONITRILE; 4 [4 [1 (CYANOMETHYL) 3 (3 HYDROXY 5 METHYLPHENYL) 1H PYRAZOL 4 YL]PYRIDIN 2 YL]BENZONITRILE; 4 [4 [1 (CYANOMETHYL) 3 (3 METHOXY 5 METHYLPHENYL) 1H PYRAZOL 4 YL]PYRIDIN 2 YL]BENZONITRILE; ANTINEOPLASTIC AGENT; CD135 ANTIGEN; N [3 [4 [1 (CYANOMETHYL) 3 (3 METHOXY 5 METHYLPHENYL) 1H PYRAZOL 4 YL]PYRIDIN 2 YL]PHENYL]ACETAMIDE; N [3 [4 [1 (CYANOMETHYL) 5 (3 METHOXY 5 METHYLPHENYL) 1H PYRAZOL 4 YL]PYRIDIN 2 YL]PHENYL]ACETAMIDE; PHOSPHOTRANSFERASE INHIBITOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; PROTEIN KINASE INHIBITORS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77953128237     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.04.029     Document Type: Article

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