Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 292, Issue 6, 2007, Pages

  Torella, Daniele ^a,b   Curcio, Antonio ^a   Gasparri, Cosimo ^a   Galuppo, Valentina ^a   De Serio, Daniela ^a   Surace, Francesca C ^a   Cavaliere, Anna Lucia ^a   Leone, Angelo ^a   Coppola, Carmela ^c   Ellison, Georgina M ^b   Indolfi, Ciro ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

Drug eluting stents; Signal transduction; Smooth muscle cells

Indexed keywords

FLUDARABINE; STAT1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY INJURY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ELUTING STENT; IN VITRO STUDY; IN VIVO STUDY; IN-STENT RESTENOSIS; MALE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

ANGIOPLASTY, BALLOON; ANIMALS; AORTA; CARDIOVASCULAR AGENTS; CAROTID ARTERY INJURIES; CAROTID STENOSIS; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEASIBILITY STUDIES; HYPERPLASIA; JANUS KINASE 2; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHOSPHORYLATION; PROSTHESIS DESIGN; RABBITS; RATS; RATS, WISTAR; RNA, ANTISENSE; STAT1 TRANSCRIPTION FACTOR; STENTS; TIME FACTORS; TRANSFECTION; TUNICA INTIMA; VIDARABINE;

EID: 34447502104     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00887.2006     Document Type: Article

References (32)

