Alantolactone from Saussurea lappa Exerts Antiinflammatory Effects by Inhibiting Chemokine Production and STAT1 Phosphorylation in TNF-α and IFN-γ-induced in HaCaT cells

Phytotherapy Research

Volumn 29, Issue 7, 2015, Pages 1088-1096

  Lim, Hye Sun ^a,b   Jin, Sung Eun ^a   Kim, Ohn Soon ^a   Shin, Hyeun Kyoo ^a   Jeong, Soo Jin ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b Korea National Institute of Health   (South Korea)

Author keywords

alantolactone; chemokines; keratinocytes; Saussurea lappa; STAT1

Indexed keywords

ALANTOLACTONE; CARYOPHYLLENE; CHEMOKINE; COSTIC ACID; COSTUNOLIDE; DEHYDROCOSTUSLACTONE; GAMMA INTERFERON; INTERLEUKIN 8; RANTES; SAUSSUREA LAPPA EXTRACT; STAT1 PROTEIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; DEHYDROCOSTUS LACTONE; LACTONE; MACROPHAGE DERIVED CHEMOKINE; PLANT EXTRACT; SESQUITERPENE; STAT1 PROTEIN, HUMAN; STAT5 PROTEIN; STAT5A PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ALLERGIC REACTION; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DERMATITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HERB; HUMAN; HUMAN CELL; IMMUNOBLOTTING; KERATINOCYTE; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAUSSUREA; SAUSSUREA LAPPA; CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION;

SAUSSUREA LAPPA;

ANTI-INFLAMMATORY AGENTS; CELL LINE; CHEMOKINE CCL17; CHEMOKINE CCL22; CHEMOKINE CCL5; CHEMOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-8; KERATINOCYTES; LACTONES; PHOSPHORYLATION; PLANT EXTRACTS; SAUSSUREA; SESQUITERPENES; SESQUITERPENES, EUDESMANE; STAT1 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEINS;

EID: 84936863883     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5354     Document Type: Article

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