1. Alp NJ, West NE, Arnold N, Gunn J, Banning AP, Channon KM. Increased intimal hyperplasia in experimental vein graft stenting compared with arterial stenting: comparisons in a new rabbit model of stent injury. Cardiovasc Res 56: 164-172, 2002.
2. Curcio A, Torella D, Cuda G, Coppola C, Faniello MC, Achille F, Russo VG, Chiariello M, Indolfi C. Effect of stent coating alone on in vitro vascular smooth muscle cell proliferation and apoptosis. Am J Physiol Heart Circ Physiol 286: H902-H908, 2004.
3. Frank DA, Mahajan S, Ritz J. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat Med 5: 444-447, 1999.
4. Friedberg JW, Dong DA, Li S, Kim H, Stephans K, Noonan K, Neuberg D, Gribben JG, Fisher DC, Freedman AS, Takvorian T, Jurgens R, Battle TE, Frank DA. Oral fludarabine has significant activity in patients with previously untreated chronic lymphocytic leukemia, and leads to increased STAT1 levels in vivo. Leuk Res 28: 139-147, 2004.
5. Ganesh SK, Nabel EG. Genomics of in-stent restenosis: early insights into a complex disease. Circulation 112: 2378-2379, 2005.
6. Holmes DR Jr, Teirstein P, Satler L, Sketch M, O'Malley J, Popma JJ, Kuntz RE, Fitzgerald PJ, Wang H, Caramanica E, Cohen SA, SISR Investigators. Sirolimus-eluting stents vs vascular brachytherapy for in-stent restenosis within bare-metal stents: the SISR randomized trial. JAMA 295: 1264-1273, 2006.
7. Ihle JN. STATs: signal transducers and activators of transcription. Cell 84: 331-334, 1996.
8. Indolfi C, Avvedimento EV, Rapacciuolo A, Di Lorenzo E, Esposito G, Stabile E, Feliciello A, Mele E, Giuliano P, Condorelli G, Chiariello M. Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo. Nat Med 1: 541-545, 1995.
9. Indolfi C, Avvedimento EV, Di Lorenzo E, Esposito G, Rapacciuolo A, Giuliano P, Grieco D, Cavuto L, Stingone AM, Ciullo I, Condorelli G, Chiariello M. Activation of cAMP-PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury. Nat Med 3: 775-779, 1997.
10. Indolfi C, Coppola C, Torella D, Arcucci O, Chiariello M. Gene therapy for restenosis after balloon angioplasty and stenting. Cardiol Rev 7: 324-331, 1999.
11. Indolfi C, Esposito G, Stabile E, Cavuto L, Pisani A, Coppola C, Torella D, Perrino C, Di Lorenzo E, Curcio A, Palombini L, Chiariello M. A new rat model of small vessel stenting. Basic Res Cardiol 95: 179-185, 2000.
12. Indolfi C, Stabile E, Coppola C, Gallo A, Perrino C, Allevato G, Cavuto L, Torella D, Di Lorenzo E, Troncone G, Feliciello A, Avvedimento E, Chiariello M. Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals. Circ Res 88: 319-324, 2001.
13. Indolfi C, Torella D, Cavuto L, Davalli AM, Coppola C, Esposito G, Carriero MV, Rapacciuolo A, Di Lorenzo E, Stabile E, Perrino C, Chieffo A, Pardo F, Chiariello M. Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats. Circulation 103: 2980-2986, 2001.
14. Indolfi C, Torella D, Coppola C, Stabile E, Esposito G, Curcio A, Pisani A, Cavuto L, Arcucci O, Cireddu M, Troncone G, Chiariello M. Rat carotid artery dilation by PTCA balloon catheter induces neointima formation in presence of IEL rupture. Am J Physiol Heart Circ Physiol 283: H760-H767, 2002.
15. Indolfi C, Torella D, Coppola C, Curcio A, Rodriguez F, Bilancio A, Leccia A, Arcucci O, Falco M, Leosco D, Chiariello M. Physical training increases eNOS vascular expression and activity and reduces restenosis after balloon angioplasty or arterial stenting in rats. Circ Res 91: 1190-1197, 2002.
16. Indolfi C, Mongiardo A, Curcio A, Torella D. Molecular mechanisms of in-stent restenosis and approach to therapy with eluting stents. Trends Cardiovasc Med 13: 142-148, 2003.
17. Indolfi C, Pavia M, Angelillo I. Drug eluting stents vs. bare metal stents in percutaneous coronary interventions: a meta-analysis. Am J Cardiol 95: 1146-1152, 2005.
18. Joner M, Finn AV, Farb A, Mont EK, Kolodgie FD, Ladich E, Kutys R, Skorija K, Gold HK, Virmani R. Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk. J Am Coll Cardiol 48: 193-202, 2006.
19. Marrero MB, Schieffer B, Li B, Sun J, Harp JB, Ling BN. Role of Janus kinase/signal transducer and activator of transcription and mitogenactivated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation. J Biol Chem 272: 24684-24690, 1997.
20. Orlandi A, Marcellini M, Pesce D, Calvani M, Spagnoli LG. Propionyl-L-carnitine reduces intimal hyperplasia after injury in normocholesterolemic rabbit carotid artery by modulating proliferation and caspase 3-dependent apoptosis of vascular smooth muscle cells. Atherosclerosis 160: 81-89, 2002.
21. O'Shea JJ, Watford W. A peek at PIAS. Nat Immun 5: 875-876, 2004.
22. Plosker GL, Figgitt DP. Fludarabine. Drugs 63: 2317-2323, 2003.
23. Rawlings JS, Rosler KM, Harrison DA. The JAK/STAT signaling pathway. J Cell Sci 117: 1281-1283, 2004.
24. Reich NC, Liu L. Tracking STAT nuclear traffic. Nat Rev Immunol 6: 602-612, 2006.
25. Schwartz RS, Chronos NA, Virmani R. Preclinical restenosis models and drug-eluting stents: still important, still much to learn. J Am Coll Cardiol 44: 1373-1385, 2004.
26. Seki Y, Kai H, Shibata R, Nagata T, Yasukawa H, Yoshimura A, Imaizumi T. Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injury. Circ Res 87: 12-18, 2000.
27. Serruys PW. Fourth annual American College of Cardiology international lecture: a journey in the interventional field. J Am Coll Cardiol 47: 1754-1768, 2006.
28. Serruys PW, Kutryk MJ, Ong AT. Coronary-artery stents. N Engl J Med 354: 483-495, 2006.
29. Sousa JE, Serruys PW, Costa MA. New frontiers in cardiology drug eluting stents: part I. Circulation 107: 2274-2279, 2003.
30. Sousa JE, Serruys PW, Costa MA. New frontiers in cardiology drug eluting stents: part II. Circulation 107: 2383-2389, 2003.
31. Stone GW, Ellis SG, O'Shaughnessy CD, Martin SL, Satler L, McGarry T, Turco MA, Kereiakes DJ, Kelley L, Popma JJ, Russell ME, Investigators TAXUSVISR. Paclitaxel-eluting stents vs vascular brachytherapy for in-stent restenosis within bare-metal stents: the TAXUS V ISR randomized trial. JAMA 295: 1253-1263, 2006.
32. Torella D, Leosco D, Indolfi C, Curcio A, Coppola C, Ellison GM, Russo VG, Torella M, Li Volti G, Rengo F, Chiariello M. Aging exacerbates negative remodeling and impairs endothelial regeneration after balloon injury. Am J Physiol Heart Circ Physiol 287: H2850-H2860, 2004.